Mutagenetix > Incidental Mutation

Incidental Mutation 'R6367:Vmn2r111'

512763

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r111

Ensembl Gene

ENSMUSG00000095093

Gene Name

vomeronasal 2, receptor 111

Synonyms

EG210876

MMRRC Submission

044517-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

R6367 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

22766922-22792254 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 22778032 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 549 (N549S)

Ref Sequence

ENSEMBL: ENSMUSP00000090148 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092491]

AlphaFold

K7N674

Predicted Effect

possibly damaging
Transcript: ENSMUST00000092491
AA Change: N549S

PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000090148
Gene: ENSMUSG00000095093
AA Change: N549S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	2.5e-29	PFAM
Pfam:NCD3G	512	565	1.1e-20	PFAM
Pfam:7tm_3	595	833	5.6e-54	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 97.9%
20x: 93.7%

Validation Efficiency

98% (44/45)

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	G	11: 9,166,248 (GRCm39)	N54D	possibly damaging	Het
Abca4	A	C	3: 121,897,229 (GRCm39)	Q636P	probably damaging	Het
Agk	T	C	6: 40,363,875 (GRCm39)	F285S	probably benign	Het
Als2	C	A	1: 59,238,299 (GRCm39)	V678L	probably benign	Het
Arhgap17	T	C	7: 122,907,586 (GRCm39)	*231W	probably null	Het
Atp11b	A	G	3: 35,838,686 (GRCm39)	T89A	probably damaging	Het
Axl	A	T	7: 25,486,858 (GRCm39)	C50S	probably damaging	Het
Cachd1	A	G	4: 100,860,167 (GRCm39)	D1246G	probably damaging	Het
Dip2b	A	T	15: 100,013,795 (GRCm39)	Q57L	possibly damaging	Het
Dnah14	A	G	1: 181,582,951 (GRCm39)		probably null	Het
Enpep	G	T	3: 129,125,730 (GRCm39)	T134N	possibly damaging	Het
Ets1	C	T	9: 32,645,256 (GRCm39)	Q168*	probably null	Het
Fanci	T	C	7: 79,075,943 (GRCm39)	C529R	probably damaging	Het
Fbxw28	A	G	9: 109,168,599 (GRCm39)		probably null	Het
Gucy2c	C	T	6: 136,686,776 (GRCm39)	E796K	probably damaging	Het
Igsf9b	G	A	9: 27,220,821 (GRCm39)	W62*	probably null	Het
Kcng1	C	A	2: 168,104,572 (GRCm39)	V425L	probably damaging	Het
Kndc1	T	C	7: 139,493,422 (GRCm39)	S463P	probably damaging	Het
Lrba	G	C	3: 86,275,869 (GRCm39)	A1746P	probably benign	Het
Mgat4c	G	T	10: 102,221,015 (GRCm39)		probably null	Het
Nckap1l	G	A	15: 103,384,149 (GRCm39)	M582I	probably benign	Het
Oacyl	G	T	18: 65,858,515 (GRCm39)	R207L	probably damaging	Het
Or12e13	T	C	2: 87,663,937 (GRCm39)	C185R	probably damaging	Het
Or2m12	C	T	16: 19,104,822 (GRCm39)	V224M	probably damaging	Het
Or4c52	A	G	2: 89,845,360 (GRCm39)	I29V	probably benign	Het
Or51f5	C	A	7: 102,424,036 (GRCm39)	Q102K	possibly damaging	Het
Pacsin2	C	T	15: 83,266,033 (GRCm39)	A55T	probably benign	Het
Plekhm2	T	C	4: 141,367,016 (GRCm39)	D208G	probably damaging	Het
Ptpru	T	C	4: 131,501,663 (GRCm39)	D1181G	probably benign	Het
Safb	A	G	17: 56,900,845 (GRCm39)		probably benign	Het
Scp2	T	A	4: 107,969,447 (GRCm39)	Y35F	probably damaging	Het
Secisbp2	A	G	13: 51,836,177 (GRCm39)	Y757C	probably damaging	Het
Sp110	C	T	1: 85,522,013 (GRCm39)	V97M	probably benign	Het
Ssx2ip	A	G	3: 146,124,921 (GRCm39)	Y82C	probably benign	Het
Svopl	A	T	6: 37,996,614 (GRCm39)	W288R	possibly damaging	Het
Tdg	T	C	10: 82,483,822 (GRCm39)	Y345H	possibly damaging	Het
Tmem109	A	G	19: 10,851,727 (GRCm39)	F53S	possibly damaging	Het
Tpsab1	G	T	17: 25,562,448 (GRCm39)	T293N	probably damaging	Het
Trpm8	A	G	1: 88,287,405 (GRCm39)	D796G	probably damaging	Het
Tuba1c	T	C	15: 98,935,334 (GRCm39)	I265T	probably damaging	Het
Unc80	T	C	1: 66,711,925 (GRCm39)	V2749A	probably benign	Het
Utrn	A	G	10: 12,623,719 (GRCm39)	L173P	probably damaging	Het
Wbp2	G	T	11: 115,974,741 (GRCm39)	T31N	probably benign	Het
Wdr1	G	T	5: 38,703,189 (GRCm39)	A129D	possibly damaging	Het
Yod1	G	A	1: 130,645,275 (GRCm39)	G19S	probably damaging	Het

Other mutations in Vmn2r111

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00932:Vmn2r111	APN	17	22,767,734 (GRCm39)	missense	probably benign	0.00
IGL01306:Vmn2r111	APN	17	22,787,965 (GRCm39)	missense	probably damaging	0.99
IGL01309:Vmn2r111	APN	17	22,787,997 (GRCm39)	missense	possibly damaging	0.51
IGL01457:Vmn2r111	APN	17	22,790,966 (GRCm39)	nonsense	probably null
IGL01465:Vmn2r111	APN	17	22,767,718 (GRCm39)	missense	probably benign	0.00
IGL01505:Vmn2r111	APN	17	22,767,553 (GRCm39)	missense	probably benign	0.00
IGL01571:Vmn2r111	APN	17	22,790,373 (GRCm39)	missense	probably damaging	0.99
IGL01715:Vmn2r111	APN	17	22,788,054 (GRCm39)	splice site	probably benign
IGL01962:Vmn2r111	APN	17	22,767,265 (GRCm39)	missense	possibly damaging	0.90
IGL02190:Vmn2r111	APN	17	22,789,754 (GRCm39)	missense	probably benign	0.00
IGL02496:Vmn2r111	APN	17	22,787,837 (GRCm39)	missense	probably benign
IGL02519:Vmn2r111	APN	17	22,767,320 (GRCm39)	missense	possibly damaging	0.80
IGL02616:Vmn2r111	APN	17	22,790,031 (GRCm39)	missense	possibly damaging	0.67
IGL02641:Vmn2r111	APN	17	22,792,205 (GRCm39)	missense	possibly damaging	0.82
IGL02690:Vmn2r111	APN	17	22,778,023 (GRCm39)	critical splice donor site	probably null
IGL02698:Vmn2r111	APN	17	22,790,226 (GRCm39)	missense	probably damaging	1.00
IGL03017:Vmn2r111	APN	17	22,789,839 (GRCm39)	missense	probably damaging	1.00
R0046:Vmn2r111	UTSW	17	22,766,990 (GRCm39)	missense	probably benign
R0064:Vmn2r111	UTSW	17	22,791,053 (GRCm39)	missense	probably benign	0.00
R0519:Vmn2r111	UTSW	17	22,792,102 (GRCm39)	missense	probably benign	0.02
R1439:Vmn2r111	UTSW	17	22,790,097 (GRCm39)	missense	probably benign	0.00
R1467:Vmn2r111	UTSW	17	22,790,028 (GRCm39)	missense	probably damaging	0.99
R1467:Vmn2r111	UTSW	17	22,790,028 (GRCm39)	missense	probably damaging	0.99
R1636:Vmn2r111	UTSW	17	22,790,380 (GRCm39)	missense	probably damaging	1.00
R1647:Vmn2r111	UTSW	17	22,788,042 (GRCm39)	missense	probably benign	0.03
R1648:Vmn2r111	UTSW	17	22,788,042 (GRCm39)	missense	probably benign	0.03
R1697:Vmn2r111	UTSW	17	22,767,041 (GRCm39)	missense	probably benign	0.26
R1996:Vmn2r111	UTSW	17	22,767,062 (GRCm39)	missense	probably benign	0.21
R2040:Vmn2r111	UTSW	17	22,767,395 (GRCm39)	missense	probably damaging	1.00
R2075:Vmn2r111	UTSW	17	22,778,043 (GRCm39)	missense	probably damaging	1.00
R2134:Vmn2r111	UTSW	17	22,792,085 (GRCm39)	missense	possibly damaging	0.68
R2357:Vmn2r111	UTSW	17	22,778,151 (GRCm39)	splice site	probably benign
R3700:Vmn2r111	UTSW	17	22,790,142 (GRCm39)	nonsense	probably null
R3782:Vmn2r111	UTSW	17	22,790,301 (GRCm39)	missense	possibly damaging	0.89
R4085:Vmn2r111	UTSW	17	22,778,096 (GRCm39)	missense	probably benign	0.00
R4323:Vmn2r111	UTSW	17	22,792,159 (GRCm39)	missense	probably benign	0.02
R4900:Vmn2r111	UTSW	17	22,767,637 (GRCm39)	missense	possibly damaging	0.94
R5072:Vmn2r111	UTSW	17	22,767,022 (GRCm39)	missense	probably damaging	0.99
R5123:Vmn2r111	UTSW	17	22,790,124 (GRCm39)	missense	possibly damaging	0.82
R5181:Vmn2r111	UTSW	17	22,790,001 (GRCm39)	missense	possibly damaging	0.56
R5357:Vmn2r111	UTSW	17	22,767,083 (GRCm39)	nonsense	probably null
R5398:Vmn2r111	UTSW	17	22,792,252 (GRCm39)	start codon destroyed	probably null	0.88
R5434:Vmn2r111	UTSW	17	22,767,470 (GRCm39)	missense	probably damaging	0.99
R5462:Vmn2r111	UTSW	17	22,767,238 (GRCm39)	missense	probably damaging	1.00
R6149:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6149:Vmn2r111	UTSW	17	22,767,796 (GRCm39)	missense	probably benign	0.00
R6207:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6281:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6282:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6283:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6307:Vmn2r111	UTSW	17	22,792,070 (GRCm39)	missense	probably benign	0.00
R6323:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6325:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6368:Vmn2r111	UTSW	17	22,790,889 (GRCm39)	missense	probably benign	0.38
R6369:Vmn2r111	UTSW	17	22,767,583 (GRCm39)	missense	probably damaging	1.00
R6489:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6490:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6546:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6547:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6557:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6654:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6655:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6657:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6659:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6660:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6664:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6798:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6799:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6801:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6893:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6895:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6897:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6922:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6923:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6944:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6945:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7017:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7018:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7024:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7031:Vmn2r111	UTSW	17	22,790,226 (GRCm39)	missense	probably damaging	1.00
R7039:Vmn2r111	UTSW	17	22,767,165 (GRCm39)	missense	probably damaging	1.00
R7053:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7054:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7055:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7056:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7145:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7146:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7246:Vmn2r111	UTSW	17	22,767,695 (GRCm39)	missense	probably damaging	1.00
R7259:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7260:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7327:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7401:Vmn2r111	UTSW	17	22,790,067 (GRCm39)	missense	possibly damaging	0.93
R7514:Vmn2r111	UTSW	17	22,767,380 (GRCm39)	missense	probably benign	0.05
R7651:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7781:Vmn2r111	UTSW	17	22,789,714 (GRCm39)	missense	probably benign	0.17
R7816:Vmn2r111	UTSW	17	22,792,083 (GRCm39)	missense	probably damaging	0.97
R7821:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7838:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R8078:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R8080:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R8117:Vmn2r111	UTSW	17	22,790,469 (GRCm39)	missense	probably benign	0.12
R8171:Vmn2r111	UTSW	17	22,792,073 (GRCm39)	missense	probably benign	0.10
R8195:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R8197:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R8411:Vmn2r111	UTSW	17	22,767,562 (GRCm39)	missense	probably benign	0.03
R8539:Vmn2r111	UTSW	17	22,790,274 (GRCm39)	missense	probably benign	0.23
R8540:Vmn2r111	UTSW	17	22,778,024 (GRCm39)	missense	probably damaging	1.00
R8540:Vmn2r111	UTSW	17	22,778,023 (GRCm39)	critical splice donor site	probably null
R8557:Vmn2r111	UTSW	17	22,790,910 (GRCm39)	nonsense	probably null
R8720:Vmn2r111	UTSW	17	22,792,194 (GRCm39)	missense	possibly damaging	0.88
R8729:Vmn2r111	UTSW	17	22,767,239 (GRCm39)	missense	probably damaging	1.00
R8843:Vmn2r111	UTSW	17	22,767,011 (GRCm39)	missense	probably benign	0.00
R9184:Vmn2r111	UTSW	17	22,790,822 (GRCm39)	missense	probably benign
R9374:Vmn2r111	UTSW	17	22,787,859 (GRCm39)	missense	probably benign	0.17
R9452:Vmn2r111	UTSW	17	22,778,132 (GRCm39)	missense	probably damaging	1.00
X0026:Vmn2r111	UTSW	17	22,767,676 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- AGGTGTAAAAGATGCAGCCC -3'
(R):5'- TCAAGGAGTTGGGAAACAATTCAAC -3'

Sequencing Primer
(F):5'- GGTGTAAAAGATGCAGCCCAATTTC -3'
(R):5'- ACAATGCACTAAATAAGGTCTGC -3'

Posted On

2018-04-27