Mutagenetix > Incidental Mutation

Incidental Mutation 'R7266:Vmn2r72'

564928

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

Vmn2r72-ps, EG244114

MMRRC Submission

045389-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

R7266 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

85737784-85754981 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to T at 85738274 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Stop codon at position 694 (S694*)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

AlphaFold

D3Z4N8

Predicted Effect

probably null
Transcript: ENSMUST00000063425
AA Change: S694*

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: S694*

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam18	T	A	8: 24,667,623 (GRCm38)	I104F	probably benign	Het
Adgrg7	C	T	16: 56,770,311 (GRCm38)	V166I	probably benign	Het
Agfg1	G	T	1: 82,882,245 (GRCm38)	V278L	probably benign	Het
Alpk3	A	G	7: 81,092,580 (GRCm38)	E715G	possibly damaging	Het
Ap2m1	A	G	16: 20,543,345 (GRCm38)	Y401C	probably damaging	Het
Arhgef28	C	T	13: 97,965,452 (GRCm38)	S838N	probably benign	Het
Ash2l	A	T	8: 25,827,205 (GRCm38)	Y373*	probably null	Het
Best2	C	T	8: 85,007,764 (GRCm38)	V442I	probably benign	Het
Col4a2	T	C	8: 11,425,542 (GRCm38)		probably null	Het
Fat2	T	A	11: 55,285,030 (GRCm38)	D1619V	probably damaging	Het
Fer1l6	A	T	15: 58,627,597 (GRCm38)	N1272I	probably benign	Het
Gcc1	T	A	6: 28,417,996 (GRCm38)	*779C	probably null	Het
Gm12216	G	A	11: 53,859,251 (GRCm38)		probably benign	Het
Gm17657	C	A	17: 29,519,373 (GRCm38)	V140L	probably benign	Het
Gm7102	A	G	19: 61,175,535 (GRCm38)	V154A	possibly damaging	Het
Grm2	C	T	9: 106,647,171 (GRCm38)	V311I		Het
Immt	T	A	6: 71,874,705 (GRCm38)	D683E	probably benign	Het
Itga8	T	G	2: 12,232,901 (GRCm38)	D336A	probably damaging	Het
Jhy	T	C	9: 40,961,157 (GRCm38)	T19A	probably benign	Het
Kcnq2	T	C	2: 181,135,092 (GRCm38)	M1V	probably null	Het
Kctd17	A	T	15: 78,433,014 (GRCm38)	I117F	probably damaging	Het
Lrp6	T	C	6: 134,507,401 (GRCm38)	T420A	probably damaging	Het
Manba	T	C	3: 135,517,912 (GRCm38)	S187P	probably damaging	Het
Mef2b	A	T	8: 70,164,288 (GRCm38)	D13V	probably damaging	Het
Mical2	T	C	7: 112,303,756 (GRCm38)	F145L	probably damaging	Het
Mphosph8	T	A	14: 56,685,040 (GRCm38)	D551E	possibly damaging	Het
Myo10	C	G	15: 25,782,981 (GRCm38)	R1170G	probably damaging	Het
Myo16	A	C	8: 10,272,687 (GRCm38)	Q39P	unknown	Het
Myo1f	A	G	17: 33,601,694 (GRCm38)	E837G	probably benign	Het
Nell2	T	A	15: 95,435,393 (GRCm38)	I128F	possibly damaging	Het
Olfr1357	A	G	10: 78,612,614 (GRCm38)	V9A	probably benign	Het
Pcdh15	A	T	10: 74,379,390 (GRCm38)	R659*	probably null	Het
Pcdhga1	A	G	18: 37,839,975 (GRCm38)	Q881R	possibly damaging	Het
Plekhm2	T	G	4: 141,642,459 (GRCm38)	E75A	possibly damaging	Het
Prc1	A	G	7: 80,307,657 (GRCm38)	K357E	possibly damaging	Het
Pxk	T	A	14: 8,146,220 (GRCm38)	C377S	probably benign	Het
Ralgapa2	T	C	2: 146,334,568 (GRCm38)	E1696G	probably damaging	Het
Rbbp6	T	A	7: 123,001,367 (GRCm38)	S1532R	unknown	Het
Scn5a	G	T	9: 119,562,560 (GRCm38)	A22E	probably benign	Het
Sctr	G	A	1: 120,022,225 (GRCm38)	R48Q	probably benign	Het
Siae	T	C	9: 37,623,013 (GRCm38)	V115A	probably damaging	Het
Slc16a6	A	G	11: 109,453,281 (GRCm38)	C563R	probably benign	Het
Sntg1	A	C	1: 8,682,019 (GRCm38)	V58G	possibly damaging	Het
Snx11	C	T	11: 96,773,159 (GRCm38)	V36M	probably damaging	Het
Stk3	C	A	15: 34,959,036 (GRCm38)	S330I	probably benign	Het
Synpo	A	G	18: 60,629,559 (GRCm38)	F92S	probably benign	Het
Tle1	A	G	4: 72,139,687 (GRCm38)		probably null	Het
Tmem117	A	G	15: 94,931,803 (GRCm38)	D173G	possibly damaging	Het
Tmprss5	T	C	9: 49,114,541 (GRCm38)	W338R	probably benign	Het
Tnfrsf19	T	C	14: 60,974,698 (GRCm38)	T168A	possibly damaging	Het
Trhde	C	T	10: 114,800,871 (GRCm38)	G144S	possibly damaging	Het
Trim56	G	T	5: 137,114,243 (GRCm38)	Q140K	probably damaging	Het
Ttn	C	T	2: 76,732,574 (GRCm38)	V28679M	probably damaging	Het
Ubxn8	G	A	8: 33,623,203 (GRCm38)	R208C	probably damaging	Het
Wdr38	T	A	2: 39,000,264 (GRCm38)	W137R	probably damaging	Het
Zdhhc6	G	T	19: 55,304,500 (GRCm38)	N271K	probably damaging	Het
Zfyve9	A	G	4: 108,718,547 (GRCm38)	S446P	possibly damaging	Het
Zmynd8	T	C	2: 165,807,572 (GRCm38)	Q867R	possibly damaging	Het
Zswim3	T	C	2: 164,820,482 (GRCm38)	I294T	probably benign	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85,749,646 (GRCm38)	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85,738,334 (GRCm38)	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85,749,646 (GRCm38)	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85,738,367 (GRCm38)	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85,738,166 (GRCm38)	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85,738,166 (GRCm38)	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85,738,166 (GRCm38)	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85,750,711 (GRCm38)	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85,737,962 (GRCm38)	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85,750,693 (GRCm38)	missense	probably benign
IGL02514:Vmn2r72	APN	7	85,738,699 (GRCm38)	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85,738,183 (GRCm38)	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85,738,671 (GRCm38)	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85,751,813 (GRCm38)	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85,752,041 (GRCm38)	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85,751,176 (GRCm38)	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85,754,954 (GRCm38)	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85,750,867 (GRCm38)	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85,751,836 (GRCm38)	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85,754,876 (GRCm38)	missense	probably benign
R0655:Vmn2r72	UTSW	7	85,738,111 (GRCm38)	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85,749,739 (GRCm38)	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85,751,309 (GRCm38)	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85,751,944 (GRCm38)	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85,751,944 (GRCm38)	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85,751,944 (GRCm38)	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85,749,188 (GRCm38)	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85,738,257 (GRCm38)	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85,749,211 (GRCm38)	missense	probably benign
R1632:Vmn2r72	UTSW	7	85,751,792 (GRCm38)	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85,738,170 (GRCm38)	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85,749,161 (GRCm38)	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85,738,236 (GRCm38)	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85,738,341 (GRCm38)	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85,738,256 (GRCm38)	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85,750,953 (GRCm38)	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85,751,269 (GRCm38)	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85,750,836 (GRCm38)	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85,750,836 (GRCm38)	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85,750,836 (GRCm38)	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85,749,642 (GRCm38)	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85,738,077 (GRCm38)	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85,738,077 (GRCm38)	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85,749,735 (GRCm38)	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85,751,131 (GRCm38)	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85,749,809 (GRCm38)	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85,738,500 (GRCm38)	missense	probably damaging	1.00
R4421:Vmn2r72	UTSW	7	85,738,500 (GRCm38)	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85,737,828 (GRCm38)	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85,751,926 (GRCm38)	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85,751,926 (GRCm38)	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85,751,926 (GRCm38)	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85,737,911 (GRCm38)	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85,737,861 (GRCm38)	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85,750,598 (GRCm38)	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85,751,109 (GRCm38)	missense	probably benign
R4991:Vmn2r72	UTSW	7	85,751,130 (GRCm38)	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85,738,485 (GRCm38)	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85,737,853 (GRCm38)	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85,737,840 (GRCm38)	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85,738,254 (GRCm38)	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85,750,897 (GRCm38)	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85,751,942 (GRCm38)	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85,737,850 (GRCm38)	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85,737,929 (GRCm38)	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85,737,929 (GRCm38)	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85,750,539 (GRCm38)	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85,751,174 (GRCm38)	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85,749,684 (GRCm38)	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85,737,996 (GRCm38)	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85,749,803 (GRCm38)	splice site	probably null
R7189:Vmn2r72	UTSW	7	85,754,917 (GRCm38)	missense	probably benign	0.36
R7323:Vmn2r72	UTSW	7	85,750,563 (GRCm38)	missense	probably benign
R7426:Vmn2r72	UTSW	7	85,751,140 (GRCm38)	missense	probably benign
R7606:Vmn2r72	UTSW	7	85,751,154 (GRCm38)	missense	possibly damaging	0.91
R7651:Vmn2r72	UTSW	7	85,751,938 (GRCm38)	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85,754,890 (GRCm38)	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85,750,626 (GRCm38)	missense	probably damaging	1.00
R7843:Vmn2r72	UTSW	7	85,749,630 (GRCm38)	missense	probably benign	0.01
R8157:Vmn2r72	UTSW	7	85,751,233 (GRCm38)	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85,751,019 (GRCm38)	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85,751,960 (GRCm38)	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85,738,175 (GRCm38)	missense	probably benign
R8989:Vmn2r72	UTSW	7	85,754,926 (GRCm38)	missense	probably benign	0.10
R9015:Vmn2r72	UTSW	7	85,749,180 (GRCm38)	missense	probably benign	0.01
R9080:Vmn2r72	UTSW	7	85,738,256 (GRCm38)	missense	probably damaging	1.00
R9269:Vmn2r72	UTSW	7	85,751,203 (GRCm38)	missense	probably benign	0.03
R9317:Vmn2r72	UTSW	7	85,754,814 (GRCm38)	missense	probably benign	0.04
R9509:Vmn2r72	UTSW	7	85,754,867 (GRCm38)	missense	probably benign
Z1176:Vmn2r72	UTSW	7	85,749,191 (GRCm38)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- GCCCATGTATCCAAGGACACAG -3'
(R):5'- TGCGTCTTCCTGAAACACAG -3'

Sequencing Primer
(F):5'- GTAGAAGGCAATCACTGAACCTTTG -3'
(R):5'- AAACTCTCAGCTATGTACTACTCATC -3'

Posted On

2019-06-26