Incidental Mutation 'R5914:Trip12'
| ID |
461158 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip12
|
| Ensembl Gene |
ENSMUSG00000026219 |
| Gene Name |
thyroid hormone receptor interactor 12 |
| Synonyms |
Gtl6, 1110036I07Rik, 6720416K24Rik |
| MMRRC Submission |
044111-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5914 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
84698910-84818237 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 84741179 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 571
(E571G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139563
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027421]
[ENSMUST00000185909]
[ENSMUST00000186465]
[ENSMUST00000186648]
[ENSMUST00000186894]
|
| AlphaFold |
G5E870 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000027421
AA Change: E577G
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000027421
Gene: ENSMUSG00000026219
AA Change: E577G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
765 |
831 |
7.6e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000185567
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000185672
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000185909
|
| SMART Domains |
Protein: ENSMUSP00000139986
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
195 |
214 |
N/A |
INTRINSIC |
|
low complexity region
|
219 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
289 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186465
AA Change: E577G
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000140224
Gene: ENSMUSG00000026219
AA Change: E577G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
761 |
831 |
2.2e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186648
AA Change: E571G
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000139563
Gene: ENSMUSG00000026219
AA Change: E571G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
386 |
400 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
421 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
440 |
654 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
441 |
635 |
1e-5 |
PDB |
|
low complexity region
|
950 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1029 |
1040 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1311 |
N/A |
INTRINSIC |
|
low complexity region
|
1312 |
1329 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1330 |
1384 |
7e-8 |
BLAST |
|
Blast:HECTc
|
1540 |
1596 |
2e-24 |
BLAST |
|
HECTc
|
1603 |
1992 |
6.2e-180 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186894
AA Change: E577G
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000140267
Gene: ENSMUSG00000026219
AA Change: E577G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
3e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
7e-6 |
PDB |
|
Blast:ARM
|
476 |
516 |
6e-6 |
BLAST |
|
WWE
|
764 |
839 |
6.9e-25 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190464
|
| Meta Mutation Damage Score |
0.3835 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.4%
- 20x: 95.5%
|
| Validation Efficiency |
95% (87/92) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a targeted allele exhibit complete embryonic lethality during organogenesis associated with embryonic growth retardation and abnormal placenta development. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrb1 |
G |
A |
15: 74,410,219 (GRCm39) |
R286H |
possibly damaging |
Het |
| Ank3 |
A |
T |
10: 69,828,774 (GRCm39) |
|
probably benign |
Het |
| Arhgap24 |
G |
A |
5: 102,700,025 (GRCm39) |
|
probably null |
Het |
| Arhgef2 |
T |
C |
3: 88,543,176 (GRCm39) |
Y396H |
probably benign |
Het |
| Asap3 |
G |
T |
4: 135,968,720 (GRCm39) |
G722C |
probably benign |
Het |
| Birc2 |
A |
C |
9: 7,857,343 (GRCm39) |
*377E |
probably null |
Het |
| Cdc123 |
G |
T |
2: 5,803,174 (GRCm39) |
Q282K |
possibly damaging |
Het |
| Cdkl4 |
C |
T |
17: 80,855,120 (GRCm39) |
|
probably null |
Het |
| Cep97 |
T |
C |
16: 55,725,820 (GRCm39) |
N689S |
probably benign |
Het |
| Cfap97 |
T |
G |
8: 46,634,895 (GRCm39) |
S407A |
probably damaging |
Het |
| Cfh |
A |
T |
1: 140,063,967 (GRCm39) |
N436K |
probably benign |
Het |
| Chpf2 |
A |
T |
5: 24,797,421 (GRCm39) |
|
probably benign |
Het |
| Cnnm2 |
A |
G |
19: 46,751,616 (GRCm39) |
T469A |
probably benign |
Het |
| Col6a3 |
T |
A |
1: 90,703,922 (GRCm39) |
I2275F |
unknown |
Het |
| Ctdspl2 |
A |
T |
2: 121,809,414 (GRCm39) |
N122Y |
probably damaging |
Het |
| Dcaf6 |
A |
T |
1: 165,178,724 (GRCm39) |
C602S |
probably benign |
Het |
| Dda1 |
T |
A |
8: 71,927,294 (GRCm39) |
|
probably benign |
Het |
| Dixdc1 |
T |
C |
9: 50,609,888 (GRCm39) |
|
probably benign |
Het |
| Dnah2 |
C |
T |
11: 69,349,746 (GRCm39) |
R2399Q |
probably benign |
Het |
| Emilin3 |
T |
A |
2: 160,750,990 (GRCm39) |
N253I |
probably damaging |
Het |
| Epg5 |
T |
A |
18: 78,002,847 (GRCm39) |
|
probably null |
Het |
| Fam204a |
A |
T |
19: 60,209,525 (GRCm39) |
Y68* |
probably null |
Het |
| Fbln5 |
T |
G |
12: 101,727,002 (GRCm39) |
D329A |
possibly damaging |
Het |
| Fkbp15 |
T |
A |
4: 62,246,047 (GRCm39) |
|
probably null |
Het |
| Fnbp4 |
C |
G |
2: 90,605,137 (GRCm39) |
|
probably benign |
Het |
| Foxn2 |
C |
A |
17: 88,770,138 (GRCm39) |
|
probably null |
Het |
| Frem1 |
T |
C |
4: 82,920,012 (GRCm39) |
D448G |
probably damaging |
Het |
| Fzd9 |
T |
C |
5: 135,278,199 (GRCm39) |
Y562C |
probably benign |
Het |
| Gcn1 |
A |
G |
5: 115,748,194 (GRCm39) |
|
silent |
Het |
| Gm6003 |
A |
G |
7: 32,864,691 (GRCm39) |
|
noncoding transcript |
Het |
| Gnl3 |
C |
A |
14: 30,738,853 (GRCm39) |
E65D |
possibly damaging |
Het |
| Hax1 |
GTCATCATCATCATCATC |
GTCATCATCATCATCATCATC |
3: 89,905,247 (GRCm39) |
|
probably benign |
Het |
| Hk2 |
C |
T |
6: 82,713,615 (GRCm39) |
R461K |
probably benign |
Het |
| Ice1 |
A |
G |
13: 70,754,496 (GRCm39) |
F530S |
possibly damaging |
Het |
| Ing3 |
T |
A |
6: 21,968,904 (GRCm39) |
S129T |
probably benign |
Het |
| Ino80 |
G |
A |
2: 119,288,697 (GRCm39) |
S3L |
probably damaging |
Het |
| Ints2 |
T |
A |
11: 86,113,000 (GRCm39) |
Q839H |
probably benign |
Het |
| Kcnrg |
T |
C |
14: 61,849,280 (GRCm39) |
M247T |
probably benign |
Het |
| Kpna6 |
T |
C |
4: 129,566,485 (GRCm39) |
|
probably benign |
Het |
| Krtap28-13 |
T |
A |
1: 83,039,044 (GRCm39) |
|
probably benign |
Het |
| Lgr4 |
T |
A |
2: 109,748,617 (GRCm39) |
V51E |
possibly damaging |
Het |
| Map3k5 |
A |
C |
10: 19,980,001 (GRCm39) |
E836D |
probably benign |
Het |
| Mapk11 |
T |
C |
15: 89,030,038 (GRCm39) |
I193V |
probably benign |
Het |
| Marchf10 |
A |
T |
11: 105,276,308 (GRCm39) |
V660E |
probably damaging |
Het |
| Matn4 |
T |
C |
2: 164,235,144 (GRCm39) |
E435G |
probably damaging |
Het |
| Mre11a |
G |
T |
9: 14,723,232 (GRCm39) |
R402M |
probably damaging |
Het |
| Msr1 |
C |
T |
8: 40,034,868 (GRCm39) |
G428R |
probably damaging |
Het |
| Ndufv3 |
C |
T |
17: 31,750,206 (GRCm39) |
R99* |
probably null |
Het |
| Nkx6-1 |
C |
T |
5: 101,811,847 (GRCm39) |
S85N |
unknown |
Het |
| Nop2 |
A |
T |
6: 125,111,691 (GRCm39) |
E141D |
probably benign |
Het |
| Or5b3 |
A |
G |
19: 13,388,326 (GRCm39) |
H131R |
probably benign |
Het |
| Or8b1 |
G |
C |
9: 38,399,657 (GRCm39) |
E111Q |
probably damaging |
Het |
| Paox |
T |
C |
7: 139,709,101 (GRCm39) |
S205P |
probably damaging |
Het |
| Pcdh15 |
T |
C |
10: 74,466,768 (GRCm39) |
V995A |
probably benign |
Het |
| Pdcd1 |
T |
A |
1: 93,968,550 (GRCm39) |
K161N |
probably benign |
Het |
| Pfkfb2 |
C |
A |
1: 130,627,832 (GRCm39) |
V372L |
probably damaging |
Het |
| Phldb1 |
G |
A |
9: 44,622,948 (GRCm39) |
T19I |
probably damaging |
Het |
| Pik3c2g |
G |
T |
6: 139,599,477 (GRCm39) |
V198L |
probably benign |
Het |
| Pnpla8 |
T |
A |
12: 44,342,753 (GRCm39) |
L41* |
probably null |
Het |
| Postn |
C |
T |
3: 54,281,221 (GRCm39) |
Q449* |
probably null |
Het |
| Ppp1r3a |
C |
T |
6: 14,718,988 (GRCm39) |
S642N |
probably benign |
Het |
| Ptpn23 |
G |
A |
9: 110,214,511 (GRCm39) |
|
probably benign |
Het |
| Ptprj |
T |
C |
2: 90,283,684 (GRCm39) |
N923S |
possibly damaging |
Het |
| Rai1 |
T |
C |
11: 60,078,630 (GRCm39) |
V898A |
probably benign |
Het |
| Rasgef1a |
A |
T |
6: 118,057,515 (GRCm39) |
Y72F |
possibly damaging |
Het |
| Serpinb7 |
T |
C |
1: 107,379,580 (GRCm39) |
V329A |
probably damaging |
Het |
| Slc24a4 |
T |
A |
12: 102,201,049 (GRCm39) |
I311N |
probably damaging |
Het |
| Slc45a1 |
C |
A |
4: 150,713,997 (GRCm39) |
L749F |
possibly damaging |
Het |
| Spon1 |
G |
A |
7: 113,630,056 (GRCm39) |
D428N |
probably damaging |
Het |
| Tcf7l2 |
G |
A |
19: 55,886,992 (GRCm39) |
E2K |
probably benign |
Het |
| Thoc5 |
A |
G |
11: 4,870,416 (GRCm39) |
M472V |
possibly damaging |
Het |
| Tm6sf2 |
T |
C |
8: 70,528,213 (GRCm39) |
Y121H |
probably damaging |
Het |
| Tmc4 |
T |
A |
7: 3,675,008 (GRCm39) |
D221V |
probably benign |
Het |
| Trim30b |
A |
T |
7: 104,006,572 (GRCm39) |
S95T |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,781,656 (GRCm39) |
|
probably null |
Het |
| Ubp1 |
A |
T |
9: 113,785,807 (GRCm39) |
R161W |
probably benign |
Het |
| Usp21 |
G |
A |
1: 171,109,745 (GRCm39) |
|
probably benign |
Het |
| Vmn1r61 |
T |
A |
7: 5,613,529 (GRCm39) |
R262W |
probably damaging |
Het |
| Vmn2r67 |
A |
T |
7: 84,801,044 (GRCm39) |
D297E |
probably damaging |
Het |
| Vwa5a |
T |
C |
9: 38,653,038 (GRCm39) |
L784S |
probably benign |
Het |
| Vwc2 |
G |
A |
11: 11,104,244 (GRCm39) |
V259M |
probably damaging |
Het |
| Zeb2 |
T |
C |
2: 44,887,064 (GRCm39) |
I596M |
probably benign |
Het |
| Zgrf1 |
T |
A |
3: 127,354,672 (GRCm39) |
L97H |
probably damaging |
Het |
|
| Other mutations in Trip12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00331:Trip12
|
APN |
1 |
84,708,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00430:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00465:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00819:Trip12
|
APN |
1 |
84,731,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00900:Trip12
|
APN |
1 |
84,702,485 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL00990:Trip12
|
APN |
1 |
84,729,605 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01087:Trip12
|
APN |
1 |
84,735,580 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01400:Trip12
|
APN |
1 |
84,729,699 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01521:Trip12
|
APN |
1 |
84,743,919 (GRCm39) |
splice site |
probably benign |
|
|
IGL01619:Trip12
|
APN |
1 |
84,792,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01796:Trip12
|
APN |
1 |
84,705,999 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01975:Trip12
|
APN |
1 |
84,792,534 (GRCm39) |
splice site |
probably benign |
|
|
IGL02190:Trip12
|
APN |
1 |
84,743,791 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02474:Trip12
|
APN |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
IGL02517:Trip12
|
APN |
1 |
84,721,535 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02631:Trip12
|
APN |
1 |
84,743,729 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02991:Trip12
|
APN |
1 |
84,716,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03161:Trip12
|
APN |
1 |
84,738,853 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03388:Trip12
|
APN |
1 |
84,720,907 (GRCm39) |
missense |
probably damaging |
0.99 |
|
cardamom
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
pungent
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
spices
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
sulfuric
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
Turmeric
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
LCD18:Trip12
|
UTSW |
1 |
84,754,482 (GRCm38) |
unclassified |
probably benign |
|
|
R0090:Trip12
|
UTSW |
1 |
84,709,857 (GRCm39) |
splice site |
probably benign |
|
|
R0111:Trip12
|
UTSW |
1 |
84,736,854 (GRCm39) |
unclassified |
probably benign |
|
|
R0471:Trip12
|
UTSW |
1 |
84,703,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0486:Trip12
|
UTSW |
1 |
84,738,805 (GRCm39) |
nonsense |
probably null |
|
|
R0557:Trip12
|
UTSW |
1 |
84,702,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0570:Trip12
|
UTSW |
1 |
84,729,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Trip12
|
UTSW |
1 |
84,735,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0627:Trip12
|
UTSW |
1 |
84,746,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Trip12
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0657:Trip12
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0741:Trip12
|
UTSW |
1 |
84,722,902 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0862:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0864:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1124:Trip12
|
UTSW |
1 |
84,714,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1252:Trip12
|
UTSW |
1 |
84,754,071 (GRCm39) |
nonsense |
probably null |
|
|
R1455:Trip12
|
UTSW |
1 |
84,736,821 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1487:Trip12
|
UTSW |
1 |
84,746,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1781:Trip12
|
UTSW |
1 |
84,708,342 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1847:Trip12
|
UTSW |
1 |
84,726,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1854:Trip12
|
UTSW |
1 |
84,705,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1866:Trip12
|
UTSW |
1 |
84,722,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1926:Trip12
|
UTSW |
1 |
84,727,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1935:Trip12
|
UTSW |
1 |
84,771,822 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1950:Trip12
|
UTSW |
1 |
84,738,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1994:Trip12
|
UTSW |
1 |
84,726,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2014:Trip12
|
UTSW |
1 |
84,738,587 (GRCm39) |
nonsense |
probably null |
|
|
R2391:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2423:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2433:Trip12
|
UTSW |
1 |
84,721,544 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2905:Trip12
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3040:Trip12
|
UTSW |
1 |
84,719,966 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3735:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R3907:Trip12
|
UTSW |
1 |
84,709,827 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4394:Trip12
|
UTSW |
1 |
84,703,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4540:Trip12
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4859:Trip12
|
UTSW |
1 |
84,771,531 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5240:Trip12
|
UTSW |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
R5278:Trip12
|
UTSW |
1 |
84,739,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5377:Trip12
|
UTSW |
1 |
84,735,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Trip12
|
UTSW |
1 |
84,746,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5542:Trip12
|
UTSW |
1 |
84,727,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5550:Trip12
|
UTSW |
1 |
84,738,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5886:Trip12
|
UTSW |
1 |
84,708,179 (GRCm39) |
intron |
probably benign |
|
|
R5893:Trip12
|
UTSW |
1 |
84,736,884 (GRCm39) |
unclassified |
probably benign |
|
|
R5925:Trip12
|
UTSW |
1 |
84,726,974 (GRCm39) |
nonsense |
probably null |
|
|
R5985:Trip12
|
UTSW |
1 |
84,703,492 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6135:Trip12
|
UTSW |
1 |
84,738,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6158:Trip12
|
UTSW |
1 |
84,738,733 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6419:Trip12
|
UTSW |
1 |
84,771,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7144:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7194:Trip12
|
UTSW |
1 |
84,771,943 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7355:Trip12
|
UTSW |
1 |
84,792,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Trip12
|
UTSW |
1 |
84,728,163 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7588:Trip12
|
UTSW |
1 |
84,738,604 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7705:Trip12
|
UTSW |
1 |
84,755,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7818:Trip12
|
UTSW |
1 |
84,738,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8127:Trip12
|
UTSW |
1 |
84,716,463 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8221:Trip12
|
UTSW |
1 |
84,743,771 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8336:Trip12
|
UTSW |
1 |
84,743,762 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8373:Trip12
|
UTSW |
1 |
84,773,488 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8719:Trip12
|
UTSW |
1 |
84,722,790 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8771:Trip12
|
UTSW |
1 |
84,721,018 (GRCm39) |
unclassified |
probably benign |
|
|
R8997:Trip12
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9146:Trip12
|
UTSW |
1 |
84,771,881 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9236:Trip12
|
UTSW |
1 |
84,703,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9338:Trip12
|
UTSW |
1 |
84,727,019 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9391:Trip12
|
UTSW |
1 |
84,773,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9516:Trip12
|
UTSW |
1 |
84,735,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Trip12
|
UTSW |
1 |
84,738,508 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0065:Trip12
|
UTSW |
1 |
84,726,884 (GRCm39) |
missense |
probably benign |
0.21 |
|
Z1088:Trip12
|
UTSW |
1 |
84,743,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGACAATTATATGACTGGACAACAC -3'
(R):5'- GTTGAACTACATTGTGCTAATTCCTTG -3'
Sequencing Primer
(F):5'- TGACTGGACAACACATTTCAATAG -3'
(R):5'- GACTGTAGCTCTGTAAGATGCAC -3'
|
| Posted On |
2017-02-28 |
Incidental Mutation