Incidental Mutation 'R9789:Rapgef6'
| ID |
734543 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rapgef6
|
| Ensembl Gene |
ENSMUSG00000037533 |
| Gene Name |
Rap guanine nucleotide exchange factor (GEF) 6 |
| Synonyms |
PDZ-GEF2, C030018K18Rik, Pdzgef2, RA-GEF-2 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9789 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
54413673-54590111 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 54540097 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Lysine
at position 724
(T724K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000147135
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094536]
[ENSMUST00000101206]
[ENSMUST00000102743]
[ENSMUST00000108894]
[ENSMUST00000207429]
[ENSMUST00000218995]
|
| AlphaFold |
Q5NCJ1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094536
AA Change: T439K
PolyPhen 2
Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000092114
Gene: ENSMUSG00000037533
AA Change: T439K
| Domain | Start | End | E-Value | Type |
|---|
|
cNMP
|
1 |
113 |
6.64e-7 |
SMART |
|
RasGEFN
|
127 |
240 |
4.35e-33 |
SMART |
|
PDZ
|
255 |
327 |
8.86e-16 |
SMART |
|
low complexity region
|
409 |
420 |
N/A |
INTRINSIC |
|
RA
|
464 |
550 |
1.47e-20 |
SMART |
|
RasGEF
|
571 |
853 |
3.88e-84 |
SMART |
|
low complexity region
|
944 |
957 |
N/A |
INTRINSIC |
|
low complexity region
|
972 |
989 |
N/A |
INTRINSIC |
|
low complexity region
|
1016 |
1061 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000101206
AA Change: T724K
PolyPhen 2
Score 0.798 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000098766
Gene: ENSMUSG00000037533
AA Change: T724K
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
10 |
82 |
1.45e-5 |
PROSPERO |
|
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
|
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
|
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
|
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
|
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
|
RA
|
749 |
835 |
1.47e-20 |
SMART |
|
RasGEF
|
856 |
1095 |
5.35e-87 |
SMART |
|
low complexity region
|
1237 |
1250 |
N/A |
INTRINSIC |
|
low complexity region
|
1270 |
1293 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1364 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1380 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1452 |
N/A |
INTRINSIC |
|
low complexity region
|
1555 |
1568 |
N/A |
INTRINSIC |
|
low complexity region
|
1591 |
1604 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000102743
AA Change: T724K
PolyPhen 2
Score 0.798 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000099804
Gene: ENSMUSG00000037533
AA Change: T724K
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
10 |
82 |
1.42e-5 |
PROSPERO |
|
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
|
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
|
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
|
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
|
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
|
RA
|
749 |
835 |
1.47e-20 |
SMART |
|
RasGEF
|
856 |
1138 |
3.88e-84 |
SMART |
|
low complexity region
|
1229 |
1242 |
N/A |
INTRINSIC |
|
low complexity region
|
1262 |
1285 |
N/A |
INTRINSIC |
|
low complexity region
|
1337 |
1356 |
N/A |
INTRINSIC |
|
low complexity region
|
1360 |
1372 |
N/A |
INTRINSIC |
|
low complexity region
|
1436 |
1444 |
N/A |
INTRINSIC |
|
low complexity region
|
1547 |
1560 |
N/A |
INTRINSIC |
|
low complexity region
|
1583 |
1596 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000108894
AA Change: T439K
PolyPhen 2
Score 0.654 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000104522
Gene: ENSMUSG00000037533
AA Change: T439K
| Domain | Start | End | E-Value | Type |
|---|
|
cNMP
|
1 |
113 |
6.64e-7 |
SMART |
|
RasGEFN
|
127 |
240 |
4.35e-33 |
SMART |
|
PDZ
|
255 |
327 |
8.86e-16 |
SMART |
|
low complexity region
|
409 |
420 |
N/A |
INTRINSIC |
|
RA
|
464 |
550 |
1.47e-20 |
SMART |
|
RasGEF
|
571 |
810 |
5.35e-87 |
SMART |
|
low complexity region
|
952 |
965 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
997 |
N/A |
INTRINSIC |
|
low complexity region
|
1024 |
1069 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000207429
AA Change: T724K
PolyPhen 2
Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000218995
AA Change: T577K
PolyPhen 2
Score 0.786 (Sensitivity: 0.85; Specificity: 0.93)
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.8%
- 10x: 99.5%
- 20x: 98.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele exhibit an inlarged spleen, increased IgE and IgG levels and altered cytokine production. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(16) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(13) |
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
T |
A |
12: 71,231,357 (GRCm39) |
S1038R |
probably benign |
Het |
| Aar2 |
T |
C |
2: 156,392,745 (GRCm39) |
F45L |
probably damaging |
Het |
| Abcg2 |
A |
G |
6: 58,641,533 (GRCm39) |
Y122C |
probably damaging |
Het |
| Arfgef1 |
A |
T |
1: 10,243,427 (GRCm39) |
W1041R |
probably damaging |
Het |
| Ash1l |
A |
G |
3: 88,873,373 (GRCm39) |
N52S |
probably benign |
Het |
| Asrgl1 |
T |
A |
19: 9,093,974 (GRCm39) |
T185S |
probably damaging |
Het |
| Astl |
T |
A |
2: 127,192,146 (GRCm39) |
S234T |
probably damaging |
Het |
| Atp5mf |
T |
C |
5: 145,120,656 (GRCm39) |
Y87C |
probably damaging |
Het |
| Atxn7l1 |
A |
T |
12: 33,396,062 (GRCm39) |
R264W |
probably damaging |
Het |
| Axin2 |
T |
C |
11: 108,840,180 (GRCm39) |
Y828H |
probably damaging |
Het |
| Bnipl |
T |
C |
3: 95,153,140 (GRCm39) |
D145G |
possibly damaging |
Het |
| C8b |
A |
T |
4: 104,640,191 (GRCm39) |
M165L |
probably benign |
Het |
| Cd109 |
T |
C |
9: 78,541,944 (GRCm39) |
L87P |
possibly damaging |
Het |
| Cdk17 |
C |
T |
10: 93,060,891 (GRCm39) |
P232S |
probably damaging |
Het |
| Cnot1 |
T |
C |
8: 96,455,772 (GRCm39) |
E1995G |
probably damaging |
Het |
| Csf2rb2 |
G |
A |
15: 78,169,196 (GRCm39) |
A653V |
probably benign |
Het |
| Cutc |
A |
G |
19: 43,756,699 (GRCm39) |
N264D |
probably benign |
Het |
| Cxcr4 |
C |
T |
1: 128,516,884 (GRCm39) |
W259* |
probably null |
Het |
| Dnah8 |
T |
C |
17: 30,980,104 (GRCm39) |
|
probably null |
Het |
| Dsp |
T |
C |
13: 38,367,937 (GRCm39) |
I652T |
probably benign |
Het |
| Dstyk |
A |
T |
1: 132,381,859 (GRCm39) |
M538L |
probably benign |
Het |
| Eppk1 |
T |
A |
15: 75,993,219 (GRCm39) |
I1221F |
probably benign |
Het |
| Ern2 |
T |
A |
7: 121,769,485 (GRCm39) |
Y847F |
probably damaging |
Het |
| Exosc7 |
T |
A |
9: 122,959,990 (GRCm39) |
V197D |
probably damaging |
Het |
| Gabra1 |
T |
C |
11: 42,024,352 (GRCm39) |
Y441C |
probably damaging |
Het |
| Garem1 |
G |
A |
18: 21,262,985 (GRCm39) |
P610S |
possibly damaging |
Het |
| Garem2 |
T |
A |
5: 30,319,330 (GRCm39) |
V264E |
probably damaging |
Het |
| Gata2 |
G |
A |
6: 88,177,272 (GRCm39) |
G101S |
probably benign |
Het |
| Gcnt4 |
A |
G |
13: 97,083,429 (GRCm39) |
T242A |
probably benign |
Het |
| Ghitm |
A |
C |
14: 36,852,719 (GRCm39) |
Y120* |
probably null |
Het |
| Gimap7 |
A |
G |
6: 48,700,470 (GRCm39) |
S19G |
probably damaging |
Het |
| Gm5475 |
G |
A |
15: 100,324,881 (GRCm39) |
G103E |
unknown |
Het |
| Gstcd |
A |
T |
3: 132,790,357 (GRCm39) |
C137S |
probably damaging |
Het |
| Gtf2b |
AATCATC |
AATC |
3: 142,477,178 (GRCm39) |
|
probably benign |
Het |
| Hfm1 |
T |
C |
5: 107,065,346 (GRCm39) |
D111G |
probably benign |
Het |
| Ighg2b |
A |
G |
12: 113,270,304 (GRCm39) |
I238T |
|
Het |
| Il2ra |
A |
C |
2: 11,685,161 (GRCm39) |
M166L |
probably benign |
Het |
| Itga1 |
A |
T |
13: 115,171,820 (GRCm39) |
L95* |
probably null |
Het |
| Itpr3 |
A |
G |
17: 27,308,915 (GRCm39) |
T373A |
probably benign |
Het |
| Klhl28 |
A |
G |
12: 64,996,871 (GRCm39) |
V490A |
probably damaging |
Het |
| Kntc1 |
A |
T |
5: 123,898,706 (GRCm39) |
N200I |
possibly damaging |
Het |
| L3mbtl4 |
A |
G |
17: 68,766,794 (GRCm39) |
K167R |
probably benign |
Het |
| Lgals1 |
A |
T |
15: 78,813,930 (GRCm39) |
T63S |
probably benign |
Het |
| Lnpep |
C |
A |
17: 17,795,596 (GRCm39) |
C305F |
probably damaging |
Het |
| Mcm5 |
C |
T |
8: 75,844,168 (GRCm39) |
S313F |
probably benign |
Het |
| Mcmbp |
A |
G |
7: 128,311,583 (GRCm39) |
I310T |
possibly damaging |
Het |
| Mical2 |
G |
A |
7: 111,945,996 (GRCm39) |
R986H |
probably damaging |
Het |
| Muc5b |
A |
T |
7: 141,415,330 (GRCm39) |
S2759C |
possibly damaging |
Het |
| Myh7 |
A |
G |
14: 55,229,384 (GRCm39) |
V138A |
possibly damaging |
Het |
| Ncr1 |
T |
G |
7: 4,344,300 (GRCm39) |
|
probably null |
Het |
| Ndufa10 |
A |
T |
1: 92,397,610 (GRCm39) |
D145E |
possibly damaging |
Het |
| Neo1 |
T |
A |
9: 58,801,307 (GRCm39) |
|
probably null |
Het |
| Ninl |
A |
T |
2: 150,791,701 (GRCm39) |
S941T |
probably benign |
Het |
| Nrm |
T |
A |
17: 36,172,411 (GRCm39) |
|
probably null |
Het |
| Nup214 |
T |
C |
2: 31,907,227 (GRCm39) |
V1018A |
possibly damaging |
Het |
| Odf1 |
A |
G |
15: 38,219,716 (GRCm39) |
I15V |
probably benign |
Het |
| Or10al2 |
T |
A |
17: 37,983,059 (GRCm39) |
N48K |
probably damaging |
Het |
| Or10j7 |
C |
T |
1: 173,011,458 (GRCm39) |
R181H |
probably benign |
Het |
| Or1e1c |
A |
T |
11: 73,265,710 (GRCm39) |
N48I |
probably damaging |
Het |
| Or4b1d |
T |
A |
2: 89,969,004 (GRCm39) |
T160S |
probably benign |
Het |
| Or52e18 |
A |
T |
7: 104,609,657 (GRCm39) |
I94N |
probably damaging |
Het |
| Or5m10 |
C |
T |
2: 85,717,338 (GRCm39) |
H65Y |
probably damaging |
Het |
| Or5p66 |
A |
T |
7: 107,885,898 (GRCm39) |
V145D |
probably benign |
Het |
| Or7g32 |
C |
A |
9: 19,389,382 (GRCm39) |
D55Y |
probably benign |
Het |
| Osgin2 |
A |
T |
4: 15,998,957 (GRCm39) |
Y222N |
probably damaging |
Het |
| Pcdhga10 |
T |
C |
18: 37,882,363 (GRCm39) |
V708A |
probably benign |
Het |
| Pfn3 |
T |
C |
13: 55,562,900 (GRCm39) |
D27G |
possibly damaging |
Het |
| Plch2 |
A |
G |
4: 155,095,322 (GRCm39) |
|
probably null |
Het |
| Plin2 |
C |
A |
4: 86,576,914 (GRCm39) |
Q270H |
probably damaging |
Het |
| Polk |
A |
G |
13: 96,630,403 (GRCm39) |
F386S |
probably damaging |
Het |
| Prkar1a |
G |
A |
11: 109,556,778 (GRCm39) |
G286E |
probably damaging |
Het |
| Prodh |
A |
T |
16: 17,898,049 (GRCm39) |
L276Q |
probably damaging |
Het |
| Ranbp10 |
T |
C |
8: 106,513,306 (GRCm39) |
N202S |
probably damaging |
Het |
| Rnf144a |
T |
A |
12: 26,377,574 (GRCm39) |
K56N |
probably benign |
Het |
| Rpa1 |
T |
A |
11: 75,203,938 (GRCm39) |
K303I |
probably damaging |
Het |
| Slc16a9 |
A |
C |
10: 70,118,340 (GRCm39) |
N220H |
possibly damaging |
Het |
| Slc28a3 |
T |
C |
13: 58,724,664 (GRCm39) |
I197V |
probably benign |
Het |
| Slc35d1 |
A |
T |
4: 103,071,946 (GRCm39) |
F19I |
|
Het |
| Sohlh2 |
A |
T |
3: 55,099,721 (GRCm39) |
E164D |
probably damaging |
Het |
| Sord |
A |
T |
2: 122,093,765 (GRCm39) |
K295* |
probably null |
Het |
| Spata31d1b |
A |
G |
13: 59,860,196 (GRCm39) |
Y23C |
probably benign |
Het |
| Stard9 |
T |
A |
2: 120,510,417 (GRCm39) |
Y333N |
probably damaging |
Het |
| Tas2r107 |
A |
G |
6: 131,636,753 (GRCm39) |
F99L |
probably damaging |
Het |
| Thap12 |
C |
T |
7: 98,352,592 (GRCm39) |
|
probably benign |
Het |
| Tmprss9 |
A |
T |
10: 80,730,993 (GRCm39) |
T840S |
probably benign |
Het |
| Trim16 |
T |
A |
11: 62,720,026 (GRCm39) |
|
probably null |
Het |
| Ttc16 |
C |
T |
2: 32,664,805 (GRCm39) |
|
probably null |
Het |
| Ttn |
C |
T |
2: 76,715,357 (GRCm39) |
E7912K |
unknown |
Het |
| Unc80 |
A |
T |
1: 66,651,371 (GRCm39) |
Y1572F |
possibly damaging |
Het |
| Usp42 |
G |
T |
5: 143,706,060 (GRCm39) |
A320D |
possibly damaging |
Het |
| Vmn2r94 |
T |
C |
17: 18,464,038 (GRCm39) |
T751A |
probably damaging |
Het |
| Zbtb41 |
C |
T |
1: 139,368,084 (GRCm39) |
L591F |
probably damaging |
Het |
| Zdhhc5 |
T |
A |
2: 84,524,662 (GRCm39) |
E219D |
probably damaging |
Het |
| Zfp248 |
A |
T |
6: 118,406,012 (GRCm39) |
F526I |
probably damaging |
Het |
| Zfp322a |
T |
C |
13: 23,540,558 (GRCm39) |
K395E |
possibly damaging |
Het |
| Zfp423 |
G |
A |
8: 88,506,877 (GRCm39) |
P1156S |
probably benign |
Het |
| Zfp644 |
T |
C |
5: 106,786,131 (GRCm39) |
T139A |
possibly damaging |
Het |
|
| Other mutations in Rapgef6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00436:Rapgef6
|
APN |
11 |
54,570,091 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00507:Rapgef6
|
APN |
11 |
54,554,935 (GRCm39) |
nonsense |
probably null |
|
|
IGL00809:Rapgef6
|
APN |
11 |
54,540,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00843:Rapgef6
|
APN |
11 |
54,582,099 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00899:Rapgef6
|
APN |
11 |
54,510,844 (GRCm39) |
nonsense |
probably null |
|
|
IGL01372:Rapgef6
|
APN |
11 |
54,559,437 (GRCm39) |
splice site |
probably benign |
|
|
IGL01604:Rapgef6
|
APN |
11 |
54,585,389 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01935:Rapgef6
|
APN |
11 |
54,501,668 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL01991:Rapgef6
|
APN |
11 |
54,443,695 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL02243:Rapgef6
|
APN |
11 |
54,567,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02407:Rapgef6
|
APN |
11 |
54,567,181 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02676:Rapgef6
|
APN |
11 |
54,540,172 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02934:Rapgef6
|
APN |
11 |
54,516,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03076:Rapgef6
|
APN |
11 |
54,516,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03110:Rapgef6
|
APN |
11 |
54,586,915 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03256:Rapgef6
|
APN |
11 |
54,548,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
shocker
|
UTSW |
11 |
54,510,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
D4216:Rapgef6
|
UTSW |
11 |
54,559,572 (GRCm39) |
splice site |
probably benign |
|
|
PIT4305001:Rapgef6
|
UTSW |
11 |
54,570,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4366001:Rapgef6
|
UTSW |
11 |
54,582,446 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0047:Rapgef6
|
UTSW |
11 |
54,437,204 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0047:Rapgef6
|
UTSW |
11 |
54,437,204 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0125:Rapgef6
|
UTSW |
11 |
54,516,701 (GRCm39) |
nonsense |
probably null |
|
|
R0189:Rapgef6
|
UTSW |
11 |
54,582,075 (GRCm39) |
missense |
probably benign |
|
|
R0201:Rapgef6
|
UTSW |
11 |
54,510,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Rapgef6
|
UTSW |
11 |
54,516,789 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0524:Rapgef6
|
UTSW |
11 |
54,581,110 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0853:Rapgef6
|
UTSW |
11 |
54,559,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1203:Rapgef6
|
UTSW |
11 |
54,582,525 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1440:Rapgef6
|
UTSW |
11 |
54,517,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1453:Rapgef6
|
UTSW |
11 |
54,530,553 (GRCm39) |
splice site |
probably null |
|
|
R1530:Rapgef6
|
UTSW |
11 |
54,552,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1593:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1620:Rapgef6
|
UTSW |
11 |
54,517,420 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1628:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1629:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1630:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1634:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1640:Rapgef6
|
UTSW |
11 |
54,548,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1686:Rapgef6
|
UTSW |
11 |
54,582,458 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1722:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1743:Rapgef6
|
UTSW |
11 |
54,567,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1816:Rapgef6
|
UTSW |
11 |
54,585,314 (GRCm39) |
missense |
probably benign |
|
|
R1851:Rapgef6
|
UTSW |
11 |
54,533,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1852:Rapgef6
|
UTSW |
11 |
54,533,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1868:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1888:Rapgef6
|
UTSW |
11 |
54,551,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Rapgef6
|
UTSW |
11 |
54,551,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1942:Rapgef6
|
UTSW |
11 |
54,548,089 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1943:Rapgef6
|
UTSW |
11 |
54,548,089 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2031:Rapgef6
|
UTSW |
11 |
54,443,684 (GRCm39) |
missense |
probably benign |
0.30 |
|
R2087:Rapgef6
|
UTSW |
11 |
54,522,075 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2106:Rapgef6
|
UTSW |
11 |
54,559,512 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2362:Rapgef6
|
UTSW |
11 |
54,585,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2484:Rapgef6
|
UTSW |
11 |
54,533,582 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2566:Rapgef6
|
UTSW |
11 |
54,578,537 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2872:Rapgef6
|
UTSW |
11 |
54,552,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2872:Rapgef6
|
UTSW |
11 |
54,552,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3744:Rapgef6
|
UTSW |
11 |
54,516,760 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3848:Rapgef6
|
UTSW |
11 |
54,582,134 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4823:Rapgef6
|
UTSW |
11 |
54,585,326 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4859:Rapgef6
|
UTSW |
11 |
54,526,989 (GRCm39) |
missense |
probably benign |
|
|
R4906:Rapgef6
|
UTSW |
11 |
54,443,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4911:Rapgef6
|
UTSW |
11 |
54,513,143 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4937:Rapgef6
|
UTSW |
11 |
54,548,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5033:Rapgef6
|
UTSW |
11 |
54,582,207 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5249:Rapgef6
|
UTSW |
11 |
54,413,943 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5304:Rapgef6
|
UTSW |
11 |
54,548,200 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5656:Rapgef6
|
UTSW |
11 |
54,526,962 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5701:Rapgef6
|
UTSW |
11 |
54,567,220 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5758:Rapgef6
|
UTSW |
11 |
54,559,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5973:Rapgef6
|
UTSW |
11 |
54,530,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6177:Rapgef6
|
UTSW |
11 |
54,510,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6268:Rapgef6
|
UTSW |
11 |
54,540,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6287:Rapgef6
|
UTSW |
11 |
54,517,164 (GRCm39) |
splice site |
probably null |
|
|
R6293:Rapgef6
|
UTSW |
11 |
54,525,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6471:Rapgef6
|
UTSW |
11 |
54,582,563 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6863:Rapgef6
|
UTSW |
11 |
54,437,206 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6950:Rapgef6
|
UTSW |
11 |
54,567,206 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7144:Rapgef6
|
UTSW |
11 |
54,548,191 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7171:Rapgef6
|
UTSW |
11 |
54,567,189 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7199:Rapgef6
|
UTSW |
11 |
54,437,252 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7291:Rapgef6
|
UTSW |
11 |
54,582,065 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7436:Rapgef6
|
UTSW |
11 |
54,501,747 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7498:Rapgef6
|
UTSW |
11 |
54,510,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7506:Rapgef6
|
UTSW |
11 |
54,526,997 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7527:Rapgef6
|
UTSW |
11 |
54,525,787 (GRCm39) |
missense |
unknown |
|
|
R7646:Rapgef6
|
UTSW |
11 |
54,516,780 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7655:Rapgef6
|
UTSW |
11 |
54,585,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7656:Rapgef6
|
UTSW |
11 |
54,585,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7687:Rapgef6
|
UTSW |
11 |
54,551,901 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7768:Rapgef6
|
UTSW |
11 |
54,517,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7788:Rapgef6
|
UTSW |
11 |
54,585,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7890:Rapgef6
|
UTSW |
11 |
54,517,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8113:Rapgef6
|
UTSW |
11 |
54,516,784 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8337:Rapgef6
|
UTSW |
11 |
54,522,127 (GRCm39) |
nonsense |
probably null |
|
|
R8393:Rapgef6
|
UTSW |
11 |
54,578,487 (GRCm39) |
missense |
probably benign |
|
|
R8465:Rapgef6
|
UTSW |
11 |
54,582,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8492:Rapgef6
|
UTSW |
11 |
54,581,063 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8791:Rapgef6
|
UTSW |
11 |
54,459,295 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8866:Rapgef6
|
UTSW |
11 |
54,443,700 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8917:Rapgef6
|
UTSW |
11 |
54,582,392 (GRCm39) |
nonsense |
probably null |
|
|
R8921:Rapgef6
|
UTSW |
11 |
54,570,065 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9031:Rapgef6
|
UTSW |
11 |
54,578,667 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9093:Rapgef6
|
UTSW |
11 |
54,487,912 (GRCm39) |
nonsense |
probably null |
|
|
R9354:Rapgef6
|
UTSW |
11 |
54,510,749 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9514:Rapgef6
|
UTSW |
11 |
54,443,684 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9516:Rapgef6
|
UTSW |
11 |
54,582,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9739:Rapgef6
|
UTSW |
11 |
54,513,189 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGACTAGCAAATTTTAAGCAGTCCC -3'
(R):5'- TCCCACTAGCTCTTTGCATGAAG -3'
Sequencing Primer
(F):5'- GCACCATTTTTGTTTACTGAGATG -3'
(R):5'- GAGTCGTATGAGTTACATGGG -3'
|
| Posted On |
2022-11-14 |
Incidental Mutation