Incidental Mutation 'R0086:Prr14l'
ID 19888
Institutional Source Beutler Lab
Gene Symbol Prr14l
Ensembl Gene ENSMUSG00000054280
Gene Name proline rich 14-like
Synonyms
MMRRC Submission 038373-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.269) question?
Stock # R0086 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 32789820-32854256 bp(-) (GRCm38)
Type of Mutation unclassified
DNA Base Change (assembly) T to A at 32831559 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000119569 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000120129] [ENSMUST00000130134] [ENSMUST00000144673] [ENSMUST00000155392]
AlphaFold E9Q7C4
Predicted Effect probably benign
Transcript: ENSMUST00000120129
SMART Domains Protein: ENSMUSP00000113259
Gene: ENSMUSG00000054280

DomainStartEndE-ValueType
low complexity region 720 731 N/A INTRINSIC
low complexity region 1433 1446 N/A INTRINSIC
low complexity region 1471 1480 N/A INTRINSIC
Pfam:Tantalus 1838 1895 2.9e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000130134
Predicted Effect probably benign
Transcript: ENSMUST00000144673
SMART Domains Protein: ENSMUSP00000124923
Gene: ENSMUSG00000093574

DomainStartEndE-ValueType
Pfam:Tantalus 158 193 1.2e-15 PFAM
Pfam:PS_Dcarbxylase 332 575 2.1e-71 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000155392
SMART Domains Protein: ENSMUSP00000119569
Gene: ENSMUSG00000054280

DomainStartEndE-ValueType
low complexity region 276 289 N/A INTRINSIC
low complexity region 314 323 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.0%
  • 10x: 94.6%
  • 20x: 86.6%
Validation Efficiency 96% (91/95)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik T A 15: 82,062,601 (GRCm38) V233D probably benign Het
Abcg8 T C 17: 84,692,771 (GRCm38) V252A probably damaging Het
Adam39 C T 8: 40,826,360 (GRCm38) T596I possibly damaging Het
Agap2 C A 10: 127,087,882 (GRCm38) probably null Het
Ap4b1 T G 3: 103,814,860 (GRCm38) V50G probably damaging Het
Atp13a1 T A 8: 69,797,774 (GRCm38) I381N possibly damaging Het
Bcl2 G A 1: 106,712,562 (GRCm38) R107C probably damaging Het
Birc6 T C 17: 74,593,166 (GRCm38) V1113A possibly damaging Het
C1galt1 T A 6: 7,867,051 (GRCm38) probably benign Het
Capza2 A G 6: 17,660,774 (GRCm38) K158E probably damaging Het
Cenpe C T 3: 135,264,424 (GRCm38) probably benign Het
Cercam T C 2: 29,871,064 (GRCm38) L42P probably damaging Het
Cfap54 T C 10: 93,028,594 (GRCm38) E807G possibly damaging Het
Cog6 A G 3: 52,993,570 (GRCm38) V157A probably damaging Het
Cts6 A T 13: 61,196,457 (GRCm38) probably benign Het
Cyp2c39 A T 19: 39,510,913 (GRCm38) I15F unknown Het
Dock7 A T 4: 98,945,144 (GRCm38) V1970D probably damaging Het
Exph5 A G 9: 53,337,930 (GRCm38) D73G possibly damaging Het
Gjc2 A T 11: 59,176,846 (GRCm38) M270K probably benign Het
Gns G A 10: 121,391,473 (GRCm38) D463N probably damaging Het
Hoxd8 G T 2: 74,705,932 (GRCm38) G129W probably damaging Het
Ina A G 19: 47,023,591 (GRCm38) T483A possibly damaging Het
Lmod3 T A 6: 97,247,345 (GRCm38) Q505L probably damaging Het
Map3k13 A G 16: 21,914,225 (GRCm38) N526D probably damaging Het
Map3k2 A T 18: 32,218,468 (GRCm38) I435F probably damaging Het
Mfsd6l A G 11: 68,556,565 (GRCm38) T81A probably benign Het
Micall1 T C 15: 79,125,489 (GRCm38) probably benign Het
Mkrn2 G T 6: 115,613,335 (GRCm38) M217I possibly damaging Het
Myh11 C A 16: 14,224,019 (GRCm38) Q720H probably damaging Het
Ncapg A G 5: 45,676,744 (GRCm38) probably null Het
Nlrp9a G A 7: 26,558,547 (GRCm38) C530Y probably damaging Het
Numb T C 12: 83,795,930 (GRCm38) T442A probably damaging Het
Oip5 C T 2: 119,617,929 (GRCm38) probably benign Het
Olfr1224-ps1 C T 2: 89,156,476 (GRCm38) R233H probably benign Het
Olfr342 A T 2: 36,527,450 (GRCm38) I13F possibly damaging Het
Olfr639 A G 7: 104,012,054 (GRCm38) I216T probably benign Het
Olfr936 T C 9: 39,046,895 (GRCm38) T175A probably benign Het
Pcnx T C 12: 81,992,058 (GRCm38) probably benign Het
Pkhd1l1 T A 15: 44,556,008 (GRCm38) N2956K possibly damaging Het
Plcl1 T A 1: 55,715,583 (GRCm38) W1030R probably damaging Het
Polr2i G A 7: 30,233,086 (GRCm38) V73M probably damaging Het
Pxdn G T 12: 30,002,419 (GRCm38) R865L possibly damaging Het
Scnn1a T C 6: 125,342,587 (GRCm38) probably benign Het
Shkbp1 G T 7: 27,352,026 (GRCm38) H203N probably benign Het
Skiv2l2 G T 13: 112,927,328 (GRCm38) F10L probably benign Het
Slc22a14 C T 9: 119,222,738 (GRCm38) probably benign Het
Snap29 C A 16: 17,428,236 (GRCm38) T240K probably damaging Het
Sp2 C A 11: 96,957,427 (GRCm38) G457C probably damaging Het
Ssr2 C T 3: 88,576,880 (GRCm38) probably benign Het
Synpo2 A T 3: 123,117,104 (GRCm38) C297* probably null Het
Tpm3 T A 3: 90,090,092 (GRCm38) probably benign Het
Trmt6 CTG C 2: 132,809,017 (GRCm38) probably benign Het
Trp63 T C 16: 25,871,087 (GRCm38) Y431H probably damaging Het
Tuba3b T A 6: 145,621,160 (GRCm38) C376S probably damaging Het
Ubxn4 G A 1: 128,262,904 (GRCm38) E256K probably benign Het
Ulk1 G A 5: 110,787,707 (GRCm38) probably benign Het
Usp24 T C 4: 106,392,360 (GRCm38) S1425P probably damaging Het
Xdh T C 17: 73,884,438 (GRCm38) I1335V probably benign Het
Zmynd15 T C 11: 70,464,232 (GRCm38) Y352H probably damaging Het
Other mutations in Prr14l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00229:Prr14l APN 5 32,830,676 (GRCm38) missense probably benign 0.04
IGL00331:Prr14l APN 5 32,831,066 (GRCm38) missense probably benign 0.02
IGL01571:Prr14l APN 5 32,828,806 (GRCm38) missense probably benign 0.01
IGL01795:Prr14l APN 5 32,831,845 (GRCm38) unclassified probably benign
IGL01929:Prr14l APN 5 32,828,243 (GRCm38) missense probably benign 0.09
IGL01959:Prr14l APN 5 32,830,205 (GRCm38) missense possibly damaging 0.84
IGL02139:Prr14l APN 5 32,827,532 (GRCm38) missense probably damaging 1.00
IGL02321:Prr14l APN 5 32,827,807 (GRCm38) missense probably benign 0.10
IGL02508:Prr14l APN 5 32,830,942 (GRCm38) missense probably benign 0.01
IGL02551:Prr14l APN 5 32,831,484 (GRCm38) missense probably damaging 1.00
IGL02585:Prr14l APN 5 32,829,484 (GRCm38) missense possibly damaging 0.59
IGL02614:Prr14l APN 5 32,830,543 (GRCm38) missense possibly damaging 0.76
IGL02808:Prr14l APN 5 32,828,182 (GRCm38) missense possibly damaging 0.94
IGL02836:Prr14l APN 5 32,831,096 (GRCm38) missense probably benign 0.42
IGL02952:Prr14l APN 5 32,835,670 (GRCm38) missense unknown
IGL03034:Prr14l APN 5 32,827,438 (GRCm38) missense possibly damaging 0.48
Polymer UTSW 5 32,827,145 (GRCm38) missense probably benign 0.34
Postwar UTSW 5 32,830,684 (GRCm38) missense probably benign 0.17
H8562:Prr14l UTSW 5 32,793,728 (GRCm38) missense probably damaging 1.00
R0149:Prr14l UTSW 5 32,793,641 (GRCm38) missense probably damaging 1.00
R0333:Prr14l UTSW 5 32,827,993 (GRCm38) missense probably damaging 1.00
R0361:Prr14l UTSW 5 32,793,641 (GRCm38) missense probably damaging 1.00
R0416:Prr14l UTSW 5 32,828,717 (GRCm38) missense probably benign 0.25
R0480:Prr14l UTSW 5 32,829,880 (GRCm38) missense probably benign 0.02
R0511:Prr14l UTSW 5 32,844,216 (GRCm38) intron probably benign
R0639:Prr14l UTSW 5 32,828,915 (GRCm38) missense probably benign 0.02
R0673:Prr14l UTSW 5 32,828,915 (GRCm38) missense probably benign 0.02
R0743:Prr14l UTSW 5 32,831,194 (GRCm38) missense possibly damaging 0.55
R0792:Prr14l UTSW 5 32,828,423 (GRCm38) missense probably damaging 1.00
R1006:Prr14l UTSW 5 32,829,482 (GRCm38) missense probably benign 0.00
R1342:Prr14l UTSW 5 32,830,260 (GRCm38) missense probably damaging 1.00
R1433:Prr14l UTSW 5 32,828,833 (GRCm38) missense probably damaging 1.00
R1527:Prr14l UTSW 5 32,827,949 (GRCm38) missense possibly damaging 0.75
R1704:Prr14l UTSW 5 32,830,282 (GRCm38) missense probably benign 0.01
R1967:Prr14l UTSW 5 32,844,469 (GRCm38) intron probably benign
R2129:Prr14l UTSW 5 32,831,828 (GRCm38) unclassified probably benign
R2150:Prr14l UTSW 5 32,830,702 (GRCm38) missense probably benign 0.14
R2318:Prr14l UTSW 5 32,830,078 (GRCm38) missense probably benign 0.04
R2915:Prr14l UTSW 5 32,829,768 (GRCm38) missense probably benign 0.04
R3551:Prr14l UTSW 5 32,828,619 (GRCm38) splice site probably null
R3820:Prr14l UTSW 5 32,828,984 (GRCm38) missense probably damaging 0.99
R3852:Prr14l UTSW 5 32,830,345 (GRCm38) missense probably damaging 1.00
R4126:Prr14l UTSW 5 32,828,003 (GRCm38) missense probably damaging 0.97
R4345:Prr14l UTSW 5 32,828,576 (GRCm38) missense probably damaging 1.00
R4388:Prr14l UTSW 5 32,829,254 (GRCm38) missense probably damaging 1.00
R4575:Prr14l UTSW 5 32,793,644 (GRCm38) missense probably damaging 1.00
R4596:Prr14l UTSW 5 32,829,308 (GRCm38) missense probably benign 0.01
R4690:Prr14l UTSW 5 32,844,156 (GRCm38) intron probably benign
R4824:Prr14l UTSW 5 32,844,399 (GRCm38) intron probably benign
R4868:Prr14l UTSW 5 32,829,937 (GRCm38) missense probably benign 0.04
R4869:Prr14l UTSW 5 32,828,833 (GRCm38) missense probably damaging 1.00
R5201:Prr14l UTSW 5 32,830,247 (GRCm38) missense possibly damaging 0.52
R5328:Prr14l UTSW 5 32,830,021 (GRCm38) missense probably benign 0.00
R5410:Prr14l UTSW 5 32,827,777 (GRCm38) missense probably damaging 0.98
R5476:Prr14l UTSW 5 32,844,138 (GRCm38) intron probably benign
R5623:Prr14l UTSW 5 32,844,508 (GRCm38) intron probably benign
R5730:Prr14l UTSW 5 32,793,603 (GRCm38) missense probably damaging 1.00
R5988:Prr14l UTSW 5 32,830,851 (GRCm38) missense probably damaging 0.98
R6261:Prr14l UTSW 5 32,829,404 (GRCm38) missense possibly damaging 0.46
R6283:Prr14l UTSW 5 32,830,264 (GRCm38) missense probably benign 0.14
R6307:Prr14l UTSW 5 32,827,525 (GRCm38) missense probably damaging 0.97
R6825:Prr14l UTSW 5 32,828,548 (GRCm38) missense possibly damaging 0.86
R6862:Prr14l UTSW 5 32,827,759 (GRCm38) missense probably damaging 1.00
R6880:Prr14l UTSW 5 32,830,867 (GRCm38) missense probably benign 0.01
R6931:Prr14l UTSW 5 32,830,691 (GRCm38) missense probably damaging 0.98
R7101:Prr14l UTSW 5 32,829,427 (GRCm38) missense probably damaging 1.00
R7164:Prr14l UTSW 5 32,829,166 (GRCm38) missense probably damaging 1.00
R7203:Prr14l UTSW 5 32,827,145 (GRCm38) missense probably benign 0.34
R7211:Prr14l UTSW 5 32,830,087 (GRCm38) missense probably damaging 0.98
R7305:Prr14l UTSW 5 32,831,101 (GRCm38) missense probably benign 0.14
R7346:Prr14l UTSW 5 32,830,684 (GRCm38) missense probably benign 0.17
R7395:Prr14l UTSW 5 32,828,638 (GRCm38) missense probably benign 0.00
R7624:Prr14l UTSW 5 32,829,623 (GRCm38) missense possibly damaging 0.54
R7649:Prr14l UTSW 5 32,828,245 (GRCm38) missense probably benign 0.18
R7753:Prr14l UTSW 5 32,827,253 (GRCm38) missense probably damaging 1.00
R7828:Prr14l UTSW 5 32,844,391 (GRCm38) intron probably benign
R7898:Prr14l UTSW 5 32,829,966 (GRCm38) missense probably benign 0.04
R8071:Prr14l UTSW 5 32,831,164 (GRCm38) missense probably benign 0.02
R9052:Prr14l UTSW 5 32,830,134 (GRCm38) nonsense probably null
R9136:Prr14l UTSW 5 32,828,736 (GRCm38) missense
R9682:Prr14l UTSW 5 32,830,679 (GRCm38) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GGTTACTGGATTCCACAGCCCTTTC -3'
(R):5'- TGGCACTGTGAGACAACATCTGAC -3'

Sequencing Primer
(F):5'- GGGTTTTTTCAGCACACGC -3'
(R):5'- GACCAGCAATGAGTTTTGGG -3'
Posted On 2013-04-11