Mutagenetix > Incidental Mutations

Incidental Mutation 'R7266:Vmn2r72'

564928

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

Vmn2r72-ps, EG244114

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

R7266 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

85737784-85754981 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to T at 85738274 bp

Zygosity

Heterozygous

Amino Acid Change

Serine to Stop codon at position 694 (S694*)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

Predicted Effect

probably null
Transcript: ENSMUST00000063425
AA Change: S694*

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: S694*

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam18	T	A	8: 24,667,623	I104F	probably benign	Het
Adgrg7	C	T	16: 56,770,311	V166I	probably benign	Het
Agfg1	G	T	1: 82,882,245	V278L	probably benign	Het
Alpk3	A	G	7: 81,092,580	E715G	possibly damaging	Het
Ap2m1	A	G	16: 20,543,345	Y401C	probably damaging	Het
Arhgef28	C	T	13: 97,965,452	S838N	probably benign	Het
Ash2l	A	T	8: 25,827,205	Y373*	probably null	Het
Best2	C	T	8: 85,007,764	V442I	probably benign	Het
Col4a2	T	C	8: 11,425,542		probably null	Het
Fat2	T	A	11: 55,285,030	D1619V	probably damaging	Het
Fer1l6	A	T	15: 58,627,597	N1272I	probably benign	Het
Gcc1	T	A	6: 28,417,996	*779C	probably null	Het
Gm12216	G	A	11: 53,859,251		probably benign	Het
Gm17657	C	A	17: 29,519,373	V140L	probably benign	Het
Gm7102	A	G	19: 61,175,535	V154A	possibly damaging	Het
Grm2	C	T	9: 106,647,171	V311I		Het
Immt	T	A	6: 71,874,705	D683E	probably benign	Het
Itga8	T	G	2: 12,232,901	D336A	probably damaging	Het
Jhy	T	C	9: 40,961,157	T19A	probably benign	Het
Kcnq2	T	C	2: 181,135,092	M1V	probably null	Het
Kctd17	A	T	15: 78,433,014	I117F	probably damaging	Het
Lrp6	T	C	6: 134,507,401	T420A	probably damaging	Het
Manba	T	C	3: 135,517,912	S187P	probably damaging	Het
Mef2b	A	T	8: 70,164,288	D13V	probably damaging	Het
Mical2	T	C	7: 112,303,756	F145L	probably damaging	Het
Mphosph8	T	A	14: 56,685,040	D551E	possibly damaging	Het
Myo10	C	G	15: 25,782,981	R1170G	probably damaging	Het
Myo16	A	C	8: 10,272,687	Q39P	unknown	Het
Myo1f	A	G	17: 33,601,694	E837G	probably benign	Het
Nell2	T	A	15: 95,435,393	I128F	possibly damaging	Het
Olfr1357	A	G	10: 78,612,614	V9A	probably benign	Het
Pcdh15	A	T	10: 74,379,390	R659*	probably null	Het
Pcdhga1	A	G	18: 37,839,975	Q881R	possibly damaging	Het
Plekhm2	T	G	4: 141,642,459	E75A	possibly damaging	Het
Prc1	A	G	7: 80,307,657	K357E	possibly damaging	Het
Pxk	T	A	14: 8,146,220	C377S	probably benign	Het
Ralgapa2	T	C	2: 146,334,568	E1696G	probably damaging	Het
Rbbp6	T	A	7: 123,001,367	S1532R	unknown	Het
Scn5a	G	T	9: 119,562,560	A22E	probably benign	Het
Sctr	G	A	1: 120,022,225	R48Q	probably benign	Het
Siae	T	C	9: 37,623,013	V115A	probably damaging	Het
Slc16a6	A	G	11: 109,453,281	C563R	probably benign	Het
Sntg1	A	C	1: 8,682,019	V58G	possibly damaging	Het
Snx11	C	T	11: 96,773,159	V36M	probably damaging	Het
Stk3	C	A	15: 34,959,036	S330I	probably benign	Het
Synpo	A	G	18: 60,629,559	F92S	probably benign	Het
Tle1	A	G	4: 72,139,687		probably null	Het
Tmem117	A	G	15: 94,931,803	D173G	possibly damaging	Het
Tmprss5	T	C	9: 49,114,541	W338R	probably benign	Het
Tnfrsf19	T	C	14: 60,974,698	T168A	possibly damaging	Het
Trhde	C	T	10: 114,800,871	G144S	possibly damaging	Het
Trim56	G	T	5: 137,114,243	Q140K	probably damaging	Het
Ttn	C	T	2: 76,732,574	V28679M	probably damaging	Het
Ubxn8	G	A	8: 33,623,203	R208C	probably damaging	Het
Wdr38	T	A	2: 39,000,264	W137R	probably damaging	Het
Zdhhc6	G	T	19: 55,304,500	N271K	probably damaging	Het
Zfyve9	A	G	4: 108,718,547	S446P	possibly damaging	Het
Zmynd8	T	C	2: 165,807,572	Q867R	possibly damaging	Het
Zswim3	T	C	2: 164,820,482	I294T	probably benign	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85749646	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85738334	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85749646	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85738367	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85750711	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85737962	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85750693	missense	probably benign
IGL02514:Vmn2r72	APN	7	85738699	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85738183	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85738671	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85751813	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85752041	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85751176	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85754954	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85750867	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85751836	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85754876	missense	probably benign
R0655:Vmn2r72	UTSW	7	85738111	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85749739	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85751309	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85749188	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85738257	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85749211	missense	probably benign
R1632:Vmn2r72	UTSW	7	85751792	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85738170	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85749161	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85738236	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85738341	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85738256	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85750953	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85751269	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85749642	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85749735	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85751131	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85749809	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4421:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85737828	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85737911	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85737861	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85750598	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85751109	missense	probably benign
R4991:Vmn2r72	UTSW	7	85751130	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85738485	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85737853	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85737840	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85738254	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85750897	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85751942	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85737850	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85750539	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85751174	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85749684	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85737996	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85749803	splice site	probably null
R7189:Vmn2r72	UTSW	7	85754917	missense	probably benign	0.36
R7323:Vmn2r72	UTSW	7	85750563	missense	probably benign
R7426:Vmn2r72	UTSW	7	85751140	missense	probably benign
R7606:Vmn2r72	UTSW	7	85751154	missense	possibly damaging	0.91
R7651:Vmn2r72	UTSW	7	85751938	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85754890	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85750626	missense	probably damaging	1.00
R7843:Vmn2r72	UTSW	7	85749630	missense	probably benign	0.01
R8157:Vmn2r72	UTSW	7	85751233	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85751019	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85751960	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85738175	missense	probably benign
Z1176:Vmn2r72	UTSW	7	85749191	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- GCCCATGTATCCAAGGACACAG -3'
(R):5'- TGCGTCTTCCTGAAACACAG -3'

Sequencing Primer
(F):5'- GTAGAAGGCAATCACTGAACCTTTG -3'
(R):5'- AAACTCTCAGCTATGTACTACTCATC -3'

Posted On

2019-06-26