Mutagenetix > Incidental Mutations

Incidental Mutation 'R2201:Vmn2r72'

238659

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

Vmn2r72-ps, EG244114

MMRRC Submission

040203-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

R2201 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

85737784-85754981 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 85738236 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 707 (I707V)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

Predicted Effect

probably benign
Transcript: ENSMUST00000063425
AA Change: I707V

PolyPhen 2 Score 0.117 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: I707V

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.5%
20x: 95.9%

Validation Efficiency

98% (59/60)

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932431P20Rik	T	A	7: 29,536,525		noncoding transcript	Het
A2ml1	A	T	6: 128,547,305	N1121K	probably null	Het
Actr10	A	G	12: 70,960,021	N351D	probably damaging	Het
Adcy7	G	A	8: 88,317,978	A500T	probably damaging	Het
Ankrd35	T	C	3: 96,679,248	I80T	possibly damaging	Het
Arap2	G	A	5: 62,706,685	T532I	probably damaging	Het
Bag3	AAAGG	AAAGGAAGG	7: 128,545,769		probably null	Het
C77080	A	G	4: 129,222,639	V732A	probably benign	Het
Cc2d2a	T	C	5: 43,684,033		probably benign	Het
Cep85l	A	T	10: 53,348,731	M254K	probably benign	Het
Clic4	A	G	4: 135,223,539	S114P	probably damaging	Het
Ctsj	T	C	13: 61,002,549	Y213C	probably damaging	Het
Ddx28	A	G	8: 106,010,574	V284A	probably damaging	Het
Dnase2b	T	A	3: 146,584,688	D176V	probably damaging	Het
Dsg2	T	A	18: 20,596,054	N663K	probably damaging	Het
Dst	T	A	1: 34,195,921	S3694T	possibly damaging	Het
Emilin1	T	C	5: 30,915,692	S158P	probably benign	Het
Eng	T	C	2: 32,673,740		probably benign	Het
Fam160a2	T	C	7: 105,388,191	N395S	probably damaging	Het
Fam189a1	T	A	7: 64,759,393	M418L	probably benign	Het
Fdxr	C	A	11: 115,270,382	V223L	probably benign	Het
Frem2	T	A	3: 53,516,573	M3148L	probably benign	Het
Hip1	A	T	5: 135,431,730	D114E	probably benign	Het
Itga9	T	C	9: 118,877,115		probably benign	Het
Kcnt2	T	A	1: 140,509,441	N487K	probably damaging	Het
Krt6a	A	G	15: 101,693,171	F172L	probably benign	Het
Megf8	C	T	7: 25,340,745	R1034W	probably damaging	Het
Muc6	C	T	7: 141,649,810	D451N	probably damaging	Het
Myo5a	A	G	9: 75,217,943	T1838A	possibly damaging	Het
N4bp2l2	A	T	5: 150,661,608	D302E	probably damaging	Het
Nbeal2	T	A	9: 110,630,250	I1930F	probably benign	Het
Npas4	A	T	19: 4,987,364	Y301N	probably benign	Het
Nt5m	A	G	11: 59,875,915	K211E	probably benign	Het
Pfn4	A	G	12: 4,774,382		probably null	Het
Pfpl	A	C	19: 12,430,479	D698A	probably benign	Het
Pias1	G	T	9: 62,951,855	H124N	possibly damaging	Het
Pja2	A	T	17: 64,311,167		probably benign	Het
Polr3e	T	C	7: 120,932,242	Y185H	probably benign	Het
Pomc	T	C	12: 3,960,275	L172S	probably benign	Het
Rapgef4	A	G	2: 72,045,189	T129A	probably damaging	Het
Reep1	T	C	6: 71,773,294	S97P	probably damaging	Het
Rttn	T	A	18: 89,010,943	I595N	possibly damaging	Het
Sap30	T	C	8: 57,485,472		probably null	Het
Slc1a7	T	C	4: 107,993,006	Y105H	probably damaging	Het
Slc5a5	C	T	8: 70,892,458	M68I	probably damaging	Het
Stab2	T	A	10: 86,940,639	Y791F	probably benign	Het
Tdrd1	C	A	19: 56,858,661	S911R	probably benign	Het
Tdrd1	C	A	19: 56,858,662	H912N	probably benign	Het
Tgm7	A	T	2: 121,098,581	F278Y	probably damaging	Het
Tln2	T	C	9: 67,375,757	T310A	probably damaging	Het
Tmem256	T	C	11: 69,839,445	I93T	probably benign	Het
Trpm2	G	A	10: 77,920,471	Q1172*	probably null	Het
Ttll8	A	G	15: 88,933,953	V173A	possibly damaging	Het
Ubr5	T	C	15: 38,002,299	S1497G	possibly damaging	Het
Ubr7	G	A	12: 102,761,505		probably null	Het
Vmn1r37	T	A	6: 66,731,894	M1K	probably null	Het
Vmn2r14	A	G	5: 109,218,832		probably null	Het
Vps8	A	G	16: 21,576,757	R1266G	probably damaging	Het
Zfhx4	A	G	3: 5,242,289	N192D	probably damaging	Het
Zfp638	G	C	6: 83,929,518	D222H	probably damaging	Het
Zscan29	A	C	2: 121,169,402	V106G	probably damaging	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85749646	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85738334	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85749646	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85738367	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85750711	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85737962	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85750693	missense	probably benign
IGL02514:Vmn2r72	APN	7	85738699	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85738183	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85738671	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85751813	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85752041	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85751176	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85754954	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85750867	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85751836	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85754876	missense	probably benign
R0655:Vmn2r72	UTSW	7	85738111	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85749739	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85751309	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85749188	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85738257	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85749211	missense	probably benign
R1632:Vmn2r72	UTSW	7	85751792	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85738170	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85749161	missense	probably benign	0.00
R2290:Vmn2r72	UTSW	7	85738341	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85738256	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85750953	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85751269	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85749642	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85749735	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85751131	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85749809	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4421:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85737828	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85737911	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85737861	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85750598	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85751109	missense	probably benign
R4991:Vmn2r72	UTSW	7	85751130	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85738485	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85737853	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85737840	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85738254	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85750897	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85751942	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85737850	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85750539	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85751174	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85749684	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85737996	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85749803	synonymous	probably null
R7189:Vmn2r72	UTSW	7	85754917	missense	probably benign	0.36
R7266:Vmn2r72	UTSW	7	85738274	nonsense	probably null
R7323:Vmn2r72	UTSW	7	85750563	missense	probably benign
R7426:Vmn2r72	UTSW	7	85751140	missense	probably benign
R7606:Vmn2r72	UTSW	7	85751154	missense	possibly damaging	0.91
R7651:Vmn2r72	UTSW	7	85751938	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85754890	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85750626	missense	probably damaging	1.00
R7843:Vmn2r72	UTSW	7	85749630	missense	probably benign	0.01
R7926:Vmn2r72	UTSW	7	85749630	missense	probably benign	0.01
Z1176:Vmn2r72	UTSW	7	85749191	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- TGAATGTATCAGGCAGGTTCC -3'
(R):5'- ATTGGTCATCCCACTACGGTC -3'

Sequencing Primer
(F):5'- GGTTCCTGGCCAAGAAAGCTAC -3'
(R):5'- GGTCATCTGTATCCTGCAGCAG -3'

Posted On

2014-10-02