Incidental Mutation 'R1680:Mical3'
ID 188411
Institutional Source Beutler Lab
Gene Symbol Mical3
Ensembl Gene ENSMUSG00000051586
Gene Name microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms MICAL-3, C130040D16Rik
MMRRC Submission 039716-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.173) question?
Stock # R1680 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 120931707-121130999 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 120959643 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 1307 (S1307R)
Ref Sequence ENSEMBL: ENSMUSP00000146544 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000207889]
AlphaFold Q8CJ19
Predicted Effect noncoding transcript
Transcript: ENSMUST00000098457
SMART Domains Protein: ENSMUSP00000096056
Gene: ENSMUSG00000051586

DomainStartEndE-ValueType
low complexity region 33 45 N/A INTRINSIC
low complexity region 57 80 N/A INTRINSIC
coiled coil region 114 148 N/A INTRINSIC
low complexity region 191 225 N/A INTRINSIC
coiled coil region 238 265 N/A INTRINSIC
low complexity region 317 330 N/A INTRINSIC
low complexity region 374 383 N/A INTRINSIC
low complexity region 548 562 N/A INTRINSIC
low complexity region 582 592 N/A INTRINSIC
low complexity region 625 637 N/A INTRINSIC
low complexity region 794 824 N/A INTRINSIC
low complexity region 861 882 N/A INTRINSIC
low complexity region 911 929 N/A INTRINSIC
low complexity region 950 962 N/A INTRINSIC
DUF3585 968 1110 1.39e-65 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124669
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142924
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150503
SMART Domains Protein: ENSMUSP00000115131
Gene: ENSMUSG00000051586

DomainStartEndE-ValueType
SCOP:d1bjt__ 41 141 8e-3 SMART
coiled coil region 192 219 N/A INTRINSIC
low complexity region 271 284 N/A INTRINSIC
low complexity region 328 337 N/A INTRINSIC
low complexity region 502 516 N/A INTRINSIC
low complexity region 536 546 N/A INTRINSIC
low complexity region 579 591 N/A INTRINSIC
low complexity region 748 778 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151602
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203013
Predicted Effect probably benign
Transcript: ENSMUST00000207889
AA Change: S1307R

PolyPhen 2 Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect unknown
Transcript: ENSMUST00000212333
AA Change: S435R
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik C G 10: 100,603,528 (GRCm38) P187R probably damaging Het
Ahnak T A 19: 9,009,963 (GRCm38) H2870Q probably benign Het
Arhgef33 C T 17: 80,347,651 (GRCm38) S95F probably damaging Het
Atp1a2 T A 1: 172,278,954 (GRCm38) D827V probably damaging Het
Bcat1 T G 6: 145,039,628 (GRCm38) D96A probably damaging Het
Birc6 A T 17: 74,548,746 (GRCm38) I184L probably benign Het
Ccdc129 C T 6: 55,968,766 (GRCm38) T824I probably damaging Het
Clca3b A T 3: 144,837,824 (GRCm38) L415M probably damaging Het
Clstn1 T C 4: 149,643,726 (GRCm38) V617A probably benign Het
Col22a1 G A 15: 71,799,361 (GRCm38) A1050V unknown Het
Col5a3 C T 9: 20,784,668 (GRCm38) probably null Het
Csmd3 G A 15: 47,741,170 (GRCm38) T1059I probably damaging Het
Dclk2 C T 3: 86,805,639 (GRCm38) R503Q possibly damaging Het
Dnm3 A G 1: 162,010,976 (GRCm38) V272A probably benign Het
Dnmt3a A G 12: 3,873,361 (GRCm38) Q187R probably damaging Het
Dpp9 A G 17: 56,190,103 (GRCm38) Y710H probably benign Het
Eef1a2 A T 2: 181,152,941 (GRCm38) M155K possibly damaging Het
Entpd8 G A 2: 25,084,024 (GRCm38) C331Y probably damaging Het
Erc1 A C 6: 119,575,761 (GRCm38) L1072R probably damaging Het
Fam160b2 T C 14: 70,586,851 (GRCm38) Y482C probably damaging Het
Gtf3c2 A G 5: 31,173,868 (GRCm38) S155P probably damaging Het
Gucy2c A G 6: 136,722,493 (GRCm38) S617P probably damaging Het
Ice1 T C 13: 70,605,448 (GRCm38) R840G probably benign Het
Il1rl2 T C 1: 40,351,793 (GRCm38) Y299H possibly damaging Het
Ints7 T G 1: 191,621,162 (GRCm38) probably null Het
Ireb2 C T 9: 54,881,518 (GRCm38) T92I probably damaging Het
Kcnj8 A T 6: 142,570,189 (GRCm38) L64* probably null Het
Mapk8ip3 A G 17: 24,901,011 (GRCm38) V983A probably damaging Het
Mertk A G 2: 128,801,636 (GRCm38) D985G probably benign Het
Ncaph2 A G 15: 89,364,622 (GRCm38) D222G probably benign Het
Nf1 C A 11: 79,550,998 (GRCm38) S295* probably null Het
Nlrp12 T A 7: 3,241,174 (GRCm38) D236V probably damaging Het
Npnt A G 3: 132,906,802 (GRCm38) V74A probably benign Het
Oasl1 A G 5: 114,935,944 (GRCm38) D304G probably damaging Het
Olfr1098 C T 2: 86,923,161 (GRCm38) V124I probably benign Het
Olfr556 A G 7: 102,670,733 (GRCm38) D271G possibly damaging Het
Olfr834 A G 9: 18,988,516 (GRCm38) H176R possibly damaging Het
Olfr936 T C 9: 39,047,000 (GRCm38) I140V probably benign Het
Patz1 A G 11: 3,307,812 (GRCm38) K604E probably damaging Het
Pcsk6 T A 7: 66,035,250 (GRCm38) V793E probably benign Het
Pla2g4d C T 2: 120,277,750 (GRCm38) probably null Het
Plxnc1 A C 10: 94,841,551 (GRCm38) L938R probably benign Het
Pou4f2 G T 8: 78,434,831 (GRCm38) A381D probably damaging Het
Prdm4 A G 10: 85,899,223 (GRCm38) L685P possibly damaging Het
Pxn T A 5: 115,552,147 (GRCm38) V383E probably damaging Het
Rbl1 A G 2: 157,174,783 (GRCm38) L632P probably damaging Het
Rnf135 T A 11: 80,196,881 (GRCm38) S219T possibly damaging Het
Sdk2 T C 11: 113,791,436 (GRCm38) D2039G possibly damaging Het
Sdk2 C T 11: 113,838,646 (GRCm38) silent Het
Slc5a6 A G 5: 31,042,644 (GRCm38) Y131H probably damaging Het
Slc9a1 T C 4: 133,418,080 (GRCm38) I492T probably damaging Het
Soga3 A T 10: 29,196,839 (GRCm38) Q709L probably damaging Het
Spag5 A G 11: 78,320,616 (GRCm38) K993E probably damaging Het
Sptbn1 T G 11: 30,159,371 (GRCm38) I75L possibly damaging Het
Syngap1 T C 17: 26,952,579 (GRCm38) S46P possibly damaging Het
Tfcp2l1 T A 1: 118,675,605 (GRCm38) F458I probably damaging Het
Tmem67 A G 4: 12,087,840 (GRCm38) V102A probably benign Het
Tomm70a T C 16: 57,121,961 (GRCm38) S34P unknown Het
Txlnb G T 10: 17,843,233 (GRCm38) G604V probably benign Het
Ube2q1 A G 3: 89,776,176 (GRCm38) T143A probably benign Het
Unc80 C T 1: 66,503,669 (GRCm38) R361* probably null Het
Vcan T C 13: 89,703,547 (GRCm38) D1098G probably benign Het
Vmn1r176 T A 7: 23,835,381 (GRCm38) T116S probably damaging Het
Wdr81 C T 11: 75,454,423 (GRCm38) R6K probably benign Het
Zan T A 5: 137,403,050 (GRCm38) T4136S unknown Het
Zbtb14 C A 17: 69,388,502 (GRCm38) F398L probably damaging Het
Zfp606 A T 7: 12,493,971 (GRCm38) H615L probably damaging Het
Zp3r A T 1: 130,582,880 (GRCm38) N433K probably benign Het
Other mutations in Mical3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00569:Mical3 APN 6 120,961,624 (GRCm38) missense possibly damaging 0.73
IGL00718:Mical3 APN 6 121,040,449 (GRCm38) missense probably damaging 0.98
IGL00940:Mical3 APN 6 121,022,410 (GRCm38) missense possibly damaging 0.55
IGL00973:Mical3 APN 6 120,934,924 (GRCm38) splice site probably benign
IGL01503:Mical3 APN 6 120,958,576 (GRCm38) missense probably benign 0.09
IGL01991:Mical3 APN 6 120,935,211 (GRCm38) missense probably damaging 0.98
IGL02794:Mical3 APN 6 121,007,309 (GRCm38) missense probably damaging 0.99
IGL02996:Mical3 APN 6 120,958,558 (GRCm38) missense probably damaging 1.00
IGL03105:Mical3 APN 6 121,042,238 (GRCm38) missense probably benign 0.01
IGL03109:Mical3 APN 6 121,009,124 (GRCm38) missense probably damaging 1.00
IGL03236:Mical3 APN 6 120,969,384 (GRCm38) missense probably benign 0.00
P0028:Mical3 UTSW 6 121,024,689 (GRCm38) missense probably benign 0.33
R0244:Mical3 UTSW 6 120,957,722 (GRCm38) missense probably benign 0.00
R0494:Mical3 UTSW 6 120,959,201 (GRCm38) missense possibly damaging 0.94
R0586:Mical3 UTSW 6 121,029,641 (GRCm38) unclassified probably benign
R1029:Mical3 UTSW 6 120,934,678 (GRCm38) missense probably benign 0.02
R1263:Mical3 UTSW 6 120,952,469 (GRCm38) missense probably damaging 0.99
R1507:Mical3 UTSW 6 121,042,238 (GRCm38) missense probably benign 0.36
R1527:Mical3 UTSW 6 121,024,779 (GRCm38) missense probably damaging 0.99
R1623:Mical3 UTSW 6 121,024,807 (GRCm38) missense probably damaging 0.99
R1697:Mical3 UTSW 6 121,007,408 (GRCm38) missense possibly damaging 0.84
R1817:Mical3 UTSW 6 121,042,235 (GRCm38) missense probably benign 0.06
R1875:Mical3 UTSW 6 121,042,064 (GRCm38) missense probably damaging 1.00
R1961:Mical3 UTSW 6 120,982,607 (GRCm38) missense possibly damaging 0.94
R2004:Mical3 UTSW 6 120,951,322 (GRCm38) missense probably damaging 1.00
R2093:Mical3 UTSW 6 121,040,386 (GRCm38) missense probably damaging 1.00
R2141:Mical3 UTSW 6 121,031,134 (GRCm38) splice site probably null
R2142:Mical3 UTSW 6 121,031,134 (GRCm38) splice site probably null
R2257:Mical3 UTSW 6 121,033,735 (GRCm38) missense possibly damaging 0.94
R2404:Mical3 UTSW 6 120,959,828 (GRCm38) missense probably benign 0.01
R2419:Mical3 UTSW 6 120,959,923 (GRCm38) missense probably benign
R2509:Mical3 UTSW 6 121,034,157 (GRCm38) missense probably damaging 1.00
R3784:Mical3 UTSW 6 121,021,337 (GRCm38) missense probably benign 0.00
R4342:Mical3 UTSW 6 120,934,838 (GRCm38) nonsense probably null
R4343:Mical3 UTSW 6 120,934,838 (GRCm38) nonsense probably null
R4579:Mical3 UTSW 6 120,958,699 (GRCm38) missense probably benign
R4603:Mical3 UTSW 6 120,934,838 (GRCm38) nonsense probably null
R4605:Mical3 UTSW 6 121,034,080 (GRCm38) nonsense probably null
R4610:Mical3 UTSW 6 120,934,838 (GRCm38) nonsense probably null
R4611:Mical3 UTSW 6 120,934,838 (GRCm38) nonsense probably null
R4623:Mical3 UTSW 6 120,961,625 (GRCm38) nonsense probably null
R4669:Mical3 UTSW 6 120,957,703 (GRCm38) missense probably damaging 0.98
R4704:Mical3 UTSW 6 120,958,688 (GRCm38) missense probably benign 0.00
R4722:Mical3 UTSW 6 121,038,525 (GRCm38) missense probably benign 0.00
R4863:Mical3 UTSW 6 121,033,787 (GRCm38) missense probably damaging 0.99
R4878:Mical3 UTSW 6 120,969,387 (GRCm38) missense possibly damaging 0.51
R4885:Mical3 UTSW 6 120,935,253 (GRCm38) missense probably damaging 1.00
R4907:Mical3 UTSW 6 121,007,298 (GRCm38) missense probably benign 0.00
R5007:Mical3 UTSW 6 121,038,069 (GRCm38) missense probably damaging 0.98
R5299:Mical3 UTSW 6 120,959,512 (GRCm38) missense possibly damaging 0.71
R5303:Mical3 UTSW 6 120,959,980 (GRCm38) missense probably benign
R5368:Mical3 UTSW 6 120,959,473 (GRCm38) missense probably damaging 1.00
R5955:Mical3 UTSW 6 121,033,750 (GRCm38) missense probably damaging 0.99
R5970:Mical3 UTSW 6 120,958,271 (GRCm38) nonsense probably null
R6000:Mical3 UTSW 6 121,021,320 (GRCm38) missense probably benign 0.06
R6101:Mical3 UTSW 6 121,033,710 (GRCm38) missense probably damaging 1.00
R6195:Mical3 UTSW 6 121,016,835 (GRCm38) intron probably benign
R6210:Mical3 UTSW 6 121,040,517 (GRCm38) splice site probably null
R6225:Mical3 UTSW 6 120,958,723 (GRCm38) missense probably damaging 0.98
R6258:Mical3 UTSW 6 121,009,030 (GRCm38) missense probably damaging 1.00
R6260:Mical3 UTSW 6 121,009,030 (GRCm38) missense probably damaging 1.00
R6349:Mical3 UTSW 6 120,959,525 (GRCm38) missense probably benign
R6352:Mical3 UTSW 6 120,952,473 (GRCm38) missense probably damaging 0.97
R6480:Mical3 UTSW 6 121,034,275 (GRCm38) missense possibly damaging 0.76
R6704:Mical3 UTSW 6 121,009,800 (GRCm38) intron probably benign
R6783:Mical3 UTSW 6 120,958,825 (GRCm38) missense possibly damaging 0.85
R6925:Mical3 UTSW 6 120,959,390 (GRCm38) missense probably benign 0.05
R6960:Mical3 UTSW 6 120,958,543 (GRCm38) missense probably damaging 1.00
R7170:Mical3 UTSW 6 120,973,733 (GRCm38) splice site probably null
R7344:Mical3 UTSW 6 121,036,544 (GRCm38) nonsense probably null
R7414:Mical3 UTSW 6 121,034,113 (GRCm38) missense probably damaging 1.00
R7455:Mical3 UTSW 6 120,958,744 (GRCm38) missense probably damaging 1.00
R7649:Mical3 UTSW 6 120,934,948 (GRCm38) missense probably damaging 1.00
R8236:Mical3 UTSW 6 121,012,543 (GRCm38) missense
R8286:Mical3 UTSW 6 121,021,188 (GRCm38) missense possibly damaging 0.68
R8316:Mical3 UTSW 6 120,934,983 (GRCm38) missense probably damaging 1.00
R8328:Mical3 UTSW 6 120,935,177 (GRCm38) missense probably damaging 0.98
R8354:Mical3 UTSW 6 120,973,420 (GRCm38) missense probably damaging 0.99
R8511:Mical3 UTSW 6 121,038,552 (GRCm38) missense possibly damaging 0.78
R8687:Mical3 UTSW 6 120,959,477 (GRCm38) missense probably benign 0.19
R8728:Mical3 UTSW 6 120,973,553 (GRCm38) missense probably damaging 0.99
R8925:Mical3 UTSW 6 121,007,364 (GRCm38) missense probably benign 0.00
R8927:Mical3 UTSW 6 121,007,364 (GRCm38) missense probably benign 0.00
R8986:Mical3 UTSW 6 121,014,861 (GRCm38) missense
R9026:Mical3 UTSW 6 121,009,887 (GRCm38) splice site probably benign
R9415:Mical3 UTSW 6 120,957,751 (GRCm38) missense probably damaging 1.00
R9515:Mical3 UTSW 6 121,024,797 (GRCm38) missense probably damaging 1.00
R9720:Mical3 UTSW 6 120,958,277 (GRCm38) missense probably damaging 0.99
R9777:Mical3 UTSW 6 120,982,568 (GRCm38) missense possibly damaging 0.91
U24488:Mical3 UTSW 6 121,001,496 (GRCm38) missense possibly damaging 0.90
Z1177:Mical3 UTSW 6 120,959,728 (GRCm38) missense possibly damaging 0.71
Z1190:Mical3 UTSW 6 121,021,358 (GRCm38) critical splice acceptor site probably null
Predicted Primers PCR Primer
(F):5'- TTCAGAAGGCAGAGACCCTCATCC -3'
(R):5'- AGAAAGCTGTACTCTCGCCCATCC -3'

Sequencing Primer
(F):5'- ATCCTGAGGTGACTTGTCAAC -3'
(R):5'- CAGCTTACAGCCAGAGTCTC -3'
Posted On 2014-05-09