Incidental Mutation 'R1966:Kdm5b'
| ID |
218903 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kdm5b
|
| Ensembl Gene |
ENSMUSG00000042207 |
| Gene Name |
lysine demethylase 5B |
| Synonyms |
2010009J12Rik, PLU-1, Rb-Bp2, Jarid1b, D1Ertd202e, Plu1, 2210016I17Rik |
| MMRRC Submission |
039979-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.451)
|
| Stock # |
R1966 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
134487916-134560621 bp(+) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to A
at 134541611 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107817
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047714]
[ENSMUST00000112198]
|
| AlphaFold |
Q80Y84 |
| PDB Structure |
Solution structure of the ARID domain of Jarid1b protein [SOLUTION NMR]
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000047714
|
| SMART Domains |
Protein: ENSMUSP00000038138
Gene: ENSMUSG00000042207
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
744 |
2.2e-17 |
PFAM |
|
Pfam:PLU-1
|
757 |
1088 |
5.6e-92 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
PHD
|
1486 |
1536 |
1.18e-6 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000112198
|
| SMART Domains |
Protein: ENSMUSP00000107817
Gene: ENSMUSG00000042207
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
745 |
6.7e-21 |
PFAM |
|
Pfam:PLU-1
|
756 |
1088 |
6e-94 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Homozygous mutant mice display decreased body weight, decreased female fertility, lower uterine weight, and a delay in mammary development. Knockout of this gene has also been associated with embryonic lethality. [provided by RefSeq, Dec 2016]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit decreased body weight, background-sensitive premature mortality, decreased female fertility, delayed mammary gland development, decreased serum estradiol levels, and reduced mammary epithelial cell proliferation in early puberty. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2410002F23Rik |
T |
A |
7: 43,900,650 (GRCm39) |
V185E |
probably benign |
Het |
| Abca1 |
A |
C |
4: 53,050,409 (GRCm39) |
V1608G |
probably damaging |
Het |
| Ap2b1 |
T |
C |
11: 83,237,721 (GRCm39) |
I557T |
probably benign |
Het |
| Arhgef15 |
G |
T |
11: 68,845,501 (GRCm39) |
P117Q |
probably damaging |
Het |
| Arhgef39 |
T |
C |
4: 43,496,710 (GRCm39) |
S335G |
probably benign |
Het |
| Blm |
A |
T |
7: 80,162,934 (GRCm39) |
F139Y |
possibly damaging |
Het |
| Cacna2d1 |
C |
T |
5: 16,538,783 (GRCm39) |
R581* |
probably null |
Het |
| Cadps |
C |
A |
14: 12,822,450 (GRCm38) |
E97* |
probably null |
Het |
| Cavin2 |
T |
A |
1: 51,328,801 (GRCm39) |
L86Q |
probably damaging |
Het |
| Ccdc136 |
A |
G |
6: 29,418,091 (GRCm39) |
E787G |
probably damaging |
Het |
| Ccdc39 |
T |
C |
3: 33,880,629 (GRCm39) |
K446R |
probably damaging |
Het |
| Cdh23 |
T |
C |
10: 60,159,361 (GRCm39) |
Y2138C |
probably damaging |
Het |
| Cdk12 |
T |
A |
11: 98,094,916 (GRCm39) |
Y241* |
probably null |
Het |
| Clcn4 |
T |
A |
7: 7,287,184 (GRCm39) |
*688L |
probably null |
Het |
| Cntnap1 |
T |
C |
11: 101,071,212 (GRCm39) |
V375A |
possibly damaging |
Het |
| Coq5 |
T |
A |
5: 115,432,890 (GRCm39) |
|
probably null |
Het |
| Cyp4b1 |
A |
G |
4: 115,483,076 (GRCm39) |
I405T |
probably benign |
Het |
| Det1 |
T |
C |
7: 78,492,966 (GRCm39) |
Y346C |
probably damaging |
Het |
| Enpp3 |
A |
T |
10: 24,683,389 (GRCm39) |
V276E |
probably damaging |
Het |
| Epb41l2 |
G |
A |
10: 25,317,666 (GRCm39) |
R61Q |
probably benign |
Het |
| Fam76b |
G |
A |
9: 13,739,362 (GRCm39) |
|
probably null |
Het |
| Fbxo45 |
A |
T |
16: 32,052,048 (GRCm39) |
D238E |
probably benign |
Het |
| Fnip2 |
G |
A |
3: 79,400,779 (GRCm39) |
T314I |
probably benign |
Het |
| Fsip2 |
T |
C |
2: 82,823,124 (GRCm39) |
S6286P |
possibly damaging |
Het |
| Gbf1 |
T |
C |
19: 46,260,003 (GRCm39) |
F999L |
probably damaging |
Het |
| Gnao1 |
C |
A |
8: 94,670,827 (GRCm39) |
T102K |
probably benign |
Het |
| Gpatch2 |
T |
A |
1: 187,054,498 (GRCm39) |
D76E |
probably damaging |
Het |
| Gpd1l |
A |
G |
9: 114,743,462 (GRCm39) |
I146T |
probably benign |
Het |
| Grik2 |
A |
T |
10: 49,232,005 (GRCm39) |
H508Q |
probably damaging |
Het |
| Hapstr1 |
A |
G |
16: 8,648,445 (GRCm39) |
E41G |
possibly damaging |
Het |
| Hk3 |
A |
T |
13: 55,162,268 (GRCm39) |
F112Y |
probably damaging |
Het |
| Hmcn2 |
T |
G |
2: 31,279,341 (GRCm39) |
I1781S |
probably damaging |
Het |
| Inhba |
A |
T |
13: 16,201,221 (GRCm39) |
K261M |
probably damaging |
Het |
| Jarid2 |
T |
A |
13: 45,059,752 (GRCm39) |
N661K |
probably damaging |
Het |
| Kcna2 |
T |
C |
3: 107,011,946 (GRCm39) |
S176P |
probably damaging |
Het |
| Kcnj3 |
A |
T |
2: 55,327,343 (GRCm39) |
Q44L |
probably damaging |
Het |
| Kcns1 |
G |
T |
2: 164,010,455 (GRCm39) |
F101L |
probably damaging |
Het |
| Klhl14 |
C |
T |
18: 21,687,730 (GRCm39) |
G564D |
probably damaging |
Het |
| Klhl18 |
A |
T |
9: 110,305,658 (GRCm39) |
V2E |
probably benign |
Het |
| Klhl6 |
T |
C |
16: 19,801,572 (GRCm39) |
E61G |
probably damaging |
Het |
| Krt1 |
T |
C |
15: 101,757,427 (GRCm39) |
D261G |
probably benign |
Het |
| Lama5 |
C |
A |
2: 179,830,145 (GRCm39) |
C1896F |
probably damaging |
Het |
| Lrba |
A |
G |
3: 86,513,175 (GRCm39) |
|
probably null |
Het |
| Lrch3 |
A |
G |
16: 32,734,755 (GRCm39) |
T82A |
possibly damaging |
Het |
| Maml3 |
C |
G |
3: 52,011,560 (GRCm39) |
G2A |
unknown |
Het |
| Mapkap1 |
T |
A |
2: 34,408,691 (GRCm39) |
N34K |
probably damaging |
Het |
| Muc13 |
A |
T |
16: 33,634,909 (GRCm39) |
I488F |
probably damaging |
Het |
| Muc5ac |
A |
G |
7: 141,357,113 (GRCm39) |
D1129G |
possibly damaging |
Het |
| Nacc1 |
A |
T |
8: 85,403,010 (GRCm39) |
N288K |
probably damaging |
Het |
| Nek1 |
T |
G |
8: 61,469,330 (GRCm39) |
I129R |
probably damaging |
Het |
| Nf1 |
T |
A |
11: 79,302,390 (GRCm39) |
S319R |
possibly damaging |
Het |
| Nle1 |
C |
T |
11: 82,792,614 (GRCm39) |
G432D |
probably damaging |
Het |
| Nol4l |
A |
G |
2: 153,371,375 (GRCm39) |
V103A |
probably benign |
Het |
| Oca2 |
A |
G |
7: 56,064,215 (GRCm39) |
I737V |
probably damaging |
Het |
| Or12k5 |
A |
T |
2: 36,894,960 (GRCm39) |
F222Y |
possibly damaging |
Het |
| Or1j17 |
G |
A |
2: 36,578,796 (GRCm39) |
V261I |
probably benign |
Het |
| Or4b1 |
T |
C |
2: 89,979,748 (GRCm39) |
S201G |
probably damaging |
Het |
| Or51l4 |
G |
T |
7: 103,404,375 (GRCm39) |
T139K |
probably damaging |
Het |
| Or52ac1 |
A |
G |
7: 104,246,008 (GRCm39) |
C127R |
probably damaging |
Het |
| Or6k6 |
G |
T |
1: 173,944,817 (GRCm39) |
S255* |
probably null |
Het |
| Or6s1 |
T |
A |
14: 51,308,614 (GRCm39) |
I79F |
probably damaging |
Het |
| Orc1 |
T |
A |
4: 108,469,414 (GRCm39) |
I746N |
probably damaging |
Het |
| Pbxip1 |
A |
G |
3: 89,352,795 (GRCm39) |
D147G |
probably damaging |
Het |
| Pirb |
A |
T |
7: 3,720,637 (GRCm39) |
L287Q |
probably benign |
Het |
| Plin5 |
T |
A |
17: 56,419,186 (GRCm39) |
D412V |
probably damaging |
Het |
| Plxna2 |
A |
T |
1: 194,327,008 (GRCm39) |
Y314F |
possibly damaging |
Het |
| Ppid |
A |
T |
3: 79,509,606 (GRCm39) |
K308* |
probably null |
Het |
| Prss38 |
T |
C |
11: 59,264,310 (GRCm39) |
Y219C |
probably damaging |
Het |
| Ptx3 |
C |
T |
3: 66,132,042 (GRCm39) |
R188C |
probably damaging |
Het |
| Ralgds |
T |
A |
2: 28,435,887 (GRCm39) |
V504E |
probably damaging |
Het |
| Rere |
T |
C |
4: 150,701,330 (GRCm39) |
Y1237H |
probably damaging |
Het |
| Rpp30 |
C |
T |
19: 36,066,549 (GRCm39) |
S94L |
probably damaging |
Het |
| Rrp15 |
C |
T |
1: 186,468,402 (GRCm39) |
V205I |
possibly damaging |
Het |
| Scpep1 |
A |
G |
11: 88,843,240 (GRCm39) |
W73R |
probably damaging |
Het |
| Sec23ip |
A |
G |
7: 128,357,077 (GRCm39) |
H376R |
probably damaging |
Het |
| Serping1 |
G |
T |
2: 84,596,072 (GRCm39) |
T454K |
probably damaging |
Het |
| Shtn1 |
T |
G |
19: 58,963,470 (GRCm39) |
Y615S |
probably benign |
Het |
| Slc20a2 |
C |
A |
8: 23,035,553 (GRCm39) |
P184T |
probably damaging |
Het |
| Slc22a29 |
C |
A |
19: 8,195,772 (GRCm39) |
R89L |
probably damaging |
Het |
| Slc2a2 |
A |
G |
3: 28,773,634 (GRCm39) |
Q313R |
probably damaging |
Het |
| Tas2r122 |
A |
T |
6: 132,688,157 (GRCm39) |
Y245* |
probably null |
Het |
| Ticrr |
C |
A |
7: 79,344,483 (GRCm39) |
C1449* |
probably null |
Het |
| Tmem181a |
T |
C |
17: 6,353,501 (GRCm39) |
V412A |
probably benign |
Het |
| Tmtc4 |
T |
A |
14: 123,165,011 (GRCm39) |
E616V |
probably benign |
Het |
| Tnrc6b |
A |
G |
15: 80,764,640 (GRCm39) |
K714R |
probably damaging |
Het |
| Trpm8 |
T |
A |
1: 88,260,470 (GRCm39) |
|
probably null |
Het |
| Ubr2 |
T |
C |
17: 47,265,845 (GRCm39) |
T1163A |
probably benign |
Het |
| Ubr4 |
A |
G |
4: 139,178,555 (GRCm39) |
|
probably null |
Het |
| Ulk2 |
A |
T |
11: 61,710,297 (GRCm39) |
|
probably null |
Het |
| Ulk4 |
T |
A |
9: 121,086,182 (GRCm39) |
M350L |
probably benign |
Het |
| Vmn1r185 |
T |
C |
7: 26,310,956 (GRCm39) |
E183G |
probably benign |
Het |
| Vmn1r76 |
T |
A |
7: 11,664,441 (GRCm39) |
I223F |
probably damaging |
Het |
| Wdr27 |
T |
C |
17: 15,154,861 (GRCm39) |
T19A |
possibly damaging |
Het |
| Wdr59 |
T |
G |
8: 112,177,535 (GRCm39) |
T973P |
possibly damaging |
Het |
| Wnk2 |
A |
G |
13: 49,192,487 (GRCm39) |
S664P |
probably damaging |
Het |
| Zfp1004 |
T |
A |
2: 150,033,827 (GRCm39) |
D49E |
probably benign |
Het |
| Zfp120 |
A |
T |
2: 149,959,318 (GRCm39) |
C335S |
probably damaging |
Het |
| Zfp30 |
C |
A |
7: 29,491,877 (GRCm39) |
Q44K |
probably benign |
Het |
| Zfp541 |
T |
C |
7: 15,812,996 (GRCm39) |
S550P |
probably benign |
Het |
| Zw10 |
C |
A |
9: 48,980,133 (GRCm39) |
N421K |
probably damaging |
Het |
|
| Other mutations in Kdm5b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00230:Kdm5b
|
APN |
1 |
134,548,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01458:Kdm5b
|
APN |
1 |
134,549,724 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL01567:Kdm5b
|
APN |
1 |
134,530,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01625:Kdm5b
|
APN |
1 |
134,545,706 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
IGL01970:Kdm5b
|
APN |
1 |
134,528,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02183:Kdm5b
|
APN |
1 |
134,552,669 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02592:Kdm5b
|
APN |
1 |
134,552,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02695:Kdm5b
|
APN |
1 |
134,532,223 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02697:Kdm5b
|
APN |
1 |
134,516,511 (GRCm39) |
splice site |
probably benign |
|
|
IGL03036:Kdm5b
|
APN |
1 |
134,536,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03056:Kdm5b
|
APN |
1 |
134,515,717 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03206:Kdm5b
|
APN |
1 |
134,555,055 (GRCm39) |
missense |
probably benign |
|
|
IGL03342:Kdm5b
|
APN |
1 |
134,530,314 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03388:Kdm5b
|
APN |
1 |
134,555,060 (GRCm39) |
missense |
probably benign |
|
|
amaryllis
|
UTSW |
1 |
134,536,799 (GRCm39) |
critical splice donor site |
probably null |
|
|
PIT4486001:Kdm5b
|
UTSW |
1 |
134,556,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0233:Kdm5b
|
UTSW |
1 |
134,532,372 (GRCm39) |
splice site |
probably benign |
|
|
R0334:Kdm5b
|
UTSW |
1 |
134,532,260 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0504:Kdm5b
|
UTSW |
1 |
134,548,761 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0505:Kdm5b
|
UTSW |
1 |
134,530,309 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0521:Kdm5b
|
UTSW |
1 |
134,545,771 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R1004:Kdm5b
|
UTSW |
1 |
134,516,642 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1087:Kdm5b
|
UTSW |
1 |
134,528,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1126:Kdm5b
|
UTSW |
1 |
134,541,729 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1221:Kdm5b
|
UTSW |
1 |
134,526,829 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1230:Kdm5b
|
UTSW |
1 |
134,540,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1345:Kdm5b
|
UTSW |
1 |
134,558,288 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1482:Kdm5b
|
UTSW |
1 |
134,552,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1582:Kdm5b
|
UTSW |
1 |
134,552,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1653:Kdm5b
|
UTSW |
1 |
134,530,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1693:Kdm5b
|
UTSW |
1 |
134,525,314 (GRCm39) |
splice site |
probably benign |
|
|
R1721:Kdm5b
|
UTSW |
1 |
134,540,919 (GRCm39) |
splice site |
probably benign |
|
|
R1741:Kdm5b
|
UTSW |
1 |
134,545,755 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1762:Kdm5b
|
UTSW |
1 |
134,532,205 (GRCm39) |
nonsense |
probably null |
|
|
R1820:Kdm5b
|
UTSW |
1 |
134,525,408 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1872:Kdm5b
|
UTSW |
1 |
134,552,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2056:Kdm5b
|
UTSW |
1 |
134,540,952 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2059:Kdm5b
|
UTSW |
1 |
134,540,952 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2405:Kdm5b
|
UTSW |
1 |
134,536,754 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3417:Kdm5b
|
UTSW |
1 |
134,515,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3771:Kdm5b
|
UTSW |
1 |
134,541,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3783:Kdm5b
|
UTSW |
1 |
134,558,280 (GRCm39) |
missense |
probably benign |
|
|
R3803:Kdm5b
|
UTSW |
1 |
134,543,679 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3980:Kdm5b
|
UTSW |
1 |
134,547,408 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3983:Kdm5b
|
UTSW |
1 |
134,559,042 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4013:Kdm5b
|
UTSW |
1 |
134,555,067 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4162:Kdm5b
|
UTSW |
1 |
134,552,899 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4701:Kdm5b
|
UTSW |
1 |
134,533,750 (GRCm39) |
intron |
probably benign |
|
|
R4791:Kdm5b
|
UTSW |
1 |
134,558,538 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4836:Kdm5b
|
UTSW |
1 |
134,521,053 (GRCm39) |
splice site |
probably null |
|
|
R4924:Kdm5b
|
UTSW |
1 |
134,559,089 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5135:Kdm5b
|
UTSW |
1 |
134,516,484 (GRCm39) |
intron |
probably benign |
|
|
R5248:Kdm5b
|
UTSW |
1 |
134,548,735 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5290:Kdm5b
|
UTSW |
1 |
134,549,837 (GRCm39) |
splice site |
probably null |
|
|
R5358:Kdm5b
|
UTSW |
1 |
134,535,432 (GRCm39) |
nonsense |
probably null |
|
|
R5388:Kdm5b
|
UTSW |
1 |
134,536,635 (GRCm39) |
nonsense |
probably null |
|
|
R5396:Kdm5b
|
UTSW |
1 |
134,549,836 (GRCm39) |
splice site |
probably null |
|
|
R5397:Kdm5b
|
UTSW |
1 |
134,549,836 (GRCm39) |
splice site |
probably null |
|
|
R5398:Kdm5b
|
UTSW |
1 |
134,549,836 (GRCm39) |
splice site |
probably null |
|
|
R5399:Kdm5b
|
UTSW |
1 |
134,549,836 (GRCm39) |
splice site |
probably null |
|
|
R5529:Kdm5b
|
UTSW |
1 |
134,515,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5540:Kdm5b
|
UTSW |
1 |
134,558,979 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5661:Kdm5b
|
UTSW |
1 |
134,526,811 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5663:Kdm5b
|
UTSW |
1 |
134,558,373 (GRCm39) |
missense |
probably benign |
|
|
R5822:Kdm5b
|
UTSW |
1 |
134,516,511 (GRCm39) |
splice site |
probably benign |
|
|
R6226:Kdm5b
|
UTSW |
1 |
134,536,616 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6368:Kdm5b
|
UTSW |
1 |
134,526,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6681:Kdm5b
|
UTSW |
1 |
134,541,007 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6715:Kdm5b
|
UTSW |
1 |
134,536,799 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7132:Kdm5b
|
UTSW |
1 |
134,526,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7202:Kdm5b
|
UTSW |
1 |
134,552,497 (GRCm39) |
missense |
probably benign |
|
|
R7258:Kdm5b
|
UTSW |
1 |
134,548,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7335:Kdm5b
|
UTSW |
1 |
134,488,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7420:Kdm5b
|
UTSW |
1 |
134,532,235 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7426:Kdm5b
|
UTSW |
1 |
134,523,571 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7452:Kdm5b
|
UTSW |
1 |
134,552,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7595:Kdm5b
|
UTSW |
1 |
134,536,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7612:Kdm5b
|
UTSW |
1 |
134,552,656 (GRCm39) |
nonsense |
probably null |
|
|
R7704:Kdm5b
|
UTSW |
1 |
134,515,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Kdm5b
|
UTSW |
1 |
134,545,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8115:Kdm5b
|
UTSW |
1 |
134,547,411 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8146:Kdm5b
|
UTSW |
1 |
134,552,864 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8160:Kdm5b
|
UTSW |
1 |
134,541,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8527:Kdm5b
|
UTSW |
1 |
134,533,512 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8542:Kdm5b
|
UTSW |
1 |
134,533,512 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8930:Kdm5b
|
UTSW |
1 |
134,544,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8932:Kdm5b
|
UTSW |
1 |
134,544,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8950:Kdm5b
|
UTSW |
1 |
134,541,664 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9089:Kdm5b
|
UTSW |
1 |
134,535,506 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9109:Kdm5b
|
UTSW |
1 |
134,528,493 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9133:Kdm5b
|
UTSW |
1 |
134,530,323 (GRCm39) |
missense |
probably benign |
|
|
R9298:Kdm5b
|
UTSW |
1 |
134,528,493 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9423:Kdm5b
|
UTSW |
1 |
134,515,705 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9630:Kdm5b
|
UTSW |
1 |
134,512,971 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9670:Kdm5b
|
UTSW |
1 |
134,558,240 (GRCm39) |
nonsense |
probably null |
|
|
X0063:Kdm5b
|
UTSW |
1 |
134,516,614 (GRCm39) |
missense |
probably benign |
0.07 |
|
Z1176:Kdm5b
|
UTSW |
1 |
134,552,773 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Kdm5b
|
UTSW |
1 |
134,523,536 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
|
| Posted On |
2014-08-25 |
Incidental Mutation