Incidental Mutation 'R5802:Stk10'
ID 501565
Institutional Source Beutler Lab
Gene Symbol Stk10
Ensembl Gene ENSMUSG00000020272
Gene Name serine/threonine kinase 10
Synonyms Lok, Gek1
MMRRC Submission 043391-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # R5802 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 32483305-32574587 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 32546748 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 335 (P335L)
Ref Sequence ENSEMBL: ENSMUSP00000099885 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102821]
AlphaFold O55098
Predicted Effect probably benign
Transcript: ENSMUST00000102821
AA Change: P335L

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000099885
Gene: ENSMUSG00000020272
AA Change: P335L

DomainStartEndE-ValueType
S_TKc 36 294 8.66e-92 SMART
low complexity region 316 334 N/A INTRINSIC
low complexity region 544 577 N/A INTRINSIC
Pfam:PKK 586 724 1.9e-41 PFAM
Pfam:PKK 754 894 2.2e-37 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143397
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 97% (63/65)
MGI Phenotype FUNCTION: This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. Mice deficient for this gene product are viable, but exhibit altered integrin-mediated lymphocyte adhesion characteristics. The orthologous gene product in humans can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted disruption of this gene results in enhanced cell adhesion in mitogen-stimulated T cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik A T 1: 12,021,188 (GRCm39) D383V probably damaging Het
AAdacl4fm3 T A 4: 144,430,206 (GRCm39) D261V probably damaging Het
Abca4 A T 3: 121,847,881 (GRCm39) L67F probably damaging Het
Abcc9 C A 6: 142,602,402 (GRCm39) probably null Het
Atp2a3 T C 11: 72,863,708 (GRCm39) V175A probably damaging Het
B3galt4 T A 17: 34,169,731 (GRCm39) D169V probably damaging Het
Bsn C T 9: 107,990,208 (GRCm39) R1848Q possibly damaging Het
Camkk2 T C 5: 122,872,307 (GRCm39) E90G probably damaging Het
Cdon T A 9: 35,365,716 (GRCm39) I155N probably damaging Het
Cep70 A G 9: 99,178,458 (GRCm39) N519D probably damaging Het
Clgn T C 8: 84,152,243 (GRCm39) S582P probably damaging Het
Cnga3 T C 1: 37,300,006 (GRCm39) F280S probably damaging Het
Dennd4c C T 4: 86,729,690 (GRCm39) T764M probably benign Het
Dis3 A T 14: 99,337,100 (GRCm39) S4T probably damaging Het
Dlgap1 T C 17: 71,073,086 (GRCm39) probably null Het
Dnah17 C T 11: 117,927,272 (GRCm39) V3839I possibly damaging Het
Dnajc1 A G 2: 18,289,550 (GRCm39) Y286H probably benign Het
Dynap T A 18: 70,374,073 (GRCm39) D151V unknown Het
Ednrb A G 14: 104,059,150 (GRCm39) F292S probably damaging Het
Eef1a1 A G 9: 78,386,318 (GRCm39) S396P probably damaging Het
Fancg A G 4: 43,006,582 (GRCm39) F324S probably benign Het
Fbxw11 T A 11: 32,661,790 (GRCm39) S56T probably benign Het
Gm17535 G C 9: 3,035,758 (GRCm39) V209L probably benign Homo
Gm5592 C T 7: 40,868,529 (GRCm39) probably benign Het
Gpr137 C T 19: 6,919,373 (GRCm39) W51* probably null Het
H2-T9 A G 17: 36,422,179 (GRCm39) probably benign Het
Hbb-bs T C 7: 103,475,879 (GRCm39) Y146C probably damaging Het
Herc1 G T 9: 66,370,160 (GRCm39) C2982F probably damaging Het
Hnrnpa3 T A 2: 75,495,400 (GRCm39) N309K unknown Het
Hydin A T 8: 111,178,692 (GRCm39) I1096F possibly damaging Het
Klf12 A G 14: 100,260,330 (GRCm39) V133A probably benign Het
Lats2 A T 14: 57,931,875 (GRCm39) Y848N probably damaging Het
Loxl3 A G 6: 83,026,270 (GRCm39) T453A possibly damaging Het
Ltn1 T G 16: 87,212,569 (GRCm39) H664P probably benign Het
Lypd6 C T 2: 50,063,613 (GRCm39) T40I probably benign Het
Nbeal1 A T 1: 60,311,380 (GRCm39) T1817S probably benign Het
Nub1 A C 5: 24,907,439 (GRCm39) Y350S possibly damaging Het
Pbp2 A G 6: 135,286,874 (GRCm39) Y158H possibly damaging Het
Ptpru C T 4: 131,515,688 (GRCm39) E827K possibly damaging Het
Rap1a A G 3: 105,653,252 (GRCm39) Y32H probably damaging Het
Raph1 T C 1: 60,527,832 (GRCm39) N1143S possibly damaging Het
Rbl1 T C 2: 157,003,353 (GRCm39) T859A probably benign Het
Rom1 A G 19: 8,906,188 (GRCm39) L117P probably damaging Het
Senp6 T C 9: 80,025,926 (GRCm39) probably benign Het
Sirpb1c T C 3: 15,886,240 (GRCm39) M379V probably benign Het
Slc6a4 C T 11: 76,910,062 (GRCm39) T439M probably damaging Het
Srsf12 G T 4: 33,230,929 (GRCm39) R141L probably damaging Het
Tcstv2c G A 13: 120,616,449 (GRCm39) S96N possibly damaging Het
Tecpr1 A T 5: 144,143,364 (GRCm39) N670K probably benign Het
Tgds T C 14: 118,370,119 (GRCm39) E8G probably benign Het
Tmem129 A G 5: 33,815,060 (GRCm39) S38P probably damaging Het
Trappc9 T C 15: 72,557,188 (GRCm39) E812G probably damaging Het
Trmt10b T A 4: 45,314,236 (GRCm39) probably benign Het
Wapl A G 14: 34,414,277 (GRCm39) T380A probably damaging Het
Xylt1 A T 7: 117,255,914 (GRCm39) T829S probably benign Het
Zc3h6 C T 2: 128,857,479 (GRCm39) P666L possibly damaging Het
Zfp1010 T C 2: 176,957,049 (GRCm39) T150A possibly damaging Het
Zfp703 C T 8: 27,469,233 (GRCm39) P299L probably damaging Het
Other mutations in Stk10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01105:Stk10 APN 11 32,527,740 (GRCm39) missense probably benign 0.33
IGL01285:Stk10 APN 11 32,560,653 (GRCm39) missense possibly damaging 0.91
IGL01983:Stk10 APN 11 32,539,460 (GRCm39) missense probably benign 0.05
IGL03177:Stk10 APN 11 32,564,592 (GRCm39) missense probably damaging 1.00
IGL03183:Stk10 APN 11 32,554,143 (GRCm39) missense possibly damaging 0.50
coquet UTSW 11 32,527,764 (GRCm39) missense
legacy UTSW 11 32,554,166 (GRCm39) nonsense probably null
mignon UTSW 11 32,537,363 (GRCm39) missense probably damaging 1.00
R0481_stk10_383 UTSW 11 32,564,708 (GRCm39) missense probably damaging 1.00
FR4976:Stk10 UTSW 11 32,564,520 (GRCm39) critical splice acceptor site probably benign
R0003:Stk10 UTSW 11 32,539,460 (GRCm39) missense probably benign 0.05
R0008:Stk10 UTSW 11 32,537,305 (GRCm39) splice site probably benign
R0056:Stk10 UTSW 11 32,567,851 (GRCm39) missense possibly damaging 0.95
R0076:Stk10 UTSW 11 32,553,722 (GRCm39) missense probably benign
R0227:Stk10 UTSW 11 32,567,859 (GRCm39) missense probably damaging 1.00
R0440:Stk10 UTSW 11 32,554,190 (GRCm39) missense probably damaging 1.00
R0454:Stk10 UTSW 11 32,546,724 (GRCm39) missense probably damaging 0.99
R0481:Stk10 UTSW 11 32,564,708 (GRCm39) missense probably damaging 1.00
R0504:Stk10 UTSW 11 32,567,882 (GRCm39) missense probably benign 0.04
R0790:Stk10 UTSW 11 32,548,653 (GRCm39) missense probably benign 0.00
R1439:Stk10 UTSW 11 32,567,919 (GRCm39) missense probably damaging 0.98
R1539:Stk10 UTSW 11 32,483,440 (GRCm39) missense possibly damaging 0.85
R1770:Stk10 UTSW 11 32,572,464 (GRCm39) missense possibly damaging 0.94
R4304:Stk10 UTSW 11 32,560,634 (GRCm39) missense probably damaging 0.97
R4430:Stk10 UTSW 11 32,483,552 (GRCm39) missense possibly damaging 0.81
R4702:Stk10 UTSW 11 32,505,172 (GRCm39) missense probably benign 0.28
R4797:Stk10 UTSW 11 32,548,471 (GRCm39) missense probably benign 0.01
R5447:Stk10 UTSW 11 32,554,166 (GRCm39) nonsense probably null
R5801:Stk10 UTSW 11 32,546,748 (GRCm39) missense probably benign 0.01
R6129:Stk10 UTSW 11 32,565,871 (GRCm39) missense probably damaging 1.00
R6154:Stk10 UTSW 11 32,553,654 (GRCm39) splice site probably null
R6175:Stk10 UTSW 11 32,553,761 (GRCm39) missense possibly damaging 0.46
R6185:Stk10 UTSW 11 32,527,749 (GRCm39) missense probably benign 0.13
R6520:Stk10 UTSW 11 32,538,839 (GRCm39) missense probably damaging 1.00
R6824:Stk10 UTSW 11 32,537,363 (GRCm39) missense probably damaging 1.00
R7259:Stk10 UTSW 11 32,548,497 (GRCm39) missense probably benign 0.00
R7649:Stk10 UTSW 11 32,527,764 (GRCm39) missense
R8331:Stk10 UTSW 11 32,538,928 (GRCm39) missense
R8847:Stk10 UTSW 11 32,539,427 (GRCm39) missense
R9252:Stk10 UTSW 11 32,538,915 (GRCm39) missense
R9367:Stk10 UTSW 11 32,538,878 (GRCm39) missense
X0027:Stk10 UTSW 11 32,537,361 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CCAGAGTTGTTCCTCGTTGC -3'
(R):5'- GCATGCTCCAGAACTTAGACC -3'

Sequencing Primer
(F):5'- TCGTTGCTTCAGGACCAAG -3'
(R):5'- AACTTAGACCTGGCCAGTTG -3'
Posted On 2017-12-01