Mutagenetix > Incidental Mutation

Incidental Mutation 'R6753:Son'

530929

Institutional Source

Beutler Lab

Gene Symbol

Son

Ensembl Gene

ENSMUSG00000022961

Gene Name

Son DNA binding protein

Synonyms

2900011L12Rik

MMRRC Submission

044870-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.956) question?

Stock #

R6753 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

91647506-91679221 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 91657188 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Arginine at position 941 (Q941R)

Ref Sequence

ENSEMBL: ENSMUSP00000122320 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000114036] [ENSMUST00000114037] [ENSMUST00000117633] [ENSMUST00000119368] [ENSMUST00000122302] [ENSMUST00000140312]

AlphaFold

Q9QX47

Predicted Effect

possibly damaging
Transcript: ENSMUST00000114036
AA Change: Q941R

PolyPhen 2 Score 0.719 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000109670
Gene: ENSMUSG00000022961
AA Change: Q941R

Domain	Start	End	E-Value	Type
coiled coil region	106	132	N/A	INTRINSIC
internal_repeat_1	155	350	1.65e-7	PROSPERO
internal_repeat_2	214	362	6.55e-6	PROSPERO
low complexity region	391	403	N/A	INTRINSIC
low complexity region	459	469	N/A	INTRINSIC
internal_repeat_1	507	750	1.65e-7	PROSPERO
low complexity region	975	1021	N/A	INTRINSIC
low complexity region	1124	1135	N/A	INTRINSIC
low complexity region	1141	1172	N/A	INTRINSIC
internal_repeat_2	1208	1347	6.55e-6	PROSPERO
low complexity region	1354	1376	N/A	INTRINSIC
low complexity region	1386	1407	N/A	INTRINSIC
low complexity region	1805	1811	N/A	INTRINSIC
low complexity region	1838	2067	N/A	INTRINSIC
low complexity region	2080	2091	N/A	INTRINSIC
low complexity region	2094	2105	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000114037
AA Change: Q941R

PolyPhen 2 Score 0.719 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000109671
Gene: ENSMUSG00000022961
AA Change: Q941R

Domain	Start	End	E-Value	Type
coiled coil region	106	132	N/A	INTRINSIC
internal_repeat_1	155	350	1.71e-7	PROSPERO
internal_repeat_2	214	362	7.05e-6	PROSPERO
low complexity region	391	403	N/A	INTRINSIC
low complexity region	459	469	N/A	INTRINSIC
internal_repeat_1	507	750	1.71e-7	PROSPERO
low complexity region	975	1021	N/A	INTRINSIC
low complexity region	1124	1135	N/A	INTRINSIC
low complexity region	1141	1172	N/A	INTRINSIC
internal_repeat_2	1208	1347	7.05e-6	PROSPERO
low complexity region	1354	1376	N/A	INTRINSIC
low complexity region	1386	1407	N/A	INTRINSIC
low complexity region	1805	1811	N/A	INTRINSIC
low complexity region	1838	2067	N/A	INTRINSIC
low complexity region	2080	2091	N/A	INTRINSIC
low complexity region	2094	2105	N/A	INTRINSIC
low complexity region	2149	2155	N/A	INTRINSIC
G_patch	2321	2367	1.15e-17	SMART
Pfam:DND1_DSRM	2388	2442	5.7e-15	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000117633
AA Change: Q941R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000112453
Gene: ENSMUSG00000022961
AA Change: Q941R

Domain	Start	End	E-Value	Type
coiled coil region	106	132	N/A	INTRINSIC
internal_repeat_1	155	350	1.59e-7	PROSPERO
internal_repeat_2	214	362	6.63e-6	PROSPERO
low complexity region	391	403	N/A	INTRINSIC
low complexity region	459	469	N/A	INTRINSIC
internal_repeat_1	507	750	1.59e-7	PROSPERO
low complexity region	975	1021	N/A	INTRINSIC
low complexity region	1124	1135	N/A	INTRINSIC
low complexity region	1141	1172	N/A	INTRINSIC
internal_repeat_2	1208	1347	6.63e-6	PROSPERO
low complexity region	1354	1376	N/A	INTRINSIC
low complexity region	1386	1407	N/A	INTRINSIC
low complexity region	1805	1811	N/A	INTRINSIC
Pfam:RSRP	1909	2216	1e-12	PFAM
G_patch	2321	2367	1.15e-17	SMART
DSRM	2390	2458	5.37e-20	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000119368
AA Change: Q941R

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000113129
Gene: ENSMUSG00000022961
AA Change: Q941R

Domain	Start	End	E-Value	Type
coiled coil region	106	132	N/A	INTRINSIC
internal_repeat_1	155	350	2.22e-7	PROSPERO
internal_repeat_2	214	362	8.67e-6	PROSPERO
low complexity region	391	403	N/A	INTRINSIC
low complexity region	459	469	N/A	INTRINSIC
internal_repeat_1	507	750	2.22e-7	PROSPERO
low complexity region	975	1021	N/A	INTRINSIC
low complexity region	1124	1135	N/A	INTRINSIC
low complexity region	1141	1172	N/A	INTRINSIC
internal_repeat_2	1208	1347	8.67e-6	PROSPERO
low complexity region	1354	1376	N/A	INTRINSIC
low complexity region	1386	1407	N/A	INTRINSIC
low complexity region	1805	1811	N/A	INTRINSIC
low complexity region	1838	2067	N/A	INTRINSIC
low complexity region	2080	2091	N/A	INTRINSIC
low complexity region	2094	2105	N/A	INTRINSIC
low complexity region	2149	2155	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000122302

SMART Domains

Protein: ENSMUSP00000113615
Gene: ENSMUSG00000022961

Domain	Start	End	E-Value	Type
low complexity region	90	101	N/A	INTRINSIC
low complexity region	104	115	N/A	INTRINSIC
low complexity region	159	165	N/A	INTRINSIC
G_patch	331	377	1.15e-17	SMART
Pfam:DND1_DSRM	398	452	7.9e-16	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000140312
AA Change: Q941R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000122320
Gene: ENSMUSG00000022961
AA Change: Q941R

Domain	Start	End	E-Value	Type
coiled coil region	106	132	N/A	INTRINSIC
internal_repeat_1	155	350	2.93e-7	PROSPERO
internal_repeat_2	214	362	1.1e-5	PROSPERO
low complexity region	391	403	N/A	INTRINSIC
low complexity region	459	469	N/A	INTRINSIC
internal_repeat_1	507	750	2.93e-7	PROSPERO
low complexity region	975	1021	N/A	INTRINSIC
low complexity region	1124	1135	N/A	INTRINSIC
low complexity region	1141	1172	N/A	INTRINSIC
internal_repeat_2	1208	1347	1.1e-5	PROSPERO
low complexity region	1354	1376	N/A	INTRINSIC
low complexity region	1386	1407	N/A	INTRINSIC
low complexity region	1805	1811	N/A	INTRINSIC
low complexity region	1838	2067	N/A	INTRINSIC
low complexity region	2080	2091	N/A	INTRINSIC
low complexity region	2094	2105	N/A	INTRINSIC
low complexity region	2149	2155	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000147891

SMART Domains

Protein: ENSMUSP00000122544
Gene: ENSMUSG00000022961

Domain	Start	End	E-Value	Type
Pfam:RSRP	61	358	2.9e-13	PFAM
low complexity region	466	477	N/A	INTRINSIC

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.3%
20x: 95.1%

Validation Efficiency

99% (68/69)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequence found in the human hepatitis B virus (HBV) and represses HBV core promoter activity. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aatk	G	A	11: 120,010,151 (GRCm38)	P1083S	probably benign	Het
Abcb5	T	A	12: 118,944,906 (GRCm38)	N101I	possibly damaging	Het
Adrb2	A	G	18: 62,179,553 (GRCm38)	V67A	possibly damaging	Het
Agk	T	A	6: 40,368,570 (GRCm38)		probably null	Het
Akap10	A	T	11: 61,886,777 (GRCm38)	M586K	probably damaging	Het
Akt3	A	T	1: 177,050,190 (GRCm38)	Y337*	probably null	Het
Armc1	A	G	3: 19,144,398 (GRCm38)	F133L	possibly damaging	Het
Bank1	T	C	3: 136,093,308 (GRCm38)	E424G	probably damaging	Het
Cacna1a	A	G	8: 84,580,205 (GRCm38)	E1363G	probably damaging	Het
Cacna1d	C	A	14: 30,042,786 (GRCm38)	A2076S	probably damaging	Het
Ccdc73	T	A	2: 104,991,524 (GRCm38)	L606*	probably null	Het
Ccdc8	C	T	7: 16,996,637 (GRCm38)	Q684*	probably null	Het
Ces1b	T	A	8: 93,067,020 (GRCm38)	K314*	probably null	Het
Ces1e	T	A	8: 93,215,128 (GRCm38)	N238I	probably damaging	Het
Chd4	A	G	6: 125,114,300 (GRCm38)	N1238S	probably benign	Het
Cmtr2	T	A	8: 110,222,979 (GRCm38)	D640E	probably damaging	Het
Col7a1	C	T	9: 108,958,128 (GRCm38)	T559I	unknown	Het
Comt	T	C	16: 18,408,021 (GRCm38)	K205R	probably benign	Het
Dbp	A	T	7: 45,708,404 (GRCm38)	E232V	probably damaging	Het
Dcbld2	A	G	16: 58,456,130 (GRCm38)	T470A	possibly damaging	Het
Eml6	T	A	11: 29,754,987 (GRCm38)	D1519V	probably damaging	Het
Evpl	T	A	11: 116,237,906 (GRCm38)	H31L	possibly damaging	Het
Exoc1	T	A	5: 76,563,339 (GRCm38)	I86N	probably damaging	Het
Fat3	C	T	9: 15,915,061 (GRCm38)	E4532K	possibly damaging	Het
Fgfr3	T	C	5: 33,732,159 (GRCm38)	S301P	probably benign	Het
Gas2l1	C	T	11: 5,064,254 (GRCm38)	V69I	probably damaging	Het
Gm2042	T	A	12: 87,958,084 (GRCm38)	I107K	probably damaging	Het
Gucy1b1	T	C	3: 82,039,747 (GRCm38)	D385G	probably null	Het
Ints1	T	A	5: 139,765,175 (GRCm38)	E824D	probably damaging	Het
Itfg1	T	C	8: 85,835,078 (GRCm38)	D142G	probably benign	Het
Jaml	A	G	9: 45,107,379 (GRCm38)	N359D	probably benign	Het
Kcnh7	T	A	2: 62,850,377 (GRCm38)	I289L	probably benign	Het
Klf12	G	A	14: 100,109,776 (GRCm38)	Q40*	probably null	Het
Mcm4	A	C	16: 15,629,362 (GRCm38)	N579K	possibly damaging	Het
Mfsd2b	A	T	12: 4,867,358 (GRCm38)	F179I	possibly damaging	Het
Mmp11	C	T	10: 75,928,374 (GRCm38)	V86M	probably damaging	Het
Mogs	T	C	6: 83,115,882 (GRCm38)	V101A	probably damaging	Het
Narf	T	A	11: 121,242,626 (GRCm38)	H84Q	probably benign	Het
Olfr987	C	A	2: 85,331,798 (GRCm38)	M33I	probably benign	Het
Otog	A	C	7: 46,249,071 (GRCm38)	E204D	probably benign	Het
Parp8	G	A	13: 116,895,115 (GRCm38)	H354Y	possibly damaging	Het
Pcnx	C	A	12: 81,964,480 (GRCm38)	D1238E	probably damaging	Het
Pi4ka	A	G	16: 17,376,982 (GRCm38)	L184P	possibly damaging	Het
Pkd1l3	C	T	8: 109,624,449 (GRCm38)	T642I	probably damaging	Het
Pkhd1l1	G	A	15: 44,589,663 (GRCm38)	E3995K	probably benign	Het
Prdm9	A	T	17: 15,544,956 (GRCm38)	Y521N	probably benign	Het
Prex2	A	G	1: 11,184,456 (GRCm38)	S1105G	probably damaging	Het
Prss35	T	A	9: 86,756,100 (GRCm38)	F308I	probably damaging	Het
Rab22a	C	T	2: 173,701,055 (GRCm38)	A167V	probably benign	Het
Rims2	A	G	15: 39,566,973 (GRCm38)	Q871R	possibly damaging	Het
Rorb	A	T	19: 18,957,247 (GRCm38)	M253K	probably benign	Het
Ryr3	T	C	2: 112,652,610 (GRCm38)	D4269G	probably damaging	Het
Snx11	T	C	11: 96,769,906 (GRCm38)		probably benign	Het
Sptbn2	G	T	19: 4,747,785 (GRCm38)	R1880L	probably benign	Het
Sun1	G	A	5: 139,215,259 (GRCm38)		probably null	Het
Tprn	A	G	2: 25,264,038 (GRCm38)	R451G	probably benign	Het
Trbv30	T	A	6: 41,281,377 (GRCm38)	M1K	probably null	Het
Ttn	C	A	2: 76,738,221 (GRCm38)	G25697W	probably damaging	Het
Ubb	T	G	11: 62,551,527 (GRCm38)		probably null	Het
Unc13b	C	T	4: 43,239,331 (GRCm38)	R1038C	probably damaging	Het
Usp7	T	C	16: 8,696,911 (GRCm38)	M687V	probably benign	Het
Zfp160	G	A	17: 21,020,734 (GRCm38)	M21I	probably benign	Het
Zfp868	T	C	8: 69,612,096 (GRCm38)	N196S	probably benign	Het
Zufsp	A	T	10: 33,928,029 (GRCm38)	I483N	probably damaging	Het

Other mutations in Son

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00531:Son	APN	16	91,664,322 (GRCm38)	missense	probably damaging	0.99
IGL01024:Son	APN	16	91,655,910 (GRCm38)	missense	probably damaging	1.00
IGL01066:Son	APN	16	91,660,136 (GRCm38)	intron	probably benign
IGL01083:Son	APN	16	91,657,391 (GRCm38)	missense	probably damaging	1.00
IGL01115:Son	APN	16	91,659,458 (GRCm38)	missense	probably benign	0.31
IGL01467:Son	APN	16	91,657,277 (GRCm38)	missense	possibly damaging	0.93
IGL01506:Son	APN	16	91,657,286 (GRCm38)	missense	possibly damaging	0.67
IGL01933:Son	APN	16	91,658,015 (GRCm38)	missense	probably benign	0.00
IGL02156:Son	APN	16	91,656,104 (GRCm38)	missense	possibly damaging	0.93
IGL02473:Son	APN	16	91,658,795 (GRCm38)	missense	probably damaging	0.99
IGL02498:Son	APN	16	91,656,825 (GRCm38)	missense	probably damaging	0.99
IGL02517:Son	APN	16	91,655,211 (GRCm38)	missense	possibly damaging	0.92
IGL02530:Son	APN	16	91,658,471 (GRCm38)	missense	possibly damaging	0.50
IGL02865:Son	APN	16	91,651,752 (GRCm38)	missense	probably damaging	1.00
IGL03180:Son	APN	16	91,657,008 (GRCm38)	missense	probably damaging	1.00
R0013:Son	UTSW	16	91,651,662 (GRCm38)	missense	probably damaging	1.00
R0036:Son	UTSW	16	91,660,166 (GRCm38)	intron	probably benign
R0037:Son	UTSW	16	91,664,728 (GRCm38)	missense	probably damaging	1.00
R0041:Son	UTSW	16	91,659,333 (GRCm38)	missense	probably damaging	1.00
R0048:Son	UTSW	16	91,658,977 (GRCm38)	missense	possibly damaging	0.94
R0048:Son	UTSW	16	91,658,977 (GRCm38)	missense	possibly damaging	0.94
R0056:Son	UTSW	16	91,678,155 (GRCm38)	missense	possibly damaging	0.86
R0227:Son	UTSW	16	91,656,873 (GRCm38)	missense	probably damaging	0.99
R0256:Son	UTSW	16	91,656,584 (GRCm38)	missense	possibly damaging	0.95
R0302:Son	UTSW	16	91,656,144 (GRCm38)	missense	probably damaging	1.00
R0815:Son	UTSW	16	91,655,484 (GRCm38)	missense	probably damaging	0.98
R1225:Son	UTSW	16	91,657,340 (GRCm38)	missense	probably damaging	1.00
R1255:Son	UTSW	16	91,664,695 (GRCm38)	missense	probably damaging	1.00
R1457:Son	UTSW	16	91,657,086 (GRCm38)	missense	probably damaging	1.00
R1459:Son	UTSW	16	91,655,342 (GRCm38)	missense	possibly damaging	0.93
R1535:Son	UTSW	16	91,659,734 (GRCm38)	missense	probably damaging	0.99
R1587:Son	UTSW	16	91,659,718 (GRCm38)	missense	probably damaging	1.00
R1605:Son	UTSW	16	91,657,664 (GRCm38)	missense	probably damaging	1.00
R1629:Son	UTSW	16	91,657,622 (GRCm38)	missense	probably damaging	1.00
R1711:Son	UTSW	16	91,660,226 (GRCm38)	intron	probably benign
R2138:Son	UTSW	16	91,659,372 (GRCm38)	missense	possibly damaging	0.95
R2245:Son	UTSW	16	91,647,960 (GRCm38)	splice site	probably null
R2351:Son	UTSW	16	91,657,659 (GRCm38)	missense	probably damaging	0.98
R2434:Son	UTSW	16	91,654,687 (GRCm38)	missense	probably damaging	1.00
R2870:Son	UTSW	16	91,664,317 (GRCm38)	splice site	probably null
R2871:Son	UTSW	16	91,664,317 (GRCm38)	splice site	probably null
R2872:Son	UTSW	16	91,664,317 (GRCm38)	splice site	probably null
R2889:Son	UTSW	16	91,659,899 (GRCm38)	unclassified	probably benign
R3712:Son	UTSW	16	91,656,726 (GRCm38)	missense	probably damaging	0.99
R3913:Son	UTSW	16	91,660,111 (GRCm38)	intron	probably benign
R4172:Son	UTSW	16	91,659,362 (GRCm38)	missense	probably damaging	1.00
R4301:Son	UTSW	16	91,658,411 (GRCm38)	missense	possibly damaging	0.53
R4302:Son	UTSW	16	91,658,411 (GRCm38)	missense	possibly damaging	0.53
R4770:Son	UTSW	16	91,658,868 (GRCm38)	missense	probably damaging	0.96
R4881:Son	UTSW	16	91,675,509 (GRCm38)	missense	probably benign	0.31
R5020:Son	UTSW	16	91,656,375 (GRCm38)	missense	probably damaging	1.00
R5032:Son	UTSW	16	91,657,664 (GRCm38)	missense	probably damaging	1.00
R5151:Son	UTSW	16	91,655,699 (GRCm38)	missense	probably damaging	1.00
R5153:Son	UTSW	16	91,655,022 (GRCm38)	missense	possibly damaging	0.86
R5215:Son	UTSW	16	91,656,675 (GRCm38)	missense	probably damaging	0.99
R5243:Son	UTSW	16	91,654,733 (GRCm38)	missense	probably damaging	1.00
R5354:Son	UTSW	16	91,655,739 (GRCm38)	missense	probably damaging	0.99
R5529:Son	UTSW	16	91,655,466 (GRCm38)	missense	probably damaging	1.00
R5696:Son	UTSW	16	91,671,413 (GRCm38)	missense	possibly damaging	0.67
R5763:Son	UTSW	16	91,657,490 (GRCm38)	missense	probably damaging	1.00
R5766:Son	UTSW	16	91,664,987 (GRCm38)	intron	probably benign
R5788:Son	UTSW	16	91,660,052 (GRCm38)	intron	probably benign
R5992:Son	UTSW	16	91,658,904 (GRCm38)	missense	probably benign	0.04
R6314:Son	UTSW	16	91,660,410 (GRCm38)	intron	probably benign
R6371:Son	UTSW	16	91,674,741 (GRCm38)
R6429:Son	UTSW	16	91,658,166 (GRCm38)	missense	probably benign	0.33
R6451:Son	UTSW	16	91,657,602 (GRCm38)	missense	probably damaging	0.99
R6489:Son	UTSW	16	91,655,156 (GRCm38)	missense	possibly damaging	0.70
R6513:Son	UTSW	16	91,659,947 (GRCm38)	intron	probably benign
R6916:Son	UTSW	16	91,654,785 (GRCm38)	missense	probably damaging	0.97
R7070:Son	UTSW	16	91,656,841 (GRCm38)	unclassified	probably benign
R7079:Son	UTSW	16	91,656,841 (GRCm38)	unclassified	probably benign
R7110:Son	UTSW	16	91,656,518 (GRCm38)	missense	probably benign	0.01
R7120:Son	UTSW	16	91,670,526 (GRCm38)	missense	unknown
R7120:Son	UTSW	16	91,656,691 (GRCm38)	unclassified	probably benign
R7167:Son	UTSW	16	91,660,334 (GRCm38)	small deletion	probably benign
R7205:Son	UTSW	16	91,660,295 (GRCm38)	small deletion	probably benign
R7208:Son	UTSW	16	91,662,102 (GRCm38)	missense	unknown
R7219:Son	UTSW	16	91,665,001 (GRCm38)	missense	unknown
R7249:Son	UTSW	16	91,660,334 (GRCm38)	small deletion	probably benign
R7328:Son	UTSW	16	91,658,390 (GRCm38)	missense	probably benign	0.33
R7330:Son	UTSW	16	91,656,598 (GRCm38)	unclassified	probably benign
R7374:Son	UTSW	16	91,660,334 (GRCm38)	small deletion	probably benign
R7405:Son	UTSW	16	91,656,691 (GRCm38)	unclassified	probably benign
R7420:Son	UTSW	16	91,660,334 (GRCm38)	small deletion	probably benign
R7424:Son	UTSW	16	91,660,334 (GRCm38)	small deletion	probably benign
R7464:Son	UTSW	16	91,656,691 (GRCm38)	unclassified	probably benign
R7514:Son	UTSW	16	91,654,860 (GRCm38)	missense	probably damaging	0.99
R7555:Son	UTSW	16	91,658,922 (GRCm38)	missense	probably damaging	0.99
R7645:Son	UTSW	16	91,660,295 (GRCm38)	small deletion	probably benign
R7716:Son	UTSW	16	91,656,691 (GRCm38)	unclassified	probably benign
R7718:Son	UTSW	16	91,660,334 (GRCm38)	small deletion	probably benign
R7778:Son	UTSW	16	91,656,528 (GRCm38)	missense	probably damaging	0.99
R7824:Son	UTSW	16	91,656,528 (GRCm38)	missense	probably damaging	0.99
R7856:Son	UTSW	16	91,659,258 (GRCm38)	missense	probably damaging	0.99
R7870:Son	UTSW	16	91,656,598 (GRCm38)	unclassified	probably benign
R7928:Son	UTSW	16	91,656,841 (GRCm38)	unclassified	probably benign
R7972:Son	UTSW	16	91,660,334 (GRCm38)	small deletion	probably benign
R7978:Son	UTSW	16	91,660,334 (GRCm38)	small deletion	probably benign
R8000:Son	UTSW	16	91,660,334 (GRCm38)	small deletion	probably benign
R8192:Son	UTSW	16	91,655,549 (GRCm38)	missense	possibly damaging	0.91
R8221:Son	UTSW	16	91,656,846 (GRCm38)	missense	probably damaging	1.00
R8227:Son	UTSW	16	91,656,691 (GRCm38)	unclassified	probably benign
R8233:Son	UTSW	16	91,660,334 (GRCm38)	small deletion	probably benign
R8255:Son	UTSW	16	91,664,936 (GRCm38)	missense	unknown
R8292:Son	UTSW	16	91,656,657 (GRCm38)	missense	possibly damaging	0.93
R8407:Son	UTSW	16	91,660,334 (GRCm38)	small deletion	probably benign
R8468:Son	UTSW	16	91,656,691 (GRCm38)	unclassified	probably benign
R8495:Son	UTSW	16	91,660,295 (GRCm38)	small deletion	probably benign
R8772:Son	UTSW	16	91,657,938 (GRCm38)	missense	possibly damaging	0.65
R8796:Son	UTSW	16	91,660,334 (GRCm38)	small deletion	probably benign
R8862:Son	UTSW	16	91,656,846 (GRCm38)	missense	probably damaging	1.00
R8962:Son	UTSW	16	91,658,169 (GRCm38)	missense	possibly damaging	0.91
R8972:Son	UTSW	16	91,660,334 (GRCm38)	small deletion	probably benign
R8991:Son	UTSW	16	91,656,720 (GRCm38)	missense	possibly damaging	0.95
R8991:Son	UTSW	16	91,656,478 (GRCm38)	missense	probably benign	0.04
R9086:Son	UTSW	16	91,670,530 (GRCm38)	missense	unknown
R9138:Son	UTSW	16	91,655,118 (GRCm38)	missense	possibly damaging	0.80
R9232:Son	UTSW	16	91,656,691 (GRCm38)	unclassified	probably benign
R9241:Son	UTSW	16	91,657,234 (GRCm38)	missense	probably damaging	0.96
R9258:Son	UTSW	16	91,677,682 (GRCm38)	missense	unknown
R9328:Son	UTSW	16	91,655,757 (GRCm38)	missense	possibly damaging	0.67
R9420:Son	UTSW	16	91,657,620 (GRCm38)	missense	probably damaging	0.98
R9468:Son	UTSW	16	91,657,551 (GRCm38)	missense	possibly damaging	0.53
R9500:Son	UTSW	16	91,660,334 (GRCm38)	small deletion	probably benign
R9516:Son	UTSW	16	91,656,691 (GRCm38)	unclassified	probably benign
R9595:Son	UTSW	16	91,657,353 (GRCm38)	missense	possibly damaging	0.73
R9679:Son	UTSW	16	91,660,334 (GRCm38)	small deletion	probably benign
R9719:Son	UTSW	16	91,659,552 (GRCm38)	missense	probably damaging	0.96
R9749:Son	UTSW	16	91,656,691 (GRCm38)	unclassified	probably benign
R9772:Son	UTSW	16	91,660,334 (GRCm38)	small deletion	probably benign
R9782:Son	UTSW	16	91,647,950 (GRCm38)	missense	probably damaging	0.99
R9788:Son	UTSW	16	91,656,811 (GRCm38)	unclassified	probably benign
RF007:Son	UTSW	16	91,659,369 (GRCm38)	missense	possibly damaging	0.53
RF041:Son	UTSW	16	91,656,691 (GRCm38)	unclassified	probably benign
Z1176:Son	UTSW	16	91,655,801 (GRCm38)	missense	possibly damaging	0.80

Predicted Primers

PCR Primer
(F):5'- AGATGTTAGCTTCTGGCACTATG -3'
(R):5'- CGTTCTGCAGCATAGGACATC -3'

Sequencing Primer
(F):5'- CACTATGGATGCTCAGATGTTAGC -3'
(R):5'- TCTGCAGCATAGGACATCATCATAG -3'

Posted On

2018-08-01