Incidental Mutation 'R0122:Vmn2r98'
| ID |
218450 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r98
|
| Ensembl Gene |
ENSMUSG00000096717 |
| Gene Name |
vomeronasal 2, receptor 98 |
| Synonyms |
EG224552 |
| MMRRC Submission |
038407-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.141)
|
| Stock # |
R0122 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
(trace)
|
| Chromosome |
17 |
| Chromosomal Location |
19053460-19082411 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 19066400 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 387
(I387V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131261
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170424]
|
| AlphaFold |
E9PZ56 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170424
AA Change: I387V
PolyPhen 2
Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: I387V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
460 |
2.6e-35 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
7.4e-22 |
PFAM |
|
Pfam:7tm_3
|
594 |
830 |
1.4e-52 |
PFAM |
|
low complexity region
|
844 |
856 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.2%
- 10x: 95.9%
- 20x: 91.3%
|
| Validation Efficiency |
99% (78/79) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2010315B03Rik |
T |
C |
9: 124,295,159 (GRCm38) |
|
probably benign |
Het |
| Adam12 |
T |
A |
7: 134,012,348 (GRCm38) |
I60F |
probably benign |
Het |
| Adamts10 |
A |
G |
17: 33,528,480 (GRCm38) |
|
probably benign |
Het |
| Adamts12 |
C |
T |
15: 11,215,624 (GRCm38) |
R244C |
probably damaging |
Het |
| Adamts7 |
A |
G |
9: 90,179,421 (GRCm38) |
E360G |
probably damaging |
Het |
| Atn1 |
A |
T |
6: 124,743,234 (GRCm38) |
|
probably benign |
Het |
| Avl9 |
G |
T |
6: 56,736,483 (GRCm38) |
R242L |
probably benign |
Het |
| Baz2b |
G |
T |
2: 59,913,619 (GRCm38) |
|
probably null |
Het |
| Bloc1s6 |
G |
C |
2: 122,746,043 (GRCm38) |
|
probably benign |
Het |
| Btbd9 |
C |
T |
17: 30,274,942 (GRCm38) |
D492N |
possibly damaging |
Het |
| C1qa |
T |
A |
4: 136,897,831 (GRCm38) |
T3S |
probably benign |
Het |
| Cacna1e |
A |
T |
1: 154,443,901 (GRCm38) |
F1351Y |
probably damaging |
Het |
| Car9 |
C |
T |
4: 43,512,206 (GRCm38) |
A356V |
probably benign |
Het |
| Ccdc116 |
T |
A |
16: 17,142,734 (GRCm38) |
D73V |
probably damaging |
Het |
| Ces2g |
T |
C |
8: 104,968,300 (GRCm38) |
Y518H |
probably damaging |
Het |
| Ciz1 |
A |
G |
2: 32,371,419 (GRCm38) |
|
probably benign |
Het |
| Cmc1 |
A |
T |
9: 118,065,320 (GRCm38) |
C29S |
probably damaging |
Het |
| Coil |
T |
A |
11: 88,985,007 (GRCm38) |
|
probably benign |
Het |
| Col3a1 |
C |
T |
1: 45,340,897 (GRCm38) |
|
probably benign |
Het |
| Cox15 |
A |
G |
19: 43,748,790 (GRCm38) |
I135T |
possibly damaging |
Het |
| Cyld |
T |
C |
8: 88,742,292 (GRCm38) |
S564P |
probably damaging |
Het |
| Dnah5 |
T |
A |
15: 28,378,363 (GRCm38) |
N2948K |
probably damaging |
Het |
| Dnah7a |
G |
A |
1: 53,397,142 (GRCm38) |
R4014W |
probably damaging |
Het |
| Dnmt3b |
T |
C |
2: 153,676,698 (GRCm38) |
Y594H |
probably damaging |
Het |
| Dntt |
A |
G |
19: 41,053,038 (GRCm38) |
K387R |
possibly damaging |
Het |
| Efcab7 |
G |
A |
4: 99,892,363 (GRCm38) |
|
probably benign |
Het |
| Flvcr1 |
G |
T |
1: 191,021,226 (GRCm38) |
P250T |
possibly damaging |
Het |
| Gga2 |
C |
A |
7: 121,991,574 (GRCm38) |
V504L |
probably damaging |
Het |
| Gm12239 |
T |
A |
11: 56,015,912 (GRCm38) |
|
noncoding transcript |
Het |
| Gm13089 |
A |
T |
4: 143,698,404 (GRCm38) |
D156E |
probably benign |
Het |
| Gm6327 |
T |
C |
16: 12,761,026 (GRCm38) |
|
noncoding transcript |
Het |
| Krt26 |
G |
T |
11: 99,333,719 (GRCm38) |
Y324* |
probably null |
Het |
| Lamb2 |
A |
T |
9: 108,486,514 (GRCm38) |
H939L |
probably benign |
Het |
| Lipo3 |
C |
T |
19: 33,622,686 (GRCm38) |
|
probably benign |
Het |
| Mmp1b |
G |
A |
9: 7,386,689 (GRCm38) |
T145M |
probably damaging |
Het |
| Mrps27 |
G |
T |
13: 99,365,228 (GRCm38) |
V76L |
probably benign |
Het |
| Mup6 |
T |
A |
4: 60,003,995 (GRCm38) |
Y29* |
probably null |
Het |
| Nlrc3 |
T |
C |
16: 3,958,958 (GRCm38) |
K756E |
probably damaging |
Het |
| Nnt |
T |
C |
13: 119,368,597 (GRCm38) |
H527R |
probably damaging |
Het |
| Nudt8 |
T |
C |
19: 4,001,306 (GRCm38) |
V59A |
probably benign |
Het |
| Ofcc1 |
A |
T |
13: 40,280,556 (GRCm38) |
|
probably null |
Het |
| Olfr447 |
T |
C |
6: 42,911,955 (GRCm38) |
V144A |
probably benign |
Het |
| Olfr638 |
T |
C |
7: 104,003,358 (GRCm38) |
W28R |
probably damaging |
Het |
| Olfr959 |
A |
T |
9: 39,572,724 (GRCm38) |
D178E |
probably damaging |
Het |
| Pdgfd |
T |
C |
9: 6,293,851 (GRCm38) |
S142P |
probably damaging |
Het |
| Pias4 |
G |
T |
10: 81,157,087 (GRCm38) |
Q22K |
probably damaging |
Het |
| Pin1 |
T |
C |
9: 20,662,304 (GRCm38) |
I95T |
probably benign |
Het |
| Prickle2 |
G |
A |
6: 92,411,345 (GRCm38) |
Q359* |
probably null |
Het |
| Qrich2 |
G |
T |
11: 116,446,813 (GRCm38) |
Q1950K |
possibly damaging |
Het |
| Rab10 |
C |
A |
12: 3,309,357 (GRCm38) |
G21V |
probably damaging |
Het |
| Rbm27 |
T |
A |
18: 42,313,968 (GRCm38) |
|
probably benign |
Het |
| Samd4 |
C |
A |
14: 47,016,560 (GRCm38) |
S160R |
probably benign |
Het |
| Scube3 |
A |
C |
17: 28,166,528 (GRCm38) |
|
probably benign |
Het |
| Serpinf2 |
A |
G |
11: 75,436,546 (GRCm38) |
L185P |
probably damaging |
Het |
| Slc16a12 |
A |
G |
19: 34,674,864 (GRCm38) |
I294T |
probably benign |
Het |
| Slc45a3 |
T |
A |
1: 131,977,740 (GRCm38) |
M167K |
probably damaging |
Het |
| Sspo |
T |
A |
6: 48,473,976 (GRCm38) |
L2673Q |
possibly damaging |
Het |
| Supt3 |
A |
G |
17: 45,003,141 (GRCm38) |
D139G |
probably damaging |
Het |
| Tas1r3 |
T |
C |
4: 155,860,833 (GRCm38) |
M644V |
probably benign |
Het |
| Tgfbi |
A |
G |
13: 56,627,968 (GRCm38) |
T276A |
probably damaging |
Het |
| Tmem177 |
T |
C |
1: 119,910,578 (GRCm38) |
I124V |
probably benign |
Het |
| Tmprss11f |
G |
T |
5: 86,533,625 (GRCm38) |
|
probably benign |
Het |
| Tmprss3 |
G |
A |
17: 31,193,902 (GRCm38) |
|
probably benign |
Het |
| Twf1 |
A |
G |
15: 94,586,549 (GRCm38) |
|
probably benign |
Het |
| Uba52 |
T |
A |
8: 70,509,301 (GRCm38) |
Q166L |
probably damaging |
Het |
| Ubr3 |
G |
T |
2: 69,979,412 (GRCm38) |
G1242V |
probably damaging |
Het |
| Unc13d |
C |
T |
11: 116,065,482 (GRCm38) |
S835N |
probably benign |
Het |
| Ush2a |
A |
G |
1: 188,948,455 (GRCm38) |
K4877E |
possibly damaging |
Het |
| Vps11 |
A |
T |
9: 44,354,512 (GRCm38) |
I490N |
probably damaging |
Het |
| Vstm4 |
T |
A |
14: 32,863,811 (GRCm38) |
|
probably null |
Het |
| Zfp110 |
C |
A |
7: 12,848,597 (GRCm38) |
H391N |
possibly damaging |
Het |
| Zfp212 |
C |
T |
6: 47,931,023 (GRCm38) |
P312L |
possibly damaging |
Het |
| Zfp329 |
A |
T |
7: 12,810,987 (GRCm38) |
H203Q |
probably damaging |
Het |
| Zscan12 |
G |
A |
13: 21,368,969 (GRCm38) |
G321E |
probably damaging |
Het |
|
| Other mutations in Vmn2r98 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00897:Vmn2r98
|
APN |
17 |
19,065,745 (GRCm38) |
splice site |
probably benign |
|
|
IGL01296:Vmn2r98
|
APN |
17 |
19,065,185 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01363:Vmn2r98
|
APN |
17 |
19,065,758 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01618:Vmn2r98
|
APN |
17 |
19,065,259 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
IGL01746:Vmn2r98
|
APN |
17 |
19,066,451 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01747:Vmn2r98
|
APN |
17 |
19,066,440 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01770:Vmn2r98
|
APN |
17 |
19,066,440 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01868:Vmn2r98
|
APN |
17 |
19,066,286 (GRCm38) |
missense |
probably benign |
|
|
IGL02123:Vmn2r98
|
APN |
17 |
19,080,679 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02323:Vmn2r98
|
APN |
17 |
19,065,851 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02543:Vmn2r98
|
APN |
17 |
19,065,821 (GRCm38) |
missense |
probably benign |
|
|
IGL02650:Vmn2r98
|
APN |
17 |
19,080,961 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02676:Vmn2r98
|
APN |
17 |
19,065,259 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02803:Vmn2r98
|
APN |
17 |
19,066,013 (GRCm38) |
missense |
probably benign |
|
|
IGL02807:Vmn2r98
|
APN |
17 |
19,081,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03307:Vmn2r98
|
APN |
17 |
19,065,980 (GRCm38) |
missense |
possibly damaging |
0.62 |
|
IGL03396:Vmn2r98
|
APN |
17 |
19,069,845 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
PIT4131001:Vmn2r98
|
UTSW |
17 |
19,080,961 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0329:Vmn2r98
|
UTSW |
17 |
19,066,347 (GRCm38) |
missense |
probably benign |
0.21 |
|
R0330:Vmn2r98
|
UTSW |
17 |
19,066,347 (GRCm38) |
missense |
probably benign |
0.21 |
|
R0368:Vmn2r98
|
UTSW |
17 |
19,065,827 (GRCm38) |
nonsense |
probably null |
|
|
R0545:Vmn2r98
|
UTSW |
17 |
19,053,613 (GRCm38) |
missense |
probably benign |
0.15 |
|
R0635:Vmn2r98
|
UTSW |
17 |
19,080,497 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0689:Vmn2r98
|
UTSW |
17 |
19,080,520 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R1035:Vmn2r98
|
UTSW |
17 |
19,080,749 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R1243:Vmn2r98
|
UTSW |
17 |
19,065,948 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R1421:Vmn2r98
|
UTSW |
17 |
19,065,178 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1629:Vmn2r98
|
UTSW |
17 |
19,067,383 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R1643:Vmn2r98
|
UTSW |
17 |
19,080,908 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1795:Vmn2r98
|
UTSW |
17 |
19,066,440 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1958:Vmn2r98
|
UTSW |
17 |
19,066,418 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R1962:Vmn2r98
|
UTSW |
17 |
19,065,333 (GRCm38) |
nonsense |
probably null |
|
|
R2165:Vmn2r98
|
UTSW |
17 |
19,081,291 (GRCm38) |
missense |
unknown |
|
|
R2238:Vmn2r98
|
UTSW |
17 |
19,065,951 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2252:Vmn2r98
|
UTSW |
17 |
19,080,436 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2323:Vmn2r98
|
UTSW |
17 |
19,065,819 (GRCm38) |
missense |
probably benign |
0.18 |
|
R2887:Vmn2r98
|
UTSW |
17 |
19,081,177 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R2909:Vmn2r98
|
UTSW |
17 |
19,067,402 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3001:Vmn2r98
|
UTSW |
17 |
19,065,863 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3002:Vmn2r98
|
UTSW |
17 |
19,065,863 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3003:Vmn2r98
|
UTSW |
17 |
19,065,863 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3788:Vmn2r98
|
UTSW |
17 |
19,080,625 (GRCm38) |
missense |
probably benign |
0.31 |
|
R4570:Vmn2r98
|
UTSW |
17 |
19,066,092 (GRCm38) |
missense |
probably benign |
0.11 |
|
R4706:Vmn2r98
|
UTSW |
17 |
19,069,745 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4723:Vmn2r98
|
UTSW |
17 |
19,066,340 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5036:Vmn2r98
|
UTSW |
17 |
19,066,157 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5072:Vmn2r98
|
UTSW |
17 |
19,066,044 (GRCm38) |
missense |
probably benign |
0.07 |
|
R5121:Vmn2r98
|
UTSW |
17 |
19,053,553 (GRCm38) |
missense |
probably benign |
0.13 |
|
R5283:Vmn2r98
|
UTSW |
17 |
19,080,719 (GRCm38) |
missense |
probably benign |
0.05 |
|
R5294:Vmn2r98
|
UTSW |
17 |
19,069,754 (GRCm38) |
nonsense |
probably null |
|
|
R5371:Vmn2r98
|
UTSW |
17 |
19,069,753 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5532:Vmn2r98
|
UTSW |
17 |
19,067,383 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5598:Vmn2r98
|
UTSW |
17 |
19,080,899 (GRCm38) |
missense |
probably benign |
0.37 |
|
R5800:Vmn2r98
|
UTSW |
17 |
19,065,998 (GRCm38) |
missense |
probably benign |
0.17 |
|
R6089:Vmn2r98
|
UTSW |
17 |
19,066,074 (GRCm38) |
missense |
probably benign |
0.29 |
|
R6155:Vmn2r98
|
UTSW |
17 |
19,065,881 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R6853:Vmn2r98
|
UTSW |
17 |
19,065,801 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6920:Vmn2r98
|
UTSW |
17 |
19,065,248 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7012:Vmn2r98
|
UTSW |
17 |
19,066,268 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7042:Vmn2r98
|
UTSW |
17 |
19,080,922 (GRCm38) |
missense |
probably benign |
|
|
R7068:Vmn2r98
|
UTSW |
17 |
19,065,313 (GRCm38) |
missense |
probably benign |
|
|
R7607:Vmn2r98
|
UTSW |
17 |
19,067,308 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R7763:Vmn2r98
|
UTSW |
17 |
19,080,535 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7771:Vmn2r98
|
UTSW |
17 |
19,067,198 (GRCm38) |
splice site |
probably null |
|
|
R7915:Vmn2r98
|
UTSW |
17 |
19,067,231 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8028:Vmn2r98
|
UTSW |
17 |
19,053,650 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8205:Vmn2r98
|
UTSW |
17 |
19,081,163 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8241:Vmn2r98
|
UTSW |
17 |
19,080,769 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8906:Vmn2r98
|
UTSW |
17 |
19,066,270 (GRCm38) |
missense |
probably benign |
|
|
R8952:Vmn2r98
|
UTSW |
17 |
19,065,269 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
R9147:Vmn2r98
|
UTSW |
17 |
19,066,121 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9148:Vmn2r98
|
UTSW |
17 |
19,066,121 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9187:Vmn2r98
|
UTSW |
17 |
19,081,219 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9344:Vmn2r98
|
UTSW |
17 |
19,066,515 (GRCm38) |
missense |
probably benign |
0.14 |
|
R9467:Vmn2r98
|
UTSW |
17 |
19,067,255 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9487:Vmn2r98
|
UTSW |
17 |
19,081,234 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R9753:Vmn2r98
|
UTSW |
17 |
19,065,403 (GRCm38) |
missense |
probably benign |
0.27 |
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,067,423 (GRCm38) |
nonsense |
probably null |
|
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,065,136 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGAGAAATGGCATCTGCCTAGCTTTTG -3'
(R):5'- AAAGCGTATTTGCTCCTGGTATCTTGT -3'
Sequencing Primer
(F):5'- GGGAGCCTCATTTTTAAGCAC -3'
(R):5'- GCATAACTCTTATGCCAGATTGCTG -3'
|
| Posted On |
2014-08-11 |
Incidental Mutation