Incidental Mutation 'R5254:Igf1r'
| ID |
399346 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Igf1r
|
| Ensembl Gene |
ENSMUSG00000005533 |
| Gene Name |
insulin-like growth factor I receptor |
| Synonyms |
IGF-1R, line 186, A330103N21Rik, hyft, CD221 |
| MMRRC Submission |
042825-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5254 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
67602575-67883416 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 67857067 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 1010
(S1010T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000005671
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005671]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000005671
AA Change: S1010T
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000005671
Gene: ENSMUSG00000005533
AA Change: S1010T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Recep_L_domain
|
51 |
161 |
1.6e-29 |
PFAM |
|
FU
|
227 |
270 |
2.98e-12 |
SMART |
|
Pfam:Recep_L_domain
|
353 |
467 |
3.8e-32 |
PFAM |
|
FN3
|
490 |
593 |
4.67e-2 |
SMART |
|
FN3
|
612 |
815 |
1.95e-4 |
SMART |
|
FN3
|
833 |
915 |
7.4e-5 |
SMART |
|
low complexity region
|
937 |
954 |
N/A |
INTRINSIC |
|
TyrKc
|
1000 |
1268 |
8.51e-141 |
SMART |
|
low complexity region
|
1285 |
1303 |
N/A |
INTRINSIC |
|
low complexity region
|
1306 |
1319 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000208731
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000208871
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
| Validation Efficiency |
98% (82/84) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
PHENOTYPE: Targeted null mutants die at birth of respiratory failure; fetuses exhibit retarded growth, organ hypoplasia, ossification delay and nervous system and epidermal abnormalities. hyft homozygous fetuses are growth retarded and exhibit hydrops fetalis and focal hepatic ischemia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd8 |
G |
T |
8: 71,911,042 (GRCm39) |
C296* |
probably null |
Het |
| Adam11 |
T |
A |
11: 102,665,098 (GRCm39) |
Y413* |
probably null |
Het |
| Ankhd1 |
A |
G |
18: 36,789,768 (GRCm39) |
I907V |
probably benign |
Het |
| Arrdc5 |
A |
G |
17: 56,604,897 (GRCm39) |
I130T |
probably benign |
Het |
| Asic5 |
T |
A |
3: 81,928,294 (GRCm39) |
I419K |
probably damaging |
Het |
| Atp4a |
A |
T |
7: 30,414,955 (GRCm39) |
E248V |
probably damaging |
Het |
| Avil |
C |
A |
10: 126,847,630 (GRCm39) |
V154L |
probably benign |
Het |
| Bclaf1 |
T |
A |
10: 20,199,282 (GRCm39) |
H226Q |
possibly damaging |
Het |
| Cald1 |
A |
G |
6: 34,723,351 (GRCm39) |
|
probably benign |
Het |
| Cd200r4 |
A |
C |
16: 44,652,453 (GRCm39) |
D27A |
possibly damaging |
Het |
| Cdsn |
T |
A |
17: 35,863,099 (GRCm39) |
M1K |
probably null |
Het |
| Cfap46 |
T |
A |
7: 139,258,430 (GRCm39) |
H281L |
possibly damaging |
Het |
| Chaf1a |
T |
C |
17: 56,369,606 (GRCm39) |
F533L |
probably benign |
Het |
| Chil4 |
T |
A |
3: 106,126,768 (GRCm39) |
I5F |
probably benign |
Het |
| Ctu2 |
A |
T |
8: 123,203,327 (GRCm39) |
R48W |
probably damaging |
Het |
| Daam1 |
A |
T |
12: 71,993,350 (GRCm39) |
H373L |
unknown |
Het |
| Dcaf10 |
T |
A |
4: 45,370,415 (GRCm39) |
Y328N |
possibly damaging |
Het |
| Dst |
A |
T |
1: 34,217,012 (GRCm39) |
K1151* |
probably null |
Het |
| Ect2 |
T |
C |
3: 27,184,219 (GRCm39) |
D503G |
probably damaging |
Het |
| Epm2a |
C |
A |
10: 11,333,089 (GRCm39) |
D307E |
probably benign |
Het |
| Exph5 |
A |
T |
9: 53,249,230 (GRCm39) |
D73V |
probably damaging |
Het |
| Fam20b |
C |
T |
1: 156,533,310 (GRCm39) |
G102D |
probably damaging |
Het |
| Fat2 |
T |
C |
11: 55,172,001 (GRCm39) |
N2904S |
probably damaging |
Het |
| Flt3 |
T |
A |
5: 147,312,500 (GRCm39) |
Q147L |
possibly damaging |
Het |
| Fndc11 |
A |
G |
2: 180,863,956 (GRCm39) |
T254A |
possibly damaging |
Het |
| Galnt15 |
C |
T |
14: 31,780,244 (GRCm39) |
R514* |
probably null |
Het |
| Gbgt1 |
A |
G |
2: 28,395,220 (GRCm39) |
D286G |
probably damaging |
Het |
| Ggt1 |
T |
A |
10: 75,415,032 (GRCm39) |
|
probably null |
Het |
| Gm26526 |
A |
T |
7: 39,238,658 (GRCm39) |
|
noncoding transcript |
Het |
| H2-K2 |
T |
C |
17: 34,216,436 (GRCm39) |
T237A |
probably damaging |
Het |
| Il21 |
T |
C |
3: 37,281,884 (GRCm39) |
T87A |
possibly damaging |
Het |
| Kmt2b |
G |
A |
7: 30,268,600 (GRCm39) |
R2010C |
probably damaging |
Het |
| Kmt2c |
G |
A |
5: 25,519,592 (GRCm39) |
P2173S |
probably benign |
Het |
| Krt1 |
A |
T |
15: 101,754,803 (GRCm39) |
S512T |
unknown |
Het |
| Krtap16-1 |
G |
A |
11: 99,876,424 (GRCm39) |
R327* |
probably null |
Het |
| Lama1 |
T |
A |
17: 68,063,711 (GRCm39) |
I745N |
probably benign |
Het |
| Lrrk1 |
T |
A |
7: 65,956,855 (GRCm39) |
N372I |
probably benign |
Het |
| Lyst |
A |
T |
13: 13,857,655 (GRCm39) |
E2481D |
probably benign |
Het |
| Map2k1 |
A |
T |
9: 64,095,027 (GRCm39) |
|
probably benign |
Het |
| Mbip |
A |
G |
12: 56,384,228 (GRCm39) |
V215A |
probably damaging |
Het |
| Mdc1 |
T |
A |
17: 36,158,814 (GRCm39) |
V398D |
probably benign |
Het |
| Mog |
T |
G |
17: 37,323,264 (GRCm39) |
I225L |
probably benign |
Het |
| Mrgprx3-ps |
T |
A |
7: 46,959,184 (GRCm39) |
|
noncoding transcript |
Het |
| Muc5b |
C |
T |
7: 141,418,277 (GRCm39) |
S3741L |
probably benign |
Het |
| Myo5a |
A |
T |
9: 75,037,402 (GRCm39) |
I202F |
probably damaging |
Het |
| Myo5b |
A |
T |
18: 74,833,677 (GRCm39) |
I818F |
possibly damaging |
Het |
| Nfia |
T |
A |
4: 97,902,534 (GRCm39) |
M262K |
probably damaging |
Het |
| Nisch |
C |
T |
14: 30,928,524 (GRCm39) |
|
probably null |
Het |
| Nkd1 |
A |
G |
8: 89,315,822 (GRCm39) |
D64G |
probably damaging |
Het |
| Nt5c2 |
T |
A |
19: 46,881,999 (GRCm39) |
K284* |
probably null |
Het |
| Or14a259 |
A |
T |
7: 86,013,398 (GRCm39) |
V49E |
possibly damaging |
Het |
| Or4k15b |
C |
A |
14: 50,272,135 (GRCm39) |
A242S |
possibly damaging |
Het |
| Or4l1 |
A |
T |
14: 50,166,236 (GRCm39) |
I255N |
probably damaging |
Het |
| Or52z14 |
T |
G |
7: 103,252,996 (GRCm39) |
I45R |
probably benign |
Het |
| Or5an1c |
A |
G |
19: 12,218,612 (GRCm39) |
S138P |
probably damaging |
Het |
| Or5j3 |
A |
T |
2: 86,128,265 (GRCm39) |
Y35F |
probably damaging |
Het |
| Or8g55 |
A |
T |
9: 39,784,741 (GRCm39) |
T57S |
possibly damaging |
Het |
| Or8k24 |
A |
T |
2: 86,216,484 (GRCm39) |
S93T |
possibly damaging |
Het |
| Pcdhb17 |
A |
T |
18: 37,619,878 (GRCm39) |
D556V |
probably damaging |
Het |
| Pcdhga8 |
A |
T |
18: 37,859,673 (GRCm39) |
D243V |
probably benign |
Het |
| Polq |
A |
T |
16: 36,909,681 (GRCm39) |
Q2355L |
probably damaging |
Het |
| Slc22a30 |
G |
A |
19: 8,321,757 (GRCm39) |
Q436* |
probably null |
Het |
| Slc5a4a |
C |
A |
10: 76,018,572 (GRCm39) |
Y506* |
probably null |
Het |
| Sp110 |
G |
C |
1: 85,504,923 (GRCm39) |
|
probably benign |
Het |
| Tarbp1 |
G |
A |
8: 127,193,895 (GRCm39) |
H336Y |
probably damaging |
Het |
| Tas2r134 |
T |
G |
2: 51,517,559 (GRCm39) |
F13V |
probably benign |
Het |
| Tgfb2 |
A |
G |
1: 186,436,680 (GRCm39) |
Y98H |
probably damaging |
Het |
| Tmprss11a |
C |
A |
5: 86,559,665 (GRCm39) |
V376L |
probably damaging |
Het |
| Tmprss11f |
T |
A |
5: 86,685,892 (GRCm39) |
K158N |
probably benign |
Het |
| Tnip2 |
G |
T |
5: 34,660,922 (GRCm39) |
Q177K |
probably damaging |
Het |
| Trp53inp1 |
T |
A |
4: 11,165,075 (GRCm39) |
|
probably null |
Het |
| Ttc28 |
C |
T |
5: 111,419,104 (GRCm39) |
P1398S |
probably benign |
Het |
| Umodl1 |
T |
G |
17: 31,199,333 (GRCm39) |
I308S |
possibly damaging |
Het |
| Vcan |
A |
T |
13: 89,839,719 (GRCm39) |
S1942T |
probably damaging |
Het |
| Vmn2r124 |
T |
A |
17: 18,283,339 (GRCm39) |
N344K |
probably benign |
Het |
| Vmn2r25 |
C |
G |
6: 123,802,277 (GRCm39) |
C542S |
probably damaging |
Het |
| Wiz |
T |
A |
17: 32,597,470 (GRCm39) |
|
probably benign |
Het |
| Wrap73 |
A |
G |
4: 154,239,803 (GRCm39) |
Y343C |
probably benign |
Het |
|
| Other mutations in Igf1r |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00742:Igf1r
|
APN |
7 |
67,839,771 (GRCm39) |
missense |
probably benign |
|
|
IGL00837:Igf1r
|
APN |
7 |
67,851,100 (GRCm39) |
splice site |
probably benign |
|
|
IGL01515:Igf1r
|
APN |
7 |
67,857,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01572:Igf1r
|
APN |
7 |
67,843,189 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02100:Igf1r
|
APN |
7 |
67,839,706 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02506:Igf1r
|
APN |
7 |
67,843,144 (GRCm39) |
missense |
probably benign |
|
|
IGL02672:Igf1r
|
APN |
7 |
67,839,781 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02701:Igf1r
|
APN |
7 |
67,850,997 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02742:Igf1r
|
APN |
7 |
67,839,739 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03073:Igf1r
|
APN |
7 |
67,864,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03257:Igf1r
|
APN |
7 |
67,864,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Frufru
|
UTSW |
7 |
67,653,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Hungarian
|
UTSW |
7 |
67,864,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mimi
|
UTSW |
7 |
67,844,774 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
Piroshka
|
UTSW |
7 |
67,857,084 (GRCm39) |
nonsense |
probably null |
|
|
Romanian
|
UTSW |
7 |
67,653,885 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Sublime
|
UTSW |
7 |
67,653,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Toy
|
UTSW |
7 |
67,653,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB009:Igf1r
|
UTSW |
7 |
67,861,802 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
BB019:Igf1r
|
UTSW |
7 |
67,861,802 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
FR4548:Igf1r
|
UTSW |
7 |
67,875,934 (GRCm39) |
small insertion |
probably benign |
|
|
FR4737:Igf1r
|
UTSW |
7 |
67,875,929 (GRCm39) |
small insertion |
probably benign |
|
|
FR4976:Igf1r
|
UTSW |
7 |
67,875,934 (GRCm39) |
small insertion |
probably benign |
|
|
FR4976:Igf1r
|
UTSW |
7 |
67,875,929 (GRCm39) |
small insertion |
probably benign |
|
|
PIT4445001:Igf1r
|
UTSW |
7 |
67,857,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0003:Igf1r
|
UTSW |
7 |
67,814,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0184:Igf1r
|
UTSW |
7 |
67,875,941 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0538:Igf1r
|
UTSW |
7 |
67,857,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0632:Igf1r
|
UTSW |
7 |
67,814,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0727:Igf1r
|
UTSW |
7 |
67,861,906 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0750:Igf1r
|
UTSW |
7 |
67,861,839 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1104:Igf1r
|
UTSW |
7 |
67,844,774 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1169:Igf1r
|
UTSW |
7 |
67,814,875 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1348:Igf1r
|
UTSW |
7 |
67,868,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Igf1r
|
UTSW |
7 |
67,653,585 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1580:Igf1r
|
UTSW |
7 |
67,857,617 (GRCm39) |
missense |
probably benign |
|
|
R1745:Igf1r
|
UTSW |
7 |
67,819,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1772:Igf1r
|
UTSW |
7 |
67,844,822 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1789:Igf1r
|
UTSW |
7 |
67,864,681 (GRCm39) |
nonsense |
probably null |
|
|
R1823:Igf1r
|
UTSW |
7 |
67,844,729 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1902:Igf1r
|
UTSW |
7 |
67,850,997 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1962:Igf1r
|
UTSW |
7 |
67,857,023 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2179:Igf1r
|
UTSW |
7 |
67,653,698 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2215:Igf1r
|
UTSW |
7 |
67,814,982 (GRCm39) |
missense |
probably benign |
|
|
R2221:Igf1r
|
UTSW |
7 |
67,851,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2233:Igf1r
|
UTSW |
7 |
67,861,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2234:Igf1r
|
UTSW |
7 |
67,861,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2235:Igf1r
|
UTSW |
7 |
67,861,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3023:Igf1r
|
UTSW |
7 |
67,833,147 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4044:Igf1r
|
UTSW |
7 |
67,839,810 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4226:Igf1r
|
UTSW |
7 |
67,844,826 (GRCm39) |
nonsense |
probably null |
|
|
R4387:Igf1r
|
UTSW |
7 |
67,819,757 (GRCm39) |
missense |
probably benign |
|
|
R4388:Igf1r
|
UTSW |
7 |
67,819,757 (GRCm39) |
missense |
probably benign |
|
|
R4728:Igf1r
|
UTSW |
7 |
67,839,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4781:Igf1r
|
UTSW |
7 |
67,814,947 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R5278:Igf1r
|
UTSW |
7 |
67,843,166 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5510:Igf1r
|
UTSW |
7 |
67,843,107 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5522:Igf1r
|
UTSW |
7 |
67,833,258 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5527:Igf1r
|
UTSW |
7 |
67,857,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5761:Igf1r
|
UTSW |
7 |
67,857,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5849:Igf1r
|
UTSW |
7 |
67,839,781 (GRCm39) |
missense |
probably benign |
|
|
R6189:Igf1r
|
UTSW |
7 |
67,857,084 (GRCm39) |
nonsense |
probably null |
|
|
R6262:Igf1r
|
UTSW |
7 |
67,653,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6285:Igf1r
|
UTSW |
7 |
67,653,885 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6318:Igf1r
|
UTSW |
7 |
67,814,981 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6365:Igf1r
|
UTSW |
7 |
67,839,798 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6377:Igf1r
|
UTSW |
7 |
67,850,998 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6831:Igf1r
|
UTSW |
7 |
67,857,067 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R6848:Igf1r
|
UTSW |
7 |
67,653,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6902:Igf1r
|
UTSW |
7 |
67,653,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7193:Igf1r
|
UTSW |
7 |
67,836,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7373:Igf1r
|
UTSW |
7 |
67,844,826 (GRCm39) |
nonsense |
probably null |
|
|
R7442:Igf1r
|
UTSW |
7 |
67,823,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7903:Igf1r
|
UTSW |
7 |
67,834,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7923:Igf1r
|
UTSW |
7 |
67,839,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7932:Igf1r
|
UTSW |
7 |
67,861,802 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8368:Igf1r
|
UTSW |
7 |
67,836,796 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8458:Igf1r
|
UTSW |
7 |
67,845,377 (GRCm39) |
missense |
probably benign |
|
|
R8539:Igf1r
|
UTSW |
7 |
67,653,596 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8704:Igf1r
|
UTSW |
7 |
67,819,802 (GRCm39) |
splice site |
probably benign |
|
|
R8746:Igf1r
|
UTSW |
7 |
67,864,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8829:Igf1r
|
UTSW |
7 |
67,875,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8832:Igf1r
|
UTSW |
7 |
67,875,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8859:Igf1r
|
UTSW |
7 |
67,833,211 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R9057:Igf1r
|
UTSW |
7 |
67,833,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9243:Igf1r
|
UTSW |
7 |
67,861,775 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9342:Igf1r
|
UTSW |
7 |
67,844,746 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9412:Igf1r
|
UTSW |
7 |
67,857,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9525:Igf1r
|
UTSW |
7 |
67,864,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9727:Igf1r
|
UTSW |
7 |
67,857,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9730:Igf1r
|
UTSW |
7 |
67,839,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9779:Igf1r
|
UTSW |
7 |
67,654,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF025:Igf1r
|
UTSW |
7 |
67,875,927 (GRCm39) |
small insertion |
probably benign |
|
|
RF032:Igf1r
|
UTSW |
7 |
67,875,927 (GRCm39) |
small insertion |
probably benign |
|
|
RF034:Igf1r
|
UTSW |
7 |
67,875,924 (GRCm39) |
small insertion |
probably benign |
|
|
RF037:Igf1r
|
UTSW |
7 |
67,875,924 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Igf1r
|
UTSW |
7 |
67,875,924 (GRCm39) |
small insertion |
probably benign |
|
|
RF044:Igf1r
|
UTSW |
7 |
67,875,927 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,916 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,930 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,928 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,922 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,917 (GRCm39) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
67,875,918 (GRCm39) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
67,875,917 (GRCm39) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
67,875,921 (GRCm39) |
small insertion |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ATTGAGTACCCGTGCTGGAC -3'
(R):5'- CATACAGGGTGGTCCTTTCTG -3'
Sequencing Primer
(F):5'- TACCCGTGCTGGACTGTTTGTAC -3'
(R):5'- AGGGTGGTCCTTTCTGTCCATAC -3'
|
| Posted On |
2016-07-06 |
Incidental Mutation