Incidental Mutation 'R8186:Vmn2r103'
ID 634887
Institutional Source Beutler Lab
Gene Symbol Vmn2r103
Ensembl Gene ENSMUSG00000091771
Gene Name vomeronasal 2, receptor 103
Synonyms EG627636
MMRRC Submission 067609-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R8186 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 19993625-20032798 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 20032205 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 660 (T660S)
Ref Sequence ENSEMBL: ENSMUSP00000126756 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172203]
AlphaFold E9PWW0
Predicted Effect probably damaging
Transcript: ENSMUST00000172203
AA Change: T660S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: T660S

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 82 449 1.3e-37 PFAM
Pfam:NCD3G 509 562 3.5e-22 PFAM
Pfam:7tm_3 595 830 1.1e-51 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 100% (43/43)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Add2 G A 6: 86,085,002 (GRCm39) V543M probably benign Het
Agl A G 3: 116,552,557 (GRCm39) I459T possibly damaging Het
Arhgap45 G A 10: 79,863,706 (GRCm39) A819T probably damaging Het
Atg16l2 C T 7: 100,945,714 (GRCm39) probably null Het
Bltp2 A G 11: 78,177,457 (GRCm39) T1921A probably damaging Het
C130073F10Rik G A 4: 101,748,031 (GRCm39) R48* probably null Het
Cdc25b C T 2: 131,031,050 (GRCm39) T125M probably benign Het
Cdc42bpg T A 19: 6,356,895 (GRCm39) F50L probably damaging Het
Chd9 T A 8: 91,725,233 (GRCm39) D1187E unknown Het
Col4a2 T C 8: 11,475,542 (GRCm39) probably null Het
Cped1 T C 6: 22,123,587 (GRCm39) S447P probably benign Het
Ddx19a T A 8: 111,710,274 (GRCm39) M109L probably benign Het
Def8 C A 8: 124,188,215 (GRCm39) Y431* probably null Het
Gata4 A G 14: 63,438,962 (GRCm39) S373P probably benign Het
Gm9837 A T 11: 53,361,136 (GRCm39) L26* probably null Het
Hspa1b A T 17: 35,176,557 (GRCm39) V476E probably damaging Het
Htr5b G A 1: 121,456,108 (GRCm39) probably benign Het
Hydin T C 8: 111,336,277 (GRCm39) V5018A probably benign Het
Ighv1-85 A G 12: 115,963,923 (GRCm39) S26P probably benign Het
Kics2 T A 10: 121,581,247 (GRCm39) F83I possibly damaging Het
Lrrc2 A G 9: 110,789,910 (GRCm39) K56E possibly damaging Het
Macf1 A T 4: 123,266,219 (GRCm39) I6793N probably damaging Het
Macf1 A C 4: 123,275,923 (GRCm39) V6215G possibly damaging Het
Nbeal1 G C 1: 60,276,310 (GRCm39) V684L probably benign Het
Nfxl1 A G 5: 72,716,355 (GRCm39) probably null Het
Odad4 A G 11: 100,454,505 (GRCm39) D430G probably benign Het
Oprk1 A T 1: 5,672,540 (GRCm39) M226L probably benign Het
Or1e1 T C 11: 73,245,247 (GRCm39) S223P possibly damaging Het
Phf2 A G 13: 48,961,227 (GRCm39) L821P unknown Het
Rdh7 C A 10: 127,723,284 (GRCm39) probably null Het
Rpl11 A G 4: 135,778,968 (GRCm39) V74A possibly damaging Het
Safb2 G A 17: 56,873,051 (GRCm39) R790C possibly damaging Het
Sgpp2 T C 1: 78,393,609 (GRCm39) F204S probably benign Het
Sgsm3 A C 15: 80,893,643 (GRCm39) I426L possibly damaging Het
Speer1b A G 5: 11,823,926 (GRCm39) D158G probably damaging Het
Styxl2 A G 1: 165,927,648 (GRCm39) S655P probably damaging Het
Tbccd1 A G 16: 22,637,189 (GRCm39) L545P probably damaging Het
Toporsl T A 4: 52,610,489 (GRCm39) F127L probably damaging Het
Ttn T G 2: 76,749,256 (GRCm39) Q3931P probably damaging Het
Tuba1c C A 15: 98,935,396 (GRCm39) L286I probably benign Het
Usp48 A G 4: 137,348,507 (GRCm39) R528G possibly damaging Het
Utrn T C 10: 12,573,867 (GRCm39) T1068A probably benign Het
Vmn2r105 G T 17: 20,444,880 (GRCm39) Y537* probably null Het
Vmn2r88 A T 14: 51,656,157 (GRCm39) I744F Het
Wnt9b T C 11: 103,621,601 (GRCm39) E352G probably damaging Het
Zfp78 A G 7: 6,376,228 (GRCm39) N46D probably damaging Het
Other mutations in Vmn2r103
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00333:Vmn2r103 APN 17 20,013,364 (GRCm39) missense probably damaging 0.98
IGL00939:Vmn2r103 APN 17 20,015,227 (GRCm39) missense probably benign 0.00
IGL01120:Vmn2r103 APN 17 20,013,259 (GRCm39) missense probably benign 0.06
IGL01403:Vmn2r103 APN 17 20,013,229 (GRCm39) missense probably benign
IGL01404:Vmn2r103 APN 17 20,032,696 (GRCm39) missense probably damaging 1.00
IGL01713:Vmn2r103 APN 17 20,014,330 (GRCm39) missense probably damaging 1.00
IGL01802:Vmn2r103 APN 17 20,019,470 (GRCm39) missense probably benign
IGL02251:Vmn2r103 APN 17 20,014,231 (GRCm39) missense possibly damaging 0.84
IGL02466:Vmn2r103 APN 17 19,993,631 (GRCm39) missense probably benign
IGL02555:Vmn2r103 APN 17 20,031,873 (GRCm39) missense probably damaging 1.00
IGL02668:Vmn2r103 APN 17 20,014,389 (GRCm39) missense probably benign 0.03
IGL02715:Vmn2r103 APN 17 20,014,218 (GRCm39) missense probably damaging 0.97
IGL02735:Vmn2r103 APN 17 20,032,510 (GRCm39) missense probably benign 0.27
IGL03101:Vmn2r103 APN 17 19,993,782 (GRCm39) missense probably damaging 0.98
R0003:Vmn2r103 UTSW 17 20,032,241 (GRCm39) missense probably damaging 0.99
R0052:Vmn2r103 UTSW 17 20,031,903 (GRCm39) missense probably benign 0.01
R0375:Vmn2r103 UTSW 17 20,013,726 (GRCm39) missense probably benign 0.12
R0375:Vmn2r103 UTSW 17 20,013,121 (GRCm39) missense probably benign 0.06
R0755:Vmn2r103 UTSW 17 19,993,830 (GRCm39) missense probably benign 0.01
R0837:Vmn2r103 UTSW 17 20,014,189 (GRCm39) missense probably damaging 0.99
R1345:Vmn2r103 UTSW 17 20,014,509 (GRCm39) missense probably damaging 1.00
R1396:Vmn2r103 UTSW 17 20,013,230 (GRCm39) missense probably benign
R1488:Vmn2r103 UTSW 17 20,013,922 (GRCm39) missense probably damaging 0.97
R1533:Vmn2r103 UTSW 17 19,993,662 (GRCm39) missense probably benign 0.01
R1590:Vmn2r103 UTSW 17 20,014,496 (GRCm39) missense probably benign
R1928:Vmn2r103 UTSW 17 20,032,029 (GRCm39) missense possibly damaging 0.95
R1942:Vmn2r103 UTSW 17 20,032,562 (GRCm39) missense probably benign 0.02
R2071:Vmn2r103 UTSW 17 20,014,056 (GRCm39) missense probably benign
R2219:Vmn2r103 UTSW 17 20,013,909 (GRCm39) missense probably damaging 1.00
R2442:Vmn2r103 UTSW 17 19,993,793 (GRCm39) missense probably benign 0.00
R2889:Vmn2r103 UTSW 17 20,013,862 (GRCm39) missense probably damaging 1.00
R3762:Vmn2r103 UTSW 17 20,032,411 (GRCm39) missense probably damaging 0.98
R4014:Vmn2r103 UTSW 17 20,013,866 (GRCm39) missense possibly damaging 0.67
R4331:Vmn2r103 UTSW 17 20,014,495 (GRCm39) missense probably benign 0.00
R4630:Vmn2r103 UTSW 17 20,013,958 (GRCm39) missense probably benign 0.04
R4631:Vmn2r103 UTSW 17 20,013,958 (GRCm39) missense probably benign 0.04
R4632:Vmn2r103 UTSW 17 20,013,958 (GRCm39) missense probably benign 0.04
R4660:Vmn2r103 UTSW 17 20,032,077 (GRCm39) missense probably damaging 1.00
R4801:Vmn2r103 UTSW 17 20,015,338 (GRCm39) missense probably benign 0.06
R4802:Vmn2r103 UTSW 17 20,015,338 (GRCm39) missense probably benign 0.06
R4931:Vmn2r103 UTSW 17 20,032,031 (GRCm39) missense probably benign 0.01
R4995:Vmn2r103 UTSW 17 19,993,773 (GRCm39) missense probably benign 0.14
R5309:Vmn2r103 UTSW 17 20,013,296 (GRCm39) missense probably benign 0.01
R5312:Vmn2r103 UTSW 17 20,013,296 (GRCm39) missense probably benign 0.01
R5329:Vmn2r103 UTSW 17 20,032,433 (GRCm39) missense probably damaging 1.00
R5611:Vmn2r103 UTSW 17 20,013,904 (GRCm39) missense probably damaging 0.99
R5684:Vmn2r103 UTSW 17 20,013,251 (GRCm39) missense probably benign 0.02
R5715:Vmn2r103 UTSW 17 20,015,201 (GRCm39) missense probably benign 0.17
R5907:Vmn2r103 UTSW 17 20,032,715 (GRCm39) missense possibly damaging 0.67
R6029:Vmn2r103 UTSW 17 20,014,478 (GRCm39) nonsense probably null
R6114:Vmn2r103 UTSW 17 20,032,587 (GRCm39) missense probably damaging 0.99
R6285:Vmn2r103 UTSW 17 20,032,406 (GRCm39) missense probably benign
R6292:Vmn2r103 UTSW 17 20,013,866 (GRCm39) missense possibly damaging 0.67
R6334:Vmn2r103 UTSW 17 20,014,344 (GRCm39) missense probably damaging 0.97
R6501:Vmn2r103 UTSW 17 20,032,166 (GRCm39) missense probably benign 0.29
R6710:Vmn2r103 UTSW 17 20,032,239 (GRCm39) missense probably damaging 1.00
R6774:Vmn2r103 UTSW 17 19,993,773 (GRCm39) missense probably benign 0.14
R6981:Vmn2r103 UTSW 17 20,013,739 (GRCm39) missense probably benign 0.00
R7768:Vmn2r103 UTSW 17 20,032,314 (GRCm39) missense probably damaging 0.99
R7816:Vmn2r103 UTSW 17 20,014,476 (GRCm39) missense probably benign 0.06
R7885:Vmn2r103 UTSW 17 20,013,385 (GRCm39) missense probably benign 0.25
R8002:Vmn2r103 UTSW 17 20,019,511 (GRCm39) missense probably damaging 1.00
R8031:Vmn2r103 UTSW 17 20,013,759 (GRCm39) missense probably benign 0.00
R8140:Vmn2r103 UTSW 17 20,032,058 (GRCm39) missense probably damaging 1.00
R8559:Vmn2r103 UTSW 17 20,032,646 (GRCm39) missense probably benign 0.01
R9413:Vmn2r103 UTSW 17 20,032,158 (GRCm39) missense possibly damaging 0.54
R9591:Vmn2r103 UTSW 17 20,031,921 (GRCm39) missense possibly damaging 0.70
R9652:Vmn2r103 UTSW 17 20,014,027 (GRCm39) missense probably benign 0.01
R9680:Vmn2r103 UTSW 17 20,019,525 (GRCm39) nonsense probably null
R9743:Vmn2r103 UTSW 17 20,032,475 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r103 UTSW 17 20,015,309 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- TTGGGGATGACTCTAGCCAG -3'
(R):5'- GAGAAGTTGTCATCCATATTCCAC -3'

Sequencing Primer
(F):5'- GATGACTCTAGCCAGCGTAG -3'
(R):5'- TTCCACAAATAAGAAGCTGGATCAG -3'
Posted On 2020-07-13