Incidental Mutation 'R7156:Mslnl'
ID |
557342 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Mslnl
|
Ensembl Gene |
ENSMUSG00000041062 |
Gene Name |
mesothelin-like |
Synonyms |
|
MMRRC Submission |
045257-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R7156 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
25955016-25967304 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 25962184 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Glutamic Acid
at position 194
(V194E)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000049020
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047098]
|
AlphaFold |
Q8C160 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000047098
AA Change: V194E
PolyPhen 2
Score 0.202 (Sensitivity: 0.92; Specificity: 0.88)
|
SMART Domains |
Protein: ENSMUSP00000049020 Gene: ENSMUSG00000041062 AA Change: V194E
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
Pfam:Mesothelin
|
29 |
589 |
2.8e-70 |
PFAM |
low complexity region
|
633 |
653 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 98.9%
|
Validation Efficiency |
100% (81/81) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 79 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930433I11Rik |
T |
C |
7: 40,643,282 (GRCm39) |
I317T |
possibly damaging |
Het |
Acsl5 |
G |
A |
19: 55,257,260 (GRCm39) |
|
probably null |
Het |
Ahrr |
G |
A |
13: 74,378,035 (GRCm39) |
T136I |
probably damaging |
Het |
AI597479 |
G |
A |
1: 43,150,261 (GRCm39) |
D124N |
probably damaging |
Het |
Arap2 |
G |
T |
5: 62,761,914 (GRCm39) |
A1604D |
probably damaging |
Het |
Bcl6 |
G |
A |
16: 23,784,976 (GRCm39) |
R675* |
probably null |
Het |
Cadps2 |
T |
C |
6: 23,688,955 (GRCm39) |
N118S |
probably benign |
Het |
Caskin1 |
T |
A |
17: 24,719,657 (GRCm39) |
|
probably null |
Het |
Cc2d1a |
C |
T |
8: 84,862,389 (GRCm39) |
V684M |
possibly damaging |
Het |
Ccdc91 |
T |
C |
6: 147,435,676 (GRCm39) |
S87P |
possibly damaging |
Het |
Cdr2l |
A |
G |
11: 115,281,792 (GRCm39) |
Q99R |
probably benign |
Het |
Celsr3 |
T |
C |
9: 108,715,203 (GRCm39) |
L2066P |
possibly damaging |
Het |
Cep95 |
A |
C |
11: 106,700,050 (GRCm39) |
L313F |
possibly damaging |
Het |
Chst10 |
G |
A |
1: 38,913,088 (GRCm39) |
T63M |
probably damaging |
Het |
Clrn2 |
G |
A |
5: 45,611,258 (GRCm39) |
G36R |
probably damaging |
Het |
Cnn2 |
T |
G |
10: 79,830,349 (GRCm39) |
Y273* |
probably null |
Het |
Crtap |
T |
C |
9: 114,207,164 (GRCm39) |
T365A |
probably benign |
Het |
D630045J12Rik |
T |
C |
6: 38,171,964 (GRCm39) |
T735A |
possibly damaging |
Het |
Disp2 |
C |
T |
2: 118,622,292 (GRCm39) |
A1008V |
probably damaging |
Het |
Dmrt3 |
A |
G |
19: 25,588,317 (GRCm39) |
D52G |
probably damaging |
Het |
Dmrta1 |
T |
G |
4: 89,576,700 (GRCm39) |
L52R |
probably damaging |
Het |
Dmrta2 |
A |
G |
4: 109,839,185 (GRCm39) |
T311A |
probably damaging |
Het |
Dnm1 |
T |
A |
2: 32,230,479 (GRCm39) |
N112Y |
probably damaging |
Het |
Dysf |
T |
C |
6: 84,064,858 (GRCm39) |
|
probably null |
Het |
Ep400 |
A |
G |
5: 110,833,229 (GRCm39) |
F2034L |
unknown |
Het |
F12 |
G |
A |
13: 55,566,310 (GRCm39) |
A494V |
probably damaging |
Het |
Fbp2 |
A |
T |
13: 62,989,675 (GRCm39) |
F210L |
probably benign |
Het |
Fbxo31 |
T |
A |
8: 122,281,060 (GRCm39) |
Q362L |
possibly damaging |
Het |
Fkbp4 |
C |
T |
6: 128,412,787 (GRCm39) |
A95T |
probably benign |
Het |
Frmd6 |
T |
G |
12: 70,923,983 (GRCm39) |
C80W |
probably damaging |
Het |
Fsip2 |
A |
G |
2: 82,813,085 (GRCm39) |
I3135V |
probably benign |
Het |
Garre1 |
G |
T |
7: 33,945,133 (GRCm39) |
N582K |
possibly damaging |
Het |
Guca2b |
T |
A |
4: 119,514,887 (GRCm39) |
E34V |
probably damaging |
Het |
Hdlbp |
G |
A |
1: 93,341,637 (GRCm39) |
T974I |
probably damaging |
Het |
Hsdl2 |
T |
A |
4: 59,617,653 (GRCm39) |
M460K |
possibly damaging |
Het |
Ift172 |
C |
T |
5: 31,429,419 (GRCm39) |
V581M |
probably damaging |
Het |
Ift74 |
A |
G |
4: 94,549,189 (GRCm39) |
K313R |
possibly damaging |
Het |
Ints4 |
T |
A |
7: 97,184,493 (GRCm39) |
|
probably null |
Het |
Iqca1l |
C |
T |
5: 24,757,648 (GRCm39) |
E150K |
probably benign |
Het |
Kif21b |
A |
C |
1: 136,075,562 (GRCm39) |
T230P |
probably damaging |
Het |
Kit |
A |
T |
5: 75,776,034 (GRCm39) |
Y272F |
probably benign |
Het |
Krt77 |
G |
A |
15: 101,773,931 (GRCm39) |
T241M |
probably benign |
Het |
Lce1j |
T |
A |
3: 92,696,491 (GRCm39) |
S96C |
unknown |
Het |
Marveld3 |
T |
A |
8: 110,674,820 (GRCm39) |
D332V |
probably damaging |
Het |
Matr3 |
G |
T |
18: 35,705,974 (GRCm39) |
V300F |
probably damaging |
Het |
Mical1 |
T |
A |
10: 41,361,253 (GRCm39) |
|
probably null |
Het |
Mug1 |
C |
A |
6: 121,857,864 (GRCm39) |
T1119K |
probably damaging |
Het |
Mug1 |
C |
T |
6: 121,861,302 (GRCm39) |
P1308S |
probably damaging |
Het |
Neb |
C |
A |
2: 52,195,295 (GRCm39) |
|
probably null |
Het |
Neo1 |
T |
A |
9: 58,810,206 (GRCm39) |
T1082S |
probably damaging |
Het |
Nkx6-2 |
C |
T |
7: 139,162,045 (GRCm39) |
|
probably null |
Het |
Or10g6 |
T |
C |
9: 39,934,526 (GRCm39) |
I279T |
probably benign |
Het |
Or8k27 |
T |
A |
2: 86,275,652 (GRCm39) |
I225L |
probably damaging |
Het |
Orc1 |
A |
T |
4: 108,452,656 (GRCm39) |
E177V |
probably benign |
Het |
Parp1 |
G |
A |
1: 180,426,629 (GRCm39) |
V924I |
possibly damaging |
Het |
Pax2 |
A |
T |
19: 44,777,298 (GRCm39) |
I165F |
probably benign |
Het |
Pnma2 |
C |
T |
14: 67,153,980 (GRCm39) |
P135S |
probably benign |
Het |
Ranbp17 |
A |
G |
11: 33,247,420 (GRCm39) |
I718T |
probably damaging |
Het |
Rbm25 |
T |
A |
12: 83,710,965 (GRCm39) |
D359E |
unknown |
Het |
Rgs3 |
T |
C |
4: 62,535,363 (GRCm39) |
L194P |
probably damaging |
Het |
Serpinb6b |
A |
G |
13: 33,155,598 (GRCm39) |
I104V |
probably benign |
Het |
Smg9 |
A |
G |
7: 24,120,286 (GRCm39) |
D420G |
probably benign |
Het |
Smpd1 |
C |
T |
7: 105,203,693 (GRCm39) |
|
probably benign |
Het |
Snx17 |
T |
A |
5: 31,354,692 (GRCm39) |
M318K |
probably damaging |
Het |
Spata31e5 |
A |
T |
1: 28,815,848 (GRCm39) |
M728K |
possibly damaging |
Het |
Stard10 |
G |
A |
7: 100,995,258 (GRCm39) |
D337N |
probably damaging |
Het |
Tex14 |
A |
G |
11: 87,375,545 (GRCm39) |
T103A |
probably damaging |
Het |
Tle1 |
A |
G |
4: 72,088,953 (GRCm39) |
S97P |
probably benign |
Het |
Tnfrsf8 |
T |
A |
4: 145,041,654 (GRCm39) |
M1L |
unknown |
Het |
Traf3ip2 |
T |
C |
10: 39,502,173 (GRCm39) |
L107P |
possibly damaging |
Het |
Trpc7 |
A |
T |
13: 56,937,579 (GRCm39) |
S626T |
possibly damaging |
Het |
Ubl7 |
T |
A |
9: 57,837,039 (GRCm39) |
I350N |
probably damaging |
Het |
Ubr3 |
T |
A |
2: 69,851,967 (GRCm39) |
I1878N |
probably damaging |
Het |
Usp24 |
G |
T |
4: 106,245,116 (GRCm39) |
|
probably null |
Het |
Vcan |
A |
T |
13: 89,837,229 (GRCm39) |
S2772T |
possibly damaging |
Het |
Vmn2r79 |
T |
C |
7: 86,686,851 (GRCm39) |
V744A |
probably damaging |
Het |
Wbp2nl |
T |
C |
15: 82,189,903 (GRCm39) |
S32P |
probably damaging |
Het |
Wwc1 |
A |
G |
11: 35,788,201 (GRCm39) |
|
probably null |
Het |
Zfp629 |
C |
T |
7: 127,211,463 (GRCm39) |
W115* |
probably null |
Het |
|
Other mutations in Mslnl |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01621:Mslnl
|
APN |
17 |
25,962,641 (GRCm39) |
unclassified |
probably benign |
|
IGL01629:Mslnl
|
APN |
17 |
25,963,749 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02084:Mslnl
|
APN |
17 |
25,965,125 (GRCm39) |
missense |
probably benign |
0.07 |
IGL02408:Mslnl
|
APN |
17 |
25,966,972 (GRCm39) |
missense |
possibly damaging |
0.80 |
IGL02726:Mslnl
|
APN |
17 |
25,963,077 (GRCm39) |
critical splice donor site |
probably null |
|
IGL03387:Mslnl
|
APN |
17 |
25,963,051 (GRCm39) |
missense |
probably benign |
0.06 |
R0561:Mslnl
|
UTSW |
17 |
25,962,177 (GRCm39) |
nonsense |
probably null |
|
R0881:Mslnl
|
UTSW |
17 |
25,961,939 (GRCm39) |
missense |
possibly damaging |
0.82 |
R1295:Mslnl
|
UTSW |
17 |
25,962,214 (GRCm39) |
missense |
probably damaging |
1.00 |
R1296:Mslnl
|
UTSW |
17 |
25,962,214 (GRCm39) |
missense |
probably damaging |
1.00 |
R1582:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1629:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1630:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1631:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1632:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1794:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1850:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1866:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1876:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1914:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2166:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2241:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2243:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2247:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2282:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2284:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2852:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2867:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2867:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2877:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2878:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2919:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2920:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3026:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3405:Mslnl
|
UTSW |
17 |
25,965,155 (GRCm39) |
missense |
probably damaging |
1.00 |
R3406:Mslnl
|
UTSW |
17 |
25,965,155 (GRCm39) |
missense |
probably damaging |
1.00 |
R3411:Mslnl
|
UTSW |
17 |
25,963,491 (GRCm39) |
missense |
probably benign |
0.05 |
R3434:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3546:Mslnl
|
UTSW |
17 |
25,963,943 (GRCm39) |
missense |
probably damaging |
0.98 |
R3612:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3729:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3730:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3802:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3804:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3894:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3895:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4454:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4455:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4456:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4457:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4561:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4562:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4564:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4600:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4601:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4610:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4704:Mslnl
|
UTSW |
17 |
25,957,952 (GRCm39) |
missense |
possibly damaging |
0.73 |
R5155:Mslnl
|
UTSW |
17 |
25,957,942 (GRCm39) |
nonsense |
probably null |
|
R5257:Mslnl
|
UTSW |
17 |
25,965,139 (GRCm39) |
missense |
probably benign |
0.00 |
R5456:Mslnl
|
UTSW |
17 |
25,962,133 (GRCm39) |
missense |
probably damaging |
0.98 |
R5645:Mslnl
|
UTSW |
17 |
25,956,816 (GRCm39) |
missense |
possibly damaging |
0.95 |
R6007:Mslnl
|
UTSW |
17 |
25,965,749 (GRCm39) |
missense |
probably benign |
0.00 |
R6083:Mslnl
|
UTSW |
17 |
25,956,876 (GRCm39) |
missense |
possibly damaging |
0.83 |
R6142:Mslnl
|
UTSW |
17 |
25,963,531 (GRCm39) |
missense |
probably damaging |
1.00 |
R6761:Mslnl
|
UTSW |
17 |
25,965,047 (GRCm39) |
missense |
probably damaging |
1.00 |
R7058:Mslnl
|
UTSW |
17 |
25,962,186 (GRCm39) |
missense |
probably benign |
0.03 |
R7467:Mslnl
|
UTSW |
17 |
25,955,895 (GRCm39) |
start codon destroyed |
probably benign |
0.33 |
R7687:Mslnl
|
UTSW |
17 |
25,962,157 (GRCm39) |
missense |
probably damaging |
0.97 |
R7807:Mslnl
|
UTSW |
17 |
25,965,751 (GRCm39) |
missense |
probably benign |
0.03 |
R8682:Mslnl
|
UTSW |
17 |
25,965,962 (GRCm39) |
missense |
probably benign |
|
R8735:Mslnl
|
UTSW |
17 |
25,964,062 (GRCm39) |
missense |
probably benign |
0.09 |
R8742:Mslnl
|
UTSW |
17 |
25,964,047 (GRCm39) |
missense |
probably damaging |
1.00 |
R9208:Mslnl
|
UTSW |
17 |
25,961,694 (GRCm39) |
missense |
possibly damaging |
0.94 |
R9264:Mslnl
|
UTSW |
17 |
25,961,506 (GRCm39) |
intron |
probably benign |
|
RF007:Mslnl
|
UTSW |
17 |
25,962,202 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Predicted Primers |
PCR Primer
(F):5'- TTGCCCAACCAGAGAGTTG -3'
(R):5'- TTCAAACCTCAAGCCCCTTG -3'
Sequencing Primer
(F):5'- AACCAGAGAGTTGCCCTGCAG -3'
(R):5'- AAGCCCCTTGCATCTTATCTGATG -3'
|
Posted On |
2019-06-26 |