Incidental Mutation 'R8084:Grin2b'
| ID |
629514 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Grin2b
|
| Ensembl Gene |
ENSMUSG00000030209 |
| Gene Name |
glutamate receptor, ionotropic, NMDA2B (epsilon 2) |
| Synonyms |
GluRepsilon2, GluN2B, NR2B, NMDAR2B, Nmdar2b |
| MMRRC Submission |
067517-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R8084 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
135690231-136150509 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 135710486 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Arginine
at position 1020
(K1020R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000062284
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053880]
[ENSMUST00000111905]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000053880
AA Change: K1020R
PolyPhen 2
Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000062284
Gene: ENSMUSG00000030209
AA Change: K1020R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
106 |
306 |
8.6e-10 |
PFAM |
|
PBPe
|
431 |
799 |
1.06e-67 |
SMART |
|
Lig_chan-Glu_bd
|
440 |
503 |
1.82e-22 |
SMART |
|
Pfam:NMDAR2_C
|
840 |
1482 |
4.8e-270 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111905
AA Change: K1020R
PolyPhen 2
Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000107536
Gene: ENSMUSG00000030209
AA Change: K1020R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
56 |
307 |
4.2e-10 |
PFAM |
|
PBPe
|
431 |
799 |
1.06e-67 |
SMART |
|
Lig_chan-Glu_bd
|
440 |
503 |
1.82e-22 |
SMART |
|
Pfam:NMDAR2_C
|
840 |
1482 |
2.1e-245 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.7%
- 10x: 98.9%
- 20x: 96.2%
|
| Validation Efficiency |
100% (75/75) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted null mutations exhibit impairments in suckling, in hippocampal long term depression, and in pattern formation of trigeminal nucleus sensory afferent terminals. Mutants die shortly after birth. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca2 |
T |
A |
2: 25,323,979 (GRCm39) |
Y190N |
probably benign |
Het |
| Acsl3 |
G |
A |
1: 78,669,844 (GRCm39) |
D238N |
probably damaging |
Het |
| Acss1 |
T |
A |
2: 150,484,701 (GRCm39) |
I181F |
probably damaging |
Het |
| Ano5 |
A |
G |
7: 51,229,287 (GRCm39) |
I610V |
probably benign |
Het |
| Anxa6 |
A |
T |
11: 54,894,834 (GRCm39) |
F256I |
probably damaging |
Het |
| Ash2l |
A |
G |
8: 26,321,322 (GRCm39) |
S273P |
probably benign |
Het |
| Baz2b |
T |
G |
2: 59,792,580 (GRCm39) |
E516A |
probably benign |
Het |
| Bbs2 |
G |
T |
8: 94,814,056 (GRCm39) |
D187E |
probably damaging |
Het |
| Cacna1b |
T |
A |
2: 24,575,808 (GRCm39) |
M747L |
probably benign |
Het |
| Cacna2d4 |
C |
A |
6: 119,277,313 (GRCm39) |
D675E |
probably damaging |
Het |
| Calcr |
G |
A |
6: 3,687,615 (GRCm39) |
T461M |
probably benign |
Het |
| Catip |
A |
G |
1: 74,403,515 (GRCm39) |
K126E |
probably damaging |
Het |
| Chga |
T |
C |
12: 102,528,328 (GRCm39) |
I273T |
probably benign |
Het |
| Clasp2 |
G |
A |
9: 113,676,823 (GRCm39) |
V185I |
probably benign |
Het |
| Cracr2a |
A |
G |
6: 127,616,135 (GRCm39) |
N370S |
probably benign |
Het |
| Crygc |
A |
T |
1: 65,110,981 (GRCm39) |
V102D |
probably benign |
Het |
| Ddx23 |
A |
G |
15: 98,556,145 (GRCm39) |
S58P |
unknown |
Het |
| Dlgap5 |
C |
T |
14: 47,645,298 (GRCm39) |
G281D |
probably benign |
Het |
| Dnah5 |
A |
T |
15: 28,388,099 (GRCm39) |
Y3186F |
probably damaging |
Het |
| Dpp6 |
A |
C |
5: 27,836,397 (GRCm39) |
I296L |
probably benign |
Het |
| Elfn2 |
C |
T |
15: 78,556,660 (GRCm39) |
R629H |
probably damaging |
Het |
| Eml2 |
G |
T |
7: 18,915,149 (GRCm39) |
|
probably null |
Het |
| Fitm1 |
T |
A |
14: 55,813,906 (GRCm39) |
V134E |
probably damaging |
Het |
| Flnb |
A |
G |
14: 7,907,243 (GRCm38) |
N1272S |
probably benign |
Het |
| Fuca1 |
G |
A |
4: 135,662,114 (GRCm39) |
W347* |
probably null |
Het |
| Gabbr2 |
C |
T |
4: 46,736,349 (GRCm39) |
|
probably null |
Het |
| Gls2 |
G |
A |
10: 128,035,125 (GRCm39) |
R86H |
probably damaging |
Het |
| H2-DMb1 |
T |
A |
17: 34,376,327 (GRCm39) |
W149R |
probably damaging |
Het |
| Herc1 |
T |
A |
9: 66,383,217 (GRCm39) |
S3629R |
probably benign |
Het |
| Itih4 |
A |
T |
14: 30,621,400 (GRCm39) |
N821I |
possibly damaging |
Het |
| Kmt2d |
A |
T |
15: 98,739,945 (GRCm39) |
L4731Q |
unknown |
Het |
| Loxhd1 |
A |
T |
18: 77,427,845 (GRCm39) |
I472F |
possibly damaging |
Het |
| Lrp2 |
C |
A |
2: 69,339,713 (GRCm39) |
C1066F |
probably damaging |
Het |
| Mllt10 |
T |
A |
2: 18,114,637 (GRCm39) |
F114I |
probably damaging |
Het |
| N4bp1 |
T |
C |
8: 87,587,636 (GRCm39) |
E434G |
probably benign |
Het |
| N6amt1 |
T |
C |
16: 87,151,228 (GRCm39) |
F30L |
probably damaging |
Het |
| Naca |
G |
A |
10: 127,877,400 (GRCm39) |
V811I |
unknown |
Het |
| Nobox |
A |
C |
6: 43,282,101 (GRCm39) |
I324S |
possibly damaging |
Het |
| Nup210l |
T |
C |
3: 90,043,365 (GRCm39) |
S442P |
probably benign |
Het |
| Or6c2 |
A |
T |
10: 129,362,809 (GRCm39) |
T238S |
probably damaging |
Het |
| Osbpl1a |
A |
T |
18: 13,038,099 (GRCm39) |
L284Q |
probably damaging |
Het |
| Pals1 |
A |
T |
12: 78,867,625 (GRCm39) |
Q336L |
probably benign |
Het |
| Pcdhb20 |
A |
C |
18: 37,639,226 (GRCm39) |
Y584S |
possibly damaging |
Het |
| Pgpep1l |
A |
T |
7: 67,887,519 (GRCm39) |
F27Y |
probably benign |
Het |
| Pik3cg |
T |
G |
12: 32,245,687 (GRCm39) |
I854L |
probably benign |
Het |
| Pot1a |
C |
T |
6: 25,771,535 (GRCm39) |
V229M |
possibly damaging |
Het |
| Prh1 |
C |
T |
6: 132,548,822 (GRCm39) |
P110S |
unknown |
Het |
| Prkag3 |
C |
T |
1: 74,786,366 (GRCm39) |
C193Y |
probably damaging |
Het |
| Prl2c5 |
T |
C |
13: 13,360,539 (GRCm39) |
F69L |
probably benign |
Het |
| Ptprq |
T |
C |
10: 107,444,294 (GRCm39) |
T1437A |
probably benign |
Het |
| Rabgap1 |
T |
C |
2: 37,427,317 (GRCm39) |
Y633H |
probably damaging |
Het |
| Rad54l2 |
G |
A |
9: 106,590,701 (GRCm39) |
T475I |
possibly damaging |
Het |
| Retreg1 |
C |
A |
15: 25,969,885 (GRCm39) |
A130E |
probably benign |
Het |
| Rps6kb1 |
G |
T |
11: 86,426,262 (GRCm39) |
H56N |
probably benign |
Het |
| Sars2 |
A |
G |
7: 28,449,710 (GRCm39) |
H385R |
probably damaging |
Het |
| Sbpl |
T |
G |
17: 24,172,244 (GRCm39) |
N225T |
unknown |
Het |
| Scml4 |
T |
C |
10: 42,806,602 (GRCm39) |
|
probably null |
Het |
| Scrib |
G |
A |
15: 75,937,940 (GRCm39) |
T302M |
probably benign |
Het |
| Sdk2 |
G |
A |
11: 113,717,915 (GRCm39) |
T1483I |
possibly damaging |
Het |
| Sh3bgrl3 |
A |
G |
4: 133,855,390 (GRCm39) |
S19P |
probably damaging |
Het |
| Slc10a6 |
C |
T |
5: 103,760,327 (GRCm39) |
V223I |
probably benign |
Het |
| Slc4a3 |
A |
G |
1: 75,532,589 (GRCm39) |
T950A |
probably benign |
Het |
| Spats2 |
A |
T |
15: 99,064,961 (GRCm39) |
D9V |
possibly damaging |
Het |
| Sphk1 |
A |
T |
11: 116,425,904 (GRCm39) |
|
probably null |
Het |
| Tex10 |
A |
T |
4: 48,431,066 (GRCm39) |
S897R |
probably benign |
Het |
| Tmco3 |
T |
C |
8: 13,353,873 (GRCm39) |
V395A |
probably damaging |
Het |
| Ttc7b |
A |
G |
12: 100,350,432 (GRCm39) |
L478P |
probably damaging |
Het |
| Ubac2 |
T |
C |
14: 122,220,717 (GRCm39) |
M184T |
probably benign |
Het |
| Wdr95 |
T |
C |
5: 149,511,598 (GRCm39) |
S433P |
probably damaging |
Het |
| Zfp202 |
T |
A |
9: 40,122,538 (GRCm39) |
H433Q |
probably benign |
Het |
| Zfp526 |
G |
T |
7: 24,924,737 (GRCm39) |
R332L |
probably damaging |
Het |
|
| Other mutations in Grin2b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00494:Grin2b
|
APN |
6 |
135,713,329 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL00835:Grin2b
|
APN |
6 |
135,710,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01401:Grin2b
|
APN |
6 |
135,713,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01523:Grin2b
|
APN |
6 |
136,021,263 (GRCm39) |
missense |
probably null |
0.99 |
|
IGL01719:Grin2b
|
APN |
6 |
135,710,379 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01907:Grin2b
|
APN |
6 |
135,710,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01996:Grin2b
|
APN |
6 |
135,709,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02309:Grin2b
|
APN |
6 |
135,713,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02312:Grin2b
|
APN |
6 |
135,716,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02409:Grin2b
|
APN |
6 |
136,020,906 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02527:Grin2b
|
APN |
6 |
135,900,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02535:Grin2b
|
APN |
6 |
135,756,367 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02570:Grin2b
|
APN |
6 |
135,899,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02702:Grin2b
|
APN |
6 |
135,716,130 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03001:Grin2b
|
APN |
6 |
135,716,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03274:Grin2b
|
APN |
6 |
135,757,253 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0055:Grin2b
|
UTSW |
6 |
135,900,201 (GRCm39) |
missense |
probably benign |
|
|
R0055:Grin2b
|
UTSW |
6 |
135,900,201 (GRCm39) |
missense |
probably benign |
|
|
R0164:Grin2b
|
UTSW |
6 |
135,755,646 (GRCm39) |
splice site |
probably benign |
|
|
R0194:Grin2b
|
UTSW |
6 |
135,756,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0594:Grin2b
|
UTSW |
6 |
135,710,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1434:Grin2b
|
UTSW |
6 |
135,820,193 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1928:Grin2b
|
UTSW |
6 |
136,021,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1942:Grin2b
|
UTSW |
6 |
135,709,730 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1996:Grin2b
|
UTSW |
6 |
136,021,209 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R2002:Grin2b
|
UTSW |
6 |
135,710,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2020:Grin2b
|
UTSW |
6 |
135,710,894 (GRCm39) |
missense |
probably benign |
0.12 |
|
R2103:Grin2b
|
UTSW |
6 |
135,757,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2127:Grin2b
|
UTSW |
6 |
135,755,698 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2495:Grin2b
|
UTSW |
6 |
135,710,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2656:Grin2b
|
UTSW |
6 |
135,710,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2847:Grin2b
|
UTSW |
6 |
135,717,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2866:Grin2b
|
UTSW |
6 |
135,710,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2867:Grin2b
|
UTSW |
6 |
135,710,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2867:Grin2b
|
UTSW |
6 |
135,710,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3196:Grin2b
|
UTSW |
6 |
135,709,453 (GRCm39) |
small deletion |
probably benign |
|
|
R3418:Grin2b
|
UTSW |
6 |
135,820,108 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3808:Grin2b
|
UTSW |
6 |
135,900,269 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4028:Grin2b
|
UTSW |
6 |
135,713,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4602:Grin2b
|
UTSW |
6 |
135,755,739 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4624:Grin2b
|
UTSW |
6 |
135,710,823 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4677:Grin2b
|
UTSW |
6 |
135,751,870 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4744:Grin2b
|
UTSW |
6 |
135,755,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5020:Grin2b
|
UTSW |
6 |
135,710,405 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5051:Grin2b
|
UTSW |
6 |
135,756,393 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5105:Grin2b
|
UTSW |
6 |
135,709,439 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5125:Grin2b
|
UTSW |
6 |
135,900,297 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5146:Grin2b
|
UTSW |
6 |
135,756,340 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5318:Grin2b
|
UTSW |
6 |
135,710,916 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5349:Grin2b
|
UTSW |
6 |
136,021,281 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5426:Grin2b
|
UTSW |
6 |
135,709,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5438:Grin2b
|
UTSW |
6 |
135,713,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5439:Grin2b
|
UTSW |
6 |
135,713,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5440:Grin2b
|
UTSW |
6 |
135,713,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5530:Grin2b
|
UTSW |
6 |
135,710,721 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5603:Grin2b
|
UTSW |
6 |
135,900,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5657:Grin2b
|
UTSW |
6 |
135,710,085 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5788:Grin2b
|
UTSW |
6 |
135,717,962 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5941:Grin2b
|
UTSW |
6 |
135,713,371 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6057:Grin2b
|
UTSW |
6 |
135,710,942 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6137:Grin2b
|
UTSW |
6 |
135,900,456 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6216:Grin2b
|
UTSW |
6 |
135,749,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6309:Grin2b
|
UTSW |
6 |
135,710,025 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6316:Grin2b
|
UTSW |
6 |
135,757,277 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6419:Grin2b
|
UTSW |
6 |
135,717,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6551:Grin2b
|
UTSW |
6 |
135,710,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6612:Grin2b
|
UTSW |
6 |
135,717,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6616:Grin2b
|
UTSW |
6 |
135,709,549 (GRCm39) |
missense |
probably benign |
|
|
R6647:Grin2b
|
UTSW |
6 |
135,710,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6806:Grin2b
|
UTSW |
6 |
135,751,826 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6976:Grin2b
|
UTSW |
6 |
135,757,198 (GRCm39) |
missense |
probably benign |
|
|
R7033:Grin2b
|
UTSW |
6 |
135,900,036 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7058:Grin2b
|
UTSW |
6 |
135,757,304 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7144:Grin2b
|
UTSW |
6 |
135,710,474 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R7190:Grin2b
|
UTSW |
6 |
135,709,946 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7238:Grin2b
|
UTSW |
6 |
135,757,249 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7453:Grin2b
|
UTSW |
6 |
135,717,947 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7553:Grin2b
|
UTSW |
6 |
135,749,394 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7585:Grin2b
|
UTSW |
6 |
135,756,301 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7615:Grin2b
|
UTSW |
6 |
135,900,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7632:Grin2b
|
UTSW |
6 |
135,709,553 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7779:Grin2b
|
UTSW |
6 |
135,755,792 (GRCm39) |
nonsense |
probably null |
|
|
R8058:Grin2b
|
UTSW |
6 |
135,710,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8145:Grin2b
|
UTSW |
6 |
135,709,497 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8308:Grin2b
|
UTSW |
6 |
135,900,074 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8357:Grin2b
|
UTSW |
6 |
135,709,197 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8379:Grin2b
|
UTSW |
6 |
135,899,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8429:Grin2b
|
UTSW |
6 |
135,710,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8457:Grin2b
|
UTSW |
6 |
135,709,197 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8746:Grin2b
|
UTSW |
6 |
135,899,985 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8925:Grin2b
|
UTSW |
6 |
135,749,339 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8927:Grin2b
|
UTSW |
6 |
135,749,339 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8963:Grin2b
|
UTSW |
6 |
136,021,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9075:Grin2b
|
UTSW |
6 |
135,709,509 (GRCm39) |
frame shift |
probably null |
|
|
R9076:Grin2b
|
UTSW |
6 |
135,709,509 (GRCm39) |
frame shift |
probably null |
|
|
R9172:Grin2b
|
UTSW |
6 |
135,756,255 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9520:Grin2b
|
UTSW |
6 |
135,710,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9740:Grin2b
|
UTSW |
6 |
135,899,868 (GRCm39) |
critical splice donor site |
probably null |
|
|
RF001:Grin2b
|
UTSW |
6 |
136,021,238 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGCCCTCGATGTTGCCATAG -3'
(R):5'- AGCTTCACGCATTCAGACTGC -3'
Sequencing Primer
(F):5'- CCTCGATGTTGCCATAGGTGAC -3'
(R):5'- CCCTGTGAGGAAAACCTGTTCAG -3'
|
| Posted On |
2020-06-30 |
Incidental Mutation