Incidental Mutation 'R4737:Erbb4'
| ID |
359299 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Erbb4
|
| Ensembl Gene |
ENSMUSG00000062209 |
| Gene Name |
erb-b2 receptor tyrosine kinase 4 |
| Synonyms |
Her4, ErbB4 |
| MMRRC Submission |
042024-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4737 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
68071345-69147218 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 68383059 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Valine
at position 313
(M313V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000115373
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000119142]
[ENSMUST00000121473]
[ENSMUST00000153432]
|
| AlphaFold |
Q61527 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000119142
AA Change: M313V
PolyPhen 2
Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000112713
Gene: ENSMUSG00000062209
AA Change: M313V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
5e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
1e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000121473
AA Change: M313V
PolyPhen 2
Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000114123
Gene: ENSMUSG00000062209
AA Change: M313V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.6e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.5e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000153432
AA Change: M313V
PolyPhen 2
Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000115373
Gene: ENSMUSG00000062209
AA Change: M313V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.7e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.7e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
649 |
2.98e0 |
SMART |
|
PDB:2R4B|B
|
680 |
732 |
1e-25 |
PDB |
|
| Meta Mutation Damage Score |
0.0983 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.3%
|
| Validation Efficiency |
100% (94/94) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit cardiac defects, alterations in hindbrain development, and midgestational lethality. Heterozygotes show schizophrenia-like behavior. Genetically rescued females show mammary defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(7) : Targeted(6) Gene trapped(1)
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A430110L20Rik |
A |
G |
1: 181,055,384 (GRCm39) |
|
noncoding transcript |
Het |
| Acp2 |
A |
T |
2: 91,041,068 (GRCm39) |
R419W |
probably benign |
Het |
| Actr5 |
A |
G |
2: 158,469,991 (GRCm39) |
N207S |
probably damaging |
Het |
| Afap1 |
G |
A |
5: 36,119,126 (GRCm39) |
V254M |
probably benign |
Het |
| Arfgef1 |
A |
T |
1: 10,259,836 (GRCm39) |
M544K |
possibly damaging |
Het |
| Arhgap5 |
A |
T |
12: 52,565,860 (GRCm39) |
M944L |
probably benign |
Het |
| Bnip3l-ps |
G |
A |
12: 18,266,773 (GRCm39) |
|
noncoding transcript |
Het |
| Carf |
A |
G |
1: 60,148,477 (GRCm39) |
T58A |
probably benign |
Het |
| Carns1 |
A |
G |
19: 4,220,927 (GRCm39) |
|
probably benign |
Het |
| Ccp110 |
T |
A |
7: 118,323,771 (GRCm39) |
I670K |
possibly damaging |
Het |
| Cftr |
T |
A |
6: 18,299,882 (GRCm39) |
D1218E |
probably benign |
Het |
| Chrna9 |
A |
T |
5: 66,125,214 (GRCm39) |
T52S |
probably damaging |
Het |
| Chst9 |
T |
C |
18: 15,585,834 (GRCm39) |
Y243C |
probably damaging |
Het |
| Ciao3 |
A |
T |
17: 26,000,283 (GRCm39) |
H322L |
probably damaging |
Het |
| Cilk1 |
A |
G |
9: 78,057,936 (GRCm39) |
T162A |
probably damaging |
Het |
| Clk2 |
A |
T |
3: 89,076,016 (GRCm39) |
H62L |
probably benign |
Het |
| Cntnap2 |
A |
T |
6: 45,037,251 (GRCm39) |
R10W |
possibly damaging |
Het |
| Cpt1b |
C |
T |
15: 89,305,609 (GRCm39) |
D369N |
probably benign |
Het |
| Crhr2 |
G |
T |
6: 55,068,290 (GRCm39) |
H423Q |
probably damaging |
Het |
| D8Ertd738e |
T |
A |
8: 84,976,150 (GRCm39) |
I33F |
probably damaging |
Het |
| Dbt |
T |
C |
3: 116,332,781 (GRCm39) |
I200T |
probably damaging |
Het |
| Ddhd1 |
A |
T |
14: 45,866,278 (GRCm39) |
|
probably benign |
Het |
| Ddx27 |
A |
G |
2: 166,871,219 (GRCm39) |
I480V |
probably benign |
Het |
| Dpp9 |
A |
C |
17: 56,505,970 (GRCm39) |
|
probably null |
Het |
| Dpy19l3 |
A |
T |
7: 35,402,926 (GRCm39) |
M562K |
probably damaging |
Het |
| Dus3l |
T |
C |
17: 57,074,868 (GRCm39) |
L330P |
probably damaging |
Het |
| Efcab7 |
C |
T |
4: 99,719,805 (GRCm39) |
Q96* |
probably null |
Het |
| Egfr |
T |
C |
11: 16,819,231 (GRCm39) |
F254L |
probably damaging |
Het |
| Eml5 |
C |
T |
12: 98,765,111 (GRCm39) |
V1566M |
probably damaging |
Het |
| Entpd7 |
T |
A |
19: 43,679,634 (GRCm39) |
Y62* |
probably null |
Het |
| Gm5528 |
A |
G |
1: 72,043,711 (GRCm39) |
|
noncoding transcript |
Het |
| H2-M9 |
G |
T |
17: 36,951,631 (GRCm39) |
Y281* |
probably null |
Het |
| Hmcn1 |
T |
G |
1: 150,565,346 (GRCm39) |
K2260N |
possibly damaging |
Het |
| Hnf4a |
A |
G |
2: 163,406,139 (GRCm39) |
I259V |
probably benign |
Het |
| Insm1 |
A |
T |
2: 146,064,822 (GRCm39) |
T213S |
probably benign |
Het |
| Iqca1 |
T |
C |
1: 90,005,544 (GRCm39) |
D488G |
probably damaging |
Het |
| Kdm5a |
T |
A |
6: 120,382,976 (GRCm39) |
|
probably benign |
Het |
| Kdm7a |
G |
C |
6: 39,129,773 (GRCm39) |
L468V |
possibly damaging |
Het |
| Lck |
G |
A |
4: 129,449,777 (GRCm39) |
T229I |
possibly damaging |
Het |
| Lig3 |
T |
C |
11: 82,678,553 (GRCm39) |
L265P |
probably damaging |
Het |
| Lipa |
T |
A |
19: 34,479,034 (GRCm39) |
K229* |
probably null |
Het |
| Lrrk1 |
C |
T |
7: 65,956,621 (GRCm39) |
S418N |
probably benign |
Het |
| Mark2 |
A |
G |
19: 7,258,597 (GRCm39) |
V126A |
probably damaging |
Het |
| Met |
T |
C |
6: 17,491,540 (GRCm39) |
C101R |
probably damaging |
Het |
| Mkln1 |
A |
T |
6: 31,403,734 (GRCm39) |
K85M |
probably damaging |
Het |
| Mst1 |
A |
G |
9: 107,957,720 (GRCm39) |
R15G |
probably benign |
Het |
| Muc6 |
T |
G |
7: 141,226,426 (GRCm39) |
|
probably benign |
Het |
| Muc6 |
G |
T |
7: 141,218,685 (GRCm39) |
T1996N |
possibly damaging |
Het |
| Myo7b |
T |
C |
18: 32,131,655 (GRCm39) |
S514G |
probably damaging |
Het |
| Nars1 |
T |
C |
18: 64,649,498 (GRCm39) |
E11G |
probably benign |
Het |
| Ogdh |
T |
A |
11: 6,247,044 (GRCm39) |
F23I |
probably benign |
Het |
| Or10g9 |
A |
T |
9: 39,911,718 (GRCm39) |
D268E |
probably damaging |
Het |
| Or12e9 |
T |
C |
2: 87,202,665 (GRCm39) |
I263T |
probably damaging |
Het |
| Or4a39 |
C |
T |
2: 89,236,830 (GRCm39) |
V198I |
probably benign |
Het |
| Or4b1b |
A |
G |
2: 90,112,725 (GRCm39) |
S65P |
probably damaging |
Het |
| Or4c100 |
C |
T |
2: 88,356,569 (GRCm39) |
S214F |
probably damaging |
Het |
| Or52r1c |
C |
T |
7: 102,735,121 (GRCm39) |
A127V |
probably damaging |
Het |
| Or9k2 |
T |
A |
10: 129,998,707 (GRCm39) |
T163S |
probably benign |
Het |
| Otub2 |
T |
A |
12: 103,359,103 (GRCm39) |
L64Q |
probably benign |
Het |
| Pappa2 |
T |
C |
1: 158,784,582 (GRCm39) |
R143G |
probably benign |
Het |
| Patl2 |
T |
A |
2: 121,955,787 (GRCm39) |
T250S |
probably damaging |
Het |
| Pcdhac2 |
C |
T |
18: 37,278,952 (GRCm39) |
T644I |
possibly damaging |
Het |
| Pi4kb |
C |
T |
3: 94,911,649 (GRCm39) |
T690I |
probably damaging |
Het |
| Pla2g4d |
T |
C |
2: 120,097,271 (GRCm39) |
Y776C |
probably benign |
Het |
| Plekhh2 |
C |
T |
17: 84,871,387 (GRCm39) |
S215L |
probably benign |
Het |
| Psmd2 |
T |
G |
16: 20,478,565 (GRCm39) |
|
probably benign |
Het |
| Ptpn21 |
T |
C |
12: 98,675,103 (GRCm39) |
E183G |
probably benign |
Het |
| Ptprg |
T |
A |
14: 12,226,314 (GRCm38) |
D527E |
probably damaging |
Het |
| Rhobtb1 |
T |
A |
10: 69,115,327 (GRCm39) |
|
probably null |
Het |
| Scel |
T |
A |
14: 103,809,473 (GRCm39) |
M271K |
possibly damaging |
Het |
| Senp3 |
A |
T |
11: 69,569,655 (GRCm39) |
C310* |
probably null |
Het |
| Slc25a3 |
T |
C |
10: 90,958,050 (GRCm39) |
T97A |
possibly damaging |
Het |
| Srsf11 |
A |
T |
3: 157,732,369 (GRCm39) |
Y82* |
probably null |
Het |
| Tbc1d8 |
G |
A |
1: 39,441,959 (GRCm39) |
T211I |
possibly damaging |
Het |
| Tbkbp1 |
T |
C |
11: 97,039,474 (GRCm39) |
E145G |
probably damaging |
Het |
| Tln1 |
T |
C |
4: 43,540,588 (GRCm39) |
N1471S |
probably benign |
Het |
| Tnn |
T |
G |
1: 159,973,659 (GRCm39) |
D236A |
probably damaging |
Het |
| Trmt2a |
C |
T |
16: 18,069,150 (GRCm39) |
|
probably benign |
Het |
| Ttn |
A |
T |
2: 76,641,587 (GRCm39) |
L5176Q |
possibly damaging |
Het |
| Ubxn10 |
G |
A |
4: 138,463,259 (GRCm39) |
|
probably benign |
Het |
| Ulk4 |
G |
A |
9: 120,902,938 (GRCm39) |
Q1180* |
probably null |
Het |
| Usp43 |
T |
A |
11: 67,746,331 (GRCm39) |
K1120N |
probably damaging |
Het |
| Uspl1 |
T |
A |
5: 149,131,149 (GRCm39) |
L244Q |
possibly damaging |
Het |
| Vmn1r32 |
T |
C |
6: 66,530,629 (GRCm39) |
H49R |
probably damaging |
Het |
| Vmn2r4 |
T |
C |
3: 64,317,384 (GRCm39) |
D118G |
probably damaging |
Het |
| Vwce |
A |
G |
19: 10,627,943 (GRCm39) |
I468V |
probably benign |
Het |
| Zbtb7c |
G |
T |
18: 76,279,225 (GRCm39) |
R561L |
probably benign |
Het |
| Zfp956 |
T |
C |
6: 47,939,476 (GRCm39) |
S175P |
probably damaging |
Het |
|
| Other mutations in Erbb4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Erbb4
|
APN |
1 |
68,110,789 (GRCm39) |
nonsense |
probably null |
|
|
IGL01020:Erbb4
|
APN |
1 |
68,337,608 (GRCm39) |
splice site |
probably benign |
|
|
IGL01349:Erbb4
|
APN |
1 |
68,385,752 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01386:Erbb4
|
APN |
1 |
68,383,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Erbb4
|
APN |
1 |
68,367,404 (GRCm39) |
nonsense |
probably null |
|
|
IGL01536:Erbb4
|
APN |
1 |
68,329,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01721:Erbb4
|
APN |
1 |
68,293,722 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL01832:Erbb4
|
APN |
1 |
68,293,725 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02002:Erbb4
|
APN |
1 |
68,119,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02040:Erbb4
|
APN |
1 |
68,081,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02371:Erbb4
|
APN |
1 |
68,329,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02399:Erbb4
|
APN |
1 |
68,081,596 (GRCm39) |
splice site |
probably benign |
|
|
IGL02553:Erbb4
|
APN |
1 |
68,345,023 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03118:Erbb4
|
APN |
1 |
68,081,878 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03329:Erbb4
|
APN |
1 |
68,367,281 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL03405:Erbb4
|
APN |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
earthworm
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
excrescence
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mole
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0018:Erbb4
|
UTSW |
1 |
68,110,835 (GRCm39) |
missense |
probably benign |
0.05 |
|
PIT4480001:Erbb4
|
UTSW |
1 |
68,114,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Erbb4
|
UTSW |
1 |
68,083,119 (GRCm39) |
intron |
probably benign |
|
|
R0329:Erbb4
|
UTSW |
1 |
68,337,439 (GRCm39) |
splice site |
probably benign |
|
|
R0335:Erbb4
|
UTSW |
1 |
68,298,418 (GRCm39) |
missense |
probably benign |
|
|
R0362:Erbb4
|
UTSW |
1 |
68,369,429 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0579:Erbb4
|
UTSW |
1 |
68,081,621 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0730:Erbb4
|
UTSW |
1 |
68,298,449 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1029:Erbb4
|
UTSW |
1 |
68,348,773 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1444:Erbb4
|
UTSW |
1 |
68,293,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1503:Erbb4
|
UTSW |
1 |
68,385,705 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1523:Erbb4
|
UTSW |
1 |
68,435,411 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1528:Erbb4
|
UTSW |
1 |
68,117,741 (GRCm39) |
nonsense |
probably null |
|
|
R1604:Erbb4
|
UTSW |
1 |
68,385,728 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1611:Erbb4
|
UTSW |
1 |
68,079,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Erbb4
|
UTSW |
1 |
68,370,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1905:Erbb4
|
UTSW |
1 |
68,114,569 (GRCm39) |
splice site |
probably benign |
|
|
R1929:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2046:Erbb4
|
UTSW |
1 |
68,337,482 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2139:Erbb4
|
UTSW |
1 |
68,385,788 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2271:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2298:Erbb4
|
UTSW |
1 |
68,081,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2356:Erbb4
|
UTSW |
1 |
68,117,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3821:Erbb4
|
UTSW |
1 |
68,345,072 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4007:Erbb4
|
UTSW |
1 |
68,779,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4012:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4077:Erbb4
|
UTSW |
1 |
68,079,496 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4196:Erbb4
|
UTSW |
1 |
68,383,014 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4536:Erbb4
|
UTSW |
1 |
68,385,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4561:Erbb4
|
UTSW |
1 |
68,383,080 (GRCm39) |
nonsense |
probably null |
|
|
R4642:Erbb4
|
UTSW |
1 |
68,289,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4739:Erbb4
|
UTSW |
1 |
68,383,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4780:Erbb4
|
UTSW |
1 |
68,337,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4802:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4811:Erbb4
|
UTSW |
1 |
68,293,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4832:Erbb4
|
UTSW |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5068:Erbb4
|
UTSW |
1 |
68,083,061 (GRCm39) |
splice site |
probably null |
|
|
R5546:Erbb4
|
UTSW |
1 |
68,337,452 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5755:Erbb4
|
UTSW |
1 |
68,599,678 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6189:Erbb4
|
UTSW |
1 |
68,083,075 (GRCm39) |
missense |
probably benign |
|
|
R6257:Erbb4
|
UTSW |
1 |
68,435,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6276:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6521:Erbb4
|
UTSW |
1 |
68,081,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6602:Erbb4
|
UTSW |
1 |
68,409,662 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6808:Erbb4
|
UTSW |
1 |
68,079,462 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7087:Erbb4
|
UTSW |
1 |
68,779,650 (GRCm39) |
missense |
probably null |
1.00 |
|
R7215:Erbb4
|
UTSW |
1 |
68,378,619 (GRCm39) |
missense |
probably benign |
|
|
R7356:Erbb4
|
UTSW |
1 |
68,378,514 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7509:Erbb4
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7593:Erbb4
|
UTSW |
1 |
68,293,758 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7743:Erbb4
|
UTSW |
1 |
68,367,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7784:Erbb4
|
UTSW |
1 |
68,114,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7815:Erbb4
|
UTSW |
1 |
68,081,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7923:Erbb4
|
UTSW |
1 |
68,298,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Erbb4
|
UTSW |
1 |
68,435,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Erbb4
|
UTSW |
1 |
68,337,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8356:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8456:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8464:Erbb4
|
UTSW |
1 |
68,348,785 (GRCm39) |
missense |
probably benign |
|
|
R8783:Erbb4
|
UTSW |
1 |
68,079,331 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8830:Erbb4
|
UTSW |
1 |
68,114,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8881:Erbb4
|
UTSW |
1 |
68,382,997 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9053:Erbb4
|
UTSW |
1 |
68,289,779 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9142:Erbb4
|
UTSW |
1 |
68,388,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9237:Erbb4
|
UTSW |
1 |
68,081,601 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9350:Erbb4
|
UTSW |
1 |
68,329,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9374:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9434:Erbb4
|
UTSW |
1 |
68,081,773 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9499:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9551:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9753:Erbb4
|
UTSW |
1 |
68,238,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0019:Erbb4
|
UTSW |
1 |
68,112,304 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Erbb4
|
UTSW |
1 |
68,367,418 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Erbb4
|
UTSW |
1 |
68,337,561 (GRCm39) |
frame shift |
probably null |
|
|
Z1177:Erbb4
|
UTSW |
1 |
68,348,802 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,329,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,298,342 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CTGAGTAGCTAATCCCACTGG -3'
(R):5'- ATGTATGTGGTTCAGAGGAAGAGTC -3'
Sequencing Primer
(F):5'- CTAGACCAGACTGTTCTAGAGTTCG -3'
(R):5'- TGTGGTTCAGAGGAAGAGTCATAAAC -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation