Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02323:Vmn2r98'

288309

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r98

Ensembl Gene

ENSMUSG00000096717

Gene Name

vomeronasal 2, receptor 98

Synonyms

EG224552

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.150) question?

Stock #

IGL02323

Quality Score

Status

Chromosome

Chromosomal Location

19053460-19082411 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 19065851 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 204 (I204F)

Ref Sequence

ENSEMBL: ENSMUSP00000131261 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170424]

AlphaFold

E9PZ56

Predicted Effect

probably damaging
Transcript: ENSMUST00000170424
AA Change: I204F

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: I204F

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	460	2.6e-35	PFAM
Pfam:NCD3G	509	562	7.4e-22	PFAM
Pfam:7tm_3	594	830	1.4e-52	PFAM
low complexity region	844	856	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ache	A	G	5: 137,291,064	E344G	probably damaging	Het
Actrt2	T	C	4: 154,666,798	T294A	probably benign	Het
Afg1l	C	A	10: 42,454,510	E54*	probably null	Het
Ahi1	T	C	10: 20,972,034	I447T	probably damaging	Het
Akap6	T	C	12: 53,140,429	I1542T	probably benign	Het
Ankrd34c	A	C	9: 89,729,980	S103A	possibly damaging	Het
Apc	C	T	18: 34,315,810	Q1886*	probably null	Het
Bcas3	A	G	11: 85,495,845	T148A	probably damaging	Het
Bud13	A	G	9: 46,283,052	T8A	probably benign	Het
Casr	A	T	16: 36,509,710	Y421N	probably damaging	Het
Cd163l1	G	T	7: 140,228,659	A828S	probably benign	Het
Clasp2	T	C	9: 113,868,726		probably benign	Het
Clca4b	T	C	3: 144,913,321	T686A	probably benign	Het
Cntln	T	A	4: 85,049,789	H748Q	probably benign	Het
D430042O09Rik	T	A	7: 125,842,829	S637T	probably benign	Het
Dmtf1	A	T	5: 9,120,056	D683E	possibly damaging	Het
Dnmt3l	A	G	10: 78,063,318	K117R	probably damaging	Het
Eif2a	T	C	3: 58,548,603	M341T	possibly damaging	Het
Epg5	T	A	18: 78,012,832	Y1740*	probably null	Het
Fam149b	C	T	14: 20,363,301	T157I	possibly damaging	Het
Fam89b	A	G	19: 5,728,871		probably null	Het
Fbxo3	T	A	2: 104,047,951	N232K	probably benign	Het
Gm5415	A	T	1: 32,545,704	L375*	probably null	Het
Gm6588	A	G	5: 112,449,734	Y49C	probably benign	Het
Gnl3	A	C	14: 31,017,402	H16Q	probably damaging	Het
Gpld1	T	G	13: 24,982,774	V669G	probably damaging	Het
Grik3	A	G	4: 125,685,990		probably benign	Het
Gzmg	A	C	14: 56,157,272	Y180D	probably benign	Het
H2-M9	A	T	17: 36,640,741	Y281N	probably damaging	Het
Mical1	G	A	10: 41,486,664	E932K	possibly damaging	Het
Mrs2	T	A	13: 25,004,957	I125F	probably damaging	Het
Nfam1	T	A	15: 83,022,951	N15I	probably benign	Het
Nol8	T	A	13: 49,655,245		probably benign	Het
Obscn	A	G	11: 59,008,522	V6483A	possibly damaging	Het
Olfr444	A	T	6: 42,955,983	I162F	probably benign	Het
Osbpl3	A	G	6: 50,346,326		probably null	Het
Pla2g16	G	A	19: 7,574,992	W24*	probably null	Het
Ppfibp2	A	T	7: 107,738,629	Q652H	probably damaging	Het
Rbm47	A	G	5: 66,026,429	V277A	probably damaging	Het
Robo3	G	A	9: 37,422,201	A716V	probably benign	Het
Slc29a4	A	G	5: 142,717,652	E227G	probably damaging	Het
Slf1	T	C	13: 77,051,294	D656G	possibly damaging	Het
Sox1	A	G	8: 12,396,692	H111R	possibly damaging	Het
Svep1	G	A	4: 58,070,236	Q2517*	probably null	Het
Syndig1	G	T	2: 149,899,787	V98L	probably benign	Het
Synpo2	T	C	3: 123,117,534	E154G	probably benign	Het
Tex37	A	G	6: 70,913,695		probably benign	Het
Tkt	G	A	14: 30,571,035	G490S	possibly damaging	Het
Tmem200a	T	C	10: 25,993,430	N314D	probably benign	Het
Tnfaip8l1	A	T	17: 56,172,009	T100S	probably damaging	Het
Traf7	C	A	17: 24,513,046	C193F	possibly damaging	Het
Trim12c	C	T	7: 104,348,266	A28T	probably benign	Het
Trpc7	C	A	13: 56,783,751	V595L	possibly damaging	Het
Ttc39c	A	G	18: 12,736,743	R575G	probably null	Het
Ttn	T	G	2: 76,851,575		probably benign	Het
Ttn	C	T	2: 76,723,265	V31003M	probably damaging	Het
Ugt2b37	A	T	5: 87,250,564		probably benign	Het
Uqcrb	A	T	13: 66,902,810		probably benign	Het
Usp33	T	A	3: 152,370,387	W415R	probably benign	Het
Vmn2r110	A	T	17: 20,596,137	D41E	probably damaging	Het

Other mutations in Vmn2r98

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r98	APN	17	19065745	splice site	probably benign
IGL01296:Vmn2r98	APN	17	19065185	missense	probably damaging	1.00
IGL01363:Vmn2r98	APN	17	19065758	missense	probably benign	0.01
IGL01618:Vmn2r98	APN	17	19065259	missense	possibly damaging	0.93
IGL01746:Vmn2r98	APN	17	19066451	missense	probably damaging	1.00
IGL01747:Vmn2r98	APN	17	19066440	missense	probably damaging	1.00
IGL01770:Vmn2r98	APN	17	19066440	missense	probably damaging	1.00
IGL01868:Vmn2r98	APN	17	19066286	missense	probably benign
IGL02123:Vmn2r98	APN	17	19080679	missense	probably damaging	1.00
IGL02543:Vmn2r98	APN	17	19065821	missense	probably benign
IGL02650:Vmn2r98	APN	17	19080961	missense	probably benign	0.00
IGL02676:Vmn2r98	APN	17	19065259	missense	probably benign	0.00
IGL02803:Vmn2r98	APN	17	19066013	missense	probably benign
IGL02807:Vmn2r98	APN	17	19081021	missense	probably damaging	1.00
IGL03307:Vmn2r98	APN	17	19065980	missense	possibly damaging	0.62
IGL03396:Vmn2r98	APN	17	19069845	missense	possibly damaging	0.92
PIT4131001:Vmn2r98	UTSW	17	19080961	missense	probably benign	0.00
R0122:Vmn2r98	UTSW	17	19066400	missense	probably benign	0.06
R0329:Vmn2r98	UTSW	17	19066347	missense	probably benign	0.21
R0330:Vmn2r98	UTSW	17	19066347	missense	probably benign	0.21
R0368:Vmn2r98	UTSW	17	19065827	nonsense	probably null
R0545:Vmn2r98	UTSW	17	19053613	missense	probably benign	0.15
R0635:Vmn2r98	UTSW	17	19080497	missense	probably benign	0.00
R0689:Vmn2r98	UTSW	17	19080520	missense	possibly damaging	0.83
R1035:Vmn2r98	UTSW	17	19080749	missense	possibly damaging	0.90
R1243:Vmn2r98	UTSW	17	19065948	missense	possibly damaging	0.52
R1421:Vmn2r98	UTSW	17	19065178	missense	probably damaging	1.00
R1629:Vmn2r98	UTSW	17	19067383	missense	possibly damaging	0.94
R1643:Vmn2r98	UTSW	17	19080908	missense	probably damaging	1.00
R1795:Vmn2r98	UTSW	17	19066440	missense	probably damaging	1.00
R1958:Vmn2r98	UTSW	17	19066418	missense	possibly damaging	0.70
R1962:Vmn2r98	UTSW	17	19065333	nonsense	probably null
R2165:Vmn2r98	UTSW	17	19081291	missense	unknown
R2238:Vmn2r98	UTSW	17	19065951	missense	probably damaging	1.00
R2252:Vmn2r98	UTSW	17	19080436	missense	probably benign	0.00
R2323:Vmn2r98	UTSW	17	19065819	missense	probably benign	0.18
R2887:Vmn2r98	UTSW	17	19081177	missense	possibly damaging	0.83
R2909:Vmn2r98	UTSW	17	19067402	missense	probably damaging	1.00
R3001:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3002:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3003:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3788:Vmn2r98	UTSW	17	19080625	missense	probably benign	0.31
R4570:Vmn2r98	UTSW	17	19066092	missense	probably benign	0.11
R4706:Vmn2r98	UTSW	17	19069745	missense	probably damaging	1.00
R4723:Vmn2r98	UTSW	17	19066340	missense	probably benign	0.01
R5036:Vmn2r98	UTSW	17	19066157	missense	probably benign	0.00
R5072:Vmn2r98	UTSW	17	19066044	missense	probably benign	0.07
R5121:Vmn2r98	UTSW	17	19053553	missense	probably benign	0.13
R5283:Vmn2r98	UTSW	17	19080719	missense	probably benign	0.05
R5294:Vmn2r98	UTSW	17	19069754	nonsense	probably null
R5371:Vmn2r98	UTSW	17	19069753	missense	probably damaging	1.00
R5532:Vmn2r98	UTSW	17	19067383	missense	possibly damaging	0.94
R5598:Vmn2r98	UTSW	17	19080899	missense	probably benign	0.37
R5800:Vmn2r98	UTSW	17	19065998	missense	probably benign	0.17
R6089:Vmn2r98	UTSW	17	19066074	missense	probably benign	0.29
R6155:Vmn2r98	UTSW	17	19065881	missense	possibly damaging	0.87
R6853:Vmn2r98	UTSW	17	19065801	missense	probably benign	0.00
R6920:Vmn2r98	UTSW	17	19065248	missense	probably damaging	0.98
R7012:Vmn2r98	UTSW	17	19066268	missense	probably benign	0.06
R7042:Vmn2r98	UTSW	17	19080922	missense	probably benign
R7068:Vmn2r98	UTSW	17	19065313	missense	probably benign
R7607:Vmn2r98	UTSW	17	19067308	missense	possibly damaging	0.95
R7763:Vmn2r98	UTSW	17	19080535	missense	probably benign	0.00
R7771:Vmn2r98	UTSW	17	19067198	splice site	probably null
R7915:Vmn2r98	UTSW	17	19067231	missense	probably benign	0.10
R8028:Vmn2r98	UTSW	17	19053650	missense	probably benign	0.00
R8205:Vmn2r98	UTSW	17	19081163	missense	probably damaging	0.99
R8241:Vmn2r98	UTSW	17	19080769	missense	probably damaging	0.99
R8906:Vmn2r98	UTSW	17	19066270	missense	probably benign
R8952:Vmn2r98	UTSW	17	19065269	missense	possibly damaging	0.76
R9147:Vmn2r98	UTSW	17	19066121	missense	probably benign	0.04
R9148:Vmn2r98	UTSW	17	19066121	missense	probably benign	0.04
R9187:Vmn2r98	UTSW	17	19081219	missense	probably damaging	1.00
R9344:Vmn2r98	UTSW	17	19066515	missense	probably benign	0.14
R9467:Vmn2r98	UTSW	17	19067255	missense	probably benign	0.01
R9487:Vmn2r98	UTSW	17	19081234	missense	possibly damaging	0.78
R9753:Vmn2r98	UTSW	17	19065403	missense	probably benign	0.27
Z1177:Vmn2r98	UTSW	17	19065136	critical splice acceptor site	probably null
Z1177:Vmn2r98	UTSW	17	19067423	nonsense	probably null

Posted On

2015-04-16