Incidental Mutation 'R5304:Trpm1'
| ID |
404431 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trpm1
|
| Ensembl Gene |
ENSMUSG00000030523 |
| Gene Name |
transient receptor potential cation channel, subfamily M, member 1 |
| Synonyms |
Mlsn1, melastatin, 4732499L03Rik, LTRPC1 |
| MMRRC Submission |
042887-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5304 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
63803583-63919523 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 63858694 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Phenylalanine
at position 239
(Y239F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000146265
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000085222]
[ENSMUST00000177102]
[ENSMUST00000205348]
[ENSMUST00000206277]
[ENSMUST00000206263]
[ENSMUST00000206706]
[ENSMUST00000205731]
[ENSMUST00000206314]
[ENSMUST00000205994]
|
| AlphaFold |
Q2TV84 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000083651
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000085222
AA Change: Y372F
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000082318
Gene: ENSMUSG00000030523
AA Change: Y372F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
183 |
195 |
N/A |
INTRINSIC |
|
low complexity region
|
289 |
307 |
N/A |
INTRINSIC |
|
low complexity region
|
456 |
491 |
N/A |
INTRINSIC |
|
Blast:ANK
|
505 |
533 |
1e-5 |
BLAST |
|
low complexity region
|
621 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
823 |
835 |
N/A |
INTRINSIC |
|
transmembrane domain
|
876 |
895 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
907 |
1120 |
6e-16 |
PFAM |
|
transmembrane domain
|
1150 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1216 |
1225 |
N/A |
INTRINSIC |
|
PDB:3E7K|H
|
1228 |
1279 |
1e-7 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107515
AA Change: Y239F
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000103139
Gene: ENSMUSG00000030523
AA Change: Y239F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
50 |
62 |
N/A |
INTRINSIC |
|
low complexity region
|
156 |
174 |
N/A |
INTRINSIC |
|
low complexity region
|
323 |
358 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000107516
AA Change: I372F
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141574
AA Change: Y428F
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177102
AA Change: Y256F
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000134947
Gene: ENSMUSG00000030523
AA Change: Y256F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
67 |
79 |
N/A |
INTRINSIC |
|
low complexity region
|
173 |
191 |
N/A |
INTRINSIC |
|
low complexity region
|
340 |
375 |
N/A |
INTRINSIC |
|
Blast:ANK
|
389 |
417 |
1e-5 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205348
AA Change: Y372F
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206277
AA Change: Y372F
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206263
AA Change: Y256F
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206706
AA Change: Y239F
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205731
AA Change: Y256F
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206314
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206453
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205994
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205434
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205960
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206404
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205610
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205684
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.8%
- 10x: 97.5%
- 20x: 95.9%
|
| Validation Efficiency |
99% (87/88) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous mutants have defects in rod and cone electrophysiology affecting the photoresponses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcy1 |
C |
T |
11: 7,014,198 (GRCm39) |
A200V |
probably benign |
Het |
| Adgrv1 |
T |
C |
13: 81,726,372 (GRCm39) |
D551G |
possibly damaging |
Het |
| Aldh3a2 |
A |
G |
11: 61,144,538 (GRCm39) |
V340A |
probably damaging |
Het |
| Amy1 |
C |
A |
3: 113,352,013 (GRCm39) |
C393F |
probably damaging |
Het |
| Ankrd16 |
T |
C |
2: 11,794,545 (GRCm39) |
V310A |
probably benign |
Het |
| Arhgef15 |
T |
C |
11: 68,838,063 (GRCm39) |
S686G |
probably null |
Het |
| Arid4b |
T |
A |
13: 14,361,514 (GRCm39) |
N659K |
probably benign |
Het |
| Asz1 |
C |
T |
6: 18,076,619 (GRCm39) |
R191Q |
probably benign |
Het |
| Atp2a3 |
A |
G |
11: 72,879,383 (GRCm39) |
I947V |
probably damaging |
Het |
| AW011738 |
G |
A |
4: 156,287,969 (GRCm39) |
|
probably benign |
Het |
| Bfsp1 |
G |
T |
2: 143,669,211 (GRCm39) |
T456K |
probably benign |
Het |
| Cdc25c |
T |
C |
18: 34,883,864 (GRCm39) |
T40A |
possibly damaging |
Het |
| Cdh20 |
G |
A |
1: 110,036,569 (GRCm39) |
C583Y |
probably damaging |
Het |
| Ceacam23 |
A |
C |
7: 17,636,617 (GRCm39) |
E231D |
probably benign |
Het |
| Cfap54 |
A |
T |
10: 92,656,968 (GRCm39) |
L3028Q |
probably damaging |
Het |
| Chd1 |
A |
G |
17: 15,975,213 (GRCm39) |
S1088G |
probably benign |
Het |
| Chd1 |
A |
T |
17: 15,990,530 (GRCm39) |
H1694L |
possibly damaging |
Het |
| Cstf3 |
G |
T |
2: 104,493,735 (GRCm39) |
E580* |
probably null |
Het |
| Dip2a |
A |
T |
10: 76,130,357 (GRCm39) |
M622K |
possibly damaging |
Het |
| Dlgap1 |
A |
T |
17: 71,122,202 (GRCm39) |
H877L |
probably damaging |
Het |
| Egfr |
G |
T |
11: 16,834,260 (GRCm39) |
M122I |
probably benign |
Het |
| Etfbkmt |
T |
A |
6: 149,048,704 (GRCm39) |
D114E |
probably damaging |
Het |
| Eva1c |
T |
C |
16: 90,666,551 (GRCm39) |
L158P |
probably damaging |
Het |
| Exo1 |
G |
A |
1: 175,720,542 (GRCm39) |
V287M |
probably damaging |
Het |
| Fam171a1 |
T |
C |
2: 3,226,654 (GRCm39) |
Y471H |
probably damaging |
Het |
| Fermt1 |
T |
A |
2: 132,783,986 (GRCm39) |
T8S |
probably benign |
Het |
| Fgfr2 |
G |
T |
7: 129,769,504 (GRCm39) |
P630T |
probably damaging |
Het |
| Fmo5 |
G |
A |
3: 97,558,938 (GRCm39) |
G466E |
probably damaging |
Het |
| Hcn4 |
A |
G |
9: 58,751,215 (GRCm39) |
I280M |
probably benign |
Het |
| Ifi208 |
A |
C |
1: 173,511,174 (GRCm39) |
K443T |
probably benign |
Het |
| Irs3 |
A |
G |
5: 137,643,003 (GRCm39) |
F145S |
probably benign |
Het |
| Kirrel1 |
T |
A |
3: 86,996,902 (GRCm39) |
H300L |
probably benign |
Het |
| Krit1 |
A |
G |
5: 3,869,326 (GRCm39) |
Q340R |
probably damaging |
Het |
| Lipo5 |
T |
C |
19: 33,445,149 (GRCm39) |
D140G |
unknown |
Het |
| Lrrtm4 |
A |
T |
6: 79,999,683 (GRCm39) |
Q365L |
probably benign |
Het |
| Lrwd1 |
G |
T |
5: 136,160,004 (GRCm39) |
T353K |
possibly damaging |
Het |
| Lsm14a |
A |
T |
7: 34,053,154 (GRCm39) |
S240R |
possibly damaging |
Het |
| Map3k5 |
A |
G |
10: 19,983,984 (GRCm39) |
I870V |
probably benign |
Het |
| Matcap2 |
A |
T |
9: 22,335,528 (GRCm39) |
T49S |
probably benign |
Het |
| Mmp17 |
A |
T |
5: 129,671,678 (GRCm39) |
E76V |
probably null |
Het |
| Mphosph10 |
A |
G |
7: 64,038,732 (GRCm39) |
F272L |
probably damaging |
Het |
| Mtcl2 |
G |
A |
2: 156,865,737 (GRCm39) |
Q1127* |
probably null |
Het |
| Myh10 |
A |
G |
11: 68,655,071 (GRCm39) |
K380R |
probably damaging |
Het |
| Myo3b |
C |
T |
2: 70,257,232 (GRCm39) |
P1282L |
probably damaging |
Het |
| Nemp2 |
T |
C |
1: 52,682,238 (GRCm39) |
|
probably benign |
Het |
| Ola1 |
T |
C |
2: 73,029,778 (GRCm39) |
I114V |
probably damaging |
Het |
| Or4c3d |
T |
A |
2: 89,882,257 (GRCm39) |
H137L |
probably benign |
Het |
| Or8k28 |
T |
A |
2: 86,285,779 (GRCm39) |
T279S |
probably damaging |
Het |
| Pabpc4 |
T |
G |
4: 123,184,100 (GRCm39) |
D204E |
probably benign |
Het |
| Pigr |
A |
T |
1: 130,777,230 (GRCm39) |
M679L |
probably benign |
Het |
| Pik3c2b |
A |
T |
1: 132,998,146 (GRCm39) |
M341L |
possibly damaging |
Het |
| Plin4 |
T |
A |
17: 56,413,132 (GRCm39) |
T498S |
probably benign |
Het |
| Ppp2r5e |
A |
G |
12: 75,562,459 (GRCm39) |
S15P |
possibly damaging |
Het |
| Prdm13 |
T |
C |
4: 21,678,984 (GRCm39) |
Y502C |
probably damaging |
Het |
| Ptprk |
T |
C |
10: 28,468,050 (GRCm39) |
|
probably null |
Het |
| Rapgef6 |
T |
C |
11: 54,548,200 (GRCm39) |
S505P |
probably benign |
Het |
| Rgmb |
G |
T |
17: 16,040,990 (GRCm39) |
S199* |
probably null |
Het |
| Rgsl1 |
T |
C |
1: 153,703,238 (GRCm39) |
T173A |
probably damaging |
Het |
| Rhobtb1 |
G |
T |
10: 69,105,742 (GRCm39) |
K102N |
probably damaging |
Het |
| Ripor2 |
A |
T |
13: 24,858,649 (GRCm39) |
D147V |
probably damaging |
Het |
| Rsad2 |
A |
T |
12: 26,500,681 (GRCm39) |
V202E |
probably damaging |
Het |
| Slc1a6 |
A |
G |
10: 78,629,141 (GRCm39) |
N186S |
probably damaging |
Het |
| Sorbs3 |
G |
A |
14: 70,422,345 (GRCm39) |
R622* |
probably null |
Het |
| Spag9 |
C |
A |
11: 93,959,838 (GRCm39) |
D342E |
probably damaging |
Het |
| Srgap3 |
T |
C |
6: 112,743,900 (GRCm39) |
Y446C |
probably damaging |
Het |
| Thsd7b |
C |
T |
1: 129,605,980 (GRCm39) |
R574* |
probably null |
Het |
| Tmem74 |
A |
T |
15: 43,730,217 (GRCm39) |
Y275* |
probably null |
Het |
| Topors |
A |
T |
4: 40,262,541 (GRCm39) |
S248T |
possibly damaging |
Het |
| Ttn |
T |
A |
2: 76,548,527 (GRCm39) |
Y30179F |
possibly damaging |
Het |
| Ugt2b34 |
A |
T |
5: 87,040,724 (GRCm39) |
F399L |
probably damaging |
Het |
| Ush2a |
A |
T |
1: 188,088,995 (GRCm39) |
I317F |
probably damaging |
Het |
| Usp1 |
T |
C |
4: 98,822,855 (GRCm39) |
V723A |
probably benign |
Het |
| Usp34 |
T |
G |
11: 23,293,616 (GRCm39) |
L237V |
probably damaging |
Het |
| Vgf |
A |
T |
5: 137,061,140 (GRCm39) |
D434V |
probably damaging |
Het |
| Vmn1r179 |
A |
G |
7: 23,628,100 (GRCm39) |
N97S |
probably benign |
Het |
| Vps13a |
A |
G |
19: 16,687,751 (GRCm39) |
L899P |
possibly damaging |
Het |
| Vps33b |
A |
T |
7: 79,924,001 (GRCm39) |
I41F |
probably damaging |
Het |
| Zap70 |
A |
T |
1: 36,817,299 (GRCm39) |
H210L |
probably damaging |
Het |
| Zc3h8 |
T |
C |
2: 128,770,835 (GRCm39) |
D300G |
probably benign |
Het |
| Zfp958 |
C |
A |
8: 4,676,196 (GRCm39) |
H55N |
possibly damaging |
Het |
|
| Other mutations in Trpm1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00093:Trpm1
|
APN |
7 |
63,893,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00465:Trpm1
|
APN |
7 |
63,897,215 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01118:Trpm1
|
APN |
7 |
63,885,572 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01148:Trpm1
|
APN |
7 |
63,893,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01303:Trpm1
|
APN |
7 |
63,860,578 (GRCm39) |
critical splice acceptor site |
probably benign |
0.00 |
|
IGL01432:Trpm1
|
APN |
7 |
63,884,767 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01433:Trpm1
|
APN |
7 |
63,854,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01506:Trpm1
|
APN |
7 |
63,893,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01626:Trpm1
|
APN |
7 |
63,918,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01640:Trpm1
|
APN |
7 |
63,876,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01899:Trpm1
|
APN |
7 |
63,884,742 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01959:Trpm1
|
APN |
7 |
63,858,723 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02210:Trpm1
|
APN |
7 |
63,860,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02268:Trpm1
|
APN |
7 |
63,867,362 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02331:Trpm1
|
APN |
7 |
63,884,800 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL02334:Trpm1
|
APN |
7 |
63,895,690 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02407:Trpm1
|
APN |
7 |
63,868,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02425:Trpm1
|
APN |
7 |
63,890,175 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02485:Trpm1
|
APN |
7 |
63,918,862 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL02635:Trpm1
|
APN |
7 |
63,848,972 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02640:Trpm1
|
APN |
7 |
63,868,881 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02827:Trpm1
|
APN |
7 |
63,868,908 (GRCm39) |
missense |
probably null |
1.00 |
|
PIT4458001:Trpm1
|
UTSW |
7 |
63,918,309 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
PIT4544001:Trpm1
|
UTSW |
7 |
63,848,998 (GRCm39) |
intron |
probably benign |
|
|
R0012:Trpm1
|
UTSW |
7 |
63,918,339 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0014:Trpm1
|
UTSW |
7 |
63,897,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0056:Trpm1
|
UTSW |
7 |
63,893,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0445:Trpm1
|
UTSW |
7 |
63,894,590 (GRCm39) |
unclassified |
probably benign |
|
|
R0463:Trpm1
|
UTSW |
7 |
63,870,002 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0469:Trpm1
|
UTSW |
7 |
63,873,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0510:Trpm1
|
UTSW |
7 |
63,873,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1301:Trpm1
|
UTSW |
7 |
63,852,801 (GRCm39) |
splice site |
probably null |
|
|
R1397:Trpm1
|
UTSW |
7 |
63,867,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1588:Trpm1
|
UTSW |
7 |
63,873,565 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1618:Trpm1
|
UTSW |
7 |
63,890,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1724:Trpm1
|
UTSW |
7 |
63,885,569 (GRCm39) |
nonsense |
probably null |
|
|
R1827:Trpm1
|
UTSW |
7 |
63,884,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1829:Trpm1
|
UTSW |
7 |
63,876,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1835:Trpm1
|
UTSW |
7 |
63,880,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Trpm1
|
UTSW |
7 |
63,917,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1895:Trpm1
|
UTSW |
7 |
63,873,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1946:Trpm1
|
UTSW |
7 |
63,873,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1959:Trpm1
|
UTSW |
7 |
63,879,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1960:Trpm1
|
UTSW |
7 |
63,879,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1980:Trpm1
|
UTSW |
7 |
63,858,182 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1989:Trpm1
|
UTSW |
7 |
63,858,780 (GRCm39) |
intron |
probably null |
|
|
R2054:Trpm1
|
UTSW |
7 |
63,890,303 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R2156:Trpm1
|
UTSW |
7 |
63,884,736 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2251:Trpm1
|
UTSW |
7 |
63,859,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3051:Trpm1
|
UTSW |
7 |
63,918,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3148:Trpm1
|
UTSW |
7 |
63,884,760 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3195:Trpm1
|
UTSW |
7 |
63,849,061 (GRCm39) |
nonsense |
probably null |
|
|
R3615:Trpm1
|
UTSW |
7 |
63,893,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3616:Trpm1
|
UTSW |
7 |
63,893,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3623:Trpm1
|
UTSW |
7 |
63,894,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3624:Trpm1
|
UTSW |
7 |
63,894,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3721:Trpm1
|
UTSW |
7 |
63,867,475 (GRCm39) |
intron |
probably benign |
|
|
R3822:Trpm1
|
UTSW |
7 |
63,867,451 (GRCm39) |
intron |
probably benign |
|
|
R4441:Trpm1
|
UTSW |
7 |
63,851,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4490:Trpm1
|
UTSW |
7 |
63,858,660 (GRCm39) |
nonsense |
probably null |
|
|
R4666:Trpm1
|
UTSW |
7 |
63,852,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4701:Trpm1
|
UTSW |
7 |
63,893,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4781:Trpm1
|
UTSW |
7 |
63,884,800 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4811:Trpm1
|
UTSW |
7 |
63,858,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5017:Trpm1
|
UTSW |
7 |
63,894,580 (GRCm39) |
unclassified |
probably benign |
|
|
R5030:Trpm1
|
UTSW |
7 |
63,885,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5195:Trpm1
|
UTSW |
7 |
63,887,441 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5238:Trpm1
|
UTSW |
7 |
63,918,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5575:Trpm1
|
UTSW |
7 |
63,870,018 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5613:Trpm1
|
UTSW |
7 |
63,858,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5855:Trpm1
|
UTSW |
7 |
63,918,710 (GRCm39) |
nonsense |
probably null |
|
|
R5947:Trpm1
|
UTSW |
7 |
63,873,547 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5988:Trpm1
|
UTSW |
7 |
63,876,553 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6054:Trpm1
|
UTSW |
7 |
63,918,450 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6088:Trpm1
|
UTSW |
7 |
63,917,724 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6259:Trpm1
|
UTSW |
7 |
63,918,226 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6379:Trpm1
|
UTSW |
7 |
63,848,942 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6380:Trpm1
|
UTSW |
7 |
63,918,045 (GRCm39) |
missense |
probably benign |
0.24 |
|
R6429:Trpm1
|
UTSW |
7 |
63,918,252 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6600:Trpm1
|
UTSW |
7 |
63,803,781 (GRCm39) |
start codon destroyed |
probably null |
0.56 |
|
R6622:Trpm1
|
UTSW |
7 |
63,890,343 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6939:Trpm1
|
UTSW |
7 |
63,918,045 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6944:Trpm1
|
UTSW |
7 |
63,893,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7025:Trpm1
|
UTSW |
7 |
63,876,462 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7112:Trpm1
|
UTSW |
7 |
63,885,593 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7168:Trpm1
|
UTSW |
7 |
63,918,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7219:Trpm1
|
UTSW |
7 |
63,854,333 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7224:Trpm1
|
UTSW |
7 |
63,868,854 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7285:Trpm1
|
UTSW |
7 |
63,859,729 (GRCm39) |
nonsense |
probably null |
|
|
R7367:Trpm1
|
UTSW |
7 |
63,918,549 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7449:Trpm1
|
UTSW |
7 |
63,858,723 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7466:Trpm1
|
UTSW |
7 |
63,890,330 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7498:Trpm1
|
UTSW |
7 |
63,858,657 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7581:Trpm1
|
UTSW |
7 |
63,854,303 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7776:Trpm1
|
UTSW |
7 |
63,897,939 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8062:Trpm1
|
UTSW |
7 |
63,851,689 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8069:Trpm1
|
UTSW |
7 |
63,858,718 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R8157:Trpm1
|
UTSW |
7 |
63,849,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8219:Trpm1
|
UTSW |
7 |
63,851,699 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8258:Trpm1
|
UTSW |
7 |
63,918,777 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8259:Trpm1
|
UTSW |
7 |
63,918,777 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8320:Trpm1
|
UTSW |
7 |
63,918,541 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8536:Trpm1
|
UTSW |
7 |
63,897,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8544:Trpm1
|
UTSW |
7 |
63,874,356 (GRCm39) |
splice site |
probably null |
|
|
R8813:Trpm1
|
UTSW |
7 |
63,851,756 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8912:Trpm1
|
UTSW |
7 |
63,918,628 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8954:Trpm1
|
UTSW |
7 |
63,858,089 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9139:Trpm1
|
UTSW |
7 |
63,848,943 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9205:Trpm1
|
UTSW |
7 |
63,890,319 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9258:Trpm1
|
UTSW |
7 |
63,884,713 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9283:Trpm1
|
UTSW |
7 |
63,873,623 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9394:Trpm1
|
UTSW |
7 |
63,918,480 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9430:Trpm1
|
UTSW |
7 |
63,873,446 (GRCm39) |
missense |
probably benign |
0.38 |
|
R9537:Trpm1
|
UTSW |
7 |
63,803,616 (GRCm39) |
unclassified |
probably benign |
|
|
R9616:Trpm1
|
UTSW |
7 |
63,858,132 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9774:Trpm1
|
UTSW |
7 |
63,898,041 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
X0026:Trpm1
|
UTSW |
7 |
63,918,658 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1176:Trpm1
|
UTSW |
7 |
63,854,342 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1176:Trpm1
|
UTSW |
7 |
63,852,879 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Trpm1
|
UTSW |
7 |
63,867,439 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCTCATCCATTAGCAGTCCAAAATC -3'
(R):5'- TTCCTTCAGGGTTGCACTGG -3'
Sequencing Primer
(F):5'- TCCAAAATCAAAAGTACTGGGTG -3'
(R):5'- GGGATGAGTTCATAAGCTGCC -3'
|
| Posted On |
2016-07-22 |
Incidental Mutation