Incidental Mutation 'R0718:Plxnd1'
| ID |
63701 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Plxnd1
|
| Ensembl Gene |
ENSMUSG00000030123 |
| Gene Name |
plexin D1 |
| Synonyms |
b2b553Clo, 6230425C21Rik, b2b1863Clo |
| MMRRC Submission |
038900-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0718 (G1)
|
| Quality Score |
160 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
115954811-115995005 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 115966638 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Aspartic acid
at position 1202
(E1202D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000015511
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015511]
|
| AlphaFold |
Q3UH93 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000015511
AA Change: E1202D
PolyPhen 2
Score 0.676 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000015511
Gene: ENSMUSG00000030123
AA Change: E1202D
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
48 |
N/A |
INTRINSIC |
|
Sema
|
61 |
531 |
6.52e-90 |
SMART |
|
PSI
|
550 |
603 |
6.06e-12 |
SMART |
|
PSI
|
703 |
755 |
1.06e-2 |
SMART |
|
Blast:PSI
|
850 |
891 |
9e-20 |
BLAST |
|
IPT
|
892 |
981 |
4.43e-20 |
SMART |
|
IPT
|
982 |
1068 |
6.61e-19 |
SMART |
|
IPT
|
1070 |
1149 |
6.13e-14 |
SMART |
|
transmembrane domain
|
1271 |
1293 |
N/A |
INTRINSIC |
|
Pfam:Plexin_cytopl
|
1345 |
1888 |
5e-238 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131590
|
| SMART Domains |
Protein: ENSMUSP00000115650
Gene: ENSMUSG00000030123
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:PSI
|
2 |
34 |
1e-13 |
BLAST |
|
IPT
|
35 |
124 |
4.43e-20 |
SMART |
|
Blast:IPT
|
125 |
177 |
3e-30 |
BLAST |
|
Pfam:TIG
|
180 |
233 |
4.6e-6 |
PFAM |
|
| Meta Mutation Damage Score |
0.0622 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.6%
- 20x: 95.9%
|
| Validation Efficiency |
100% (96/96) |
| MGI Phenotype |
PHENOTYPE: Homozygous null mice display neonatal lethality, thin-walled atria, and vascular abnormalities including abnormal branchial arch artery development, cardiac outflow tract abnormalities, and reduced vascular smooth muscle around some vessels. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamtsl4 |
A |
T |
3: 95,679,608 (GRCm38) |
Y811N |
possibly damaging |
Het |
| Adrm1 |
T |
C |
2: 180,175,147 (GRCm38) |
|
probably benign |
Het |
| Alms1 |
T |
A |
6: 85,621,821 (GRCm38) |
S1210T |
probably benign |
Het |
| Ampd3 |
C |
T |
7: 110,777,808 (GRCm38) |
P11L |
probably damaging |
Het |
| Arhgap5 |
A |
G |
12: 52,516,507 (GRCm38) |
E87G |
possibly damaging |
Het |
| Armc5 |
C |
T |
7: 128,240,070 (GRCm38) |
|
probably benign |
Het |
| Asic2 |
C |
G |
11: 80,971,456 (GRCm38) |
|
probably benign |
Het |
| Asph |
A |
G |
4: 9,514,683 (GRCm38) |
|
probably benign |
Het |
| Bicd2 |
T |
A |
13: 49,377,875 (GRCm38) |
|
probably null |
Het |
| Brip1 |
A |
G |
11: 86,143,305 (GRCm38) |
L530P |
possibly damaging |
Het |
| Bsn |
G |
T |
9: 108,111,360 (GRCm38) |
|
probably benign |
Het |
| Btnl4 |
T |
A |
17: 34,469,634 (GRCm38) |
H390L |
probably benign |
Het |
| Ccdc70 |
A |
C |
8: 21,973,308 (GRCm38) |
K38T |
probably damaging |
Het |
| Ccni |
G |
A |
5: 93,202,316 (GRCm38) |
P35S |
probably benign |
Het |
| Cdh17 |
A |
G |
4: 11,810,451 (GRCm38) |
D714G |
possibly damaging |
Het |
| Cenpf |
A |
G |
1: 189,653,984 (GRCm38) |
L2033P |
probably damaging |
Het |
| Cfap69 |
A |
T |
5: 5,621,924 (GRCm38) |
M328K |
probably damaging |
Het |
| Cmah |
T |
G |
13: 24,417,210 (GRCm38) |
|
probably null |
Het |
| Cog6 |
T |
C |
3: 53,010,629 (GRCm38) |
T163A |
probably benign |
Het |
| Cyp2j8 |
G |
A |
4: 96,501,196 (GRCm38) |
S130F |
probably benign |
Het |
| Dgki |
A |
G |
6: 37,012,896 (GRCm38) |
V636A |
probably damaging |
Het |
| Dmkn |
T |
A |
7: 30,764,786 (GRCm38) |
|
probably benign |
Het |
| Dnah6 |
A |
G |
6: 73,035,293 (GRCm38) |
I3679T |
possibly damaging |
Het |
| Dsp |
A |
T |
13: 38,196,764 (GRCm38) |
Y2495F |
possibly damaging |
Het |
| Exosc4 |
C |
T |
15: 76,329,489 (GRCm38) |
A171V |
probably benign |
Het |
| Fbxw24 |
A |
G |
9: 109,623,509 (GRCm38) |
|
probably benign |
Het |
| Flvcr1 |
A |
T |
1: 191,025,582 (GRCm38) |
L171Q |
probably damaging |
Het |
| Fsd1 |
G |
T |
17: 55,996,445 (GRCm38) |
|
probably null |
Het |
| Gm7732 |
A |
G |
17: 21,129,844 (GRCm38) |
|
noncoding transcript |
Het |
| H2-K2 |
A |
C |
17: 33,975,623 (GRCm38) |
|
noncoding transcript |
Het |
| Hgf |
A |
G |
5: 16,593,859 (GRCm38) |
N295S |
probably damaging |
Het |
| Ift88 |
T |
A |
14: 57,517,413 (GRCm38) |
D811E |
probably benign |
Het |
| Igsf9b |
T |
A |
9: 27,323,361 (GRCm38) |
|
probably null |
Het |
| Immt |
T |
A |
6: 71,863,172 (GRCm38) |
V311E |
probably damaging |
Het |
| Ipo11 |
T |
A |
13: 106,919,611 (GRCm38) |
N51I |
possibly damaging |
Het |
| Isy1 |
T |
C |
6: 87,819,176 (GRCm38) |
K260E |
probably damaging |
Het |
| Jchain |
T |
G |
5: 88,526,202 (GRCm38) |
I28L |
probably benign |
Het |
| Jmjd1c |
T |
A |
10: 67,218,946 (GRCm38) |
|
probably null |
Het |
| Kif13b |
T |
C |
14: 64,751,662 (GRCm38) |
|
probably benign |
Het |
| Klhdc7b |
T |
C |
15: 89,388,169 (GRCm38) |
Y427H |
possibly damaging |
Het |
| Klhl8 |
T |
C |
5: 103,876,293 (GRCm38) |
|
probably benign |
Het |
| Lrp2 |
C |
T |
2: 69,510,948 (GRCm38) |
D963N |
probably damaging |
Het |
| Ltbp3 |
G |
T |
19: 5,746,748 (GRCm38) |
|
probably benign |
Het |
| Ltf |
C |
A |
9: 111,040,379 (GRCm38) |
Q41K |
probably benign |
Het |
| Med4 |
T |
A |
14: 73,516,657 (GRCm38) |
I148N |
probably damaging |
Het |
| Mlh3 |
T |
G |
12: 85,247,697 (GRCm38) |
S1242R |
possibly damaging |
Het |
| Mllt6 |
T |
C |
11: 97,676,359 (GRCm38) |
|
probably benign |
Het |
| Mpdz |
A |
G |
4: 81,292,473 (GRCm38) |
I1712T |
possibly damaging |
Het |
| Mrgprb4 |
T |
A |
7: 48,198,553 (GRCm38) |
H209L |
probably benign |
Het |
| Nkapl |
A |
T |
13: 21,468,440 (GRCm38) |
M1K |
probably null |
Het |
| Nmur2 |
T |
A |
11: 56,029,498 (GRCm38) |
|
probably benign |
Het |
| Nsun2 |
T |
A |
13: 69,543,697 (GRCm38) |
|
probably benign |
Het |
| Olfr1082 |
G |
A |
2: 86,594,081 (GRCm38) |
T249I |
probably benign |
Het |
| Olfr1130 |
A |
G |
2: 87,607,927 (GRCm38) |
I180V |
probably benign |
Het |
| Ovgp1 |
T |
C |
3: 105,974,830 (GRCm38) |
|
probably benign |
Het |
| Pcdh8 |
A |
G |
14: 79,770,691 (GRCm38) |
V144A |
possibly damaging |
Het |
| Pcnx3 |
G |
A |
19: 5,677,728 (GRCm38) |
|
probably benign |
Het |
| Pla2r1 |
C |
A |
2: 60,479,530 (GRCm38) |
V570L |
possibly damaging |
Het |
| Ppp1r37 |
T |
C |
7: 19,532,254 (GRCm38) |
E529G |
probably benign |
Het |
| Prdm15 |
A |
G |
16: 97,812,633 (GRCm38) |
F496L |
possibly damaging |
Het |
| Prlhr |
A |
T |
19: 60,468,005 (GRCm38) |
V41D |
probably benign |
Het |
| Prlhr |
G |
T |
19: 60,468,059 (GRCm38) |
S23* |
probably null |
Het |
| Prpf4 |
C |
T |
4: 62,414,540 (GRCm38) |
|
probably benign |
Het |
| Psg26 |
T |
C |
7: 18,478,287 (GRCm38) |
H381R |
probably benign |
Het |
| Psg26 |
C |
T |
7: 18,475,235 (GRCm38) |
R416H |
probably benign |
Het |
| Ralgds |
T |
G |
2: 28,549,116 (GRCm38) |
M717R |
probably benign |
Het |
| Rbms1 |
T |
C |
2: 60,842,412 (GRCm38) |
N44D |
probably damaging |
Het |
| Rpa1 |
T |
C |
11: 75,318,401 (GRCm38) |
|
probably benign |
Het |
| Rprd2 |
T |
C |
3: 95,766,387 (GRCm38) |
N568S |
probably benign |
Het |
| Rptor |
A |
G |
11: 119,872,376 (GRCm38) |
M929V |
probably benign |
Het |
| Rspo1 |
T |
A |
4: 125,007,149 (GRCm38) |
C97S |
possibly damaging |
Het |
| Scin |
C |
T |
12: 40,079,607 (GRCm38) |
G396S |
probably damaging |
Het |
| Scn9a |
T |
C |
2: 66,547,112 (GRCm38) |
N409D |
probably damaging |
Het |
| Sf3b1 |
A |
G |
1: 55,019,385 (GRCm38) |
I15T |
probably damaging |
Het |
| Sh3bp2 |
T |
C |
5: 34,555,495 (GRCm38) |
V149A |
probably damaging |
Het |
| Slc39a12 |
T |
A |
2: 14,407,426 (GRCm38) |
|
probably benign |
Het |
| Sp9 |
G |
T |
2: 73,273,827 (GRCm38) |
A242S |
possibly damaging |
Het |
| Srr |
A |
G |
11: 74,911,065 (GRCm38) |
V126A |
possibly damaging |
Het |
| Tatdn3 |
G |
T |
1: 191,052,849 (GRCm38) |
|
probably benign |
Het |
| Tex14 |
G |
A |
11: 87,499,613 (GRCm38) |
V379I |
probably benign |
Het |
| Tmed6 |
T |
C |
8: 107,061,724 (GRCm38) |
N197S |
probably damaging |
Het |
| Ttbk2 |
G |
A |
2: 120,748,575 (GRCm38) |
L689F |
probably benign |
Het |
| Ttbk2 |
A |
T |
2: 120,745,160 (GRCm38) |
I1043N |
probably benign |
Het |
| Ttn |
A |
G |
2: 76,810,696 (GRCm38) |
S5283P |
probably damaging |
Het |
| Ube3b |
C |
A |
5: 114,402,555 (GRCm38) |
S441* |
probably null |
Het |
| Ush2a |
G |
A |
1: 188,797,830 (GRCm38) |
C3272Y |
probably damaging |
Het |
| Vac14 |
T |
A |
8: 110,632,477 (GRCm38) |
I95K |
probably damaging |
Het |
| Vangl2 |
G |
A |
1: 172,006,217 (GRCm38) |
A433V |
probably damaging |
Het |
| Vwa5b1 |
A |
T |
4: 138,608,824 (GRCm38) |
V153D |
probably damaging |
Het |
| Zfhx3 |
T |
A |
8: 108,955,650 (GRCm38) |
D3240E |
unknown |
Het |
| Zfp945 |
A |
G |
17: 22,851,030 (GRCm38) |
C632R |
probably damaging |
Het |
| Zfyve26 |
G |
A |
12: 79,265,802 (GRCm38) |
|
probably benign |
Het |
| Zyg11b |
A |
T |
4: 108,242,076 (GRCm38) |
I606N |
possibly damaging |
Het |
|
| Other mutations in Plxnd1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00764:Plxnd1
|
APN |
6 |
115,967,972 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
IGL01099:Plxnd1
|
APN |
6 |
115,969,945 (GRCm38) |
missense |
probably benign |
|
|
IGL01323:Plxnd1
|
APN |
6 |
115,966,799 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
IGL01382:Plxnd1
|
APN |
6 |
115,960,527 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01786:Plxnd1
|
APN |
6 |
115,959,935 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02244:Plxnd1
|
APN |
6 |
115,978,257 (GRCm38) |
missense |
probably benign |
0.39 |
|
IGL02272:Plxnd1
|
APN |
6 |
115,993,628 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02293:Plxnd1
|
APN |
6 |
115,963,913 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02465:Plxnd1
|
APN |
6 |
115,955,742 (GRCm38) |
makesense |
probably null |
|
|
IGL02873:Plxnd1
|
APN |
6 |
115,959,976 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03209:Plxnd1
|
APN |
6 |
115,962,357 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Hiss
|
UTSW |
6 |
115,969,929 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
murmer
|
UTSW |
6 |
115,968,793 (GRCm38) |
missense |
probably benign |
0.00 |
|
mutter
|
UTSW |
6 |
115,968,044 (GRCm38) |
missense |
probably benign |
0.27 |
|
rattle
|
UTSW |
6 |
115,959,794 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0238:Plxnd1
|
UTSW |
6 |
115,968,793 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0238:Plxnd1
|
UTSW |
6 |
115,968,793 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0239:Plxnd1
|
UTSW |
6 |
115,968,793 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0239:Plxnd1
|
UTSW |
6 |
115,968,793 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0357:Plxnd1
|
UTSW |
6 |
115,969,460 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0646:Plxnd1
|
UTSW |
6 |
115,958,699 (GRCm38) |
splice site |
probably benign |
|
|
R0648:Plxnd1
|
UTSW |
6 |
115,994,001 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R1116:Plxnd1
|
UTSW |
6 |
115,967,005 (GRCm38) |
splice site |
probably null |
|
|
R1292:Plxnd1
|
UTSW |
6 |
115,962,683 (GRCm38) |
unclassified |
probably benign |
|
|
R1715:Plxnd1
|
UTSW |
6 |
115,968,681 (GRCm38) |
missense |
probably benign |
0.02 |
|
R1760:Plxnd1
|
UTSW |
6 |
115,967,779 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1799:Plxnd1
|
UTSW |
6 |
115,994,057 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1817:Plxnd1
|
UTSW |
6 |
115,980,601 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R1848:Plxnd1
|
UTSW |
6 |
115,966,546 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1851:Plxnd1
|
UTSW |
6 |
115,963,914 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1864:Plxnd1
|
UTSW |
6 |
115,969,441 (GRCm38) |
splice site |
probably null |
|
|
R1865:Plxnd1
|
UTSW |
6 |
115,969,441 (GRCm38) |
splice site |
probably null |
|
|
R1875:Plxnd1
|
UTSW |
6 |
115,978,084 (GRCm38) |
splice site |
probably null |
|
|
R1899:Plxnd1
|
UTSW |
6 |
115,969,363 (GRCm38) |
missense |
probably benign |
|
|
R1913:Plxnd1
|
UTSW |
6 |
115,978,017 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R1970:Plxnd1
|
UTSW |
6 |
115,962,517 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2007:Plxnd1
|
UTSW |
6 |
115,967,255 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2134:Plxnd1
|
UTSW |
6 |
115,957,548 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2202:Plxnd1
|
UTSW |
6 |
115,962,764 (GRCm38) |
missense |
probably benign |
0.45 |
|
R2230:Plxnd1
|
UTSW |
6 |
115,964,144 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2267:Plxnd1
|
UTSW |
6 |
115,962,743 (GRCm38) |
missense |
probably benign |
0.29 |
|
R2427:Plxnd1
|
UTSW |
6 |
115,967,748 (GRCm38) |
critical splice donor site |
probably null |
|
|
R4108:Plxnd1
|
UTSW |
6 |
115,959,315 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4233:Plxnd1
|
UTSW |
6 |
115,965,953 (GRCm38) |
missense |
probably benign |
0.30 |
|
R4280:Plxnd1
|
UTSW |
6 |
115,956,095 (GRCm38) |
splice site |
probably null |
|
|
R4280:Plxnd1
|
UTSW |
6 |
115,956,094 (GRCm38) |
splice site |
probably benign |
|
|
R4346:Plxnd1
|
UTSW |
6 |
115,977,980 (GRCm38) |
missense |
probably benign |
0.16 |
|
R4439:Plxnd1
|
UTSW |
6 |
115,993,976 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4572:Plxnd1
|
UTSW |
6 |
115,955,756 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4576:Plxnd1
|
UTSW |
6 |
115,968,044 (GRCm38) |
missense |
probably benign |
0.27 |
|
R4599:Plxnd1
|
UTSW |
6 |
115,994,276 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4614:Plxnd1
|
UTSW |
6 |
115,972,525 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R4700:Plxnd1
|
UTSW |
6 |
115,958,615 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4705:Plxnd1
|
UTSW |
6 |
115,958,620 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4806:Plxnd1
|
UTSW |
6 |
115,960,855 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4944:Plxnd1
|
UTSW |
6 |
115,955,765 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4977:Plxnd1
|
UTSW |
6 |
115,994,376 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5069:Plxnd1
|
UTSW |
6 |
115,965,901 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5155:Plxnd1
|
UTSW |
6 |
115,958,988 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5460:Plxnd1
|
UTSW |
6 |
115,957,648 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5729:Plxnd1
|
UTSW |
6 |
115,965,877 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5909:Plxnd1
|
UTSW |
6 |
115,968,688 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5992:Plxnd1
|
UTSW |
6 |
115,967,787 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R6129:Plxnd1
|
UTSW |
6 |
115,978,174 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6254:Plxnd1
|
UTSW |
6 |
115,977,960 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6273:Plxnd1
|
UTSW |
6 |
115,978,492 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6310:Plxnd1
|
UTSW |
6 |
115,976,736 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R6732:Plxnd1
|
UTSW |
6 |
115,969,929 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R6857:Plxnd1
|
UTSW |
6 |
115,993,763 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7243:Plxnd1
|
UTSW |
6 |
115,972,507 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7282:Plxnd1
|
UTSW |
6 |
115,960,837 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7632:Plxnd1
|
UTSW |
6 |
115,976,639 (GRCm38) |
missense |
probably benign |
|
|
R7699:Plxnd1
|
UTSW |
6 |
115,959,794 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R7915:Plxnd1
|
UTSW |
6 |
115,966,918 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8090:Plxnd1
|
UTSW |
6 |
115,956,617 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8382:Plxnd1
|
UTSW |
6 |
115,972,472 (GRCm38) |
missense |
probably benign |
|
|
R8507:Plxnd1
|
UTSW |
6 |
115,966,905 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8539:Plxnd1
|
UTSW |
6 |
115,962,807 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R8548:Plxnd1
|
UTSW |
6 |
115,957,597 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8963:Plxnd1
|
UTSW |
6 |
115,972,545 (GRCm38) |
nonsense |
probably null |
|
|
R9119:Plxnd1
|
UTSW |
6 |
115,955,871 (GRCm38) |
splice site |
probably benign |
|
|
R9177:Plxnd1
|
UTSW |
6 |
115,966,508 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9182:Plxnd1
|
UTSW |
6 |
115,993,785 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9185:Plxnd1
|
UTSW |
6 |
115,957,565 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9226:Plxnd1
|
UTSW |
6 |
115,957,563 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9433:Plxnd1
|
UTSW |
6 |
115,968,793 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9449:Plxnd1
|
UTSW |
6 |
115,955,769 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9451:Plxnd1
|
UTSW |
6 |
115,963,316 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R9599:Plxnd1
|
UTSW |
6 |
115,963,313 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R9627:Plxnd1
|
UTSW |
6 |
115,963,313 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R9644:Plxnd1
|
UTSW |
6 |
115,963,313 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R9672:Plxnd1
|
UTSW |
6 |
115,963,313 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
X0024:Plxnd1
|
UTSW |
6 |
115,963,310 (GRCm38) |
missense |
probably benign |
0.02 |
|
X0026:Plxnd1
|
UTSW |
6 |
115,966,784 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
Z1088:Plxnd1
|
UTSW |
6 |
115,967,510 (GRCm38) |
missense |
probably benign |
0.02 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCGATTTCTGTACCCAGAAGCCG -3'
(R):5'- CTGCAAGGTTCTCAACTCCACACTC -3'
Sequencing Primer
(F):5'- TGAGCAGTGGATGACTCTGT -3'
(R):5'- AGCCCTGAGCAATGCTTC -3'
|
| Posted On |
2013-07-30 |
Incidental Mutation