Mutagenetix > Incidental Mutations

Incidental Mutation 'R8559:Vmn2r103'

660955

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

R8559 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

19773363-19812536 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19812384 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 807 (M807V)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

Predicted Effect

probably benign
Transcript: ENSMUST00000172203
AA Change: M807V

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: M807V

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actr6	T	A	10: 89,732,186	H19L	probably benign	Het
Adamts9	A	T	6: 92,807,136	V1579E	probably benign	Het
Arhgap40	C	T	2: 158,541,801	R435C	probably damaging	Het
Atp1a4	T	C	1: 172,251,330	D207G	probably damaging	Het
Btaf1	A	G	19: 36,986,873	N948S	probably benign	Het
Calcr	G	A	6: 3,692,603	P417L	probably damaging	Het
Cep250	T	A	2: 155,992,736	S2194T	probably damaging	Het
Clcn6	C	T	4: 148,026,575	V102M	possibly damaging	Het
Cog2	T	C	8: 124,542,908	S396P	probably benign	Het
Col28a1	C	A	6: 8,166,681	R265L	unknown	Het
Cpa6	C	T	1: 10,408,349	W254*	probably null	Het
Crtc2	T	A	3: 90,263,597	M659K	possibly damaging	Het
Ctgf	CCCGCCAACCGC	CCCGC	10: 24,596,068		probably null	Het
Dnah7c	A	G	1: 46,725,139	Y3020C	probably damaging	Het
Dok2	C	A	14: 70,777,528	H232N	probably benign	Het
Edem3	A	G	1: 151,818,418	E834G	probably benign	Het
Elac2	T	A	11: 64,981,676		probably null	Het
Epx	T	A	11: 87,864,792	I689F	probably damaging	Het
Exd2	G	A	12: 80,475,857	R30H	probably benign	Het
Gja1	T	C	10: 56,388,208	L221P	probably damaging	Het
Gli3	T	A	13: 15,660,132	L400Q	probably damaging	Het
Gm8439	T	A	4: 120,600,811	W50R	unknown	Het
Greb1	T	A	12: 16,696,435	D1278V	probably damaging	Het
Grin3a	C	A	4: 49,770,555	C739F	probably damaging	Het
Gucy2g	C	A	19: 55,210,354	V786F	probably benign	Het
Hmcn1	G	A	1: 150,676,038	T2605I	probably benign	Het
Hmgxb3	T	A	18: 61,155,419	T459S	probably benign	Het
Ift172	T	C	5: 31,256,577	H1469R	probably damaging	Het
Il1rap	A	G	16: 26,712,134	I407V	probably benign	Het
Inppl1	G	T	7: 101,829,627	S555*	probably null	Het
Krt8	T	C	15: 102,001,544	M142V	probably benign	Het
Lrrk1	T	A	7: 66,282,327	N1049I	possibly damaging	Het
Megf10	G	A	18: 57,240,627	A166T	probably damaging	Het
Mei4	A	T	9: 82,025,631	H338L	probably benign	Het
Mfsd2b	T	C	12: 4,871,471	T33A	possibly damaging	Het
Mgat3	A	T	15: 80,212,169	Y399F	probably damaging	Het
Mtmr4	C	T	11: 87,604,124	T414I	probably damaging	Het
Muc4	T	C	16: 32,754,715	S1530P	unknown	Het
Myl4	T	C	11: 104,584,104	V93A	possibly damaging	Het
N4bp2	T	A	5: 65,825,285	S1627R	possibly damaging	Het
Narf	T	G	11: 121,250,432		probably null	Het
Nbas	A	C	12: 13,352,808	I788L	probably benign	Het
Nlrc3	A	G	16: 3,965,282	S104P	probably benign	Het
Olfr1047	A	G	2: 86,228,644	V109A	probably benign	Het
Olfr1206	A	T	2: 88,865,183	I193L	probably benign	Het
Olfr1240	T	A	2: 89,440,184	I32F	probably benign	Het
Olfr127	A	T	17: 37,903,828	Y94F	probably benign	Het
Ppp4r4	A	T	12: 103,593,161	T534S	probably benign	Het
Prg3	A	G	2: 84,989,336	E58G	probably benign	Het
Prima1	A	G	12: 103,197,253	V153A	possibly damaging	Het
Rp1	A	T	1: 4,349,561	Y443N	probably damaging	Het
Rpgrip1	T	C	14: 52,149,257	S882P	unknown	Het
Scn1a	T	A	2: 66,287,733	D412V	probably damaging	Het
Srcin1	T	C	11: 97,537,149	T180A	probably damaging	Het
Suox	A	G	10: 128,670,731	L476P	probably damaging	Het
Tas2r104	T	C	6: 131,685,425	Y107C	probably damaging	Het
Tubg2	T	C	11: 101,156,784	V65A	probably damaging	Het
Ubn1	T	C	16: 5,064,770	V365A	possibly damaging	Het
Vmn2r75	T	A	7: 86,166,272	Y128F	possibly damaging	Het
Vps13b	A	T	15: 35,876,642	I2814F	probably damaging	Het
Vps54	T	C	11: 21,264,815	Y108H	probably damaging	Het
Wdr6	T	A	9: 108,575,394	E430V	probably benign	Het
Zfp619	T	A	7: 39,537,135	V863E	probably benign	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	19793102	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	19794965	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	19792997	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	19792967	missense	probably benign
IGL01404:Vmn2r103	APN	17	19812434	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	19794068	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	19799208	missense	probably benign
IGL02251:Vmn2r103	APN	17	19793969	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19773369	missense	probably benign
IGL02555:Vmn2r103	APN	17	19811611	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	19794127	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	19793956	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	19812248	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19773520	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	19811979	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	19811641	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	19792859	missense	probably benign	0.06
R0375:Vmn2r103	UTSW	17	19793464	missense	probably benign	0.12
R0755:Vmn2r103	UTSW	17	19773568	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	19793927	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	19794247	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	19792968	missense	probably benign
R1488:Vmn2r103	UTSW	17	19793660	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19773400	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	19794234	missense	probably benign
R1928:Vmn2r103	UTSW	17	19811767	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	19812300	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	19793794	missense	probably benign
R2219:Vmn2r103	UTSW	17	19793647	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19773531	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	19793600	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	19812149	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	19794233	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	19811815	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	19811769	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	19812171	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	19793642	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	19792989	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	19794939	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	19812453	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	19794216	nonsense	probably null
R6114:Vmn2r103	UTSW	17	19812325	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	19812144	missense	probably benign
R6292:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	19794082	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	19811904	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	19811977	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	19793477	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	19812052	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	19794214	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	19793123	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	19799249	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	19793497	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	19811796	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	19811943	missense	probably damaging	1.00
Z1088:Vmn2r103	UTSW	17	19795047	missense	probably benign	0.08

Predicted Primers

PCR Primer
(F):5'- GGGATATCTCTGCTTCTTGGCC -3'
(R):5'- GAGCAGTTGAATCACCAGAGC -3'

Sequencing Primer
(F):5'- TGGCCCTTGGAAGTTACACCATG -3'
(R):5'- TTGAATCACCAGAGCAAACATGG -3'

Posted On

2021-03-08