Incidental Mutation 'IGL02123:Vmn2r98'
ID280695
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r98
Ensembl Gene ENSMUSG00000096717
Gene Namevomeronasal 2, receptor 98
SynonymsEG224552
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.143) question?
Stock #IGL02123
Quality Score
Status
Chromosome17
Chromosomal Location19053460-19082411 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 19080679 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Serine at position 648 (C648S)
Ref Sequence ENSEMBL: ENSMUSP00000131261 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170424]
Predicted Effect probably damaging
Transcript: ENSMUST00000170424
AA Change: C648S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: C648S

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 82 460 2.6e-35 PFAM
Pfam:NCD3G 509 562 7.4e-22 PFAM
Pfam:7tm_3 594 830 1.4e-52 PFAM
low complexity region 844 856 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp7 T C 7: 28,629,489 T31A probably benign Het
Aldh16a1 G A 7: 45,146,035 P400L probably damaging Het
Ampd3 T C 7: 110,802,559 V429A possibly damaging Het
Brd8 C T 18: 34,602,727 S899N probably damaging Het
Cldn11 C T 3: 31,150,187 T13M probably benign Het
Cngb3 C A 4: 19,367,801 Q237K probably damaging Het
Col12a1 A G 9: 79,662,458 probably null Het
Copa T A 1: 172,112,128 L621H probably damaging Het
Dbn1 T C 13: 55,476,740 D332G possibly damaging Het
Drc1 T C 5: 30,347,104 S197P probably benign Het
E2f2 A G 4: 136,172,848 N23S probably benign Het
Epb41l2 T A 10: 25,460,844 L246H probably damaging Het
Fam13b G A 18: 34,445,618 probably benign Het
Fam184b A G 5: 45,639,151 M30T possibly damaging Het
Fam71d T C 12: 78,734,207 probably null Het
Fn3krp G A 11: 121,429,444 R205H probably benign Het
Fndc11 A G 2: 181,221,650 I83V probably benign Het
Gm3460 C T 14: 6,619,542 R150H probably benign Het
Hs6st1 T A 1: 36,103,871 F296I possibly damaging Het
Igsf10 T A 3: 59,318,660 I2531F probably damaging Het
Klhl40 T C 9: 121,779,923 F385L probably benign Het
Krt83 A T 15: 101,487,585 M302K possibly damaging Het
Lrrc43 A T 5: 123,494,279 I162F probably damaging Het
Map3k21 A G 8: 125,926,110 E325G probably damaging Het
Mpo A T 11: 87,794,795 N33I probably benign Het
Mpp4 A G 1: 59,161,466 probably null Het
Muc5b C T 7: 141,863,757 T3480I possibly damaging Het
Myo6 T C 9: 80,264,272 probably benign Het
Nostrin C T 2: 69,156,109 probably benign Het
Nphp1 T C 2: 127,754,049 M498V probably benign Het
Nr4a2 A T 2: 57,111,655 L199Q possibly damaging Het
Pcdhb6 A T 18: 37,335,820 N598I probably damaging Het
Pex19 T A 1: 172,134,286 M207K probably damaging Het
Pfkfb4 C T 9: 109,025,110 R351W probably damaging Het
Plekha2 T C 8: 25,042,729 K409E probably damaging Het
Plxna2 T C 1: 194,794,383 L1169P probably damaging Het
Pmpcb A G 5: 21,743,375 probably benign Het
Ptrh1 T C 2: 32,776,814 probably benign Het
Rc3h2 T C 2: 37,398,253 E439G probably damaging Het
Ric1 C T 19: 29,594,800 A665V probably benign Het
Stx18 T A 5: 38,128,103 V219D probably damaging Het
Taf7 A T 18: 37,642,480 probably benign Het
Tbc1d8 A G 1: 39,380,236 S766P probably damaging Het
Tbc1d8 A G 1: 39,376,907 I895T possibly damaging Het
Tekt3 C A 11: 63,083,940 H362N probably benign Het
Tmem214 G A 5: 30,872,746 A296T probably benign Het
Tmem94 T C 11: 115,787,538 S196P possibly damaging Het
Vmn2r14 T C 5: 109,220,067 Y353C probably damaging Het
Vmn2r9 G A 5: 108,843,636 L620F probably damaging Het
Vmn2r90 T G 17: 17,733,482 M636R probably benign Het
Zfpm2 G A 15: 41,102,195 C560Y probably damaging Het
Other mutations in Vmn2r98
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00897:Vmn2r98 APN 17 19065745 splice site probably benign
IGL01296:Vmn2r98 APN 17 19065185 missense probably damaging 1.00
IGL01363:Vmn2r98 APN 17 19065758 missense probably benign 0.01
IGL01618:Vmn2r98 APN 17 19065259 missense possibly damaging 0.93
IGL01746:Vmn2r98 APN 17 19066451 missense probably damaging 1.00
IGL01747:Vmn2r98 APN 17 19066440 missense probably damaging 1.00
IGL01770:Vmn2r98 APN 17 19066440 missense probably damaging 1.00
IGL01868:Vmn2r98 APN 17 19066286 missense probably benign
IGL02323:Vmn2r98 APN 17 19065851 missense probably damaging 0.99
IGL02543:Vmn2r98 APN 17 19065821 missense probably benign
IGL02650:Vmn2r98 APN 17 19080961 missense probably benign 0.00
IGL02676:Vmn2r98 APN 17 19065259 missense probably benign 0.00
IGL02803:Vmn2r98 APN 17 19066013 missense probably benign
IGL02807:Vmn2r98 APN 17 19081021 missense probably damaging 1.00
IGL03307:Vmn2r98 APN 17 19065980 missense possibly damaging 0.62
IGL03396:Vmn2r98 APN 17 19069845 missense possibly damaging 0.92
PIT4131001:Vmn2r98 UTSW 17 19080961 missense probably benign 0.00
R0122:Vmn2r98 UTSW 17 19066400 missense probably benign 0.06
R0329:Vmn2r98 UTSW 17 19066347 missense probably benign 0.21
R0330:Vmn2r98 UTSW 17 19066347 missense probably benign 0.21
R0368:Vmn2r98 UTSW 17 19065827 nonsense probably null
R0545:Vmn2r98 UTSW 17 19053613 missense probably benign 0.15
R0635:Vmn2r98 UTSW 17 19080497 missense probably benign 0.00
R0689:Vmn2r98 UTSW 17 19080520 missense possibly damaging 0.83
R1035:Vmn2r98 UTSW 17 19080749 missense possibly damaging 0.90
R1243:Vmn2r98 UTSW 17 19065948 missense possibly damaging 0.52
R1421:Vmn2r98 UTSW 17 19065178 missense probably damaging 1.00
R1629:Vmn2r98 UTSW 17 19067383 missense possibly damaging 0.94
R1643:Vmn2r98 UTSW 17 19080908 missense probably damaging 1.00
R1795:Vmn2r98 UTSW 17 19066440 missense probably damaging 1.00
R1958:Vmn2r98 UTSW 17 19066418 missense possibly damaging 0.70
R1962:Vmn2r98 UTSW 17 19065333 nonsense probably null
R2165:Vmn2r98 UTSW 17 19081291 missense unknown
R2238:Vmn2r98 UTSW 17 19065951 missense probably damaging 1.00
R2252:Vmn2r98 UTSW 17 19080436 missense probably benign 0.00
R2323:Vmn2r98 UTSW 17 19065819 missense probably benign 0.18
R2887:Vmn2r98 UTSW 17 19081177 missense possibly damaging 0.83
R2909:Vmn2r98 UTSW 17 19067402 missense probably damaging 1.00
R3001:Vmn2r98 UTSW 17 19065863 missense probably benign 0.01
R3002:Vmn2r98 UTSW 17 19065863 missense probably benign 0.01
R3003:Vmn2r98 UTSW 17 19065863 missense probably benign 0.01
R3788:Vmn2r98 UTSW 17 19080625 missense probably benign 0.31
R4570:Vmn2r98 UTSW 17 19066092 missense probably benign 0.11
R4706:Vmn2r98 UTSW 17 19069745 missense probably damaging 1.00
R4723:Vmn2r98 UTSW 17 19066340 missense probably benign 0.01
R5036:Vmn2r98 UTSW 17 19066157 missense probably benign 0.00
R5072:Vmn2r98 UTSW 17 19066044 missense probably benign 0.07
R5121:Vmn2r98 UTSW 17 19053553 missense probably benign 0.13
R5283:Vmn2r98 UTSW 17 19080719 missense probably benign 0.05
R5294:Vmn2r98 UTSW 17 19069754 nonsense probably null
R5371:Vmn2r98 UTSW 17 19069753 missense probably damaging 1.00
R5532:Vmn2r98 UTSW 17 19067383 missense possibly damaging 0.94
R5598:Vmn2r98 UTSW 17 19080899 missense probably benign 0.37
R5800:Vmn2r98 UTSW 17 19065998 missense probably benign 0.17
R6089:Vmn2r98 UTSW 17 19066074 missense probably benign 0.29
R6155:Vmn2r98 UTSW 17 19065881 missense possibly damaging 0.87
R6853:Vmn2r98 UTSW 17 19065801 missense probably benign 0.00
R6920:Vmn2r98 UTSW 17 19065248 missense probably damaging 0.98
R7012:Vmn2r98 UTSW 17 19066268 missense probably benign 0.06
R7042:Vmn2r98 UTSW 17 19080922 missense probably benign
R7068:Vmn2r98 UTSW 17 19065313 missense probably benign
R7607:Vmn2r98 UTSW 17 19067308 missense possibly damaging 0.95
Posted On2015-04-16