Incidental Mutation 'R8921:Rapgef6'
| ID |
679267 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rapgef6
|
| Ensembl Gene |
ENSMUSG00000037533 |
| Gene Name |
Rap guanine nucleotide exchange factor (GEF) 6 |
| Synonyms |
PDZ-GEF2, C030018K18Rik, Pdzgef2, RA-GEF-2 |
| MMRRC Submission |
068707-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8921 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
54413673-54590111 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 54570065 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Serine
at position 1146
(L1146S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000147135
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094536]
[ENSMUST00000101206]
[ENSMUST00000102743]
[ENSMUST00000108894]
[ENSMUST00000207429]
|
| AlphaFold |
Q5NCJ1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094536
AA Change: L856S
PolyPhen 2
Score 0.086 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000092114
Gene: ENSMUSG00000037533
AA Change: L856S
| Domain | Start | End | E-Value | Type |
|---|
|
cNMP
|
1 |
113 |
6.64e-7 |
SMART |
|
RasGEFN
|
127 |
240 |
4.35e-33 |
SMART |
|
PDZ
|
255 |
327 |
8.86e-16 |
SMART |
|
low complexity region
|
409 |
420 |
N/A |
INTRINSIC |
|
RA
|
464 |
550 |
1.47e-20 |
SMART |
|
RasGEF
|
571 |
853 |
3.88e-84 |
SMART |
|
low complexity region
|
944 |
957 |
N/A |
INTRINSIC |
|
low complexity region
|
972 |
989 |
N/A |
INTRINSIC |
|
low complexity region
|
1016 |
1061 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000101206
AA Change: L1149S
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000098766
Gene: ENSMUSG00000037533
AA Change: L1149S
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
10 |
82 |
1.45e-5 |
PROSPERO |
|
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
|
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
|
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
|
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
|
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
|
RA
|
749 |
835 |
1.47e-20 |
SMART |
|
RasGEF
|
856 |
1095 |
5.35e-87 |
SMART |
|
low complexity region
|
1237 |
1250 |
N/A |
INTRINSIC |
|
low complexity region
|
1270 |
1293 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1364 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1380 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1452 |
N/A |
INTRINSIC |
|
low complexity region
|
1555 |
1568 |
N/A |
INTRINSIC |
|
low complexity region
|
1591 |
1604 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000099804
Gene: ENSMUSG00000037533
AA Change: L1141S
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
10 |
82 |
1.42e-5 |
PROSPERO |
|
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
|
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
|
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
|
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
|
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
|
RA
|
749 |
835 |
1.47e-20 |
SMART |
|
RasGEF
|
856 |
1138 |
3.88e-84 |
SMART |
|
low complexity region
|
1229 |
1242 |
N/A |
INTRINSIC |
|
low complexity region
|
1262 |
1285 |
N/A |
INTRINSIC |
|
low complexity region
|
1337 |
1356 |
N/A |
INTRINSIC |
|
low complexity region
|
1360 |
1372 |
N/A |
INTRINSIC |
|
low complexity region
|
1436 |
1444 |
N/A |
INTRINSIC |
|
low complexity region
|
1547 |
1560 |
N/A |
INTRINSIC |
|
low complexity region
|
1583 |
1596 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000108894
AA Change: L864S
PolyPhen 2
Score 0.730 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000104522
Gene: ENSMUSG00000037533
AA Change: L864S
| Domain | Start | End | E-Value | Type |
|---|
|
cNMP
|
1 |
113 |
6.64e-7 |
SMART |
|
RasGEFN
|
127 |
240 |
4.35e-33 |
SMART |
|
PDZ
|
255 |
327 |
8.86e-16 |
SMART |
|
low complexity region
|
409 |
420 |
N/A |
INTRINSIC |
|
RA
|
464 |
550 |
1.47e-20 |
SMART |
|
RasGEF
|
571 |
810 |
5.35e-87 |
SMART |
|
low complexity region
|
952 |
965 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
997 |
N/A |
INTRINSIC |
|
low complexity region
|
1024 |
1069 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000207429
AA Change: L1146S
PolyPhen 2
Score 0.086 (Sensitivity: 0.93; Specificity: 0.85)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (79/79) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele exhibit an inlarged spleen, increased IgE and IgG levels and altered cytokine production. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(16) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(13) |
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921536K21Rik |
T |
A |
11: 3,844,933 (GRCm39) |
E52V |
probably benign |
Het |
| 4930516K23Rik |
G |
A |
7: 103,708,083 (GRCm39) |
T242M |
probably damaging |
Het |
| Abcg5 |
T |
A |
17: 84,990,253 (GRCm39) |
I17F |
probably benign |
Het |
| Adam25 |
T |
A |
8: 41,207,710 (GRCm39) |
Y325* |
probably null |
Het |
| Adamts16 |
C |
T |
13: 70,939,910 (GRCm39) |
|
probably benign |
Het |
| Akr1b1 |
A |
T |
6: 34,289,639 (GRCm39) |
V57E |
probably benign |
Het |
| Api5 |
A |
G |
2: 94,255,374 (GRCm39) |
L267P |
probably damaging |
Het |
| Asap3 |
T |
C |
4: 135,963,726 (GRCm39) |
Y329H |
probably benign |
Het |
| Atp13a4 |
C |
T |
16: 29,273,592 (GRCm39) |
R442K |
|
Het |
| Cadps2 |
T |
C |
6: 23,302,300 (GRCm39) |
D1129G |
probably benign |
Het |
| Cd79b |
T |
A |
11: 106,203,632 (GRCm39) |
Q145L |
probably benign |
Het |
| Cdh23 |
C |
T |
10: 60,140,908 (GRCm39) |
E3147K |
probably damaging |
Het |
| Cfap251 |
A |
G |
5: 123,424,481 (GRCm39) |
D722G |
possibly damaging |
Het |
| Col4a4 |
A |
G |
1: 82,431,533 (GRCm39) |
W1584R |
unknown |
Het |
| Cops8 |
T |
C |
1: 90,532,155 (GRCm39) |
L46P |
probably damaging |
Het |
| Cpne1 |
T |
C |
2: 155,913,965 (GRCm39) |
Y146C |
probably benign |
Het |
| Ctdnep1 |
T |
A |
11: 69,875,311 (GRCm39) |
V80E |
probably damaging |
Het |
| Cttnbp2 |
A |
G |
6: 18,434,877 (GRCm39) |
I327T |
probably benign |
Het |
| Cyp4a32 |
T |
C |
4: 115,468,460 (GRCm39) |
V314A |
probably damaging |
Het |
| Dlgap3 |
C |
A |
4: 127,127,463 (GRCm39) |
H710Q |
probably damaging |
Het |
| Dnah9 |
T |
C |
11: 65,802,747 (GRCm39) |
M3448V |
probably benign |
Het |
| E030018B13Rik |
C |
A |
7: 63,569,727 (GRCm39) |
Q84K |
unknown |
Het |
| Efna5 |
A |
G |
17: 63,188,053 (GRCm39) |
S25P |
possibly damaging |
Het |
| Egfl8 |
T |
G |
17: 34,833,751 (GRCm39) |
T76P |
probably damaging |
Het |
| Endod1 |
A |
G |
9: 14,268,942 (GRCm39) |
L181P |
probably damaging |
Het |
| Epha3 |
A |
G |
16: 63,472,838 (GRCm39) |
L349P |
possibly damaging |
Het |
| Fam161b |
T |
A |
12: 84,395,056 (GRCm39) |
T553S |
probably benign |
Het |
| Fmnl1 |
T |
C |
11: 103,087,967 (GRCm39) |
F981L |
unknown |
Het |
| Galr2 |
T |
A |
11: 116,173,973 (GRCm39) |
V201E |
probably damaging |
Het |
| Gpr137b |
T |
C |
13: 13,533,991 (GRCm39) |
Y355C |
|
Het |
| Greb1l |
T |
C |
18: 10,541,825 (GRCm39) |
S1191P |
probably benign |
Het |
| Hmg20b |
T |
C |
10: 81,184,821 (GRCm39) |
R84G |
probably damaging |
Het |
| Inppl1 |
T |
C |
7: 101,472,593 (GRCm39) |
D1234G |
possibly damaging |
Het |
| Insl5 |
A |
G |
4: 102,883,760 (GRCm39) |
S54P |
probably damaging |
Het |
| Itpr1 |
T |
A |
6: 108,355,159 (GRCm39) |
F483L |
possibly damaging |
Het |
| Kif21a |
T |
C |
15: 90,855,930 (GRCm39) |
E609G |
probably benign |
Het |
| Kpna7 |
A |
T |
5: 144,941,840 (GRCm39) |
V150D |
probably damaging |
Het |
| L1td1 |
T |
A |
4: 98,622,175 (GRCm39) |
C246S |
possibly damaging |
Het |
| Laptm4a |
T |
A |
12: 8,988,139 (GRCm39) |
M292K |
possibly damaging |
Het |
| Lefty2 |
C |
G |
1: 180,725,043 (GRCm39) |
P258A |
possibly damaging |
Het |
| Map4k1 |
G |
A |
7: 28,701,052 (GRCm39) |
V719M |
probably damaging |
Het |
| Nbas |
T |
A |
12: 13,463,590 (GRCm39) |
H1292Q |
probably benign |
Het |
| Nfkbia |
C |
T |
12: 55,537,340 (GRCm39) |
G250S |
probably damaging |
Het |
| Nkain3 |
T |
C |
4: 20,245,902 (GRCm39) |
T163A |
unknown |
Het |
| Npcd |
T |
C |
15: 79,713,163 (GRCm39) |
E88G |
probably benign |
Het |
| Oas1f |
A |
T |
5: 120,989,556 (GRCm39) |
Y165F |
probably benign |
Het |
| Or10d4 |
T |
A |
9: 39,580,737 (GRCm39) |
L128* |
probably null |
Het |
| Or51aa5 |
A |
G |
7: 103,167,030 (GRCm39) |
I187T |
possibly damaging |
Het |
| Or52e2 |
T |
C |
7: 102,804,660 (GRCm39) |
D98G |
probably benign |
Het |
| Phtf2 |
T |
C |
5: 21,008,275 (GRCm39) |
I135M |
probably benign |
Het |
| Pi4ka |
T |
C |
16: 17,125,604 (GRCm39) |
E1177G |
|
Het |
| Polr3gl |
A |
T |
3: 96,485,833 (GRCm39) |
D214E |
probably damaging |
Het |
| Pramel25 |
C |
T |
4: 143,519,322 (GRCm39) |
Q28* |
probably null |
Het |
| Pramel51 |
T |
C |
12: 88,143,952 (GRCm39) |
E295G |
probably benign |
Het |
| Prkar1a |
C |
A |
11: 109,556,744 (GRCm39) |
Q275K |
probably benign |
Het |
| Ptprc |
A |
G |
1: 138,054,039 (GRCm39) |
|
probably null |
Het |
| Pwwp2a |
C |
A |
11: 43,596,344 (GRCm39) |
P503Q |
probably damaging |
Het |
| Rad17 |
T |
C |
13: 100,754,192 (GRCm39) |
|
probably benign |
Het |
| Rara |
C |
A |
11: 98,864,452 (GRCm39) |
Q460K |
unknown |
Het |
| Rassf4 |
C |
T |
6: 116,638,897 (GRCm39) |
|
probably benign |
Het |
| Rere |
A |
G |
4: 150,696,471 (GRCm39) |
D492G |
unknown |
Het |
| Selenon |
T |
G |
4: 134,268,153 (GRCm39) |
K460T |
possibly damaging |
Het |
| Sh2b1 |
TGGGGACCAGCTCAGCCACGGGGACCAGCTC |
TGGGGACCAGCTCAGCCACGGGGACCAGCTCAGCCACGGGGACCAGCTC |
7: 126,066,742 (GRCm39) |
|
probably benign |
Het |
| Slc35e1 |
T |
C |
8: 73,241,988 (GRCm39) |
T245A |
probably benign |
Het |
| Stat4 |
C |
T |
1: 52,144,892 (GRCm39) |
A726V |
probably benign |
Het |
| Stim1 |
G |
T |
7: 102,070,597 (GRCm39) |
V277L |
probably damaging |
Het |
| Strbp |
A |
G |
2: 37,514,503 (GRCm39) |
|
probably null |
Het |
| Tln2 |
T |
C |
9: 67,174,105 (GRCm39) |
Y860C |
probably damaging |
Het |
| Tmod4 |
T |
A |
3: 95,033,289 (GRCm39) |
|
probably null |
Het |
| Tpm3-rs7 |
T |
C |
14: 113,552,493 (GRCm39) |
V129A |
probably benign |
Het |
| Trp53bp2 |
C |
T |
1: 182,273,971 (GRCm39) |
P41S |
|
Het |
| Tubal3 |
G |
A |
13: 3,983,428 (GRCm39) |
D403N |
probably damaging |
Het |
| Zfp369 |
T |
C |
13: 65,444,044 (GRCm39) |
S396P |
possibly damaging |
Het |
| Zfp976 |
G |
A |
7: 42,262,575 (GRCm39) |
H422Y |
possibly damaging |
Het |
|
| Other mutations in Rapgef6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00436:Rapgef6
|
APN |
11 |
54,570,091 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00507:Rapgef6
|
APN |
11 |
54,554,935 (GRCm39) |
nonsense |
probably null |
|
|
IGL00809:Rapgef6
|
APN |
11 |
54,540,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00843:Rapgef6
|
APN |
11 |
54,582,099 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00899:Rapgef6
|
APN |
11 |
54,510,844 (GRCm39) |
nonsense |
probably null |
|
|
IGL01372:Rapgef6
|
APN |
11 |
54,559,437 (GRCm39) |
splice site |
probably benign |
|
|
IGL01604:Rapgef6
|
APN |
11 |
54,585,389 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01935:Rapgef6
|
APN |
11 |
54,501,668 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL01991:Rapgef6
|
APN |
11 |
54,443,695 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL02243:Rapgef6
|
APN |
11 |
54,567,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02407:Rapgef6
|
APN |
11 |
54,567,181 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02676:Rapgef6
|
APN |
11 |
54,540,172 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02934:Rapgef6
|
APN |
11 |
54,516,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03076:Rapgef6
|
APN |
11 |
54,516,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03110:Rapgef6
|
APN |
11 |
54,586,915 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03256:Rapgef6
|
APN |
11 |
54,548,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
shocker
|
UTSW |
11 |
54,510,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
D4216:Rapgef6
|
UTSW |
11 |
54,559,572 (GRCm39) |
splice site |
probably benign |
|
|
PIT4305001:Rapgef6
|
UTSW |
11 |
54,570,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4366001:Rapgef6
|
UTSW |
11 |
54,582,446 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0047:Rapgef6
|
UTSW |
11 |
54,437,204 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0047:Rapgef6
|
UTSW |
11 |
54,437,204 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0125:Rapgef6
|
UTSW |
11 |
54,516,701 (GRCm39) |
nonsense |
probably null |
|
|
R0189:Rapgef6
|
UTSW |
11 |
54,582,075 (GRCm39) |
missense |
probably benign |
|
|
R0201:Rapgef6
|
UTSW |
11 |
54,510,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Rapgef6
|
UTSW |
11 |
54,516,789 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0524:Rapgef6
|
UTSW |
11 |
54,581,110 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0853:Rapgef6
|
UTSW |
11 |
54,559,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1203:Rapgef6
|
UTSW |
11 |
54,582,525 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1440:Rapgef6
|
UTSW |
11 |
54,517,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1453:Rapgef6
|
UTSW |
11 |
54,530,553 (GRCm39) |
splice site |
probably null |
|
|
R1530:Rapgef6
|
UTSW |
11 |
54,552,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1593:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1620:Rapgef6
|
UTSW |
11 |
54,517,420 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1628:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1629:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1630:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1634:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1640:Rapgef6
|
UTSW |
11 |
54,548,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1686:Rapgef6
|
UTSW |
11 |
54,582,458 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1722:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1743:Rapgef6
|
UTSW |
11 |
54,567,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1816:Rapgef6
|
UTSW |
11 |
54,585,314 (GRCm39) |
missense |
probably benign |
|
|
R1851:Rapgef6
|
UTSW |
11 |
54,533,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1852:Rapgef6
|
UTSW |
11 |
54,533,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1868:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1888:Rapgef6
|
UTSW |
11 |
54,551,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Rapgef6
|
UTSW |
11 |
54,551,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1942:Rapgef6
|
UTSW |
11 |
54,548,089 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1943:Rapgef6
|
UTSW |
11 |
54,548,089 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2031:Rapgef6
|
UTSW |
11 |
54,443,684 (GRCm39) |
missense |
probably benign |
0.30 |
|
R2087:Rapgef6
|
UTSW |
11 |
54,522,075 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2106:Rapgef6
|
UTSW |
11 |
54,559,512 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2362:Rapgef6
|
UTSW |
11 |
54,585,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2484:Rapgef6
|
UTSW |
11 |
54,533,582 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2566:Rapgef6
|
UTSW |
11 |
54,578,537 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2872:Rapgef6
|
UTSW |
11 |
54,552,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2872:Rapgef6
|
UTSW |
11 |
54,552,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3744:Rapgef6
|
UTSW |
11 |
54,516,760 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3848:Rapgef6
|
UTSW |
11 |
54,582,134 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4823:Rapgef6
|
UTSW |
11 |
54,585,326 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4859:Rapgef6
|
UTSW |
11 |
54,526,989 (GRCm39) |
missense |
probably benign |
|
|
R4906:Rapgef6
|
UTSW |
11 |
54,443,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4911:Rapgef6
|
UTSW |
11 |
54,513,143 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4937:Rapgef6
|
UTSW |
11 |
54,548,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5033:Rapgef6
|
UTSW |
11 |
54,582,207 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5249:Rapgef6
|
UTSW |
11 |
54,413,943 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5304:Rapgef6
|
UTSW |
11 |
54,548,200 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5656:Rapgef6
|
UTSW |
11 |
54,526,962 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5701:Rapgef6
|
UTSW |
11 |
54,567,220 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5758:Rapgef6
|
UTSW |
11 |
54,559,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5973:Rapgef6
|
UTSW |
11 |
54,530,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6177:Rapgef6
|
UTSW |
11 |
54,510,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6268:Rapgef6
|
UTSW |
11 |
54,540,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6287:Rapgef6
|
UTSW |
11 |
54,517,164 (GRCm39) |
splice site |
probably null |
|
|
R6293:Rapgef6
|
UTSW |
11 |
54,525,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6471:Rapgef6
|
UTSW |
11 |
54,582,563 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6863:Rapgef6
|
UTSW |
11 |
54,437,206 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6950:Rapgef6
|
UTSW |
11 |
54,567,206 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7144:Rapgef6
|
UTSW |
11 |
54,548,191 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7171:Rapgef6
|
UTSW |
11 |
54,567,189 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7199:Rapgef6
|
UTSW |
11 |
54,437,252 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7291:Rapgef6
|
UTSW |
11 |
54,582,065 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7436:Rapgef6
|
UTSW |
11 |
54,501,747 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7498:Rapgef6
|
UTSW |
11 |
54,510,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7506:Rapgef6
|
UTSW |
11 |
54,526,997 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7527:Rapgef6
|
UTSW |
11 |
54,525,787 (GRCm39) |
missense |
unknown |
|
|
R7646:Rapgef6
|
UTSW |
11 |
54,516,780 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7655:Rapgef6
|
UTSW |
11 |
54,585,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7656:Rapgef6
|
UTSW |
11 |
54,585,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7687:Rapgef6
|
UTSW |
11 |
54,551,901 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7768:Rapgef6
|
UTSW |
11 |
54,517,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7788:Rapgef6
|
UTSW |
11 |
54,585,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7890:Rapgef6
|
UTSW |
11 |
54,517,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8113:Rapgef6
|
UTSW |
11 |
54,516,784 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8337:Rapgef6
|
UTSW |
11 |
54,522,127 (GRCm39) |
nonsense |
probably null |
|
|
R8393:Rapgef6
|
UTSW |
11 |
54,578,487 (GRCm39) |
missense |
probably benign |
|
|
R8465:Rapgef6
|
UTSW |
11 |
54,582,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8492:Rapgef6
|
UTSW |
11 |
54,581,063 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8791:Rapgef6
|
UTSW |
11 |
54,459,295 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8866:Rapgef6
|
UTSW |
11 |
54,443,700 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8917:Rapgef6
|
UTSW |
11 |
54,582,392 (GRCm39) |
nonsense |
probably null |
|
|
R9031:Rapgef6
|
UTSW |
11 |
54,578,667 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9093:Rapgef6
|
UTSW |
11 |
54,487,912 (GRCm39) |
nonsense |
probably null |
|
|
R9354:Rapgef6
|
UTSW |
11 |
54,510,749 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9514:Rapgef6
|
UTSW |
11 |
54,443,684 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9516:Rapgef6
|
UTSW |
11 |
54,582,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9739:Rapgef6
|
UTSW |
11 |
54,513,189 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9789:Rapgef6
|
UTSW |
11 |
54,540,097 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACTTGGCCTCAGGAGACAG -3'
(R):5'- AGCACATGGTCTTTGGCTTGTC -3'
Sequencing Primer
(F):5'- CTTGGCCTCAGGAGACAGATAATG -3'
(R):5'- CCTTTCTTCCGGATGGGG -3'
|
| Posted On |
2021-08-02 |
Incidental Mutation