Mutagenetix > Incidental Mutation

Incidental Mutation 'R9591:Vmn2r103'

723018

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

R9591 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

19993625-20032798 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 20031921 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Valine at position 565 (E565V)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

AlphaFold

E9PWW0

Predicted Effect

possibly damaging
Transcript: ENSMUST00000172203
AA Change: E565V

PolyPhen 2 Score 0.705 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: E565V

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2510039O18Rik	T	A	4: 148,029,488 (GRCm39)	I486N	probably damaging	Het
Ablim3	T	C	18: 61,954,984 (GRCm39)	Y335C	probably benign	Het
Adam24	C	A	8: 41,132,698 (GRCm39)	D55E	probably benign	Het
Ankrd13d	A	G	19: 4,320,250 (GRCm39)	*164Q	probably null	Het
Arhgap25	T	C	6: 87,440,102 (GRCm39)	N515S	probably benign	Het
Bnip3l	G	A	14: 67,246,214 (GRCm39)	P7L	possibly damaging	Het
Btbd9	T	C	17: 30,736,222 (GRCm39)	D297G	probably damaging	Het
C4b	A	T	17: 34,957,929 (GRCm39)	M584K	probably benign	Het
C9orf72	C	T	4: 35,218,557 (GRCm39)	G101R		Het
Ccdc116	T	C	16: 16,960,598 (GRCm39)	D73G	probably damaging	Het
Cd19	A	G	7: 126,011,296 (GRCm39)	V296A	probably benign	Het
Cldn19	A	G	4: 119,114,357 (GRCm39)	T133A	probably benign	Het
Crygn	G	T	5: 24,961,073 (GRCm39)	H78N	probably damaging	Het
Dhrs11	T	G	11: 84,719,584 (GRCm39)	N47T	probably benign	Het
Fat3	T	C	9: 16,288,336 (GRCm39)	S396G	probably benign	Het
Gm3667	T	C	14: 18,270,388 (GRCm39)	Y139C	probably damaging	Het
Hivep2	A	G	10: 14,019,640 (GRCm39)	N2137S	probably damaging	Het
Iapp	T	A	6: 142,249,063 (GRCm39)	C39S	probably damaging	Het
Irs1	T	C	1: 82,265,969 (GRCm39)	E749G	probably benign	Het
Lpcat1	T	G	13: 73,659,471 (GRCm39)	V411G	probably damaging	Het
Map3k4	C	A	17: 12,454,795 (GRCm39)	E1398D	possibly damaging	Het
Muc5b	A	G	7: 141,412,516 (GRCm39)	T1821A	unknown	Het
Neu1	T	C	17: 35,150,474 (GRCm39)	L31P	probably benign	Het
Nfam1	T	C	15: 82,900,581 (GRCm39)	T94A	possibly damaging	Het
Nlrc5	T	G	8: 95,249,309 (GRCm39)	S1752R	probably damaging	Het
Opn1sw	T	A	6: 29,378,926 (GRCm39)	E242V	probably damaging	Het
Or51b6	A	T	7: 103,556,470 (GRCm39)	I272F		Het
Peak1	C	A	9: 56,166,834 (GRCm39)	V365F	possibly damaging	Het
Rgl2	C	T	17: 34,151,451 (GRCm39)	T165I	possibly damaging	Het
Rnpepl1	T	C	1: 92,847,309 (GRCm39)	L632P	probably damaging	Het
Sec1	G	A	7: 45,328,102 (GRCm39)	T315M		Het
Sipa1l2	A	T	8: 126,219,112 (GRCm39)	M75K	probably damaging	Het
Smchd1	G	A	17: 71,701,828 (GRCm39)	H1055Y	probably damaging	Het
Sprr2a3	T	A	3: 92,195,961 (GRCm39)	C23S	unknown	Het
Tbck	T	A	3: 132,400,195 (GRCm39)	L82Q	probably benign	Het
Tmprss11a	C	T	5: 86,567,897 (GRCm39)	V277I	possibly damaging	Het
Zfp148	T	A	16: 33,315,737 (GRCm39)	D230E		Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	20,013,364 (GRCm39)	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	20,015,227 (GRCm39)	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	20,013,259 (GRCm39)	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	20,013,229 (GRCm39)	missense	probably benign
IGL01404:Vmn2r103	APN	17	20,032,696 (GRCm39)	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	20,014,330 (GRCm39)	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	20,019,470 (GRCm39)	missense	probably benign
IGL02251:Vmn2r103	APN	17	20,014,231 (GRCm39)	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19,993,631 (GRCm39)	missense	probably benign
IGL02555:Vmn2r103	APN	17	20,031,873 (GRCm39)	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	20,014,389 (GRCm39)	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	20,014,218 (GRCm39)	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	20,032,510 (GRCm39)	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19,993,782 (GRCm39)	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	20,032,241 (GRCm39)	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	20,031,903 (GRCm39)	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	20,013,726 (GRCm39)	missense	probably benign	0.12
R0375:Vmn2r103	UTSW	17	20,013,121 (GRCm39)	missense	probably benign	0.06
R0755:Vmn2r103	UTSW	17	19,993,830 (GRCm39)	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	20,014,189 (GRCm39)	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	20,014,509 (GRCm39)	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	20,013,230 (GRCm39)	missense	probably benign
R1488:Vmn2r103	UTSW	17	20,013,922 (GRCm39)	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19,993,662 (GRCm39)	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	20,014,496 (GRCm39)	missense	probably benign
R1928:Vmn2r103	UTSW	17	20,032,029 (GRCm39)	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	20,032,562 (GRCm39)	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	20,014,056 (GRCm39)	missense	probably benign
R2219:Vmn2r103	UTSW	17	20,013,909 (GRCm39)	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19,993,793 (GRCm39)	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	20,013,862 (GRCm39)	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	20,032,411 (GRCm39)	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	20,013,866 (GRCm39)	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	20,014,495 (GRCm39)	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	20,013,958 (GRCm39)	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	20,013,958 (GRCm39)	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	20,013,958 (GRCm39)	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	20,032,077 (GRCm39)	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	20,015,338 (GRCm39)	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	20,015,338 (GRCm39)	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	20,032,031 (GRCm39)	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19,993,773 (GRCm39)	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	20,013,296 (GRCm39)	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	20,013,296 (GRCm39)	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	20,032,433 (GRCm39)	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	20,013,904 (GRCm39)	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	20,013,251 (GRCm39)	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	20,015,201 (GRCm39)	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	20,032,715 (GRCm39)	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	20,014,478 (GRCm39)	nonsense	probably null
R6114:Vmn2r103	UTSW	17	20,032,587 (GRCm39)	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	20,032,406 (GRCm39)	missense	probably benign
R6292:Vmn2r103	UTSW	17	20,013,866 (GRCm39)	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	20,014,344 (GRCm39)	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	20,032,166 (GRCm39)	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	20,032,239 (GRCm39)	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19,993,773 (GRCm39)	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	20,013,739 (GRCm39)	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	20,032,314 (GRCm39)	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	20,014,476 (GRCm39)	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	20,013,385 (GRCm39)	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	20,019,511 (GRCm39)	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	20,013,759 (GRCm39)	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	20,032,058 (GRCm39)	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	20,032,205 (GRCm39)	missense	probably damaging	1.00
R8559:Vmn2r103	UTSW	17	20,032,646 (GRCm39)	missense	probably benign	0.01
R9413:Vmn2r103	UTSW	17	20,032,158 (GRCm39)	missense	possibly damaging	0.54
R9652:Vmn2r103	UTSW	17	20,014,027 (GRCm39)	missense	probably benign	0.01
R9680:Vmn2r103	UTSW	17	20,019,525 (GRCm39)	nonsense	probably null
R9743:Vmn2r103	UTSW	17	20,032,475 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r103	UTSW	17	20,015,309 (GRCm39)	missense	probably benign	0.08

Predicted Primers

PCR Primer
(F):5'- GCCTCTACTGAAAGAACAATGTGG -3'
(R):5'- ACTGAGAGCTCGATTATTTGCC -3'

Sequencing Primer
(F):5'- TGTGGAAAGAAATTTGGAAGCAAC -3'
(R):5'- TGCCTTTACAATCGGAGTGTC -3'

Posted On

2022-08-09