Incidental Mutation 'IGL02551:Vmn2r26'
| ID |
298063 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r26
|
| Ensembl Gene |
ENSMUSG00000096630 |
| Gene Name |
vomeronasal 2, receptor 26 |
| Synonyms |
V2r1b |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.088)
|
| Stock # |
IGL02551
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
124024758-124062035 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 124026141 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 170
(V170A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032238
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032238]
|
| AlphaFold |
Q6TAC4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000032238
AA Change: V170A
PolyPhen 2
Score 0.106 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: V170A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
471 |
1.5e-31 |
PFAM |
|
Pfam:NCD3G
|
519 |
572 |
4.6e-25 |
PFAM |
|
Pfam:7tm_3
|
603 |
840 |
1.5e-55 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 57 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1600012P17Rik |
G |
A |
1: 158,969,048 (GRCm38) |
|
noncoding transcript |
Het |
| Abca8a |
T |
C |
11: 110,084,242 (GRCm38) |
I109V |
probably benign |
Het |
| Acsm2 |
C |
T |
7: 119,573,284 (GRCm38) |
P117S |
probably damaging |
Het |
| Adamts18 |
C |
A |
8: 113,699,072 (GRCm38) |
C1186F |
probably damaging |
Het |
| Adamts5 |
A |
T |
16: 85,870,038 (GRCm38) |
V522E |
possibly damaging |
Het |
| Adcy10 |
A |
G |
1: 165,543,233 (GRCm38) |
T694A |
probably damaging |
Het |
| Adgra2 |
G |
A |
8: 27,119,222 (GRCm38) |
V609I |
probably benign |
Het |
| Agbl3 |
A |
G |
6: 34,823,071 (GRCm38) |
K638R |
possibly damaging |
Het |
| Alpk2 |
T |
A |
18: 65,372,751 (GRCm38) |
N66I |
probably damaging |
Het |
| Ap3b1 |
T |
A |
13: 94,418,091 (GRCm38) |
I245N |
probably damaging |
Het |
| Aqp9 |
A |
G |
9: 71,132,640 (GRCm38) |
V120A |
probably damaging |
Het |
| Arhgef17 |
T |
C |
7: 100,930,346 (GRCm38) |
E465G |
probably damaging |
Het |
| Btrc |
G |
T |
19: 45,423,134 (GRCm38) |
C31F |
possibly damaging |
Het |
| Calhm2 |
G |
A |
19: 47,133,100 (GRCm38) |
S210L |
probably damaging |
Het |
| Cnksr3 |
C |
A |
10: 7,152,912 (GRCm38) |
K153N |
probably damaging |
Het |
| Cnr1 |
T |
C |
4: 33,943,686 (GRCm38) |
S25P |
probably benign |
Het |
| Dnajc6 |
T |
A |
4: 101,639,353 (GRCm38) |
W838R |
probably damaging |
Het |
| Fam78a |
T |
A |
2: 32,069,556 (GRCm38) |
T181S |
probably damaging |
Het |
| Fat1 |
A |
G |
8: 45,051,398 (GRCm38) |
T4600A |
probably damaging |
Het |
| Fbxo31 |
A |
T |
8: 121,566,344 (GRCm38) |
Y101N |
probably damaging |
Het |
| Glmp |
A |
G |
3: 88,325,082 (GRCm38) |
M1V |
probably null |
Het |
| Gsdmc |
T |
A |
15: 63,801,933 (GRCm38) |
T168S |
probably benign |
Het |
| Has1 |
C |
T |
17: 17,848,298 (GRCm38) |
V265I |
probably damaging |
Het |
| Hmcn2 |
A |
G |
2: 31,454,811 (GRCm38) |
D4670G |
possibly damaging |
Het |
| Kcnj4 |
C |
T |
15: 79,484,902 (GRCm38) |
M292I |
probably benign |
Het |
| Kmo |
A |
T |
1: 175,637,919 (GRCm38) |
S80C |
probably damaging |
Het |
| Lrrc8d |
C |
T |
5: 105,813,548 (GRCm38) |
T608I |
possibly damaging |
Het |
| Mical2 |
A |
T |
7: 112,323,990 (GRCm38) |
N635I |
probably benign |
Het |
| Nags |
T |
C |
11: 102,147,941 (GRCm38) |
S403P |
probably damaging |
Het |
| Nalcn |
T |
A |
14: 123,323,338 (GRCm38) |
I776F |
probably benign |
Het |
| Ncan |
A |
T |
8: 70,102,462 (GRCm38) |
N1018K |
probably damaging |
Het |
| Notch3 |
T |
A |
17: 32,154,731 (GRCm38) |
|
probably benign |
Het |
| Nup93 |
C |
T |
8: 94,227,833 (GRCm38) |
Q53* |
probably null |
Het |
| Pdk2 |
T |
A |
11: 95,028,586 (GRCm38) |
M288L |
probably benign |
Het |
| Pkd1 |
A |
G |
17: 24,573,815 (GRCm38) |
Y1492C |
probably damaging |
Het |
| Pla2g12b |
T |
A |
10: 59,403,870 (GRCm38) |
W34R |
probably damaging |
Het |
| Pla2g6 |
T |
A |
15: 79,299,094 (GRCm38) |
D511V |
possibly damaging |
Het |
| Plin2 |
C |
A |
4: 86,658,692 (GRCm38) |
M265I |
probably benign |
Het |
| Ppp6c |
A |
T |
2: 39,206,657 (GRCm38) |
F78I |
probably damaging |
Het |
| Prop1 |
A |
T |
11: 50,950,946 (GRCm38) |
M211K |
possibly damaging |
Het |
| Prr14l |
T |
A |
5: 32,831,484 (GRCm38) |
E222D |
probably damaging |
Het |
| Rtkn |
A |
T |
6: 83,151,924 (GRCm38) |
I454F |
probably damaging |
Het |
| Serinc2 |
T |
C |
4: 130,260,774 (GRCm38) |
I226V |
probably benign |
Het |
| Sh3bp1 |
T |
A |
15: 78,904,338 (GRCm38) |
H229Q |
probably benign |
Het |
| Slc13a3 |
G |
T |
2: 165,424,573 (GRCm38) |
F348L |
probably damaging |
Het |
| Slc6a15 |
T |
A |
10: 103,404,275 (GRCm38) |
|
probably benign |
Het |
| Spg7 |
G |
A |
8: 123,076,978 (GRCm38) |
G249E |
probably damaging |
Het |
| Tbc1d2 |
T |
C |
4: 46,649,916 (GRCm38) |
D40G |
probably benign |
Het |
| Tmcc2 |
A |
G |
1: 132,357,579 (GRCm38) |
L683P |
probably damaging |
Het |
| Triobp |
T |
C |
15: 78,973,489 (GRCm38) |
S1097P |
probably benign |
Het |
| Tspan9 |
T |
C |
6: 127,965,763 (GRCm38) |
D167G |
probably null |
Het |
| Ttll6 |
T |
C |
11: 96,154,700 (GRCm38) |
I581T |
probably benign |
Het |
| Usp29 |
A |
G |
7: 6,963,353 (GRCm38) |
|
probably null |
Het |
| Vgll4 |
A |
G |
6: 114,862,293 (GRCm38) |
W246R |
probably damaging |
Het |
| Vmn2r62 |
T |
C |
7: 42,788,506 (GRCm38) |
T185A |
probably benign |
Het |
| Vwce |
A |
G |
19: 10,645,036 (GRCm38) |
H234R |
possibly damaging |
Het |
| Zfp292 |
T |
C |
4: 34,806,462 (GRCm38) |
E2194G |
possibly damaging |
Het |
|
| Other mutations in Vmn2r26 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01070:Vmn2r26
|
APN |
6 |
124,061,607 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01370:Vmn2r26
|
APN |
6 |
124,061,756 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL01603:Vmn2r26
|
APN |
6 |
124,053,874 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01651:Vmn2r26
|
APN |
6 |
124,050,673 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02282:Vmn2r26
|
APN |
6 |
124,061,625 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02425:Vmn2r26
|
APN |
6 |
124,061,818 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02690:Vmn2r26
|
APN |
6 |
124,026,132 (GRCm38) |
missense |
probably benign |
0.14 |
|
IGL03002:Vmn2r26
|
APN |
6 |
124,039,795 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
IGL03270:Vmn2r26
|
APN |
6 |
124,050,819 (GRCm38) |
missense |
probably benign |
0.16 |
|
R0032:Vmn2r26
|
UTSW |
6 |
124,039,899 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R0052:Vmn2r26
|
UTSW |
6 |
124,062,033 (GRCm38) |
makesense |
probably null |
|
|
R0083:Vmn2r26
|
UTSW |
6 |
124,053,981 (GRCm38) |
splice site |
probably null |
|
|
R0682:Vmn2r26
|
UTSW |
6 |
124,061,170 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1061:Vmn2r26
|
UTSW |
6 |
124,061,644 (GRCm38) |
missense |
probably benign |
0.12 |
|
R1077:Vmn2r26
|
UTSW |
6 |
124,053,913 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1263:Vmn2r26
|
UTSW |
6 |
124,050,708 (GRCm38) |
missense |
probably benign |
|
|
R1579:Vmn2r26
|
UTSW |
6 |
124,039,747 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1741:Vmn2r26
|
UTSW |
6 |
124,061,472 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1834:Vmn2r26
|
UTSW |
6 |
124,061,410 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R1838:Vmn2r26
|
UTSW |
6 |
124,024,771 (GRCm38) |
missense |
probably benign |
|
|
R1956:Vmn2r26
|
UTSW |
6 |
124,053,887 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1996:Vmn2r26
|
UTSW |
6 |
124,061,185 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2140:Vmn2r26
|
UTSW |
6 |
124,061,237 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2327:Vmn2r26
|
UTSW |
6 |
124,039,749 (GRCm38) |
missense |
probably benign |
0.07 |
|
R2417:Vmn2r26
|
UTSW |
6 |
124,061,350 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3930:Vmn2r26
|
UTSW |
6 |
124,025,979 (GRCm38) |
missense |
probably benign |
|
|
R4490:Vmn2r26
|
UTSW |
6 |
124,050,738 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R4629:Vmn2r26
|
UTSW |
6 |
124,061,191 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R4655:Vmn2r26
|
UTSW |
6 |
124,061,416 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4709:Vmn2r26
|
UTSW |
6 |
124,053,965 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4992:Vmn2r26
|
UTSW |
6 |
124,026,111 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5297:Vmn2r26
|
UTSW |
6 |
124,061,873 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5482:Vmn2r26
|
UTSW |
6 |
124,061,326 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R5517:Vmn2r26
|
UTSW |
6 |
124,050,717 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5737:Vmn2r26
|
UTSW |
6 |
124,039,449 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5739:Vmn2r26
|
UTSW |
6 |
124,025,966 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5873:Vmn2r26
|
UTSW |
6 |
124,061,674 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5907:Vmn2r26
|
UTSW |
6 |
124,039,871 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6086:Vmn2r26
|
UTSW |
6 |
124,039,560 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R6134:Vmn2r26
|
UTSW |
6 |
124,061,485 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6391:Vmn2r26
|
UTSW |
6 |
124,061,389 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6428:Vmn2r26
|
UTSW |
6 |
124,026,080 (GRCm38) |
missense |
probably benign |
0.17 |
|
R6637:Vmn2r26
|
UTSW |
6 |
124,061,691 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6927:Vmn2r26
|
UTSW |
6 |
124,039,098 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R6953:Vmn2r26
|
UTSW |
6 |
124,039,782 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7173:Vmn2r26
|
UTSW |
6 |
124,061,296 (GRCm38) |
missense |
probably benign |
0.16 |
|
R7206:Vmn2r26
|
UTSW |
6 |
124,039,768 (GRCm38) |
missense |
probably benign |
0.17 |
|
R7208:Vmn2r26
|
UTSW |
6 |
124,061,989 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7283:Vmn2r26
|
UTSW |
6 |
124,025,955 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7506:Vmn2r26
|
UTSW |
6 |
124,039,741 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7672:Vmn2r26
|
UTSW |
6 |
124,039,647 (GRCm38) |
missense |
probably benign |
0.25 |
|
R7674:Vmn2r26
|
UTSW |
6 |
124,039,362 (GRCm38) |
missense |
probably benign |
|
|
R7696:Vmn2r26
|
UTSW |
6 |
124,061,535 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7716:Vmn2r26
|
UTSW |
6 |
124,061,745 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7831:Vmn2r26
|
UTSW |
6 |
124,039,799 (GRCm38) |
nonsense |
probably null |
|
|
R8063:Vmn2r26
|
UTSW |
6 |
124,024,955 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8331:Vmn2r26
|
UTSW |
6 |
124,061,928 (GRCm38) |
missense |
probably benign |
0.22 |
|
R8352:Vmn2r26
|
UTSW |
6 |
124,039,618 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8445:Vmn2r26
|
UTSW |
6 |
124,026,036 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8452:Vmn2r26
|
UTSW |
6 |
124,039,618 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8681:Vmn2r26
|
UTSW |
6 |
124,024,918 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8914:Vmn2r26
|
UTSW |
6 |
124,062,024 (GRCm38) |
missense |
probably benign |
|
|
R9333:Vmn2r26
|
UTSW |
6 |
124,026,050 (GRCm38) |
missense |
probably benign |
0.13 |
|
R9351:Vmn2r26
|
UTSW |
6 |
124,039,374 (GRCm38) |
missense |
probably benign |
|
|
R9436:Vmn2r26
|
UTSW |
6 |
124,025,867 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9515:Vmn2r26
|
UTSW |
6 |
124,061,178 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF010:Vmn2r26
|
UTSW |
6 |
124,039,489 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
| Posted On |
2015-04-16 |
Incidental Mutation