Incidental Mutation 'R8140:Vmn2r103'
ID |
632503 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r103
|
Ensembl Gene |
ENSMUSG00000091771 |
Gene Name |
vomeronasal 2, receptor 103 |
Synonyms |
EG627636 |
MMRRC Submission |
067568-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.058)
|
Stock # |
R8140 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
19993625-20032798 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 20032058 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Serine
at position 611
(T611S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000126756
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172203]
|
AlphaFold |
E9PWW0 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000172203
AA Change: T611S
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000126756 Gene: ENSMUSG00000091771 AA Change: T611S
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
82 |
449 |
1.3e-37 |
PFAM |
Pfam:NCD3G
|
509 |
562 |
3.5e-22 |
PFAM |
Pfam:7tm_3
|
595 |
830 |
1.1e-51 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.6%
- 10x: 98.6%
- 20x: 93.9%
|
Validation Efficiency |
97% (64/66) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 58 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
0610040J01Rik |
T |
A |
5: 64,055,954 (GRCm39) |
V230E |
possibly damaging |
Het |
Amotl1 |
G |
A |
9: 14,484,011 (GRCm39) |
|
probably null |
Het |
Atp7b |
C |
A |
8: 22,518,576 (GRCm39) |
E87D |
probably damaging |
Het |
Bcat2 |
C |
T |
7: 45,237,775 (GRCm39) |
P347L |
probably damaging |
Het |
Brox |
A |
T |
1: 183,075,437 (GRCm39) |
|
probably null |
Het |
Cd37 |
A |
G |
7: 44,887,959 (GRCm39) |
I58T |
probably damaging |
Het |
Cep295 |
A |
T |
9: 15,252,829 (GRCm39) |
M333K |
probably benign |
Het |
Chtop |
A |
G |
3: 90,412,700 (GRCm39) |
|
probably null |
Het |
Cpa2 |
A |
T |
6: 30,544,904 (GRCm39) |
K54N |
probably benign |
Het |
Cpa6 |
A |
G |
1: 10,395,519 (GRCm39) |
S383P |
probably damaging |
Het |
Dnah7a |
A |
T |
1: 53,540,748 (GRCm39) |
I2542N |
probably benign |
Het |
Eif5b |
G |
A |
1: 38,090,357 (GRCm39) |
V1179I |
probably benign |
Het |
Erbin |
T |
C |
13: 104,056,802 (GRCm39) |
|
probably null |
Het |
Fastkd5 |
A |
T |
2: 130,457,170 (GRCm39) |
D473E |
possibly damaging |
Het |
Fchsd1 |
T |
C |
18: 38,097,395 (GRCm39) |
E372G |
probably damaging |
Het |
Fgl1 |
T |
C |
8: 41,653,646 (GRCm39) |
|
probably null |
Het |
Fzd8 |
T |
G |
18: 9,213,797 (GRCm39) |
V293G |
probably damaging |
Het |
Gm4787 |
T |
A |
12: 81,424,925 (GRCm39) |
H411L |
probably benign |
Het |
Gm49380 |
G |
T |
9: 44,023,269 (GRCm39) |
D326E |
probably benign |
Het |
Hcrtr1 |
G |
A |
4: 130,029,083 (GRCm39) |
R240C |
probably damaging |
Het |
Hdac5 |
A |
T |
11: 102,088,181 (GRCm39) |
Y948N |
probably damaging |
Het |
Hepacam |
A |
G |
9: 37,295,167 (GRCm39) |
S301G |
probably benign |
Het |
Htra4 |
A |
T |
8: 25,520,574 (GRCm39) |
D362E |
possibly damaging |
Het |
Ighv1-9 |
G |
A |
12: 114,547,361 (GRCm39) |
P60L |
probably damaging |
Het |
Kcnq3 |
A |
G |
15: 65,867,390 (GRCm39) |
I751T |
probably damaging |
Het |
Magi3 |
T |
C |
3: 103,941,402 (GRCm39) |
Y851C |
probably damaging |
Het |
Mefv |
A |
G |
16: 3,531,499 (GRCm39) |
S470P |
probably benign |
Het |
Mfsd2a |
C |
T |
4: 122,843,091 (GRCm39) |
V397I |
probably benign |
Het |
Mroh1 |
C |
A |
15: 76,318,073 (GRCm39) |
H867N |
probably benign |
Het |
Mthfd1l |
C |
T |
10: 3,957,745 (GRCm39) |
R261* |
probably null |
Het |
Myo3a |
A |
G |
2: 22,412,157 (GRCm39) |
I725M |
probably damaging |
Het |
Neb |
T |
C |
2: 52,099,552 (GRCm39) |
D4766G |
possibly damaging |
Het |
Nek11 |
G |
T |
9: 105,270,156 (GRCm39) |
P22Q |
probably damaging |
Het |
Or4p18 |
T |
C |
2: 88,232,457 (GRCm39) |
T274A |
possibly damaging |
Het |
Or5k15 |
T |
C |
16: 58,709,948 (GRCm39) |
T212A |
probably benign |
Het |
Or9q2 |
A |
T |
19: 13,772,603 (GRCm39) |
V124E |
possibly damaging |
Het |
Peg10 |
C |
G |
6: 4,756,113 (GRCm39) |
Q230E |
unknown |
Het |
Pipox |
T |
C |
11: 77,774,735 (GRCm39) |
D116G |
probably benign |
Het |
Pkd1l2 |
C |
T |
8: 117,774,236 (GRCm39) |
R993H |
probably benign |
Het |
Pkdrej |
A |
C |
15: 85,702,611 (GRCm39) |
N1108K |
probably damaging |
Het |
Polr2a |
C |
T |
11: 69,637,202 (GRCm39) |
R291Q |
probably benign |
Het |
Pomt1 |
T |
A |
2: 32,134,309 (GRCm39) |
Y277N |
probably damaging |
Het |
Rasal2 |
A |
G |
1: 157,126,805 (GRCm39) |
S78P |
probably damaging |
Het |
Rgl1 |
A |
T |
1: 152,433,252 (GRCm39) |
L171Q |
probably damaging |
Het |
Sfta2 |
A |
G |
17: 35,912,666 (GRCm39) |
E14G |
unknown |
Het |
Sh3rf3 |
T |
A |
10: 58,885,177 (GRCm39) |
S353R |
possibly damaging |
Het |
Slc37a1 |
A |
T |
17: 31,541,233 (GRCm39) |
I242F |
probably damaging |
Het |
Srfbp1 |
T |
A |
18: 52,621,762 (GRCm39) |
D274E |
probably damaging |
Het |
Syne2 |
T |
A |
12: 75,959,127 (GRCm39) |
S685R |
possibly damaging |
Het |
Tenm4 |
A |
C |
7: 96,544,383 (GRCm39) |
D2170A |
probably damaging |
Het |
Tnr |
A |
G |
1: 159,691,265 (GRCm39) |
T472A |
probably damaging |
Het |
Tspan9 |
T |
C |
6: 127,942,241 (GRCm39) |
H203R |
probably damaging |
Het |
Ttn |
T |
C |
2: 76,601,995 (GRCm39) |
T18556A |
possibly damaging |
Het |
Usp25 |
T |
A |
16: 76,868,569 (GRCm39) |
Y323* |
probably null |
Het |
Usp31 |
G |
T |
7: 121,248,249 (GRCm39) |
R1065S |
possibly damaging |
Het |
Wdfy4 |
A |
G |
14: 32,864,317 (GRCm39) |
V552A |
|
Het |
Zap70 |
G |
T |
1: 36,810,262 (GRCm39) |
R124L |
possibly damaging |
Het |
Zfand6 |
A |
T |
7: 84,281,957 (GRCm39) |
S91T |
possibly damaging |
Het |
|
Other mutations in Vmn2r103 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00333:Vmn2r103
|
APN |
17 |
20,013,364 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL00939:Vmn2r103
|
APN |
17 |
20,015,227 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01120:Vmn2r103
|
APN |
17 |
20,013,259 (GRCm39) |
missense |
probably benign |
0.06 |
IGL01403:Vmn2r103
|
APN |
17 |
20,013,229 (GRCm39) |
missense |
probably benign |
|
IGL01404:Vmn2r103
|
APN |
17 |
20,032,696 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01713:Vmn2r103
|
APN |
17 |
20,014,330 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01802:Vmn2r103
|
APN |
17 |
20,019,470 (GRCm39) |
missense |
probably benign |
|
IGL02251:Vmn2r103
|
APN |
17 |
20,014,231 (GRCm39) |
missense |
possibly damaging |
0.84 |
IGL02466:Vmn2r103
|
APN |
17 |
19,993,631 (GRCm39) |
missense |
probably benign |
|
IGL02555:Vmn2r103
|
APN |
17 |
20,031,873 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02668:Vmn2r103
|
APN |
17 |
20,014,389 (GRCm39) |
missense |
probably benign |
0.03 |
IGL02715:Vmn2r103
|
APN |
17 |
20,014,218 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL02735:Vmn2r103
|
APN |
17 |
20,032,510 (GRCm39) |
missense |
probably benign |
0.27 |
IGL03101:Vmn2r103
|
APN |
17 |
19,993,782 (GRCm39) |
missense |
probably damaging |
0.98 |
R0003:Vmn2r103
|
UTSW |
17 |
20,032,241 (GRCm39) |
missense |
probably damaging |
0.99 |
R0052:Vmn2r103
|
UTSW |
17 |
20,031,903 (GRCm39) |
missense |
probably benign |
0.01 |
R0375:Vmn2r103
|
UTSW |
17 |
20,013,726 (GRCm39) |
missense |
probably benign |
0.12 |
R0375:Vmn2r103
|
UTSW |
17 |
20,013,121 (GRCm39) |
missense |
probably benign |
0.06 |
R0755:Vmn2r103
|
UTSW |
17 |
19,993,830 (GRCm39) |
missense |
probably benign |
0.01 |
R0837:Vmn2r103
|
UTSW |
17 |
20,014,189 (GRCm39) |
missense |
probably damaging |
0.99 |
R1345:Vmn2r103
|
UTSW |
17 |
20,014,509 (GRCm39) |
missense |
probably damaging |
1.00 |
R1396:Vmn2r103
|
UTSW |
17 |
20,013,230 (GRCm39) |
missense |
probably benign |
|
R1488:Vmn2r103
|
UTSW |
17 |
20,013,922 (GRCm39) |
missense |
probably damaging |
0.97 |
R1533:Vmn2r103
|
UTSW |
17 |
19,993,662 (GRCm39) |
missense |
probably benign |
0.01 |
R1590:Vmn2r103
|
UTSW |
17 |
20,014,496 (GRCm39) |
missense |
probably benign |
|
R1928:Vmn2r103
|
UTSW |
17 |
20,032,029 (GRCm39) |
missense |
possibly damaging |
0.95 |
R1942:Vmn2r103
|
UTSW |
17 |
20,032,562 (GRCm39) |
missense |
probably benign |
0.02 |
R2071:Vmn2r103
|
UTSW |
17 |
20,014,056 (GRCm39) |
missense |
probably benign |
|
R2219:Vmn2r103
|
UTSW |
17 |
20,013,909 (GRCm39) |
missense |
probably damaging |
1.00 |
R2442:Vmn2r103
|
UTSW |
17 |
19,993,793 (GRCm39) |
missense |
probably benign |
0.00 |
R2889:Vmn2r103
|
UTSW |
17 |
20,013,862 (GRCm39) |
missense |
probably damaging |
1.00 |
R3762:Vmn2r103
|
UTSW |
17 |
20,032,411 (GRCm39) |
missense |
probably damaging |
0.98 |
R4014:Vmn2r103
|
UTSW |
17 |
20,013,866 (GRCm39) |
missense |
possibly damaging |
0.67 |
R4331:Vmn2r103
|
UTSW |
17 |
20,014,495 (GRCm39) |
missense |
probably benign |
0.00 |
R4630:Vmn2r103
|
UTSW |
17 |
20,013,958 (GRCm39) |
missense |
probably benign |
0.04 |
R4631:Vmn2r103
|
UTSW |
17 |
20,013,958 (GRCm39) |
missense |
probably benign |
0.04 |
R4632:Vmn2r103
|
UTSW |
17 |
20,013,958 (GRCm39) |
missense |
probably benign |
0.04 |
R4660:Vmn2r103
|
UTSW |
17 |
20,032,077 (GRCm39) |
missense |
probably damaging |
1.00 |
R4801:Vmn2r103
|
UTSW |
17 |
20,015,338 (GRCm39) |
missense |
probably benign |
0.06 |
R4802:Vmn2r103
|
UTSW |
17 |
20,015,338 (GRCm39) |
missense |
probably benign |
0.06 |
R4931:Vmn2r103
|
UTSW |
17 |
20,032,031 (GRCm39) |
missense |
probably benign |
0.01 |
R4995:Vmn2r103
|
UTSW |
17 |
19,993,773 (GRCm39) |
missense |
probably benign |
0.14 |
R5309:Vmn2r103
|
UTSW |
17 |
20,013,296 (GRCm39) |
missense |
probably benign |
0.01 |
R5312:Vmn2r103
|
UTSW |
17 |
20,013,296 (GRCm39) |
missense |
probably benign |
0.01 |
R5329:Vmn2r103
|
UTSW |
17 |
20,032,433 (GRCm39) |
missense |
probably damaging |
1.00 |
R5611:Vmn2r103
|
UTSW |
17 |
20,013,904 (GRCm39) |
missense |
probably damaging |
0.99 |
R5684:Vmn2r103
|
UTSW |
17 |
20,013,251 (GRCm39) |
missense |
probably benign |
0.02 |
R5715:Vmn2r103
|
UTSW |
17 |
20,015,201 (GRCm39) |
missense |
probably benign |
0.17 |
R5907:Vmn2r103
|
UTSW |
17 |
20,032,715 (GRCm39) |
missense |
possibly damaging |
0.67 |
R6029:Vmn2r103
|
UTSW |
17 |
20,014,478 (GRCm39) |
nonsense |
probably null |
|
R6114:Vmn2r103
|
UTSW |
17 |
20,032,587 (GRCm39) |
missense |
probably damaging |
0.99 |
R6285:Vmn2r103
|
UTSW |
17 |
20,032,406 (GRCm39) |
missense |
probably benign |
|
R6292:Vmn2r103
|
UTSW |
17 |
20,013,866 (GRCm39) |
missense |
possibly damaging |
0.67 |
R6334:Vmn2r103
|
UTSW |
17 |
20,014,344 (GRCm39) |
missense |
probably damaging |
0.97 |
R6501:Vmn2r103
|
UTSW |
17 |
20,032,166 (GRCm39) |
missense |
probably benign |
0.29 |
R6710:Vmn2r103
|
UTSW |
17 |
20,032,239 (GRCm39) |
missense |
probably damaging |
1.00 |
R6774:Vmn2r103
|
UTSW |
17 |
19,993,773 (GRCm39) |
missense |
probably benign |
0.14 |
R6981:Vmn2r103
|
UTSW |
17 |
20,013,739 (GRCm39) |
missense |
probably benign |
0.00 |
R7768:Vmn2r103
|
UTSW |
17 |
20,032,314 (GRCm39) |
missense |
probably damaging |
0.99 |
R7816:Vmn2r103
|
UTSW |
17 |
20,014,476 (GRCm39) |
missense |
probably benign |
0.06 |
R7885:Vmn2r103
|
UTSW |
17 |
20,013,385 (GRCm39) |
missense |
probably benign |
0.25 |
R8002:Vmn2r103
|
UTSW |
17 |
20,019,511 (GRCm39) |
missense |
probably damaging |
1.00 |
R8031:Vmn2r103
|
UTSW |
17 |
20,013,759 (GRCm39) |
missense |
probably benign |
0.00 |
R8186:Vmn2r103
|
UTSW |
17 |
20,032,205 (GRCm39) |
missense |
probably damaging |
1.00 |
R8559:Vmn2r103
|
UTSW |
17 |
20,032,646 (GRCm39) |
missense |
probably benign |
0.01 |
R9413:Vmn2r103
|
UTSW |
17 |
20,032,158 (GRCm39) |
missense |
possibly damaging |
0.54 |
R9591:Vmn2r103
|
UTSW |
17 |
20,031,921 (GRCm39) |
missense |
possibly damaging |
0.70 |
R9652:Vmn2r103
|
UTSW |
17 |
20,014,027 (GRCm39) |
missense |
probably benign |
0.01 |
R9680:Vmn2r103
|
UTSW |
17 |
20,019,525 (GRCm39) |
nonsense |
probably null |
|
R9743:Vmn2r103
|
UTSW |
17 |
20,032,475 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Vmn2r103
|
UTSW |
17 |
20,015,309 (GRCm39) |
missense |
probably benign |
0.08 |
|
Predicted Primers |
PCR Primer
(F):5'- TTGGACTCCTGTGTTCATGATAAC -3'
(R):5'- TGGCCAACACAGTAGCAAG -3'
Sequencing Primer
(F):5'- CTCACAAGATGTATACCAGTGTGTG -3'
(R):5'- CACAGTAGCAAGAGCCATAGTG -3'
|
Posted On |
2020-06-30 |