Incidental Mutation 'R1970:Scn9a'
ID 219630
Institutional Source Beutler Lab
Gene Symbol Scn9a
Ensembl Gene ENSMUSG00000075316
Gene Name sodium channel, voltage-gated, type IX, alpha
Synonyms PN1
MMRRC Submission 039983-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1970 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 66480080-66634962 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to T at 66515380 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Proline to Glutamine at position 1123 (P1123Q)
Ref Sequence ENSEMBL: ENSMUSP00000131711 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100063] [ENSMUST00000100064] [ENSMUST00000112354] [ENSMUST00000164384] [ENSMUST00000169900]
AlphaFold Q62205
Predicted Effect possibly damaging
Transcript: ENSMUST00000100063
AA Change: P1125Q

PolyPhen 2 Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000097641
Gene: ENSMUSG00000075316
AA Change: P1125Q

DomainStartEndE-ValueType
low complexity region 29 49 N/A INTRINSIC
Pfam:Ion_trans 154 403 9.5e-78 PFAM
coiled coil region 404 442 N/A INTRINSIC
Pfam:DUF3451 465 685 1.3e-62 PFAM
Pfam:Ion_trans 768 957 9.9e-48 PFAM
Pfam:Na_trans_assoc 972 1191 2.9e-72 PFAM
low complexity region 1203 1214 N/A INTRINSIC
Pfam:Ion_trans 1217 1445 2.8e-55 PFAM
PDB:1BYY|A 1447 1499 9e-27 PDB
Pfam:Ion_trans 1538 1748 3.4e-52 PFAM
Pfam:PKD_channel 1599 1755 1.1e-7 PFAM
IQ 1877 1899 1.03e-3 SMART
low complexity region 1956 1972 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000100064
AA Change: P1134Q

PolyPhen 2 Score 0.369 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000097642
Gene: ENSMUSG00000075316
AA Change: P1134Q

DomainStartEndE-ValueType
low complexity region 29 49 N/A INTRINSIC
Pfam:Ion_trans 125 412 2.2e-84 PFAM
low complexity region 433 446 N/A INTRINSIC
Pfam:Na_trans_cytopl 483 693 7.5e-76 PFAM
Pfam:Ion_trans 742 977 4.1e-57 PFAM
Pfam:Na_trans_assoc 981 1185 1.4e-58 PFAM
Pfam:Ion_trans 1189 1466 7e-67 PFAM
Pfam:Ion_trans 1512 1769 1e-55 PFAM
Pfam:PKD_channel 1605 1763 2.6e-7 PFAM
IQ 1886 1908 1.03e-3 SMART
low complexity region 1965 1981 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000112354
AA Change: P1123Q

PolyPhen 2 Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000107973
Gene: ENSMUSG00000075316
AA Change: P1123Q

DomainStartEndE-ValueType
low complexity region 29 49 N/A INTRINSIC
Pfam:Ion_trans 154 401 1.2e-77 PFAM
coiled coil region 402 449 N/A INTRINSIC
Pfam:DUF3451 463 683 1.3e-62 PFAM
Pfam:Ion_trans 766 955 9.9e-48 PFAM
Pfam:Na_trans_assoc 970 1189 2.9e-72 PFAM
low complexity region 1201 1212 N/A INTRINSIC
Pfam:Ion_trans 1215 1443 2.8e-55 PFAM
PDB:1BYY|A 1445 1497 7e-29 PDB
Pfam:Ion_trans 1536 1746 3.4e-52 PFAM
Pfam:PKD_channel 1597 1753 1.1e-7 PFAM
IQ 1875 1897 1.03e-3 SMART
low complexity region 1954 1970 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141149
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152740
Predicted Effect probably benign
Transcript: ENSMUST00000164384
AA Change: P1134Q

PolyPhen 2 Score 0.369 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000126528
Gene: ENSMUSG00000075316
AA Change: P1134Q

DomainStartEndE-ValueType
low complexity region 29 49 N/A INTRINSIC
Pfam:Ion_trans 154 401 1.1e-77 PFAM
coiled coil region 402 449 N/A INTRINSIC
Pfam:DUF3451 463 694 4.2e-66 PFAM
Pfam:Ion_trans 777 966 8.8e-48 PFAM
Pfam:Na_trans_assoc 981 1200 6e-72 PFAM
low complexity region 1212 1223 N/A INTRINSIC
Pfam:Ion_trans 1226 1454 2.5e-55 PFAM
PDB:1BYY|A 1456 1508 6e-29 PDB
Pfam:Ion_trans 1547 1757 3e-52 PFAM
Pfam:PKD_channel 1608 1764 8.1e-8 PFAM
IQ 1886 1908 1.03e-3 SMART
low complexity region 1965 1981 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000169900
AA Change: P1123Q

PolyPhen 2 Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000131711
Gene: ENSMUSG00000075316
AA Change: P1123Q

DomainStartEndE-ValueType
low complexity region 29 49 N/A INTRINSIC
Pfam:Ion_trans 154 401 3.7e-78 PFAM
coiled coil region 402 449 N/A INTRINSIC
Pfam:DUF3451 463 683 1.3e-62 PFAM
Pfam:Ion_trans 766 955 9.9e-48 PFAM
Pfam:Na_trans_assoc 970 1189 2.9e-72 PFAM
low complexity region 1201 1212 N/A INTRINSIC
Pfam:Ion_trans 1215 1443 2.8e-55 PFAM
PDB:1BYY|A 1445 1497 7e-29 PDB
Pfam:Ion_trans 1536 1746 3.4e-52 PFAM
Pfam:PKD_channel 1597 1753 1.1e-7 PFAM
IQ 1875 1897 1.03e-3 SMART
low complexity region 1954 1970 N/A INTRINSIC
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.2%
Validation Efficiency 97% (121/125)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit prenatal/neonatal lethality. Mice homozygous for a knock-in allele exhibit increased susceptibility to electrically induced seizures. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 121 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 A T 17: 24,307,575 (GRCm38) H578Q probably benign Het
Abcc12 A G 8: 86,527,281 (GRCm38) I958T probably benign Het
Abcg5 AATCATTTG AG 17: 84,673,602 (GRCm38) probably null Het
Acap2 A G 16: 31,133,527 (GRCm38) probably null Het
Adgrb1 T C 15: 74,539,877 (GRCm38) probably benign Het
Akap6 T A 12: 52,938,475 (GRCm38) V897E probably damaging Het
Als2 A T 1: 59,215,169 (GRCm38) L343Q probably benign Het
Arhgap5 A G 12: 52,542,593 (GRCm38) I1275M probably damaging Het
Arnt C T 3: 95,448,393 (GRCm38) S16L possibly damaging Het
Bglap3 C T 3: 88,376,993 (GRCm38) probably benign Het
Blnk T C 19: 40,940,165 (GRCm38) probably benign Het
C1qtnf4 T C 2: 90,889,659 (GRCm38) M92T probably damaging Het
C77080 A G 4: 129,226,017 (GRCm38) probably benign Het
Ccdc177 G A 12: 80,758,712 (GRCm38) R263C unknown Het
Ccdc83 T A 7: 90,244,154 (GRCm38) S132C probably damaging Het
Cdc7 A G 5: 106,973,074 (GRCm38) probably benign Het
Cgnl1 T A 9: 71,725,535 (GRCm38) N178I probably benign Het
Col27a1 C T 4: 63,273,117 (GRCm38) probably benign Het
Col5a1 A T 2: 27,986,754 (GRCm38) M822L unknown Het
Coro7 T C 16: 4,633,756 (GRCm38) I451V probably benign Het
Csmd3 T C 15: 48,673,531 (GRCm38) T92A probably damaging Het
Ddc A G 11: 11,815,292 (GRCm38) V460A possibly damaging Het
Ddx4 C T 13: 112,600,013 (GRCm38) V608I probably damaging Het
Ddx60 A T 8: 61,972,206 (GRCm38) H676L possibly damaging Het
Dmtf1 T C 5: 9,148,989 (GRCm38) E48G probably benign Het
Dpf3 T A 12: 83,325,035 (GRCm38) probably null Het
Dydc2 A G 14: 41,061,903 (GRCm38) C88R probably benign Het
Elovl4 A G 9: 83,780,719 (GRCm38) Y163H probably damaging Het
Enpp2 T C 15: 54,882,982 (GRCm38) D296G probably damaging Het
Fam83h G T 15: 76,006,570 (GRCm38) probably benign Het
Fbf1 T A 11: 116,151,491 (GRCm38) Q511L possibly damaging Het
Fhdc1 A T 3: 84,454,851 (GRCm38) L323Q probably damaging Het
Fmnl2 T A 2: 53,105,576 (GRCm38) V437D possibly damaging Het
Foxo3 A G 10: 42,197,262 (GRCm38) S420P probably benign Het
Foxp4 C T 17: 47,875,871 (GRCm38) R378Q unknown Het
Garem2 G T 5: 30,117,174 (GRCm38) G844* probably null Het
Glmp T C 3: 88,327,870 (GRCm38) L269S probably damaging Het
Gm2000 T G 1: 156,366,447 (GRCm38) *124G probably null Het
Gm9915 T C 1: 42,230,721 (GRCm38) noncoding transcript Het
Gnb4 A T 3: 32,598,141 (GRCm38) D27E probably damaging Het
Gnb5 A G 9: 75,344,650 (GRCm38) probably null Het
Gpr161 T G 1: 165,306,358 (GRCm38) V63G probably damaging Het
Gsk3a T A 7: 25,229,721 (GRCm38) probably benign Het
Hapln2 T C 3: 88,024,120 (GRCm38) probably null Het
Incenp G T 19: 9,885,487 (GRCm38) T401N unknown Het
Kalrn A G 16: 33,977,524 (GRCm38) probably null Het
Kcnq3 A G 15: 66,028,623 (GRCm38) probably null Het
Kif21b T C 1: 136,171,156 (GRCm38) V1394A probably damaging Het
Klhl23 T C 2: 69,833,686 (GRCm38) C460R probably damaging Het
L3mbtl1 G A 2: 162,959,572 (GRCm38) A291T probably damaging Het
Lcp1 T C 14: 75,200,506 (GRCm38) S119P probably damaging Het
Ldhc A G 7: 46,869,751 (GRCm38) I133V probably benign Het
Lmntd2 G A 7: 141,212,059 (GRCm38) probably benign Het
Lpl A T 8: 68,896,802 (GRCm38) K327* probably null Het
Lrp1b T C 2: 40,875,069 (GRCm38) D2801G probably damaging Het
Mppe1 C A 18: 67,229,772 (GRCm38) A131S probably benign Het
Msh3 T A 13: 92,249,820 (GRCm38) probably benign Het
Msh5 A G 17: 35,033,600 (GRCm38) I377T probably damaging Het
Myo1e T C 9: 70,368,773 (GRCm38) F757L probably benign Het
Myof A T 19: 37,945,634 (GRCm38) D955E probably damaging Het
Nckap1 C T 2: 80,517,942 (GRCm38) S889N probably benign Het
Ncor2 T C 5: 125,038,918 (GRCm38) D858G probably damaging Het
Neb A T 2: 52,263,905 (GRCm38) V2398D possibly damaging Het
Nefl C G 14: 68,086,672 (GRCm38) T453R probably benign Het
Nf1 A G 11: 79,553,961 (GRCm38) N371D probably benign Het
Nlrp4f T C 13: 65,194,091 (GRCm38) Y580C probably damaging Het
Nme8 A C 13: 19,652,322 (GRCm38) L228R probably damaging Het
Numa1 C T 7: 102,009,322 (GRCm38) A1605V probably damaging Het
Ofd1 T C X: 166,427,214 (GRCm38) Y205C probably benign Het
Olfr1047 T A 2: 86,228,252 (GRCm38) T240S probably damaging Het
Olfr1283 C T 2: 111,369,076 (GRCm38) S148L probably benign Het
Olfr1532-ps1 G A 7: 106,914,246 (GRCm38) G16D probably damaging Het
Olfr693 T A 7: 106,677,670 (GRCm38) N272I probably damaging Het
Olfr972 T A 9: 39,873,938 (GRCm38) I221N probably damaging Het
Pclo A G 5: 14,713,473 (GRCm38) T3987A unknown Het
Pdgfrb G A 18: 61,066,494 (GRCm38) probably benign Het
Pdxk G A 10: 78,441,154 (GRCm38) T270I probably damaging Het
Pex5 T C 6: 124,414,405 (GRCm38) E10G probably damaging Het
Pik3c2g T A 6: 139,900,386 (GRCm38) probably null Het
Pkhd1 T A 1: 20,381,523 (GRCm38) I2183F probably damaging Het
Plppr2 T C 9: 21,941,126 (GRCm38) V102A probably damaging Het
Plxnd1 T C 6: 115,962,517 (GRCm38) T1449A probably damaging Het
Pnkd T A 1: 74,285,910 (GRCm38) probably null Het
Pom121l2 A G 13: 21,983,472 (GRCm38) I638V probably damaging Het
Prag1 A G 8: 36,129,160 (GRCm38) probably null Het
Ranbp10 A G 8: 105,786,708 (GRCm38) F191L probably damaging Het
Rapgef1 T C 2: 29,733,711 (GRCm38) L824P probably damaging Het
Rec8 T C 14: 55,624,142 (GRCm38) L418P probably damaging Het
Rimbp2 T A 5: 128,797,241 (GRCm38) N429Y probably damaging Het
Rpe65 C A 3: 159,615,670 (GRCm38) T373K probably benign Het
Rrn3 T C 16: 13,789,074 (GRCm38) S151P probably damaging Het
Scn7a A G 2: 66,684,289 (GRCm38) V1047A possibly damaging Het
Secisbp2l T C 2: 125,747,510 (GRCm38) D706G probably damaging Het
Serpina5 A T 12: 104,103,857 (GRCm38) T338S probably benign Het
Sez6 G A 11: 77,954,068 (GRCm38) probably null Het
Shisa4 C T 1: 135,372,274 (GRCm38) G157D probably damaging Het
Slc1a7 G T 4: 107,968,585 (GRCm38) D14Y probably benign Het
Slc25a11 A C 11: 70,646,173 (GRCm38) L51V probably benign Het
Slit3 A G 11: 35,630,841 (GRCm38) probably null Het
Spata13 G T 14: 60,691,463 (GRCm38) G157W probably damaging Het
Spta1 T C 1: 174,240,367 (GRCm38) V2120A possibly damaging Het
Srpr T C 9: 35,213,538 (GRCm38) probably null Het
Syt6 A G 3: 103,587,420 (GRCm38) I234V probably benign Het
Thada G T 17: 84,310,042 (GRCm38) P1349T probably damaging Het
Tmem161a C T 8: 70,176,909 (GRCm38) R58W probably damaging Het
Top3b A G 16: 16,883,519 (GRCm38) I232V probably damaging Het
Tspan1 T A 4: 116,163,629 (GRCm38) Q197L possibly damaging Het
Ttc28 A C 5: 111,235,635 (GRCm38) Y1334S probably benign Het
Ubxn6 G T 17: 56,073,077 (GRCm38) N28K possibly damaging Het
Uggt1 T C 1: 36,151,781 (GRCm38) D1366G probably damaging Het
Ugp2 A G 11: 21,328,942 (GRCm38) S415P probably damaging Het
Vcan A T 13: 89,689,038 (GRCm38) S2796T probably damaging Het
Vipr2 T C 12: 116,136,206 (GRCm38) V231A probably benign Het
Vmn1r176 T C 7: 23,834,948 (GRCm38) N260S probably benign Het
Vmn1r59 A T 7: 5,454,039 (GRCm38) Y241N probably damaging Het
Vmn2r67 A T 7: 85,151,805 (GRCm38) Y308N probably benign Het
Vmn2r75 A T 7: 86,148,262 (GRCm38) M781K probably damaging Het
Vwa3a A T 7: 120,780,171 (GRCm38) I500F probably damaging Het
Zfp609 A G 9: 65,795,277 (GRCm38) V31A probably damaging Het
Zfp689 G T 7: 127,444,787 (GRCm38) Q224K probably damaging Het
Zfp81 A T 17: 33,335,501 (GRCm38) L113H probably benign Het
Other mutations in Scn9a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00514:Scn9a APN 2 66,563,601 (GRCm38) missense probably damaging 1.00
IGL00570:Scn9a APN 2 66,484,142 (GRCm38) missense probably damaging 1.00
IGL00809:Scn9a APN 2 66,483,935 (GRCm38) missense probably damaging 1.00
IGL00977:Scn9a APN 2 66,484,301 (GRCm38) missense probably damaging 0.99
IGL01120:Scn9a APN 2 66,526,972 (GRCm38) missense probably benign 0.00
IGL01134:Scn9a APN 2 66,504,968 (GRCm38) missense probably damaging 1.00
IGL01300:Scn9a APN 2 66,488,053 (GRCm38) nonsense probably null
IGL01452:Scn9a APN 2 66,527,072 (GRCm38) missense probably damaging 1.00
IGL01531:Scn9a APN 2 66,537,378 (GRCm38) missense probably benign 0.11
IGL01572:Scn9a APN 2 66,493,886 (GRCm38) missense probably benign 0.00
IGL01645:Scn9a APN 2 66,487,642 (GRCm38) missense possibly damaging 0.62
IGL01823:Scn9a APN 2 66,484,042 (GRCm38) missense probably damaging 1.00
IGL01965:Scn9a APN 2 66,484,433 (GRCm38) missense probably damaging 1.00
IGL02127:Scn9a APN 2 66,494,826 (GRCm38) missense probably damaging 1.00
IGL02127:Scn9a APN 2 66,547,135 (GRCm38) missense probably damaging 1.00
IGL02166:Scn9a APN 2 66,493,103 (GRCm38) missense possibly damaging 0.95
IGL02183:Scn9a APN 2 66,484,611 (GRCm38) splice site probably benign
IGL02640:Scn9a APN 2 66,536,096 (GRCm38) critical splice donor site probably null
IGL02685:Scn9a APN 2 66,537,293 (GRCm38) missense probably damaging 1.00
IGL02798:Scn9a APN 2 66,540,559 (GRCm38) missense possibly damaging 0.52
IGL02832:Scn9a APN 2 66,568,029 (GRCm38) missense probably damaging 1.00
IGL03008:Scn9a APN 2 66,562,511 (GRCm38) missense probably damaging 1.00
IGL03270:Scn9a APN 2 66,484,014 (GRCm38) missense probably damaging 1.00
IGL03408:Scn9a APN 2 66,526,747 (GRCm38) missense probably benign 0.00
BB007:Scn9a UTSW 2 66,504,849 (GRCm38) missense probably damaging 0.99
BB017:Scn9a UTSW 2 66,504,849 (GRCm38) missense probably damaging 0.99
R0039:Scn9a UTSW 2 66,562,444 (GRCm38) missense probably damaging 0.98
R0173:Scn9a UTSW 2 66,533,093 (GRCm38) missense probably damaging 1.00
R0323:Scn9a UTSW 2 66,568,131 (GRCm38) missense probably damaging 1.00
R0344:Scn9a UTSW 2 66,505,010 (GRCm38) missense probably damaging 0.99
R0421:Scn9a UTSW 2 66,543,277 (GRCm38) missense probably benign
R0465:Scn9a UTSW 2 66,526,996 (GRCm38) missense probably damaging 1.00
R0514:Scn9a UTSW 2 66,483,678 (GRCm38) missense probably damaging 1.00
R0599:Scn9a UTSW 2 66,526,799 (GRCm38) missense probably damaging 0.96
R0627:Scn9a UTSW 2 66,537,377 (GRCm38) missense probably benign 0.00
R0644:Scn9a UTSW 2 66,533,061 (GRCm38) critical splice donor site probably null
R0653:Scn9a UTSW 2 66,533,377 (GRCm38) missense probably damaging 1.00
R0685:Scn9a UTSW 2 66,483,499 (GRCm38) missense probably benign 0.02
R0718:Scn9a UTSW 2 66,547,112 (GRCm38) missense probably damaging 1.00
R0827:Scn9a UTSW 2 66,536,124 (GRCm38) nonsense probably null
R0890:Scn9a UTSW 2 66,483,735 (GRCm38) missense probably damaging 1.00
R1139:Scn9a UTSW 2 66,504,997 (GRCm38) missense probably benign 0.02
R1385:Scn9a UTSW 2 66,563,542 (GRCm38) missense probably damaging 1.00
R1398:Scn9a UTSW 2 66,484,586 (GRCm38) missense probably benign 0.11
R1496:Scn9a UTSW 2 66,526,888 (GRCm38) missense probably benign
R1511:Scn9a UTSW 2 66,526,813 (GRCm38) missense probably benign 0.01
R1517:Scn9a UTSW 2 66,505,027 (GRCm38) splice site probably benign
R1564:Scn9a UTSW 2 66,484,304 (GRCm38) missense probably damaging 1.00
R1634:Scn9a UTSW 2 66,488,017 (GRCm38) missense probably damaging 1.00
R1662:Scn9a UTSW 2 66,483,459 (GRCm38) missense probably benign 0.00
R1695:Scn9a UTSW 2 66,504,876 (GRCm38) nonsense probably null
R1709:Scn9a UTSW 2 66,483,506 (GRCm38) missense probably damaging 1.00
R1741:Scn9a UTSW 2 66,487,594 (GRCm38) missense probably damaging 0.99
R1755:Scn9a UTSW 2 66,501,716 (GRCm38) missense probably benign 0.38
R1914:Scn9a UTSW 2 66,566,250 (GRCm38) missense probably damaging 1.00
R1962:Scn9a UTSW 2 66,484,311 (GRCm38) missense probably damaging 1.00
R2017:Scn9a UTSW 2 66,515,321 (GRCm38) missense probably damaging 0.99
R2092:Scn9a UTSW 2 66,533,376 (GRCm38) missense probably damaging 0.99
R2105:Scn9a UTSW 2 66,568,183 (GRCm38) missense probably benign 0.25
R2114:Scn9a UTSW 2 66,484,052 (GRCm38) missense probably damaging 1.00
R2115:Scn9a UTSW 2 66,484,052 (GRCm38) missense probably damaging 1.00
R2128:Scn9a UTSW 2 66,526,654 (GRCm38) missense probably damaging 1.00
R2157:Scn9a UTSW 2 66,536,325 (GRCm38) missense probably damaging 1.00
R2162:Scn9a UTSW 2 66,534,229 (GRCm38) missense probably damaging 0.98
R2350:Scn9a UTSW 2 66,504,968 (GRCm38) missense probably damaging 1.00
R3694:Scn9a UTSW 2 66,562,405 (GRCm38) missense probably benign
R3771:Scn9a UTSW 2 66,483,648 (GRCm38) missense probably benign 0.26
R3772:Scn9a UTSW 2 66,483,648 (GRCm38) missense probably benign 0.26
R3773:Scn9a UTSW 2 66,483,648 (GRCm38) missense probably benign 0.26
R3922:Scn9a UTSW 2 66,526,873 (GRCm38) missense possibly damaging 0.88
R3926:Scn9a UTSW 2 66,526,873 (GRCm38) missense possibly damaging 0.88
R4258:Scn9a UTSW 2 66,565,054 (GRCm38) intron probably benign
R4385:Scn9a UTSW 2 66,484,556 (GRCm38) missense probably damaging 1.00
R4415:Scn9a UTSW 2 66,526,693 (GRCm38) missense probably damaging 1.00
R4570:Scn9a UTSW 2 66,483,558 (GRCm38) missense possibly damaging 0.85
R4682:Scn9a UTSW 2 66,547,018 (GRCm38) missense probably benign
R4783:Scn9a UTSW 2 66,540,623 (GRCm38) missense probably benign 0.01
R4822:Scn9a UTSW 2 66,483,749 (GRCm38) missense possibly damaging 0.55
R4829:Scn9a UTSW 2 66,551,713 (GRCm38) missense probably benign
R4908:Scn9a UTSW 2 66,526,743 (GRCm38) missense probably benign 0.03
R4983:Scn9a UTSW 2 66,566,270 (GRCm38) missense probably benign 0.02
R5047:Scn9a UTSW 2 66,562,480 (GRCm38) missense probably damaging 1.00
R5100:Scn9a UTSW 2 66,534,119 (GRCm38) missense probably damaging 1.00
R5140:Scn9a UTSW 2 66,565,167 (GRCm38) missense possibly damaging 0.81
R5398:Scn9a UTSW 2 66,488,043 (GRCm38) missense probably damaging 1.00
R5557:Scn9a UTSW 2 66,547,103 (GRCm38) missense probably damaging 0.99
R5582:Scn9a UTSW 2 66,565,029 (GRCm38) intron probably benign
R6108:Scn9a UTSW 2 66,484,049 (GRCm38) missense probably damaging 1.00
R6115:Scn9a UTSW 2 66,563,629 (GRCm38) missense possibly damaging 0.70
R6143:Scn9a UTSW 2 66,487,524 (GRCm38) missense probably benign 0.00
R6261:Scn9a UTSW 2 66,483,896 (GRCm38) missense probably damaging 1.00
R6335:Scn9a UTSW 2 66,568,264 (GRCm38) start codon destroyed possibly damaging 0.91
R6429:Scn9a UTSW 2 66,526,963 (GRCm38) missense possibly damaging 0.95
R6632:Scn9a UTSW 2 66,483,502 (GRCm38) missense probably benign 0.23
R6681:Scn9a UTSW 2 66,563,342 (GRCm38) missense possibly damaging 0.90
R6830:Scn9a UTSW 2 66,568,029 (GRCm38) missense probably damaging 1.00
R7102:Scn9a UTSW 2 66,549,015 (GRCm38) missense probably damaging 1.00
R7186:Scn9a UTSW 2 66,534,223 (GRCm38) missense probably damaging 1.00
R7243:Scn9a UTSW 2 66,540,530 (GRCm38) missense probably damaging 1.00
R7311:Scn9a UTSW 2 66,484,404 (GRCm38) missense possibly damaging 0.54
R7328:Scn9a UTSW 2 66,484,587 (GRCm38) missense probably benign
R7386:Scn9a UTSW 2 66,540,550 (GRCm38) missense probably damaging 1.00
R7438:Scn9a UTSW 2 66,547,187 (GRCm38) missense possibly damaging 0.81
R7483:Scn9a UTSW 2 66,533,348 (GRCm38) missense probably damaging 0.99
R7485:Scn9a UTSW 2 66,534,217 (GRCm38) missense probably damaging 1.00
R7526:Scn9a UTSW 2 66,483,646 (GRCm38) missense probably benign
R7617:Scn9a UTSW 2 66,540,549 (GRCm38) missense possibly damaging 0.55
R7642:Scn9a UTSW 2 66,536,236 (GRCm38) missense probably benign 0.02
R7653:Scn9a UTSW 2 66,527,080 (GRCm38) missense probably damaging 1.00
R7747:Scn9a UTSW 2 66,484,298 (GRCm38) missense probably damaging 1.00
R7823:Scn9a UTSW 2 66,483,791 (GRCm38) missense probably damaging 1.00
R7864:Scn9a UTSW 2 66,484,560 (GRCm38) missense possibly damaging 0.73
R7890:Scn9a UTSW 2 66,543,112 (GRCm38) missense probably benign 0.00
R7930:Scn9a UTSW 2 66,504,849 (GRCm38) missense probably damaging 0.99
R7975:Scn9a UTSW 2 66,484,253 (GRCm38) missense probably damaging 1.00
R8057:Scn9a UTSW 2 66,515,430 (GRCm38) missense probably benign 0.06
R8145:Scn9a UTSW 2 66,487,410 (GRCm38) missense probably damaging 1.00
R8163:Scn9a UTSW 2 66,484,401 (GRCm38) missense probably damaging 1.00
R8165:Scn9a UTSW 2 66,540,530 (GRCm38) missense probably damaging 1.00
R8342:Scn9a UTSW 2 66,536,282 (GRCm38) missense probably benign
R8345:Scn9a UTSW 2 66,494,622 (GRCm38) missense probably damaging 0.96
R8464:Scn9a UTSW 2 66,566,281 (GRCm38) missense probably damaging 0.99
R8467:Scn9a UTSW 2 66,501,671 (GRCm38) missense probably damaging 1.00
R8698:Scn9a UTSW 2 66,536,284 (GRCm38) missense probably benign 0.00
R8810:Scn9a UTSW 2 66,501,666 (GRCm38) missense probably damaging 1.00
R8822:Scn9a UTSW 2 66,540,635 (GRCm38) missense probably damaging 0.99
R8829:Scn9a UTSW 2 66,483,617 (GRCm38) missense probably benign
R9009:Scn9a UTSW 2 66,508,583 (GRCm38) missense probably damaging 1.00
R9038:Scn9a UTSW 2 66,494,803 (GRCm38) missense probably damaging 1.00
R9126:Scn9a UTSW 2 66,484,400 (GRCm38) missense probably damaging 1.00
R9205:Scn9a UTSW 2 66,533,313 (GRCm38) missense probably damaging 1.00
R9300:Scn9a UTSW 2 66,504,892 (GRCm38) missense probably benign 0.39
R9373:Scn9a UTSW 2 66,483,917 (GRCm38) missense probably benign 0.00
R9404:Scn9a UTSW 2 66,526,696 (GRCm38) missense probably benign 0.02
R9443:Scn9a UTSW 2 66,565,209 (GRCm38) missense probably damaging 1.00
R9590:Scn9a UTSW 2 66,483,984 (GRCm38) missense probably benign 0.05
R9612:Scn9a UTSW 2 66,533,364 (GRCm38) missense probably damaging 1.00
R9617:Scn9a UTSW 2 66,562,465 (GRCm38) missense probably damaging 1.00
R9717:Scn9a UTSW 2 66,526,658 (GRCm38) missense probably benign
X0003:Scn9a UTSW 2 66,508,647 (GRCm38) missense probably benign 0.02
X0062:Scn9a UTSW 2 66,568,077 (GRCm38) missense probably damaging 1.00
Z1176:Scn9a UTSW 2 66,540,592 (GRCm38) missense probably benign 0.00
Z1177:Scn9a UTSW 2 66,494,685 (GRCm38) missense possibly damaging 0.68
Predicted Primers PCR Primer
(F):5'- GTCAATAGATGTCAGACATATGGGG -3'
(R):5'- CTATGTTTTGACAGCCATCGTACTG -3'

Sequencing Primer
(F):5'- GGCACTTAAATAGAGCTCCGTGC -3'
(R):5'- TGACAGCCATCGTACTGTTAAAC -3'
Posted On 2014-08-25