Mutagenetix > Incidental Mutation

Incidental Mutation 'R8559:Vmn2r103'

660955

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

R8559 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

19773363-19812536 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19812384 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 807 (M807V)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

AlphaFold

E9PWW0

Predicted Effect

probably benign
Transcript: ENSMUST00000172203
AA Change: M807V

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: M807V

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actr6	T	A	10: 89,732,186	H19L	probably benign	Het
Adamts9	A	T	6: 92,807,136	V1579E	probably benign	Het
Arhgap40	C	T	2: 158,541,801	R435C	probably damaging	Het
Atp1a4	T	C	1: 172,251,330	D207G	probably damaging	Het
Btaf1	A	G	19: 36,986,873	N948S	probably benign	Het
Calcr	G	A	6: 3,692,603	P417L	probably damaging	Het
Cep250	T	A	2: 155,992,736	S2194T	probably damaging	Het
Clcn6	C	T	4: 148,026,575	V102M	possibly damaging	Het
Cog2	T	C	8: 124,542,908	S396P	probably benign	Het
Col28a1	C	A	6: 8,166,681	R265L	unknown	Het
Cpa6	C	T	1: 10,408,349	W254*	probably null	Het
Crtc2	T	A	3: 90,263,597	M659K	possibly damaging	Het
Ctgf	CCCGCCAACCGC	CCCGC	10: 24,596,068		probably null	Het
Dnah7c	A	G	1: 46,725,139	Y3020C	probably damaging	Het
Dok2	C	A	14: 70,777,528	H232N	probably benign	Het
Edem3	A	G	1: 151,818,418	E834G	probably benign	Het
Elac2	T	A	11: 64,981,676		probably null	Het
Epx	T	A	11: 87,864,792	I689F	probably damaging	Het
Exd2	G	A	12: 80,475,857	R30H	probably benign	Het
Gja1	T	C	10: 56,388,208	L221P	probably damaging	Het
Gli3	T	A	13: 15,660,132	L400Q	probably damaging	Het
Gm8439	T	A	4: 120,600,811	W50R	unknown	Het
Greb1	T	A	12: 16,696,435	D1278V	probably damaging	Het
Grin3a	C	A	4: 49,770,555	C739F	probably damaging	Het
Gucy2g	C	A	19: 55,210,354	V786F	probably benign	Het
Hmcn1	G	A	1: 150,676,038	T2605I	probably benign	Het
Hmgxb3	T	A	18: 61,155,419	T459S	probably benign	Het
Ift172	T	C	5: 31,256,577	H1469R	probably damaging	Het
Il1rap	A	G	16: 26,712,134	I407V	probably benign	Het
Inppl1	G	T	7: 101,829,627	S555*	probably null	Het
Krt8	T	C	15: 102,001,544	M142V	probably benign	Het
Lrrk1	T	A	7: 66,282,327	N1049I	possibly damaging	Het
Megf10	G	A	18: 57,240,627	A166T	probably damaging	Het
Mei4	A	T	9: 82,025,631	H338L	probably benign	Het
Mfsd2b	T	C	12: 4,871,471	T33A	possibly damaging	Het
Mgat3	A	T	15: 80,212,169	Y399F	probably damaging	Het
Mtmr4	C	T	11: 87,604,124	T414I	probably damaging	Het
Muc4	T	C	16: 32,754,715	S1530P	unknown	Het
Myl4	T	C	11: 104,584,104	V93A	possibly damaging	Het
N4bp2	T	A	5: 65,825,285	S1627R	possibly damaging	Het
Narf	T	G	11: 121,250,432		probably null	Het
Nbas	A	C	12: 13,352,808	I788L	probably benign	Het
Nlrc3	A	G	16: 3,965,282	S104P	probably benign	Het
Olfr1047	A	G	2: 86,228,644	V109A	probably benign	Het
Olfr1206	A	T	2: 88,865,183	I193L	probably benign	Het
Olfr1240	T	A	2: 89,440,184	I32F	probably benign	Het
Olfr127	A	T	17: 37,903,828	Y94F	probably benign	Het
Ppp4r4	A	T	12: 103,593,161	T534S	probably benign	Het
Prg3	A	G	2: 84,989,336	E58G	probably benign	Het
Prima1	A	G	12: 103,197,253	V153A	possibly damaging	Het
Rp1	A	T	1: 4,349,561	Y443N	probably damaging	Het
Rpgrip1	T	C	14: 52,149,257	S882P	unknown	Het
Scn1a	T	A	2: 66,287,733	D412V	probably damaging	Het
Srcin1	T	C	11: 97,537,149	T180A	probably damaging	Het
Suox	A	G	10: 128,670,731	L476P	probably damaging	Het
Tas2r104	T	C	6: 131,685,425	Y107C	probably damaging	Het
Tubg2	T	C	11: 101,156,784	V65A	probably damaging	Het
Ubn1	T	C	16: 5,064,770	V365A	possibly damaging	Het
Vmn2r75	T	A	7: 86,166,272	Y128F	possibly damaging	Het
Vps13b	A	T	15: 35,876,642	I2814F	probably damaging	Het
Vps54	T	C	11: 21,264,815	Y108H	probably damaging	Het
Wdr6	T	A	9: 108,575,394	E430V	probably benign	Het
Zfp619	T	A	7: 39,537,135	V863E	probably benign	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	19793102	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	19794965	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	19792997	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	19792967	missense	probably benign
IGL01404:Vmn2r103	APN	17	19812434	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	19794068	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	19799208	missense	probably benign
IGL02251:Vmn2r103	APN	17	19793969	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19773369	missense	probably benign
IGL02555:Vmn2r103	APN	17	19811611	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	19794127	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	19793956	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	19812248	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19773520	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	19811979	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	19811641	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	19792859	missense	probably benign	0.06
R0375:Vmn2r103	UTSW	17	19793464	missense	probably benign	0.12
R0755:Vmn2r103	UTSW	17	19773568	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	19793927	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	19794247	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	19792968	missense	probably benign
R1488:Vmn2r103	UTSW	17	19793660	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19773400	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	19794234	missense	probably benign
R1928:Vmn2r103	UTSW	17	19811767	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	19812300	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	19793794	missense	probably benign
R2219:Vmn2r103	UTSW	17	19793647	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19773531	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	19793600	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	19812149	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	19794233	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	19811815	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	19811769	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	19812171	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	19793642	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	19792989	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	19794939	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	19812453	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	19794216	nonsense	probably null
R6114:Vmn2r103	UTSW	17	19812325	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	19812144	missense	probably benign
R6292:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	19794082	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	19811904	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	19811977	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	19793477	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	19812052	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	19794214	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	19793123	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	19799249	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	19793497	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	19811796	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	19811943	missense	probably damaging	1.00
R9413:Vmn2r103	UTSW	17	19811896	missense	possibly damaging	0.54
R9591:Vmn2r103	UTSW	17	19811659	missense	possibly damaging	0.70
R9652:Vmn2r103	UTSW	17	19793765	missense	probably benign	0.01
R9680:Vmn2r103	UTSW	17	19799263	nonsense	probably null
R9743:Vmn2r103	UTSW	17	19812213	missense	probably damaging	1.00
Z1088:Vmn2r103	UTSW	17	19795047	missense	probably benign	0.08

Predicted Primers

PCR Primer
(F):5'- GGGATATCTCTGCTTCTTGGCC -3'
(R):5'- GAGCAGTTGAATCACCAGAGC -3'

Sequencing Primer
(F):5'- TGGCCCTTGGAAGTTACACCATG -3'
(R):5'- TTGAATCACCAGAGCAAACATGG -3'

Posted On

2021-03-08