Incidental Mutation 'R0122:Vmn2r98'
ID |
218450 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r98
|
Ensembl Gene |
ENSMUSG00000096717 |
Gene Name |
vomeronasal 2, receptor 98 |
Synonyms |
EG224552 |
MMRRC Submission |
038407-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.096)
|
Stock # |
R0122 (G1)
|
Quality Score |
225 |
Status
|
Validated
(trace)
|
Chromosome |
17 |
Chromosomal Location |
19273755-19301573 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 19286662 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Valine
at position 387
(I387V)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000131261
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170424]
|
AlphaFold |
E9PZ56 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000170424
AA Change: I387V
PolyPhen 2
Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)
|
SMART Domains |
Protein: ENSMUSP00000131261 Gene: ENSMUSG00000096717 AA Change: I387V
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
82 |
460 |
2.6e-35 |
PFAM |
Pfam:NCD3G
|
509 |
562 |
7.4e-22 |
PFAM |
Pfam:7tm_3
|
594 |
830 |
1.4e-52 |
PFAM |
low complexity region
|
844 |
856 |
N/A |
INTRINSIC |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.2%
- 10x: 95.9%
- 20x: 91.3%
|
Validation Efficiency |
99% (78/79) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 74 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2010315B03Rik |
T |
C |
9: 124,057,789 (GRCm39) |
|
probably benign |
Het |
Adam12 |
T |
A |
7: 133,614,077 (GRCm39) |
I60F |
probably benign |
Het |
Adamts10 |
A |
G |
17: 33,747,454 (GRCm39) |
|
probably benign |
Het |
Adamts12 |
C |
T |
15: 11,215,710 (GRCm39) |
R244C |
probably damaging |
Het |
Adamts7 |
A |
G |
9: 90,061,474 (GRCm39) |
E360G |
probably damaging |
Het |
Atn1 |
A |
T |
6: 124,720,197 (GRCm39) |
|
probably benign |
Het |
Avl9 |
G |
T |
6: 56,713,468 (GRCm39) |
R242L |
probably benign |
Het |
Baz2b |
G |
T |
2: 59,743,963 (GRCm39) |
|
probably null |
Het |
Bloc1s6 |
G |
C |
2: 122,587,963 (GRCm39) |
|
probably benign |
Het |
Btbd9 |
C |
T |
17: 30,493,916 (GRCm39) |
D492N |
possibly damaging |
Het |
C1qa |
T |
A |
4: 136,625,142 (GRCm39) |
T3S |
probably benign |
Het |
Cacna1e |
A |
T |
1: 154,319,647 (GRCm39) |
F1351Y |
probably damaging |
Het |
Car9 |
C |
T |
4: 43,512,206 (GRCm39) |
A356V |
probably benign |
Het |
Ccdc116 |
T |
A |
16: 16,960,598 (GRCm39) |
D73V |
probably damaging |
Het |
Ces2g |
T |
C |
8: 105,694,932 (GRCm39) |
Y518H |
probably damaging |
Het |
Ciz1 |
A |
G |
2: 32,261,431 (GRCm39) |
|
probably benign |
Het |
Cmc1 |
A |
T |
9: 117,894,388 (GRCm39) |
C29S |
probably damaging |
Het |
Coil |
T |
A |
11: 88,875,833 (GRCm39) |
|
probably benign |
Het |
Col3a1 |
C |
T |
1: 45,380,057 (GRCm39) |
|
probably benign |
Het |
Cox15 |
A |
G |
19: 43,737,229 (GRCm39) |
I135T |
possibly damaging |
Het |
Cyld |
T |
C |
8: 89,468,920 (GRCm39) |
S564P |
probably damaging |
Het |
Dnah5 |
T |
A |
15: 28,378,509 (GRCm39) |
N2948K |
probably damaging |
Het |
Dnah7a |
G |
A |
1: 53,436,301 (GRCm39) |
R4014W |
probably damaging |
Het |
Dnmt3b |
T |
C |
2: 153,518,618 (GRCm39) |
Y594H |
probably damaging |
Het |
Dntt |
A |
G |
19: 41,041,477 (GRCm39) |
K387R |
possibly damaging |
Het |
Efcab7 |
G |
A |
4: 99,749,560 (GRCm39) |
|
probably benign |
Het |
Flvcr1 |
G |
T |
1: 190,753,423 (GRCm39) |
P250T |
possibly damaging |
Het |
Gga2 |
C |
A |
7: 121,590,797 (GRCm39) |
V504L |
probably damaging |
Het |
Gm12239 |
T |
A |
11: 55,906,738 (GRCm39) |
|
noncoding transcript |
Het |
Gm6327 |
T |
C |
16: 12,578,890 (GRCm39) |
|
noncoding transcript |
Het |
Krt26 |
G |
T |
11: 99,224,545 (GRCm39) |
Y324* |
probably null |
Het |
Lamb2 |
A |
T |
9: 108,363,713 (GRCm39) |
H939L |
probably benign |
Het |
Lipo3 |
C |
T |
19: 33,600,086 (GRCm39) |
|
probably benign |
Het |
Mmp1b |
G |
A |
9: 7,386,689 (GRCm39) |
T145M |
probably damaging |
Het |
Mrps27 |
G |
T |
13: 99,501,736 (GRCm39) |
V76L |
probably benign |
Het |
Mup6 |
T |
A |
4: 60,003,995 (GRCm39) |
Y29* |
probably null |
Het |
Nlrc3 |
T |
C |
16: 3,776,822 (GRCm39) |
K756E |
probably damaging |
Het |
Nnt |
T |
C |
13: 119,505,133 (GRCm39) |
H527R |
probably damaging |
Het |
Nudt8 |
T |
C |
19: 4,051,306 (GRCm39) |
V59A |
probably benign |
Het |
Ofcc1 |
A |
T |
13: 40,434,032 (GRCm39) |
|
probably null |
Het |
Or10d1 |
A |
T |
9: 39,484,020 (GRCm39) |
D178E |
probably damaging |
Het |
Or2a25 |
T |
C |
6: 42,888,889 (GRCm39) |
V144A |
probably benign |
Het |
Or51q1c |
T |
C |
7: 103,652,565 (GRCm39) |
W28R |
probably damaging |
Het |
Pdgfd |
T |
C |
9: 6,293,851 (GRCm39) |
S142P |
probably damaging |
Het |
Pias4 |
G |
T |
10: 80,992,921 (GRCm39) |
Q22K |
probably damaging |
Het |
Pin1 |
T |
C |
9: 20,573,600 (GRCm39) |
I95T |
probably benign |
Het |
Pramel23 |
A |
T |
4: 143,424,974 (GRCm39) |
D156E |
probably benign |
Het |
Prickle2 |
G |
A |
6: 92,388,326 (GRCm39) |
Q359* |
probably null |
Het |
Qrich2 |
G |
T |
11: 116,337,639 (GRCm39) |
Q1950K |
possibly damaging |
Het |
Rab10 |
C |
A |
12: 3,359,357 (GRCm39) |
G21V |
probably damaging |
Het |
Rbm27 |
T |
A |
18: 42,447,033 (GRCm39) |
|
probably benign |
Het |
Samd4 |
C |
A |
14: 47,254,017 (GRCm39) |
S160R |
probably benign |
Het |
Scube3 |
A |
C |
17: 28,385,502 (GRCm39) |
|
probably benign |
Het |
Serpinf2 |
A |
G |
11: 75,327,372 (GRCm39) |
L185P |
probably damaging |
Het |
Slc16a12 |
A |
G |
19: 34,652,264 (GRCm39) |
I294T |
probably benign |
Het |
Slc45a3 |
T |
A |
1: 131,905,478 (GRCm39) |
M167K |
probably damaging |
Het |
Sspo |
T |
A |
6: 48,450,910 (GRCm39) |
L2673Q |
possibly damaging |
Het |
Supt3 |
A |
G |
17: 45,314,028 (GRCm39) |
D139G |
probably damaging |
Het |
Tas1r3 |
T |
C |
4: 155,945,290 (GRCm39) |
M644V |
probably benign |
Het |
Tgfbi |
A |
G |
13: 56,775,781 (GRCm39) |
T276A |
probably damaging |
Het |
Tmem177 |
T |
C |
1: 119,838,308 (GRCm39) |
I124V |
probably benign |
Het |
Tmprss11f |
G |
T |
5: 86,681,484 (GRCm39) |
|
probably benign |
Het |
Tmprss3 |
G |
A |
17: 31,412,876 (GRCm39) |
|
probably benign |
Het |
Twf1 |
A |
G |
15: 94,484,430 (GRCm39) |
|
probably benign |
Het |
Uba52 |
T |
A |
8: 70,961,951 (GRCm39) |
Q166L |
probably damaging |
Het |
Ubr3 |
G |
T |
2: 69,809,756 (GRCm39) |
G1242V |
probably damaging |
Het |
Unc13d |
C |
T |
11: 115,956,308 (GRCm39) |
S835N |
probably benign |
Het |
Ush2a |
A |
G |
1: 188,680,652 (GRCm39) |
K4877E |
possibly damaging |
Het |
Vps11 |
A |
T |
9: 44,265,809 (GRCm39) |
I490N |
probably damaging |
Het |
Vstm4 |
T |
A |
14: 32,585,768 (GRCm39) |
|
probably null |
Het |
Zfp110 |
C |
A |
7: 12,582,524 (GRCm39) |
H391N |
possibly damaging |
Het |
Zfp212 |
C |
T |
6: 47,907,957 (GRCm39) |
P312L |
possibly damaging |
Het |
Zfp329 |
A |
T |
7: 12,544,914 (GRCm39) |
H203Q |
probably damaging |
Het |
Zscan12 |
G |
A |
13: 21,553,139 (GRCm39) |
G321E |
probably damaging |
Het |
|
Other mutations in Vmn2r98 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00897:Vmn2r98
|
APN |
17 |
19,286,007 (GRCm39) |
splice site |
probably benign |
|
IGL01296:Vmn2r98
|
APN |
17 |
19,285,447 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01363:Vmn2r98
|
APN |
17 |
19,286,020 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01618:Vmn2r98
|
APN |
17 |
19,285,521 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL01746:Vmn2r98
|
APN |
17 |
19,286,713 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01747:Vmn2r98
|
APN |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01770:Vmn2r98
|
APN |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01868:Vmn2r98
|
APN |
17 |
19,286,548 (GRCm39) |
missense |
probably benign |
|
IGL02123:Vmn2r98
|
APN |
17 |
19,300,941 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02323:Vmn2r98
|
APN |
17 |
19,286,113 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02543:Vmn2r98
|
APN |
17 |
19,286,083 (GRCm39) |
missense |
probably benign |
|
IGL02650:Vmn2r98
|
APN |
17 |
19,301,223 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02676:Vmn2r98
|
APN |
17 |
19,285,521 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02803:Vmn2r98
|
APN |
17 |
19,286,275 (GRCm39) |
missense |
probably benign |
|
IGL02807:Vmn2r98
|
APN |
17 |
19,301,283 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03307:Vmn2r98
|
APN |
17 |
19,286,242 (GRCm39) |
missense |
possibly damaging |
0.62 |
IGL03396:Vmn2r98
|
APN |
17 |
19,290,107 (GRCm39) |
missense |
possibly damaging |
0.92 |
PIT4131001:Vmn2r98
|
UTSW |
17 |
19,301,223 (GRCm39) |
missense |
probably benign |
0.00 |
R0329:Vmn2r98
|
UTSW |
17 |
19,286,609 (GRCm39) |
missense |
probably benign |
0.21 |
R0330:Vmn2r98
|
UTSW |
17 |
19,286,609 (GRCm39) |
missense |
probably benign |
0.21 |
R0368:Vmn2r98
|
UTSW |
17 |
19,286,089 (GRCm39) |
nonsense |
probably null |
|
R0545:Vmn2r98
|
UTSW |
17 |
19,273,875 (GRCm39) |
missense |
probably benign |
0.15 |
R0635:Vmn2r98
|
UTSW |
17 |
19,300,759 (GRCm39) |
missense |
probably benign |
0.00 |
R0689:Vmn2r98
|
UTSW |
17 |
19,300,782 (GRCm39) |
missense |
possibly damaging |
0.83 |
R1035:Vmn2r98
|
UTSW |
17 |
19,301,011 (GRCm39) |
missense |
possibly damaging |
0.90 |
R1243:Vmn2r98
|
UTSW |
17 |
19,286,210 (GRCm39) |
missense |
possibly damaging |
0.52 |
R1421:Vmn2r98
|
UTSW |
17 |
19,285,440 (GRCm39) |
missense |
probably damaging |
1.00 |
R1629:Vmn2r98
|
UTSW |
17 |
19,287,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1643:Vmn2r98
|
UTSW |
17 |
19,301,170 (GRCm39) |
missense |
probably damaging |
1.00 |
R1795:Vmn2r98
|
UTSW |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
R1958:Vmn2r98
|
UTSW |
17 |
19,286,680 (GRCm39) |
missense |
possibly damaging |
0.70 |
R1962:Vmn2r98
|
UTSW |
17 |
19,285,595 (GRCm39) |
nonsense |
probably null |
|
R2165:Vmn2r98
|
UTSW |
17 |
19,301,553 (GRCm39) |
missense |
unknown |
|
R2238:Vmn2r98
|
UTSW |
17 |
19,286,213 (GRCm39) |
missense |
probably damaging |
1.00 |
R2252:Vmn2r98
|
UTSW |
17 |
19,300,698 (GRCm39) |
missense |
probably benign |
0.00 |
R2323:Vmn2r98
|
UTSW |
17 |
19,286,081 (GRCm39) |
missense |
probably benign |
0.18 |
R2887:Vmn2r98
|
UTSW |
17 |
19,301,439 (GRCm39) |
missense |
possibly damaging |
0.83 |
R2909:Vmn2r98
|
UTSW |
17 |
19,287,664 (GRCm39) |
missense |
probably damaging |
1.00 |
R3001:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3002:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3003:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3788:Vmn2r98
|
UTSW |
17 |
19,300,887 (GRCm39) |
missense |
probably benign |
0.31 |
R4570:Vmn2r98
|
UTSW |
17 |
19,286,354 (GRCm39) |
missense |
probably benign |
0.11 |
R4706:Vmn2r98
|
UTSW |
17 |
19,290,007 (GRCm39) |
missense |
probably damaging |
1.00 |
R4723:Vmn2r98
|
UTSW |
17 |
19,286,602 (GRCm39) |
missense |
probably benign |
0.01 |
R5036:Vmn2r98
|
UTSW |
17 |
19,286,419 (GRCm39) |
missense |
probably benign |
0.00 |
R5072:Vmn2r98
|
UTSW |
17 |
19,286,306 (GRCm39) |
missense |
probably benign |
0.07 |
R5121:Vmn2r98
|
UTSW |
17 |
19,273,815 (GRCm39) |
missense |
probably benign |
0.13 |
R5283:Vmn2r98
|
UTSW |
17 |
19,300,981 (GRCm39) |
missense |
probably benign |
0.05 |
R5294:Vmn2r98
|
UTSW |
17 |
19,290,016 (GRCm39) |
nonsense |
probably null |
|
R5371:Vmn2r98
|
UTSW |
17 |
19,290,015 (GRCm39) |
missense |
probably damaging |
1.00 |
R5532:Vmn2r98
|
UTSW |
17 |
19,287,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
R5598:Vmn2r98
|
UTSW |
17 |
19,301,161 (GRCm39) |
missense |
probably benign |
0.37 |
R5800:Vmn2r98
|
UTSW |
17 |
19,286,260 (GRCm39) |
missense |
probably benign |
0.17 |
R6089:Vmn2r98
|
UTSW |
17 |
19,286,336 (GRCm39) |
missense |
probably benign |
0.29 |
R6155:Vmn2r98
|
UTSW |
17 |
19,286,143 (GRCm39) |
missense |
possibly damaging |
0.87 |
R6853:Vmn2r98
|
UTSW |
17 |
19,286,063 (GRCm39) |
missense |
probably benign |
0.00 |
R6920:Vmn2r98
|
UTSW |
17 |
19,285,510 (GRCm39) |
missense |
probably damaging |
0.98 |
R7012:Vmn2r98
|
UTSW |
17 |
19,286,530 (GRCm39) |
missense |
probably benign |
0.06 |
R7042:Vmn2r98
|
UTSW |
17 |
19,301,184 (GRCm39) |
missense |
probably benign |
|
R7068:Vmn2r98
|
UTSW |
17 |
19,285,575 (GRCm39) |
missense |
probably benign |
|
R7607:Vmn2r98
|
UTSW |
17 |
19,287,570 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7763:Vmn2r98
|
UTSW |
17 |
19,300,797 (GRCm39) |
missense |
probably benign |
0.00 |
R7771:Vmn2r98
|
UTSW |
17 |
19,287,460 (GRCm39) |
splice site |
probably null |
|
R7915:Vmn2r98
|
UTSW |
17 |
19,287,493 (GRCm39) |
missense |
probably benign |
0.10 |
R8028:Vmn2r98
|
UTSW |
17 |
19,273,912 (GRCm39) |
missense |
probably benign |
0.00 |
R8205:Vmn2r98
|
UTSW |
17 |
19,301,425 (GRCm39) |
missense |
probably damaging |
0.99 |
R8241:Vmn2r98
|
UTSW |
17 |
19,301,031 (GRCm39) |
missense |
probably damaging |
0.99 |
R8906:Vmn2r98
|
UTSW |
17 |
19,286,532 (GRCm39) |
missense |
probably benign |
|
R8952:Vmn2r98
|
UTSW |
17 |
19,285,531 (GRCm39) |
missense |
possibly damaging |
0.76 |
R9147:Vmn2r98
|
UTSW |
17 |
19,286,383 (GRCm39) |
missense |
probably benign |
0.04 |
R9148:Vmn2r98
|
UTSW |
17 |
19,286,383 (GRCm39) |
missense |
probably benign |
0.04 |
R9187:Vmn2r98
|
UTSW |
17 |
19,301,481 (GRCm39) |
missense |
probably damaging |
1.00 |
R9344:Vmn2r98
|
UTSW |
17 |
19,286,777 (GRCm39) |
missense |
probably benign |
0.14 |
R9467:Vmn2r98
|
UTSW |
17 |
19,287,517 (GRCm39) |
missense |
probably benign |
0.01 |
R9487:Vmn2r98
|
UTSW |
17 |
19,301,496 (GRCm39) |
missense |
possibly damaging |
0.78 |
R9753:Vmn2r98
|
UTSW |
17 |
19,285,665 (GRCm39) |
missense |
probably benign |
0.27 |
Z1177:Vmn2r98
|
UTSW |
17 |
19,287,685 (GRCm39) |
nonsense |
probably null |
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,285,398 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- AGAGAAATGGCATCTGCCTAGCTTTTG -3'
(R):5'- AAAGCGTATTTGCTCCTGGTATCTTGT -3'
Sequencing Primer
(F):5'- GGGAGCCTCATTTTTAAGCAC -3'
(R):5'- GCATAACTCTTATGCCAGATTGCTG -3'
|
Posted On |
2014-08-11 |