Incidental Mutation 'R1907:Pik3c2g'
| ID |
214461 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pik3c2g
|
| Ensembl Gene |
ENSMUSG00000030228 |
| Gene Name |
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma |
| Synonyms |
|
| MMRRC Submission |
039926-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.087)
|
| Stock # |
R1907 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
139587221-139969284 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 139844042 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Glutamine
at position 304
(K304Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000151281
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087657]
[ENSMUST00000111868]
[ENSMUST00000218528]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000087657
AA Change: K54Q
PolyPhen 2
Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000084939
Gene: ENSMUSG00000030228
AA Change: K54Q
| Domain | Start | End | E-Value | Type |
|---|
|
PI3Kc
|
125 |
387 |
2.11e-109 |
SMART |
|
PX
|
411 |
515 |
1.24e-21 |
SMART |
|
C2
|
550 |
647 |
1.34e-7 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000111868
AA Change: K422Q
PolyPhen 2
Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000107499
Gene: ENSMUSG00000030228
AA Change: K422Q
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa2
|
1 |
83 |
4e-16 |
SMART |
|
PI3Ka
|
103 |
288 |
7.6e-29 |
SMART |
|
PI3Kc
|
375 |
637 |
2.11e-109 |
SMART |
|
PX
|
661 |
765 |
1.24e-21 |
SMART |
|
C2
|
800 |
897 |
1.34e-7 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000187069
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000187223
|
| SMART Domains |
Protein: ENSMUSP00000140589
Gene: ENSMUSG00000030228
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:PI3_PI4_kinase
|
123 |
226 |
3.4e-16 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000187448
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000189374
|
| SMART Domains |
Protein: ENSMUSP00000139763
Gene: ENSMUSG00000030228
| Domain | Start | End | E-Value | Type |
|---|
|
PI3Kc
|
125 |
387 |
2.11e-109 |
SMART |
|
PX
|
411 |
515 |
1.24e-21 |
SMART |
|
C2
|
550 |
647 |
1.34e-7 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000191013
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206646
AA Change: K54Q
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000218528
AA Change: K304Q
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| Meta Mutation Damage Score |
0.1901 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.6%
- 20x: 93.4%
|
| Validation Efficiency |
98% (104/106) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
PHENOTYPE: Mice homozygous for a knock-out allelel exhibit reduced liver glucogen accumulation, hyperlipidemia, adiposity and insulin resistance with age or after consumption of a high-fat diet. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 104 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca4 |
C |
A |
3: 122,069,012 (GRCm38) |
S206R |
probably damaging |
Het |
| Abcc6 |
G |
T |
7: 46,014,169 (GRCm38) |
A357E |
probably benign |
Het |
| Abhd13 |
T |
A |
8: 9,988,170 (GRCm38) |
C256S |
probably benign |
Het |
| Actrt3 |
A |
G |
3: 30,598,567 (GRCm38) |
V126A |
probably damaging |
Het |
| Adgrv1 |
A |
G |
13: 81,592,551 (GRCm38) |
|
probably benign |
Het |
| Alyref2 |
A |
G |
1: 171,504,270 (GRCm38) |
D205G |
probably damaging |
Het |
| Amigo3 |
G |
A |
9: 108,053,636 (GRCm38) |
R86Q |
probably benign |
Het |
| Ankrd50 |
G |
C |
3: 38,454,052 (GRCm38) |
P1389A |
probably damaging |
Het |
| Aoah |
A |
G |
13: 20,910,094 (GRCm38) |
D183G |
probably damaging |
Het |
| Arap3 |
A |
T |
18: 37,996,671 (GRCm38) |
S146T |
probably benign |
Het |
| Atp2c2 |
T |
C |
8: 119,749,876 (GRCm38) |
|
probably benign |
Het |
| Atp8b2 |
C |
T |
3: 89,946,276 (GRCm38) |
V682M |
probably benign |
Het |
| Cacna1i |
T |
C |
15: 80,375,264 (GRCm38) |
I1245T |
probably damaging |
Het |
| Card14 |
A |
G |
11: 119,331,259 (GRCm38) |
N460S |
probably benign |
Het |
| Ceacam5 |
A |
G |
7: 17,752,384 (GRCm38) |
D602G |
possibly damaging |
Het |
| Cecr2 |
T |
A |
6: 120,761,160 (GRCm38) |
H921Q |
probably benign |
Het |
| Cyb5d1 |
T |
C |
11: 69,394,740 (GRCm38) |
D115G |
probably benign |
Het |
| Dbp |
C |
T |
7: 45,708,320 (GRCm38) |
T67I |
possibly damaging |
Het |
| Dennd5b |
C |
T |
6: 149,041,576 (GRCm38) |
V601I |
probably benign |
Het |
| Dnah11 |
G |
A |
12: 118,127,556 (GRCm38) |
A947V |
possibly damaging |
Het |
| Dpysl3 |
T |
A |
18: 43,438,128 (GRCm38) |
D27V |
probably damaging |
Het |
| Drd1 |
A |
T |
13: 54,053,252 (GRCm38) |
D307E |
possibly damaging |
Het |
| Dscaml1 |
G |
A |
9: 45,740,480 (GRCm38) |
G277D |
probably damaging |
Het |
| Eif4g3 |
C |
T |
4: 138,158,415 (GRCm38) |
R842W |
probably damaging |
Het |
| Enam |
C |
T |
5: 88,504,622 (GRCm38) |
T1330I |
possibly damaging |
Het |
| Fabp6 |
T |
C |
11: 43,596,167 (GRCm38) |
|
probably null |
Het |
| Fcsk |
A |
T |
8: 110,893,378 (GRCm38) |
L289* |
probably null |
Het |
| Fhip1a |
T |
C |
3: 85,672,633 (GRCm38) |
D755G |
probably benign |
Het |
| Fsip2 |
C |
T |
2: 82,983,428 (GRCm38) |
P3364S |
possibly damaging |
Het |
| Gad1 |
C |
T |
2: 70,579,138 (GRCm38) |
S191F |
possibly damaging |
Het |
| Gcm1 |
A |
C |
9: 78,064,773 (GRCm38) |
N332T |
probably benign |
Het |
| Gin1 |
G |
A |
1: 97,775,447 (GRCm38) |
|
probably benign |
Het |
| Gpr25 |
T |
C |
1: 136,260,800 (GRCm38) |
D25G |
probably benign |
Het |
| Gstm4 |
T |
C |
3: 108,041,277 (GRCm38) |
T172A |
probably benign |
Het |
| Hnrnpll |
A |
G |
17: 80,035,329 (GRCm38) |
|
probably null |
Het |
| Il12rb2 |
T |
A |
6: 67,295,286 (GRCm38) |
K339* |
probably null |
Het |
| Inpp1 |
A |
G |
1: 52,789,670 (GRCm38) |
*397Q |
probably null |
Het |
| Kcp |
G |
T |
6: 29,497,835 (GRCm38) |
|
probably benign |
Het |
| Kdm1b |
G |
A |
13: 47,064,120 (GRCm38) |
V352I |
probably benign |
Het |
| Klhdc2 |
G |
T |
12: 69,296,960 (GRCm38) |
|
probably benign |
Het |
| Krt75 |
T |
A |
15: 101,573,366 (GRCm38) |
T156S |
possibly damaging |
Het |
| Lag3 |
T |
A |
6: 124,909,487 (GRCm38) |
I168F |
possibly damaging |
Het |
| Lama4 |
T |
G |
10: 39,072,758 (GRCm38) |
V839G |
probably benign |
Het |
| Lmtk2 |
G |
T |
5: 144,175,110 (GRCm38) |
V883L |
probably benign |
Het |
| Lrrc37a |
C |
A |
11: 103,457,156 (GRCm38) |
K2904N |
unknown |
Het |
| Macf1 |
A |
T |
4: 123,372,399 (GRCm38) |
I4775N |
probably damaging |
Het |
| Map2k3 |
T |
G |
11: 60,932,229 (GRCm38) |
S3A |
possibly damaging |
Het |
| Mast1 |
G |
A |
8: 84,916,266 (GRCm38) |
R967C |
probably damaging |
Het |
| Mettl2 |
T |
G |
11: 105,126,840 (GRCm38) |
S59A |
probably benign |
Het |
| Mtr |
G |
A |
13: 12,225,532 (GRCm38) |
T530I |
probably damaging |
Het |
| Myo7b |
A |
T |
18: 31,976,999 (GRCm38) |
C1137S |
possibly damaging |
Het |
| Nacad |
T |
A |
11: 6,602,540 (GRCm38) |
H217L |
probably benign |
Het |
| Ncstn |
A |
T |
1: 172,072,143 (GRCm38) |
V324E |
probably damaging |
Het |
| Ndufaf7 |
C |
A |
17: 78,942,117 (GRCm38) |
H148N |
possibly damaging |
Het |
| Or10a49 |
T |
A |
7: 108,868,498 (GRCm38) |
I219F |
possibly damaging |
Het |
| Or52a24 |
T |
A |
7: 103,731,983 (GRCm38) |
I19N |
probably damaging |
Het |
| Or52n2b |
G |
A |
7: 104,917,065 (GRCm38) |
T77I |
probably damaging |
Het |
| Or7g12 |
T |
C |
9: 18,988,441 (GRCm38) |
I151T |
possibly damaging |
Het |
| Or8b12 |
T |
G |
9: 37,746,433 (GRCm38) |
L100V |
probably benign |
Het |
| Or8k17 |
T |
C |
2: 86,236,110 (GRCm38) |
K242E |
possibly damaging |
Het |
| Pcdh20 |
T |
C |
14: 88,468,704 (GRCm38) |
I387V |
probably benign |
Het |
| Pclo |
A |
G |
5: 14,678,511 (GRCm38) |
|
probably benign |
Het |
| Pcp2 |
G |
A |
8: 3,624,904 (GRCm38) |
|
probably benign |
Het |
| Pde1a |
T |
A |
2: 79,868,307 (GRCm38) |
D393V |
probably damaging |
Het |
| Pias4 |
T |
C |
10: 81,154,363 (GRCm38) |
D421G |
possibly damaging |
Het |
| Pign |
T |
C |
1: 105,638,215 (GRCm38) |
T362A |
possibly damaging |
Het |
| Pkd2 |
T |
A |
5: 104,486,806 (GRCm38) |
W568R |
probably damaging |
Het |
| Pld2 |
T |
A |
11: 70,544,184 (GRCm38) |
I306N |
probably damaging |
Het |
| Plppr3 |
T |
C |
10: 79,874,069 (GRCm38) |
K9R |
probably damaging |
Het |
| Pramel11 |
T |
A |
4: 143,895,491 (GRCm38) |
R431S |
possibly damaging |
Het |
| Psme4 |
T |
C |
11: 30,810,922 (GRCm38) |
V397A |
probably damaging |
Het |
| Ptbp2 |
A |
T |
3: 119,761,749 (GRCm38) |
S23R |
probably damaging |
Het |
| Ptpn13 |
A |
G |
5: 103,580,709 (GRCm38) |
D2074G |
probably null |
Het |
| Rab34 |
T |
A |
11: 78,191,255 (GRCm38) |
L166H |
probably damaging |
Het |
| Rabgap1l |
T |
A |
1: 160,645,310 (GRCm38) |
R519S |
probably benign |
Het |
| Rasa1 |
A |
T |
13: 85,226,572 (GRCm38) |
L218* |
probably null |
Het |
| Reln |
A |
G |
5: 22,044,962 (GRCm38) |
|
probably null |
Het |
| Rer1 |
T |
C |
4: 155,078,499 (GRCm38) |
D94G |
possibly damaging |
Het |
| Rhpn1 |
T |
C |
15: 75,711,824 (GRCm38) |
V386A |
probably benign |
Het |
| Samd3 |
T |
A |
10: 26,271,856 (GRCm38) |
C476* |
probably null |
Het |
| Sdk2 |
C |
T |
11: 113,838,646 (GRCm38) |
|
silent |
Het |
| Sipa1l3 |
A |
G |
7: 29,339,167 (GRCm38) |
S352P |
possibly damaging |
Het |
| Slc27a2 |
A |
G |
2: 126,586,342 (GRCm38) |
Y549C |
probably benign |
Het |
| Slc7a9 |
A |
G |
7: 35,449,854 (GRCm38) |
T7A |
probably benign |
Het |
| Slco4c1 |
C |
T |
1: 96,842,499 (GRCm38) |
G280D |
probably damaging |
Het |
| Snx19 |
T |
A |
9: 30,433,576 (GRCm38) |
V657E |
probably damaging |
Het |
| Spata31d1c |
A |
G |
13: 65,035,876 (GRCm38) |
M411V |
probably benign |
Het |
| Spice1 |
T |
A |
16: 44,357,830 (GRCm38) |
L72* |
probably null |
Het |
| Stard9 |
G |
T |
2: 120,713,812 (GRCm38) |
V4471L |
probably damaging |
Het |
| Syt14 |
A |
G |
1: 192,901,835 (GRCm38) |
L707P |
probably damaging |
Het |
| Tab1 |
T |
C |
15: 80,153,668 (GRCm38) |
I234T |
probably damaging |
Het |
| Tas2r107 |
T |
C |
6: 131,659,988 (GRCm38) |
M33V |
probably benign |
Het |
| Tbx4 |
T |
A |
11: 85,914,523 (GRCm38) |
S479R |
possibly damaging |
Het |
| Tssk5 |
C |
T |
15: 76,372,893 (GRCm38) |
R263Q |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,870,856 (GRCm38) |
|
probably benign |
Het |
| Ugt2b5 |
T |
A |
5: 87,139,630 (GRCm38) |
Q226L |
probably benign |
Het |
| Ush2a |
C |
T |
1: 188,715,064 (GRCm38) |
S2483L |
probably benign |
Het |
| Wdr95 |
A |
G |
5: 149,552,426 (GRCm38) |
Y63C |
probably damaging |
Het |
| Xirp2 |
A |
G |
2: 67,516,356 (GRCm38) |
I2980M |
probably damaging |
Het |
| Yeats4 |
G |
A |
10: 117,215,731 (GRCm38) |
T207I |
probably benign |
Het |
| Ythdc1 |
A |
G |
5: 86,830,630 (GRCm38) |
R561G |
probably damaging |
Het |
| Zbtb14 |
G |
A |
17: 69,387,390 (GRCm38) |
E28K |
possibly damaging |
Het |
| Zfp931 |
A |
T |
2: 178,069,891 (GRCm38) |
L21Q |
probably damaging |
Het |
| Zyg11b |
A |
C |
4: 108,255,226 (GRCm38) |
M415R |
probably damaging |
Het |
|
| Other mutations in Pik3c2g |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00159:Pik3c2g
|
APN |
6 |
139,896,125 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01355:Pik3c2g
|
APN |
6 |
139,852,857 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01579:Pik3c2g
|
APN |
6 |
139,754,741 (GRCm38) |
nonsense |
probably null |
|
|
IGL01580:Pik3c2g
|
APN |
6 |
139,622,516 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01587:Pik3c2g
|
APN |
6 |
139,754,741 (GRCm38) |
nonsense |
probably null |
|
|
IGL01813:Pik3c2g
|
APN |
6 |
139,622,409 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
IGL02218:Pik3c2g
|
APN |
6 |
139,860,355 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02479:Pik3c2g
|
APN |
6 |
139,918,004 (GRCm38) |
missense |
probably benign |
0.40 |
|
IGL02480:Pik3c2g
|
APN |
6 |
139,852,800 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02721:Pik3c2g
|
APN |
6 |
139,736,973 (GRCm38) |
missense |
probably benign |
0.15 |
|
IGL02967:Pik3c2g
|
APN |
6 |
139,967,828 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL03221:Pik3c2g
|
APN |
6 |
139,772,407 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
FR4304:Pik3c2g
|
UTSW |
6 |
139,635,656 (GRCm38) |
frame shift |
probably null |
|
|
FR4340:Pik3c2g
|
UTSW |
6 |
139,635,656 (GRCm38) |
frame shift |
probably null |
|
|
FR4976:Pik3c2g
|
UTSW |
6 |
139,635,654 (GRCm38) |
frame shift |
probably null |
|
|
IGL02837:Pik3c2g
|
UTSW |
6 |
139,626,564 (GRCm38) |
nonsense |
probably null |
|
|
PIT4531001:Pik3c2g
|
UTSW |
6 |
139,859,370 (GRCm38) |
missense |
|
|
|
R0002:Pik3c2g
|
UTSW |
6 |
139,768,745 (GRCm38) |
missense |
probably benign |
0.08 |
|
R0081:Pik3c2g
|
UTSW |
6 |
139,957,793 (GRCm38) |
missense |
probably benign |
0.05 |
|
R0098:Pik3c2g
|
UTSW |
6 |
139,662,443 (GRCm38) |
missense |
unknown |
|
|
R0719:Pik3c2g
|
UTSW |
6 |
139,629,725 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0740:Pik3c2g
|
UTSW |
6 |
139,633,793 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0837:Pik3c2g
|
UTSW |
6 |
139,957,699 (GRCm38) |
splice site |
probably benign |
|
|
R0840:Pik3c2g
|
UTSW |
6 |
139,896,072 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1306:Pik3c2g
|
UTSW |
6 |
139,772,428 (GRCm38) |
missense |
probably benign |
|
|
R1501:Pik3c2g
|
UTSW |
6 |
139,844,070 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1591:Pik3c2g
|
UTSW |
6 |
139,748,178 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1666:Pik3c2g
|
UTSW |
6 |
139,635,636 (GRCm38) |
intron |
probably benign |
|
|
R1970:Pik3c2g
|
UTSW |
6 |
139,900,386 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1982:Pik3c2g
|
UTSW |
6 |
139,622,548 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2171:Pik3c2g
|
UTSW |
6 |
139,855,286 (GRCm38) |
nonsense |
probably null |
|
|
R2188:Pik3c2g
|
UTSW |
6 |
139,852,874 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3777:Pik3c2g
|
UTSW |
6 |
139,622,387 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3778:Pik3c2g
|
UTSW |
6 |
139,622,387 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3965:Pik3c2g
|
UTSW |
6 |
139,855,292 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R4076:Pik3c2g
|
UTSW |
6 |
139,852,863 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4078:Pik3c2g
|
UTSW |
6 |
139,635,610 (GRCm38) |
intron |
probably benign |
|
|
R4108:Pik3c2g
|
UTSW |
6 |
139,730,370 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4461:Pik3c2g
|
UTSW |
6 |
139,841,681 (GRCm38) |
intron |
probably benign |
|
|
R4474:Pik3c2g
|
UTSW |
6 |
139,633,751 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4509:Pik3c2g
|
UTSW |
6 |
139,720,006 (GRCm38) |
missense |
probably benign |
0.25 |
|
R4646:Pik3c2g
|
UTSW |
6 |
139,720,018 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4732:Pik3c2g
|
UTSW |
6 |
139,935,985 (GRCm38) |
missense |
probably benign |
0.28 |
|
R4733:Pik3c2g
|
UTSW |
6 |
139,935,985 (GRCm38) |
missense |
probably benign |
0.28 |
|
R4854:Pik3c2g
|
UTSW |
6 |
139,768,779 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4928:Pik3c2g
|
UTSW |
6 |
139,967,802 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R4959:Pik3c2g
|
UTSW |
6 |
139,843,931 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R4973:Pik3c2g
|
UTSW |
6 |
139,843,931 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R5032:Pik3c2g
|
UTSW |
6 |
139,896,202 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5071:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5072:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5073:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5074:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5107:Pik3c2g
|
UTSW |
6 |
139,635,625 (GRCm38) |
intron |
probably benign |
|
|
R5186:Pik3c2g
|
UTSW |
6 |
139,622,018 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5253:Pik3c2g
|
UTSW |
6 |
139,896,257 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5359:Pik3c2g
|
UTSW |
6 |
139,622,123 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5394:Pik3c2g
|
UTSW |
6 |
139,720,082 (GRCm38) |
missense |
probably benign |
|
|
R5417:Pik3c2g
|
UTSW |
6 |
139,736,943 (GRCm38) |
missense |
probably benign |
|
|
R5435:Pik3c2g
|
UTSW |
6 |
139,715,855 (GRCm38) |
splice site |
probably null |
|
|
R5580:Pik3c2g
|
UTSW |
6 |
139,626,533 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5664:Pik3c2g
|
UTSW |
6 |
139,737,007 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5908:Pik3c2g
|
UTSW |
6 |
139,768,710 (GRCm38) |
missense |
|
|
|
R5914:Pik3c2g
|
UTSW |
6 |
139,622,479 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6046:Pik3c2g
|
UTSW |
6 |
139,896,792 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6046:Pik3c2g
|
UTSW |
6 |
139,622,139 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R6298:Pik3c2g
|
UTSW |
6 |
139,626,563 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6382:Pik3c2g
|
UTSW |
6 |
139,719,998 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R6480:Pik3c2g
|
UTSW |
6 |
139,730,469 (GRCm38) |
missense |
probably benign |
0.27 |
|
R6917:Pik3c2g
|
UTSW |
6 |
139,896,173 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6929:Pik3c2g
|
UTSW |
6 |
139,957,776 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R7022:Pik3c2g
|
UTSW |
6 |
139,622,063 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R7144:Pik3c2g
|
UTSW |
6 |
139,629,870 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7213:Pik3c2g
|
UTSW |
6 |
139,860,264 (GRCm38) |
missense |
|
|
|
R7215:Pik3c2g
|
UTSW |
6 |
139,754,863 (GRCm38) |
missense |
|
|
|
R7332:Pik3c2g
|
UTSW |
6 |
139,896,255 (GRCm38) |
missense |
|
|
|
R7357:Pik3c2g
|
UTSW |
6 |
139,633,793 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7359:Pik3c2g
|
UTSW |
6 |
139,967,894 (GRCm38) |
missense |
unknown |
|
|
R7385:Pik3c2g
|
UTSW |
6 |
139,855,353 (GRCm38) |
missense |
|
|
|
R7455:Pik3c2g
|
UTSW |
6 |
139,967,917 (GRCm38) |
missense |
unknown |
|
|
R7651:Pik3c2g
|
UTSW |
6 |
139,622,072 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R7888:Pik3c2g
|
UTSW |
6 |
139,896,744 (GRCm38) |
missense |
|
|
|
R7923:Pik3c2g
|
UTSW |
6 |
139,633,793 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7964:Pik3c2g
|
UTSW |
6 |
139,882,060 (GRCm38) |
missense |
|
|
|
R8005:Pik3c2g
|
UTSW |
6 |
139,622,069 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8371:Pik3c2g
|
UTSW |
6 |
139,936,056 (GRCm38) |
missense |
unknown |
|
|
R8724:Pik3c2g
|
UTSW |
6 |
139,967,893 (GRCm38) |
missense |
unknown |
|
|
R8733:Pik3c2g
|
UTSW |
6 |
139,768,700 (GRCm38) |
nonsense |
probably null |
|
|
R8809:Pik3c2g
|
UTSW |
6 |
139,768,710 (GRCm38) |
missense |
|
|
|
R8888:Pik3c2g
|
UTSW |
6 |
139,730,366 (GRCm38) |
nonsense |
probably null |
|
|
R8931:Pik3c2g
|
UTSW |
6 |
139,875,367 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9188:Pik3c2g
|
UTSW |
6 |
139,622,403 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9336:Pik3c2g
|
UTSW |
6 |
139,875,435 (GRCm38) |
missense |
|
|
|
R9383:Pik3c2g
|
UTSW |
6 |
139,882,016 (GRCm38) |
nonsense |
probably null |
|
|
R9524:Pik3c2g
|
UTSW |
6 |
139,629,770 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9531:Pik3c2g
|
UTSW |
6 |
139,896,200 (GRCm38) |
missense |
|
|
|
R9630:Pik3c2g
|
UTSW |
6 |
139,622,239 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R9697:Pik3c2g
|
UTSW |
6 |
139,967,791 (GRCm38) |
missense |
unknown |
|
|
R9708:Pik3c2g
|
UTSW |
6 |
139,629,867 (GRCm38) |
missense |
probably benign |
|
|
R9717:Pik3c2g
|
UTSW |
6 |
139,896,184 (GRCm38) |
missense |
|
|
|
RF015:Pik3c2g
|
UTSW |
6 |
139,754,771 (GRCm38) |
missense |
|
|
|
RF032:Pik3c2g
|
UTSW |
6 |
139,635,658 (GRCm38) |
frame shift |
probably null |
|
|
X0024:Pik3c2g
|
UTSW |
6 |
139,860,258 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGACTTATGGTTCCTGCTGGG -3'
(R):5'- CCAGTCATTTGTGTTCCAGTG -3'
Sequencing Primer
(F):5'- GGTGGTTTAAGAAACAAAACCTCC -3'
(R):5'- CATTTGTGTTCCAGTGGTTGAGAC -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation