Incidental Mutation 'R1876:Mslnl'
| ID |
211267 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mslnl
|
| Ensembl Gene |
ENSMUSG00000041062 |
| Gene Name |
mesothelin-like |
| Synonyms |
|
| MMRRC Submission |
039898-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1876 (G1)
|
| Quality Score |
170 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
25736040-25748330 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 25742934 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 128
(V128M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000049020
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047098]
|
| AlphaFold |
Q8C160 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000047098
AA Change: V128M
PolyPhen 2
Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000049020
Gene: ENSMUSG00000041062
AA Change: V128M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:Mesothelin
|
29 |
589 |
2.8e-70 |
PFAM |
|
low complexity region
|
633 |
653 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000102319
|
| Meta Mutation Damage Score |
0.2148 |
| Coding Region Coverage |
- 1x: 97.3%
- 3x: 96.7%
- 10x: 95.1%
- 20x: 92.2%
|
| Validation Efficiency |
99% (82/83) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aasdh |
C |
A |
5: 76,877,549 (GRCm38) |
C961F |
probably damaging |
Het |
| Abca16 |
A |
C |
7: 120,433,385 (GRCm38) |
D209A |
probably damaging |
Het |
| Adamts14 |
T |
C |
10: 61,200,372 (GRCm38) |
I1047V |
probably benign |
Het |
| Ak1 |
A |
G |
2: 32,630,270 (GRCm38) |
K27E |
probably damaging |
Het |
| Akap9 |
T |
A |
5: 3,961,809 (GRCm38) |
D837E |
probably benign |
Het |
| Arfgef3 |
T |
C |
10: 18,597,356 (GRCm38) |
Y1653C |
probably damaging |
Het |
| Atad2 |
T |
G |
15: 58,106,868 (GRCm38) |
I446L |
probably benign |
Het |
| Atp8b3 |
T |
G |
10: 80,530,078 (GRCm38) |
T313P |
possibly damaging |
Het |
| Btg4 |
T |
C |
9: 51,117,189 (GRCm38) |
L72S |
probably damaging |
Het |
| Canx |
A |
G |
11: 50,304,359 (GRCm38) |
I294T |
probably damaging |
Het |
| Casp1 |
G |
A |
9: 5,303,663 (GRCm38) |
E250K |
probably benign |
Het |
| Chchd10 |
T |
A |
10: 75,936,332 (GRCm38) |
S46T |
probably benign |
Het |
| Col12a1 |
G |
T |
9: 79,678,281 (GRCm38) |
Y1271* |
probably null |
Het |
| Col3a1 |
G |
A |
1: 45,342,235 (GRCm38) |
|
probably null |
Het |
| Ctc1 |
A |
T |
11: 69,031,564 (GRCm38) |
T872S |
probably benign |
Het |
| Cx3cl1 |
T |
C |
8: 94,780,420 (GRCm38) |
F351S |
probably damaging |
Het |
| Cyb5r4 |
T |
A |
9: 87,055,814 (GRCm38) |
H295Q |
probably damaging |
Het |
| Cyp2j7 |
T |
C |
4: 96,217,419 (GRCm38) |
T285A |
probably benign |
Het |
| Dip2a |
G |
A |
10: 76,318,091 (GRCm38) |
T135M |
probably damaging |
Het |
| Eif1ad18 |
T |
G |
12: 88,084,040 (GRCm38) |
I115S |
probably damaging |
Het |
| Fgf10 |
A |
G |
13: 118,789,159 (GRCm38) |
E158G |
probably damaging |
Het |
| Ftcd |
G |
T |
10: 76,581,569 (GRCm38) |
A281S |
probably benign |
Het |
| Gpat4 |
A |
T |
8: 23,179,470 (GRCm38) |
M333K |
possibly damaging |
Het |
| Gpcpd1 |
A |
G |
2: 132,534,753 (GRCm38) |
L541P |
probably damaging |
Het |
| Grk5 |
T |
C |
19: 61,083,225 (GRCm38) |
Y408H |
probably damaging |
Het |
| Hcrtr2 |
A |
G |
9: 76,246,345 (GRCm38) |
|
probably null |
Het |
| Hsd17b13 |
T |
A |
5: 103,968,767 (GRCm38) |
N127I |
probably damaging |
Het |
| Hspa4 |
T |
G |
11: 53,284,156 (GRCm38) |
D158A |
probably benign |
Het |
| Ice2 |
G |
A |
9: 69,415,575 (GRCm38) |
A451T |
possibly damaging |
Het |
| Inpp5e |
A |
T |
2: 26,408,157 (GRCm38) |
I144K |
possibly damaging |
Het |
| Kirrel1 |
C |
T |
3: 87,089,151 (GRCm38) |
M380I |
probably null |
Het |
| Lrrc49 |
T |
C |
9: 60,587,777 (GRCm38) |
I652V |
possibly damaging |
Het |
| Man1a |
A |
T |
10: 53,919,172 (GRCm38) |
W571R |
probably damaging |
Het |
| Mecom |
A |
G |
3: 29,993,658 (GRCm38) |
S32P |
probably damaging |
Het |
| Mrpl40 |
A |
G |
16: 18,872,474 (GRCm38) |
I162T |
probably benign |
Het |
| Mtmr12 |
T |
C |
15: 12,257,630 (GRCm38) |
W265R |
probably damaging |
Het |
| Mup21 |
C |
T |
4: 62,149,426 (GRCm38) |
V79I |
probably benign |
Het |
| Myh11 |
G |
A |
16: 14,269,103 (GRCm38) |
|
probably benign |
Het |
| Myom3 |
T |
A |
4: 135,779,400 (GRCm38) |
F495I |
probably benign |
Het |
| Ncoa7 |
A |
T |
10: 30,698,126 (GRCm38) |
|
probably benign |
Het |
| Nisch |
T |
C |
14: 31,173,637 (GRCm38) |
Y45C |
probably damaging |
Het |
| Nkain2 |
T |
A |
10: 32,890,439 (GRCm38) |
|
probably benign |
Het |
| Or1ak2 |
A |
T |
2: 36,937,763 (GRCm38) |
I215F |
possibly damaging |
Het |
| Or4k1 |
A |
G |
14: 50,140,172 (GRCm38) |
S156P |
probably damaging |
Het |
| Pdcl |
A |
C |
2: 37,355,696 (GRCm38) |
H98Q |
probably damaging |
Het |
| Pink1 |
A |
G |
4: 138,315,702 (GRCm38) |
V427A |
probably damaging |
Het |
| Plce1 |
T |
C |
19: 38,780,623 (GRCm38) |
S2242P |
probably damaging |
Het |
| Plrg1 |
C |
A |
3: 83,069,068 (GRCm38) |
|
probably benign |
Het |
| Plxnc1 |
A |
G |
10: 94,866,941 (GRCm38) |
F586S |
possibly damaging |
Het |
| Pnpla7 |
G |
A |
2: 25,040,973 (GRCm38) |
V867M |
possibly damaging |
Het |
| Ppfia3 |
T |
A |
7: 45,352,207 (GRCm38) |
D427V |
possibly damaging |
Het |
| Ppp6r3 |
A |
T |
19: 3,471,971 (GRCm38) |
|
probably benign |
Het |
| Pros1 |
A |
T |
16: 62,903,518 (GRCm38) |
S210C |
probably damaging |
Het |
| Ptk2b |
A |
G |
14: 66,158,392 (GRCm38) |
S839P |
probably benign |
Het |
| Ptpre |
T |
C |
7: 135,678,317 (GRCm38) |
V570A |
possibly damaging |
Het |
| Rbm48 |
C |
T |
5: 3,595,259 (GRCm38) |
A142T |
probably damaging |
Het |
| Safb2 |
T |
C |
17: 56,576,909 (GRCm38) |
|
probably null |
Het |
| Scnn1a |
A |
G |
6: 125,338,838 (GRCm38) |
E384G |
probably benign |
Het |
| Sec23ip |
A |
G |
7: 128,752,851 (GRCm38) |
Y277C |
probably benign |
Het |
| Slc25a29 |
G |
A |
12: 108,827,711 (GRCm38) |
T42M |
probably damaging |
Het |
| Slc6a4 |
A |
T |
11: 77,015,164 (GRCm38) |
T264S |
probably benign |
Het |
| Srgap3 |
A |
G |
6: 112,775,566 (GRCm38) |
M319T |
probably damaging |
Het |
| Strn4 |
T |
A |
7: 16,838,282 (GRCm38) |
I640N |
probably damaging |
Het |
| Tacc2 |
A |
G |
7: 130,623,745 (GRCm38) |
D739G |
probably benign |
Het |
| Tigd4 |
T |
A |
3: 84,593,935 (GRCm38) |
L53* |
probably null |
Het |
| Tlr6 |
T |
A |
5: 64,955,420 (GRCm38) |
D48V |
probably damaging |
Het |
| Tmem125 |
T |
C |
4: 118,541,904 (GRCm38) |
D110G |
probably damaging |
Het |
| Tmem198 |
A |
G |
1: 75,484,923 (GRCm38) |
D341G |
probably damaging |
Het |
| Tnfaip3 |
A |
G |
10: 19,004,934 (GRCm38) |
F462L |
possibly damaging |
Het |
| Tnrc6a |
CTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTT |
CTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTT |
7: 123,162,446 (GRCm38) |
|
probably benign |
Het |
| Ush2a |
T |
A |
1: 188,678,289 (GRCm38) |
I2378N |
possibly damaging |
Het |
| Usp47 |
A |
G |
7: 112,054,920 (GRCm38) |
T108A |
probably damaging |
Het |
| Vmn1r236 |
T |
A |
17: 21,286,638 (GRCm38) |
I6K |
probably benign |
Het |
| Vmn2r65 |
A |
T |
7: 84,946,297 (GRCm38) |
V393D |
probably damaging |
Het |
|
| Other mutations in Mslnl |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01621:Mslnl
|
APN |
17 |
25,743,667 (GRCm38) |
unclassified |
probably benign |
|
|
IGL01629:Mslnl
|
APN |
17 |
25,744,775 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
IGL02084:Mslnl
|
APN |
17 |
25,746,151 (GRCm38) |
missense |
probably benign |
0.07 |
|
IGL02408:Mslnl
|
APN |
17 |
25,747,998 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
IGL02726:Mslnl
|
APN |
17 |
25,744,103 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL03387:Mslnl
|
APN |
17 |
25,744,077 (GRCm38) |
missense |
probably benign |
0.06 |
|
R0561:Mslnl
|
UTSW |
17 |
25,743,203 (GRCm38) |
nonsense |
probably null |
|
|
R0881:Mslnl
|
UTSW |
17 |
25,742,965 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R1295:Mslnl
|
UTSW |
17 |
25,743,240 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1296:Mslnl
|
UTSW |
17 |
25,743,240 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1582:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1629:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1630:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1631:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1632:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1794:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1850:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1866:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1914:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2166:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2241:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2243:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2247:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2282:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2284:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2852:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2867:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2867:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2877:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2878:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2919:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2920:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3026:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3405:Mslnl
|
UTSW |
17 |
25,746,181 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3406:Mslnl
|
UTSW |
17 |
25,746,181 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3411:Mslnl
|
UTSW |
17 |
25,744,517 (GRCm38) |
missense |
probably benign |
0.05 |
|
R3434:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3546:Mslnl
|
UTSW |
17 |
25,744,969 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R3612:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3729:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3730:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3802:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3804:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3894:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3895:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4454:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4455:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4456:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4457:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4561:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4562:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4564:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4600:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4601:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4610:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4704:Mslnl
|
UTSW |
17 |
25,738,978 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R5155:Mslnl
|
UTSW |
17 |
25,738,968 (GRCm38) |
nonsense |
probably null |
|
|
R5257:Mslnl
|
UTSW |
17 |
25,746,165 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5456:Mslnl
|
UTSW |
17 |
25,743,159 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5645:Mslnl
|
UTSW |
17 |
25,737,842 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R6007:Mslnl
|
UTSW |
17 |
25,746,775 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6083:Mslnl
|
UTSW |
17 |
25,737,902 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R6142:Mslnl
|
UTSW |
17 |
25,744,557 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6761:Mslnl
|
UTSW |
17 |
25,746,073 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7058:Mslnl
|
UTSW |
17 |
25,743,212 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7156:Mslnl
|
UTSW |
17 |
25,743,210 (GRCm38) |
missense |
probably benign |
0.20 |
|
R7467:Mslnl
|
UTSW |
17 |
25,736,921 (GRCm38) |
start codon destroyed |
probably benign |
0.33 |
|
R7687:Mslnl
|
UTSW |
17 |
25,743,183 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7807:Mslnl
|
UTSW |
17 |
25,746,777 (GRCm38) |
missense |
probably benign |
0.03 |
|
R8682:Mslnl
|
UTSW |
17 |
25,746,988 (GRCm38) |
missense |
probably benign |
|
|
R8735:Mslnl
|
UTSW |
17 |
25,745,088 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8742:Mslnl
|
UTSW |
17 |
25,745,073 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9208:Mslnl
|
UTSW |
17 |
25,742,720 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9264:Mslnl
|
UTSW |
17 |
25,742,532 (GRCm38) |
intron |
probably benign |
|
|
RF007:Mslnl
|
UTSW |
17 |
25,743,228 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCATCAGAAGGGAGGTTTGAAC -3'
(R):5'- ACAGGTCTGAAGCACTGAGC -3'
Sequencing Primer
(F):5'- TTTGAACCCAGGACTGAGGTGAC -3'
(R):5'- GCCCTGCCGAGACAGTAG -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation