Incidental Mutation 'R6189:Igf1r'
| ID |
502383 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Igf1r
|
| Ensembl Gene |
ENSMUSG00000005533 |
| Gene Name |
insulin-like growth factor I receptor |
| Synonyms |
IGF-1R, line 186, A330103N21Rik, hyft, CD221 |
| MMRRC Submission |
044329-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R6189 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
67602575-67883416 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 67857084 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 1015
(Y1015*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000005671
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005671]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000005671
AA Change: Y1015*
|
| SMART Domains |
Protein: ENSMUSP00000005671
Gene: ENSMUSG00000005533
AA Change: Y1015*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Recep_L_domain
|
51 |
161 |
1.6e-29 |
PFAM |
|
FU
|
227 |
270 |
2.98e-12 |
SMART |
|
Pfam:Recep_L_domain
|
353 |
467 |
3.8e-32 |
PFAM |
|
FN3
|
490 |
593 |
4.67e-2 |
SMART |
|
FN3
|
612 |
815 |
1.95e-4 |
SMART |
|
FN3
|
833 |
915 |
7.4e-5 |
SMART |
|
low complexity region
|
937 |
954 |
N/A |
INTRINSIC |
|
TyrKc
|
1000 |
1268 |
8.51e-141 |
SMART |
|
low complexity region
|
1285 |
1303 |
N/A |
INTRINSIC |
|
low complexity region
|
1306 |
1319 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000208731
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000208871
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.5%
|
| Validation Efficiency |
97% (74/76) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
PHENOTYPE: Targeted null mutants die at birth of respiratory failure; fetuses exhibit retarded growth, organ hypoplasia, ossification delay and nervous system and epidermal abnormalities. hyft homozygous fetuses are growth retarded and exhibit hydrops fetalis and focal hepatic ischemia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A530064D06Rik |
A |
G |
17: 48,474,222 (GRCm39) |
|
probably benign |
Het |
| Abca8a |
T |
C |
11: 109,921,710 (GRCm39) |
D1448G |
probably damaging |
Het |
| Actn2 |
C |
T |
13: 12,291,326 (GRCm39) |
D693N |
probably damaging |
Het |
| Adam3 |
A |
C |
8: 25,201,352 (GRCm39) |
I267R |
probably benign |
Het |
| Aldh1l2 |
A |
G |
10: 83,343,877 (GRCm39) |
|
probably null |
Het |
| C4bp |
T |
C |
1: 130,564,556 (GRCm39) |
Y376C |
probably damaging |
Het |
| Cacna1h |
A |
G |
17: 25,616,818 (GRCm39) |
W101R |
probably damaging |
Het |
| Ccdc97 |
T |
A |
7: 25,415,523 (GRCm39) |
T47S |
probably benign |
Het |
| Cenatac |
G |
A |
9: 44,321,618 (GRCm39) |
R328C |
probably benign |
Het |
| Cnot6l |
G |
A |
5: 96,246,136 (GRCm39) |
T171I |
probably benign |
Het |
| Cntnap2 |
T |
A |
6: 47,248,232 (GRCm39) |
S1213T |
probably damaging |
Het |
| Cxcl10 |
A |
T |
5: 92,495,972 (GRCm39) |
L55Q |
probably benign |
Het |
| Cyp1a1 |
T |
C |
9: 57,607,966 (GRCm39) |
V198A |
probably damaging |
Het |
| Dclre1b |
A |
G |
3: 103,710,849 (GRCm39) |
V354A |
probably damaging |
Het |
| Dmxl1 |
C |
T |
18: 50,026,402 (GRCm39) |
H1837Y |
probably benign |
Het |
| Dnajc13 |
G |
C |
9: 104,091,085 (GRCm39) |
D665E |
probably benign |
Het |
| Dnmbp |
T |
C |
19: 43,878,748 (GRCm39) |
T108A |
probably benign |
Het |
| Dnmbp |
T |
A |
19: 43,889,950 (GRCm39) |
T606S |
probably benign |
Het |
| Dok5 |
T |
A |
2: 170,642,771 (GRCm39) |
I23N |
probably damaging |
Het |
| Eml2 |
G |
A |
7: 18,935,088 (GRCm39) |
V432I |
probably damaging |
Het |
| Epha5 |
A |
T |
5: 84,385,399 (GRCm39) |
F311I |
probably damaging |
Het |
| Erbb4 |
T |
A |
1: 68,083,075 (GRCm39) |
M1059L |
probably benign |
Het |
| Fbxo40 |
A |
G |
16: 36,786,526 (GRCm39) |
I681T |
probably benign |
Het |
| Flg2 |
T |
A |
3: 93,127,381 (GRCm39) |
C2098S |
unknown |
Het |
| Gpr87 |
T |
A |
3: 59,086,650 (GRCm39) |
D285V |
probably damaging |
Het |
| Hrh1 |
T |
A |
6: 114,456,959 (GRCm39) |
V80D |
probably damaging |
Het |
| Hunk |
G |
A |
16: 90,284,769 (GRCm39) |
R351K |
probably benign |
Het |
| Ifna12 |
A |
G |
4: 88,521,248 (GRCm39) |
W100R |
probably damaging |
Het |
| Ift57 |
G |
A |
16: 49,584,176 (GRCm39) |
G310S |
probably damaging |
Het |
| Igkv14-130 |
T |
C |
6: 67,768,432 (GRCm39) |
I96T |
probably damaging |
Het |
| Il34 |
C |
T |
8: 111,469,350 (GRCm39) |
S155N |
probably benign |
Het |
| Itga7 |
T |
C |
10: 128,786,272 (GRCm39) |
S938P |
possibly damaging |
Het |
| Itgam |
A |
G |
7: 127,711,676 (GRCm39) |
M764V |
probably benign |
Het |
| Lao1 |
T |
A |
4: 118,825,077 (GRCm39) |
M299K |
probably benign |
Het |
| Lnpep |
A |
T |
17: 17,787,001 (GRCm39) |
S533T |
possibly damaging |
Het |
| Lrp4 |
T |
C |
2: 91,305,579 (GRCm39) |
V283A |
possibly damaging |
Het |
| Magi3 |
G |
T |
3: 103,958,181 (GRCm39) |
H635N |
probably damaging |
Het |
| Mecr |
A |
T |
4: 131,592,565 (GRCm39) |
|
probably null |
Het |
| Mgrn1 |
T |
C |
16: 4,728,674 (GRCm39) |
|
probably null |
Het |
| Mical2 |
A |
C |
7: 112,012,087 (GRCm39) |
N646H |
probably damaging |
Het |
| Mymk |
C |
T |
2: 26,957,377 (GRCm39) |
V39I |
possibly damaging |
Het |
| Nav3 |
T |
C |
10: 109,555,880 (GRCm39) |
S1684G |
probably damaging |
Het |
| Ntn5 |
A |
T |
7: 45,342,644 (GRCm39) |
D330V |
probably benign |
Het |
| Nup42 |
G |
T |
5: 24,380,452 (GRCm39) |
G149V |
probably damaging |
Het |
| Nutm2 |
T |
A |
13: 50,623,774 (GRCm39) |
V157D |
possibly damaging |
Het |
| Obscn |
T |
C |
11: 58,960,760 (GRCm39) |
I3460V |
probably benign |
Het |
| Or8u10 |
A |
T |
2: 85,915,257 (GRCm39) |
M288K |
possibly damaging |
Het |
| Pakap |
A |
G |
4: 57,855,928 (GRCm39) |
E419G |
probably benign |
Het |
| Pcdh15 |
C |
T |
10: 74,178,483 (GRCm39) |
A580V |
probably null |
Het |
| Pcdhb10 |
T |
A |
18: 37,545,456 (GRCm39) |
H177Q |
probably damaging |
Het |
| Pitx2 |
T |
C |
3: 129,012,118 (GRCm39) |
Y130H |
probably damaging |
Het |
| Pmch |
G |
T |
10: 87,927,248 (GRCm39) |
|
probably null |
Het |
| Pofut2 |
T |
A |
10: 77,104,420 (GRCm39) |
I399N |
probably damaging |
Het |
| Prr36 |
C |
A |
8: 4,264,177 (GRCm39) |
|
probably benign |
Het |
| Ptprq |
C |
A |
10: 107,353,748 (GRCm39) |
C2256F |
probably damaging |
Het |
| Rassf5 |
G |
A |
1: 131,172,716 (GRCm39) |
A51V |
probably damaging |
Het |
| Retnla |
A |
G |
16: 48,663,258 (GRCm39) |
I54V |
probably benign |
Het |
| Rimbp2 |
A |
G |
5: 128,880,961 (GRCm39) |
L142P |
probably benign |
Het |
| Ripk1 |
A |
G |
13: 34,216,484 (GRCm39) |
T564A |
probably benign |
Het |
| Robo4 |
G |
A |
9: 37,314,829 (GRCm39) |
E228K |
probably benign |
Het |
| Rsf1 |
GGCG |
GGCGACGGCTGCG |
7: 97,229,113 (GRCm39) |
|
probably benign |
Homo |
| Rusc1 |
A |
T |
3: 88,996,319 (GRCm39) |
L132Q |
probably damaging |
Het |
| Serpinb9h |
A |
T |
13: 33,588,427 (GRCm39) |
E337D |
probably benign |
Het |
| Setd1a |
T |
C |
7: 127,377,455 (GRCm39) |
|
probably null |
Het |
| Slc38a6 |
A |
T |
12: 73,356,970 (GRCm39) |
K122M |
probably damaging |
Het |
| Speer4a2 |
A |
G |
5: 26,290,691 (GRCm39) |
I160T |
probably benign |
Het |
| Susd5 |
A |
T |
9: 113,924,726 (GRCm39) |
D203V |
probably damaging |
Het |
| Trip4 |
G |
A |
9: 65,786,434 (GRCm39) |
R110* |
probably null |
Het |
| Tuba4a |
T |
A |
1: 75,193,518 (GRCm39) |
I95F |
probably benign |
Het |
| Ube2q2 |
T |
A |
9: 55,070,267 (GRCm39) |
S70T |
probably benign |
Het |
| Umodl1 |
A |
G |
17: 31,215,256 (GRCm39) |
I1027V |
possibly damaging |
Het |
| Unc80 |
G |
A |
1: 66,716,630 (GRCm39) |
V2917I |
probably benign |
Het |
| Vmn1r70 |
T |
A |
7: 10,367,598 (GRCm39) |
C29S |
probably benign |
Het |
| Vmn2r94 |
A |
T |
17: 18,477,996 (GRCm39) |
D138E |
probably benign |
Het |
| Wee2 |
C |
T |
6: 40,426,617 (GRCm39) |
H129Y |
probably damaging |
Het |
| Zfp318 |
TGAAGAAGAAGAAGAAGAAGAAGAAGAAG |
TGAAGAAGAAGAAGAAGAAGAAG |
17: 46,723,440 (GRCm39) |
|
probably benign |
Het |
| Zfp872 |
A |
T |
9: 22,108,427 (GRCm39) |
D42V |
probably benign |
Het |
| Zic5 |
T |
G |
14: 122,702,386 (GRCm39) |
D115A |
unknown |
Het |
|
| Other mutations in Igf1r |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00742:Igf1r
|
APN |
7 |
67,839,771 (GRCm39) |
missense |
probably benign |
|
|
IGL00837:Igf1r
|
APN |
7 |
67,851,100 (GRCm39) |
splice site |
probably benign |
|
|
IGL01515:Igf1r
|
APN |
7 |
67,857,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01572:Igf1r
|
APN |
7 |
67,843,189 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02100:Igf1r
|
APN |
7 |
67,839,706 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02506:Igf1r
|
APN |
7 |
67,843,144 (GRCm39) |
missense |
probably benign |
|
|
IGL02672:Igf1r
|
APN |
7 |
67,839,781 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02701:Igf1r
|
APN |
7 |
67,850,997 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02742:Igf1r
|
APN |
7 |
67,839,739 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03073:Igf1r
|
APN |
7 |
67,864,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03257:Igf1r
|
APN |
7 |
67,864,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Frufru
|
UTSW |
7 |
67,653,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Hungarian
|
UTSW |
7 |
67,864,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mimi
|
UTSW |
7 |
67,844,774 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
Piroshka
|
UTSW |
7 |
67,857,084 (GRCm39) |
nonsense |
probably null |
|
|
Romanian
|
UTSW |
7 |
67,653,885 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Sublime
|
UTSW |
7 |
67,653,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Toy
|
UTSW |
7 |
67,653,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB009:Igf1r
|
UTSW |
7 |
67,861,802 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
BB019:Igf1r
|
UTSW |
7 |
67,861,802 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
FR4548:Igf1r
|
UTSW |
7 |
67,875,934 (GRCm39) |
small insertion |
probably benign |
|
|
FR4737:Igf1r
|
UTSW |
7 |
67,875,929 (GRCm39) |
small insertion |
probably benign |
|
|
FR4976:Igf1r
|
UTSW |
7 |
67,875,934 (GRCm39) |
small insertion |
probably benign |
|
|
FR4976:Igf1r
|
UTSW |
7 |
67,875,929 (GRCm39) |
small insertion |
probably benign |
|
|
PIT4445001:Igf1r
|
UTSW |
7 |
67,857,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0003:Igf1r
|
UTSW |
7 |
67,814,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0184:Igf1r
|
UTSW |
7 |
67,875,941 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0538:Igf1r
|
UTSW |
7 |
67,857,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0632:Igf1r
|
UTSW |
7 |
67,814,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0727:Igf1r
|
UTSW |
7 |
67,861,906 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0750:Igf1r
|
UTSW |
7 |
67,861,839 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1104:Igf1r
|
UTSW |
7 |
67,844,774 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1169:Igf1r
|
UTSW |
7 |
67,814,875 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1348:Igf1r
|
UTSW |
7 |
67,868,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Igf1r
|
UTSW |
7 |
67,653,585 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1580:Igf1r
|
UTSW |
7 |
67,857,617 (GRCm39) |
missense |
probably benign |
|
|
R1745:Igf1r
|
UTSW |
7 |
67,819,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1772:Igf1r
|
UTSW |
7 |
67,844,822 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1789:Igf1r
|
UTSW |
7 |
67,864,681 (GRCm39) |
nonsense |
probably null |
|
|
R1823:Igf1r
|
UTSW |
7 |
67,844,729 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1902:Igf1r
|
UTSW |
7 |
67,850,997 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1962:Igf1r
|
UTSW |
7 |
67,857,023 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2179:Igf1r
|
UTSW |
7 |
67,653,698 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2215:Igf1r
|
UTSW |
7 |
67,814,982 (GRCm39) |
missense |
probably benign |
|
|
R2221:Igf1r
|
UTSW |
7 |
67,851,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2233:Igf1r
|
UTSW |
7 |
67,861,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2234:Igf1r
|
UTSW |
7 |
67,861,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2235:Igf1r
|
UTSW |
7 |
67,861,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3023:Igf1r
|
UTSW |
7 |
67,833,147 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4044:Igf1r
|
UTSW |
7 |
67,839,810 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4226:Igf1r
|
UTSW |
7 |
67,844,826 (GRCm39) |
nonsense |
probably null |
|
|
R4387:Igf1r
|
UTSW |
7 |
67,819,757 (GRCm39) |
missense |
probably benign |
|
|
R4388:Igf1r
|
UTSW |
7 |
67,819,757 (GRCm39) |
missense |
probably benign |
|
|
R4728:Igf1r
|
UTSW |
7 |
67,839,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4781:Igf1r
|
UTSW |
7 |
67,814,947 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R5254:Igf1r
|
UTSW |
7 |
67,857,067 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5278:Igf1r
|
UTSW |
7 |
67,843,166 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5510:Igf1r
|
UTSW |
7 |
67,843,107 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5522:Igf1r
|
UTSW |
7 |
67,833,258 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5527:Igf1r
|
UTSW |
7 |
67,857,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5761:Igf1r
|
UTSW |
7 |
67,857,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5849:Igf1r
|
UTSW |
7 |
67,839,781 (GRCm39) |
missense |
probably benign |
|
|
R6262:Igf1r
|
UTSW |
7 |
67,653,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6285:Igf1r
|
UTSW |
7 |
67,653,885 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6318:Igf1r
|
UTSW |
7 |
67,814,981 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6365:Igf1r
|
UTSW |
7 |
67,839,798 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6377:Igf1r
|
UTSW |
7 |
67,850,998 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6831:Igf1r
|
UTSW |
7 |
67,857,067 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R6848:Igf1r
|
UTSW |
7 |
67,653,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6902:Igf1r
|
UTSW |
7 |
67,653,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7193:Igf1r
|
UTSW |
7 |
67,836,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7373:Igf1r
|
UTSW |
7 |
67,844,826 (GRCm39) |
nonsense |
probably null |
|
|
R7442:Igf1r
|
UTSW |
7 |
67,823,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7903:Igf1r
|
UTSW |
7 |
67,834,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7923:Igf1r
|
UTSW |
7 |
67,839,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7932:Igf1r
|
UTSW |
7 |
67,861,802 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8368:Igf1r
|
UTSW |
7 |
67,836,796 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8458:Igf1r
|
UTSW |
7 |
67,845,377 (GRCm39) |
missense |
probably benign |
|
|
R8539:Igf1r
|
UTSW |
7 |
67,653,596 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8704:Igf1r
|
UTSW |
7 |
67,819,802 (GRCm39) |
splice site |
probably benign |
|
|
R8746:Igf1r
|
UTSW |
7 |
67,864,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8829:Igf1r
|
UTSW |
7 |
67,875,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8832:Igf1r
|
UTSW |
7 |
67,875,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8859:Igf1r
|
UTSW |
7 |
67,833,211 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R9057:Igf1r
|
UTSW |
7 |
67,833,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9243:Igf1r
|
UTSW |
7 |
67,861,775 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9342:Igf1r
|
UTSW |
7 |
67,844,746 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9412:Igf1r
|
UTSW |
7 |
67,857,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9525:Igf1r
|
UTSW |
7 |
67,864,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9727:Igf1r
|
UTSW |
7 |
67,857,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9730:Igf1r
|
UTSW |
7 |
67,839,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9779:Igf1r
|
UTSW |
7 |
67,654,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF025:Igf1r
|
UTSW |
7 |
67,875,927 (GRCm39) |
small insertion |
probably benign |
|
|
RF032:Igf1r
|
UTSW |
7 |
67,875,927 (GRCm39) |
small insertion |
probably benign |
|
|
RF034:Igf1r
|
UTSW |
7 |
67,875,924 (GRCm39) |
small insertion |
probably benign |
|
|
RF037:Igf1r
|
UTSW |
7 |
67,875,924 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Igf1r
|
UTSW |
7 |
67,875,924 (GRCm39) |
small insertion |
probably benign |
|
|
RF044:Igf1r
|
UTSW |
7 |
67,875,927 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,916 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,930 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,928 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,922 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,917 (GRCm39) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
67,875,918 (GRCm39) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
67,875,917 (GRCm39) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
67,875,921 (GRCm39) |
small insertion |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GAGATTGAGTACCCGTGCTG -3'
(R):5'- ACAGGGTGGTCCTTTCTGTC -3'
Sequencing Primer
(F):5'- ATTGAGTACCCGTGCTGGACTG -3'
(R):5'- AGGGTGGTCCTTTCTGTCCATAC -3'
|
| Posted On |
2018-02-27 |
Incidental Mutation