Incidental Mutation 'R8452:Vmn2r26'
| ID |
654803 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r26
|
| Ensembl Gene |
ENSMUSG00000096630 |
| Gene Name |
vomeronasal 2, receptor 26 |
| Synonyms |
V2r1b |
| MMRRC Submission |
067903-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.088)
|
| Stock # |
R8452 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
124024758-124062035 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 124039618 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Arginine
at position 347
(Q347R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032238
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032238]
|
| AlphaFold |
Q6TAC4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000032238
AA Change: Q347R
PolyPhen 2
Score 0.088 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: Q347R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
471 |
1.5e-31 |
PFAM |
|
Pfam:NCD3G
|
519 |
572 |
4.6e-25 |
PFAM |
|
Pfam:7tm_3
|
603 |
840 |
1.5e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
98% (50/51) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 55 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700123K08Rik |
G |
A |
5: 138,562,926 (GRCm38) |
T158M |
probably benign |
Het |
| Actl7b |
T |
A |
4: 56,740,251 (GRCm38) |
D369V |
probably damaging |
Het |
| Apc |
A |
G |
18: 34,312,751 (GRCm38) |
D900G |
possibly damaging |
Het |
| Bola1 |
G |
A |
3: 96,197,257 (GRCm38) |
A7V |
probably benign |
Het |
| Bud13 |
A |
G |
9: 46,288,079 (GRCm38) |
N246S |
possibly damaging |
Het |
| Cdkal1 |
G |
A |
13: 29,354,680 (GRCm38) |
P499S |
probably benign |
Het |
| Celsr1 |
G |
T |
15: 86,033,085 (GRCm38) |
S229* |
probably null |
Het |
| Cenpp |
A |
G |
13: 49,530,411 (GRCm38) |
|
probably null |
Het |
| Cntnap5c |
C |
T |
17: 58,055,692 (GRCm38) |
R347W |
probably damaging |
Het |
| Cox8b |
T |
A |
7: 140,899,016 (GRCm38) |
E62V |
probably null |
Het |
| Cyp2t4 |
G |
A |
7: 27,157,737 (GRCm38) |
A342T |
probably benign |
Het |
| Cyp8b1 |
A |
G |
9: 121,915,931 (GRCm38) |
Y112H |
probably damaging |
Het |
| Dlg5 |
G |
T |
14: 24,191,193 (GRCm38) |
A212D |
probably damaging |
Het |
| Dnah7a |
T |
C |
1: 53,427,827 (GRCm38) |
E3626G |
probably null |
Het |
| Dpys |
T |
C |
15: 39,793,324 (GRCm38) |
E449G |
possibly damaging |
Het |
| Fam187a |
C |
A |
11: 102,886,574 (GRCm38) |
C401* |
probably null |
Het |
| Fsip2 |
A |
T |
2: 82,984,593 (GRCm38) |
I3557L |
probably benign |
Het |
| Gm30083 |
C |
T |
14: 33,990,322 (GRCm38) |
|
probably null |
Het |
| Gpr165 |
C |
A |
X: 96,714,017 (GRCm38) |
D7E |
probably benign |
Het |
| Hist1h2bf |
A |
G |
13: 23,574,045 (GRCm38) |
V49A |
probably damaging |
Het |
| Ifi213 |
T |
C |
1: 173,595,269 (GRCm38) |
K10R |
possibly damaging |
Het |
| Morc2b |
T |
C |
17: 33,137,502 (GRCm38) |
D432G |
probably damaging |
Het |
| Mrgpra4 |
T |
A |
7: 47,981,677 (GRCm38) |
I59F |
probably damaging |
Het |
| Mttp |
A |
T |
3: 138,112,613 (GRCm38) |
D361E |
probably damaging |
Het |
| Mysm1 |
A |
G |
4: 94,975,273 (GRCm38) |
S28P |
probably damaging |
Het |
| Nrd1 |
T |
A |
4: 109,019,063 (GRCm38) |
V284D |
probably damaging |
Het |
| Nrip2 |
A |
T |
6: 128,407,994 (GRCm38) |
D203V |
probably damaging |
Het |
| Olfr251 |
A |
T |
9: 38,378,351 (GRCm38) |
M151L |
probably benign |
Het |
| Olfr648 |
A |
T |
7: 104,179,896 (GRCm38) |
C171S |
probably damaging |
Het |
| Olfr658 |
A |
T |
7: 104,644,529 (GRCm38) |
V281E |
possibly damaging |
Het |
| Olfr832 |
T |
A |
9: 18,945,163 (GRCm38) |
L172M |
possibly damaging |
Het |
| Oog4 |
A |
T |
4: 143,437,477 (GRCm38) |
Y495N |
probably benign |
Het |
| Pacrg |
T |
A |
17: 10,576,594 (GRCm38) |
R146* |
probably null |
Het |
| Pcdh18 |
A |
T |
3: 49,745,175 (GRCm38) |
M946K |
possibly damaging |
Het |
| Pign |
A |
G |
1: 105,648,192 (GRCm38) |
I241T |
probably benign |
Het |
| Pik3cg |
A |
G |
12: 32,193,640 (GRCm38) |
I944T |
probably damaging |
Het |
| Ppp2r5c |
T |
A |
12: 110,544,077 (GRCm38) |
F99L |
probably benign |
Het |
| Prex1 |
A |
T |
2: 166,589,573 (GRCm38) |
N756K |
probably benign |
Het |
| Prex2 |
T |
G |
1: 11,285,140 (GRCm38) |
M1555R |
probably benign |
Het |
| Prex2 |
A |
T |
1: 11,285,139 (GRCm38) |
M1555L |
probably benign |
Het |
| Prl3c1 |
T |
A |
13: 27,202,402 (GRCm38) |
D123E |
probably benign |
Het |
| Prr22 |
G |
A |
17: 56,771,311 (GRCm38) |
G155R |
probably damaging |
Het |
| Rev3l |
A |
G |
10: 39,822,903 (GRCm38) |
D1132G |
probably damaging |
Het |
| Rnf180 |
A |
T |
13: 105,181,548 (GRCm38) |
F452Y |
probably damaging |
Het |
| Scn4b |
A |
T |
9: 45,146,741 (GRCm38) |
I44F |
possibly damaging |
Het |
| Selenon |
A |
T |
4: 134,548,087 (GRCm38) |
|
probably null |
Het |
| Sirpb1b |
T |
A |
3: 15,542,350 (GRCm38) |
I291L |
probably benign |
Het |
| Slc12a9 |
C |
A |
5: 137,315,475 (GRCm38) |
V741L |
probably benign |
Het |
| Tbc1d8 |
G |
T |
1: 39,405,357 (GRCm38) |
R174S |
probably damaging |
Het |
| Tenm2 |
A |
G |
11: 36,023,601 (GRCm38) |
F2370L |
probably damaging |
Het |
| Tfec |
T |
A |
6: 16,844,203 (GRCm38) |
H115L |
probably damaging |
Het |
| Tnxb |
A |
T |
17: 34,689,407 (GRCm38) |
T1345S |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,738,487 (GRCm38) |
N27354I |
probably damaging |
Het |
| Unc13c |
A |
G |
9: 73,931,008 (GRCm38) |
Y854H |
probably damaging |
Het |
| Utrn |
A |
T |
10: 12,813,509 (GRCm38) |
W11R |
probably benign |
Het |
|
| Other mutations in Vmn2r26 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01070:Vmn2r26
|
APN |
6 |
124,061,607 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01370:Vmn2r26
|
APN |
6 |
124,061,756 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL01603:Vmn2r26
|
APN |
6 |
124,053,874 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01651:Vmn2r26
|
APN |
6 |
124,050,673 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02282:Vmn2r26
|
APN |
6 |
124,061,625 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02425:Vmn2r26
|
APN |
6 |
124,061,818 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02551:Vmn2r26
|
APN |
6 |
124,026,141 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL02690:Vmn2r26
|
APN |
6 |
124,026,132 (GRCm38) |
missense |
probably benign |
0.14 |
|
IGL03002:Vmn2r26
|
APN |
6 |
124,039,795 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
IGL03270:Vmn2r26
|
APN |
6 |
124,050,819 (GRCm38) |
missense |
probably benign |
0.16 |
|
R0032:Vmn2r26
|
UTSW |
6 |
124,039,899 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R0052:Vmn2r26
|
UTSW |
6 |
124,062,033 (GRCm38) |
makesense |
probably null |
|
|
R0083:Vmn2r26
|
UTSW |
6 |
124,053,981 (GRCm38) |
splice site |
probably null |
|
|
R0682:Vmn2r26
|
UTSW |
6 |
124,061,170 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1061:Vmn2r26
|
UTSW |
6 |
124,061,644 (GRCm38) |
missense |
probably benign |
0.12 |
|
R1077:Vmn2r26
|
UTSW |
6 |
124,053,913 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1263:Vmn2r26
|
UTSW |
6 |
124,050,708 (GRCm38) |
missense |
probably benign |
|
|
R1579:Vmn2r26
|
UTSW |
6 |
124,039,747 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1741:Vmn2r26
|
UTSW |
6 |
124,061,472 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1834:Vmn2r26
|
UTSW |
6 |
124,061,410 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R1838:Vmn2r26
|
UTSW |
6 |
124,024,771 (GRCm38) |
missense |
probably benign |
|
|
R1956:Vmn2r26
|
UTSW |
6 |
124,053,887 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1996:Vmn2r26
|
UTSW |
6 |
124,061,185 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2140:Vmn2r26
|
UTSW |
6 |
124,061,237 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2327:Vmn2r26
|
UTSW |
6 |
124,039,749 (GRCm38) |
missense |
probably benign |
0.07 |
|
R2417:Vmn2r26
|
UTSW |
6 |
124,061,350 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3930:Vmn2r26
|
UTSW |
6 |
124,025,979 (GRCm38) |
missense |
probably benign |
|
|
R4490:Vmn2r26
|
UTSW |
6 |
124,050,738 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R4629:Vmn2r26
|
UTSW |
6 |
124,061,191 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R4655:Vmn2r26
|
UTSW |
6 |
124,061,416 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4709:Vmn2r26
|
UTSW |
6 |
124,053,965 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4992:Vmn2r26
|
UTSW |
6 |
124,026,111 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5297:Vmn2r26
|
UTSW |
6 |
124,061,873 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5482:Vmn2r26
|
UTSW |
6 |
124,061,326 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R5517:Vmn2r26
|
UTSW |
6 |
124,050,717 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5737:Vmn2r26
|
UTSW |
6 |
124,039,449 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5739:Vmn2r26
|
UTSW |
6 |
124,025,966 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5873:Vmn2r26
|
UTSW |
6 |
124,061,674 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5907:Vmn2r26
|
UTSW |
6 |
124,039,871 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6086:Vmn2r26
|
UTSW |
6 |
124,039,560 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R6134:Vmn2r26
|
UTSW |
6 |
124,061,485 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6391:Vmn2r26
|
UTSW |
6 |
124,061,389 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6428:Vmn2r26
|
UTSW |
6 |
124,026,080 (GRCm38) |
missense |
probably benign |
0.17 |
|
R6637:Vmn2r26
|
UTSW |
6 |
124,061,691 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6927:Vmn2r26
|
UTSW |
6 |
124,039,098 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R6953:Vmn2r26
|
UTSW |
6 |
124,039,782 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7173:Vmn2r26
|
UTSW |
6 |
124,061,296 (GRCm38) |
missense |
probably benign |
0.16 |
|
R7206:Vmn2r26
|
UTSW |
6 |
124,039,768 (GRCm38) |
missense |
probably benign |
0.17 |
|
R7208:Vmn2r26
|
UTSW |
6 |
124,061,989 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7283:Vmn2r26
|
UTSW |
6 |
124,025,955 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7506:Vmn2r26
|
UTSW |
6 |
124,039,741 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7672:Vmn2r26
|
UTSW |
6 |
124,039,647 (GRCm38) |
missense |
probably benign |
0.25 |
|
R7674:Vmn2r26
|
UTSW |
6 |
124,039,362 (GRCm38) |
missense |
probably benign |
|
|
R7696:Vmn2r26
|
UTSW |
6 |
124,061,535 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7716:Vmn2r26
|
UTSW |
6 |
124,061,745 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7831:Vmn2r26
|
UTSW |
6 |
124,039,799 (GRCm38) |
nonsense |
probably null |
|
|
R8063:Vmn2r26
|
UTSW |
6 |
124,024,955 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8331:Vmn2r26
|
UTSW |
6 |
124,061,928 (GRCm38) |
missense |
probably benign |
0.22 |
|
R8352:Vmn2r26
|
UTSW |
6 |
124,039,618 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8445:Vmn2r26
|
UTSW |
6 |
124,026,036 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8681:Vmn2r26
|
UTSW |
6 |
124,024,918 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8914:Vmn2r26
|
UTSW |
6 |
124,062,024 (GRCm38) |
missense |
probably benign |
|
|
R9333:Vmn2r26
|
UTSW |
6 |
124,026,050 (GRCm38) |
missense |
probably benign |
0.13 |
|
R9351:Vmn2r26
|
UTSW |
6 |
124,039,374 (GRCm38) |
missense |
probably benign |
|
|
R9436:Vmn2r26
|
UTSW |
6 |
124,025,867 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9515:Vmn2r26
|
UTSW |
6 |
124,061,178 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF010:Vmn2r26
|
UTSW |
6 |
124,039,489 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGAGACACACATTCTCTTCTG -3'
(R):5'- TGGCATACACAGCAGCATAG -3'
Sequencing Primer
(F):5'- AGACACACATTCTCTTCTGCGAATTG -3'
(R):5'- CAGCAGCATAGACTTTGTAGC -3'
|
| Posted On |
2020-10-20 |
Incidental Mutation